Entrez Programming Utilities are tools that provide access to Entrez data outside of the regular web query interface and may be helpful for retrieving search results for future use in another environment.

• User Recommendations:  Please read for important information on scripting NCBI servers.
• EInfo:  Provides field index term counts, last update, and available links for each database.
• ESearch:  Searches and retrieves primary IDs (for use in EFetch, ELink and ESummary) and term translations, and optionally retains results for future use in the user's environment.
• EPost:  Posts a file containing a list of primary IDs for future use in the user's environment to use with subsequent search strategies.
• ESummary: Retrieves document summaries from a list of primary IDs or from the user's environment.
• EFetch:  Retrieves records in the requested format from a list of one or more primary IDs or from the user's environment.
• ELink:  Checks for the existence of an external or Related Articles link from a list of one or more primary IDs.  Retrieves primary IDs and relevancy scores for links to Entrez databases or Related Articles;  creates a hyperlink to the primary LinkOut provider for a specific ID and database, or lists LinkOut URLs and Attributes for multiple IDs.
• EGQuery: Provides Entrez database counts in XML for a single search using Global Query.

• SOAP Interface for Entrez Utilities
• MEDLINE UI / PubMed ID Matcher

• Entrez DTDs
• Demonstration Program
• Announcement Mailing List
• Help Desk

User Requirements
Do not overload NCBI's systems. Users intending to send numerous queries and/or retrieve large numbers of records from Entrez should comply with the following:

• Run retrieval scripts on weekends or between 9 PM and 5 AM ET weekdays for any series of more than 100 requests.
• Send E-utilities requests to http://eutils.ncbi.nlm.nih.gov, not the standard NCBI web address.
• Make no more than one request every 3 seconds.
• Use the URL parameter email, and tool for distributed software, so we can track your project and contact you if there is a problem.
• NCBI's Disclaimer and Copyright notice must be evident to users of your service.  NLM does not claim the copyright on the abstracts in PubMed; however, journal publishers or authors may. NLM provides no legal advice concerning distribution of copyrighted materials, consult your legal counsel.

Tool: A string with no internal spaces that identifies the resource which is using Entrez links (e.g., tool=flybase). This argument is used to help NCBI provide better service to third parties generating Entrez queries from programs. As with any query system, it is sometimes possible to ask the same question different ways, with different effects on performance. NCBI requests that developers sending batch requests include a constant 'tool' argument for all requests using the utilities.

tool=

E-mail Address: If you choose to provide an email address, we will use it to contact you if there are problems with your queries or if we are changing software interfaces that might specifically affect your requests. If you choose not to include an email address we cannot provide specific help to you,  but you can still sign up for utilities-announce to receive general announcements.

email=

Demonstration Programs
In order to demonstrate the capabilities of the E-Utilities (ESearch, EFetch and EPost, ESummary), NCBI has written two Perl scripts which may be downloaded and run from your machine.   Perl must be installed on your computer in order to run these programs, e.g., perl eutils_example.pl. After running the programs, we would recommend that you modify and extend them as you see fit to further examine the capabilities of the E-Utilities, to examine different databases, etc. Contained in the Perl script are comments describing the program design.

Click ESearch, EFetch or EPost, ESummary to retrieve the demonstration programs.  Select Save As from your web browser's File menu to save the programs on your computer. Internet Explorer users should choose Text File under Save as type.

Announcement Mailing List
For general announcements regarding the Entrez Utilities you may subscribe to the utilities-announce announcement mailing list. Please disregard the notice you receive about posting messages to the list. This mailing list is an announcement list only; individual subscribers may not send mail to this mailing list.  The list of subscribers is private.  You may subscribe on the web at:
http://www.ncbi.nlm.nih.gov/mailman/listinfo/utilities-announce

Write to the Help Desk
Suggestions, comments, and questions specifically relating to the EUtility programs may be sent to eutilities@ncbi.nlm.nih.gov. Assistance with search queries and database content or corrections should be sent to the Help Desk