ADEAR

Alzheimer's Disease Education & Referral Center

A Service of the National Institute on Aging

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Table of Contents

Preface

Introduction

The Impact of Alzheimer's Disease

Unraveling the Mystery

Part 1: A Walking Tour Through the Brain

Inside the Human Brain

Neurons and Their Jobs

Plaques and Tangles: The Hallmarks of AD

The Changing Brain in Alzheimer's Disease

Part 2: AD Research -- Finding New Answers and Asking Better Questions

The Search for Causes

Genetic Factors at Work in AD

• Genes and Early-onset Alzheimer's Disease
• A Different Genetic Story in Late-onset AD
• Other Factors at Work in AD
• Beta-amyloid
• Tau
• Cardiovascular Risk Factors
• Oxidative Damage from Free Radicals
• Inflammation
• Brain Infarction

New Techniques Help in Diagnosing AD

The Search for New Treatments

• Helping People with AD Maintain Their Mental Functioning
• Slowing, Delaying, or Preventing AD
• Managing Symptoms

Improving Support for Families and Other Caregivers

Glossary

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Credits