NHLBI Research Initiatives

From time to time, the NHLBI invites investigators to submit grant applications or contract proposals for specific research programs. We are currently soliciting applications for the programs described below. For a full details of these and other research initiatives, visit www.nhlbi.nih.gov/funding/inits/index.htm or the Web page that are linked each initiative number.

Biobehavioral Research for Effective Sleep

• Initiative Number: PA-00-046
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To understand the behavioral, psychosocial, and physiological consequences of acute and chronic partial sleep deprivation and to develop interventions to reduce sleep disturbances.

Biological Basis of Hutchinson-Gilford Syndrome: Relationship to Mutations in the Lamin A/C Gene and to Other Known Laminopathies

• Initiative Number: PA-03-069
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To understand how mutations in the gene for lamin A/C affect the structure of cell nuclei and lead to dysfunctions that, and in some instances, cause Hutchinson-Gilford syndrome.

Cellular and Molecular Imaging of the Cardiovascular, Pulmonary, and Hematopoietic Systems

• Initiative Number: RFA-HL-04-003
• Applications are due January 22, 2004.
• Objectives: To develop new methods of monitoring specific cell populations in vivo that can be used for cell-based therapies and to identify cellular pathways that regulate heart, lung, and blood functions.

Chemical Screens for New Inducers of Fetal Hemoglobin (SBIR/STTR)

• Initiative Number: PA-03-049
• Applications are accepted for April 1, August 1, and December 1 deadlines each year.
• Objectives: To develop drugs that increase fetal hemoglobin levels for the treatment of beta-chain hemoglobinopathies such as sickle cell disease and Cooley's anemia (beta-thalassemia).

Clinical Research Consortium to Improve Resuscitation Outcomes

• Initiative Number: RFA-HL-04-001
• Applications are due November 13, 2003.
• Objectives: To establish a Resuscitation Research Consortium to test research advances that may improve recovery from cardiopulmonary arrest.

Development of Diagnostic Screening Test for Salt Sensitivity (SBIR/STTR)

• Initiative Number: PA-03-123
• Applications are accepted for April 1, August 1, and December 1 deadlines each year.
• Objectives: To develop a non-invasive or minimally invasive, practical diagnostic screening test for salt sensitivity of blood pressure.

Functional Tissue Engineering for Heart, Vascular, Lung, Blood, and Sleep Disorders and Diseases (SBIR/STTR)

• Initiative Number: PAR-01-006
• Phase II applications are due March 12, 2004.
• Objectives: To develop biological substitutes for damaged tissues and organs.

Granulomatous Lung Inflammation in Sarcoidosis

• Initiative Number: RFA-HL-04-009
• Applications are due October 20, 2003.
• Objectives: To develop models of granulomatous inflammation in the lungs and to encourage investigators in other research areas to study sarcoidosis.

Immune System Development and the Genesis of Asthma

• Initiative Number: RFA-AI-03-041
• Applications are due November 21, 2003.
• Objectives: To define cellular and molecular mechanisms that lead to the development of asthma and to devise asthma prevention strategies.

Inflammation and Thrombosis

• Initiative Number: RFA-HL-04-005
• Applications are due January 22, 2004.
• Objectives: To identify new targets and develop therapies for thrombotic disorders such as heart attack, stroke, deep vein thrombosis (DVT), and pulmonary embolism in preclinical studies.

Pathogenesis and Treatment of Lymphedema

• Initiative Number: PA-01-035
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To stimulate research on the biology of the lymphatic system; the developmental, cellular, and molecular mechanisms that cause lymphedema; and new therapies for patients with lymphedema.

Pathophysiology and Treatment of Chronic Fatigue Syndrome (CFS)

• Initiative Number: PA-02-034
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To understand CFS pathogenesis and pathophysiology to improve diagnostic and treatment strategies.

Research on Ethical Issues in Human Studies

• Initiative Number: PA-02-103
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To study ethical challenges related to involving human participants in research (e.g., issues related to participant safety, informed consent, data management, and research oversight).

Restless Legs Syndrome and Periodic Limb Movement Disorder

• Initiative Number: PA-01-086
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To enhance understanding of and develop treatments for restless legs syndrome and periodic limb movement disorder.

Sleep Disturbance in Parkinson's Disease and Parkinson-like Conditions

• Initiative Number: PAS-03-131
• Applications are accepted for February 1, June 1, and October 1 deadlines each year.
• Objectives: To stimulate research on sleep disorders (e.g., the manifestation and natural history of symptoms or effects of pharmacotherapies) in Parkinson's disease and related conditions.

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