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November 17, 2004
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Birth control pills: Can antibiotics decrease their effectiveness?
Question I'm on birth control pills and currently taking antibiotics. I've heard that antibiotics can decrease the effectiveness of birth control pills. Is this true?

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Answer

The effects of antibiotics on birth control pills (oral contraceptives) may be overstated — except in the case of one antibiotic, rifampin. Studies clearly show that rifampin decreases the effectiveness of birth control pills in preventing ovulation.

Anecdotal evidence suggests this effect may also occur with other antibiotics, such as:

  • Amoxicillin
  • Metronidazole
  • Tetracycline
  • Cephalexin
  • Erythromycin
  • Isoniazid

No large studies have proved this effect. But researchers can't rule out the possibility that this may occur in a small number of women. If you're concerned, consider using a barrier method of contraception while taking antibiotics.


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By Mayo Clinic staff
March 13, 2003


AN00099

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