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Definition Return to top
Cryptococcosis is a rare fungal infection caused by inhaling the fungus, Cryptococcus neoformans.Causes, incidence, and risk factors Return to top
Cryptococcus neoformans, the fungus that causes this disease, is ordinarily found in soil. Once inhaled, infection with cryptococcosis may heal on its own, remain localized in the lungs, or spread throughout the body (disseminate).
Most cases occur in people whose resistance to infection is lowered (such as by HIV infection, high doses of corticosteroid medications, cancer chemotherapy, or Hodgkin's disease).
In people with normal immune systems, the pulmonary (lung) form may have no symptoms. However, in people with impaired immune systems, the cryptococcus organism may spread to the brain.
The onset of neurological symptoms is gradual. The majority of people with this condition have meningoencephalitis (swelling and irritation of the brain and spinal cord) at the time of diagnosis.
Cryptococcus is one of the most common life-threatening fungal infections in AIDS patients.
Symptoms Return to top
Signs and tests Return to top
Treatment Return to top
Some infections require no treatment. However, medical observation should continue for a year to detect any progression of the disease. If pulmonary lesions are present or the disease spreads, antifungal medications are prescribed, and treatment with these agents may be prolonged.Expectations (prognosis) Return to top
Central nervous system involvement often has a fatal outcome, or leads to permanent damage.Complications Return to top
Calling your health care provider Return to top
Call your health care provider if symptoms develop that are suggestive of cryptococcosis, particularly if you have an impaired immune system.Prevention Return to top
Minimize doses of corticosteroid medications. Safer sex practices reduce the risk of acquiring HIV and the subsequent opportunistic infections associated with a weakened immune system. Update Date: 7/16/2004 Updated by: Daniel Levy, M.D., Ph.D., Infectious Diseases, Greater Baltimore Medical Center, Baltimore, MD. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |