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2004
September 2004
Journal of Experimental Medicine - 2004
Varicella-Zoster
Virus Transfer to Skin by T Cells and Modulation of Viral
Replication by Epidermal Cell Interferon-{alpha}
Ku CC, Zerboni L, Ito H, Graham BS, Wallace M, Arvin AM
J Exp Med. 2004 Sep 27 [Epub ahead of print]
Journal of Immunology- 2004
Prolonged
production of TNF-alpha exacerbates illness during respiratory
syncytial virus infection.
Rutigliano JA, Graham BS.
J Immunol. 2004 Sep 1;173(5):3408-17.
Journal of Infectious Diseases- 2004
Breakthrough
infections during phase 1 and 2 prime-boost HIV-1 vaccine
trials with canarypox vectors (ALVAC) and booster dose of
recombinant gp120 or gp160.
Lee D, Graham BS, Chiu YL, Gilbert PB, McElrath MJ, Belshe
RB, Buchbinder SP, Sheppard HW, Koblin BA, Mayer KH, Keefer
MC, Mulligan MJ, Celum CL.
J Infect Dis. 2004 Sep 1;190(5):903-7
Tissue Antigens- 2004
HLA
class I serotypes and cytotoxic T-lymphocyte responses among
human immunodeficiency virus-1-uninfected Thai volunteers
immunized with ALVAC-HIV in combination with monomeric gp120
or oligomeric gp160 protein boosting.
Paris R, Bejrachandra S, Karnasuta C, Chandanayingyong D,
Kunachiwa W, Leetrakool N, Prakalapakorn S, Thongcharoen P,
Nittayaphan S, Pitisuttithum P, Suriyanon V, Gurunathan S,
McNeil JG, Brown AE, Birx DL, de Souza M.
Tissue Antigens. 2004 Sep;64(3):251-6.
Journal of Experimental Medicine- 2004
CD4+
T Cell Depletion during all Stages of HIV Disease Occurs Predominantly
in the Gastrointestinal Tract.
Brenchley JM, Schacker TW, Ruff LE, Price DA, Taylor JH, Beilman
GJ, Nguyen PL, Khoruts A, Larson M, Haase AT, Douek DC.
J Exp Med. 2004 Sep 20;200(6):749-59
American Journal of Pathology- 2004
Highly
tissue substructure-specific effects of human papilloma virus
in mucosa of HIV-infected patients revealed by laser-dissection
microscopy-assisted gene expression profiling.
Baumgarth N, Szubin R, Dolganov GM, Watnik MR, Greenspan D,
Da Costa M, Palefsky JM, Jordan R, Roederer M, Greenspan JS.
Am J Pathol. 2004 Sep;165(3):707-18.
2004
August 2004
Nature Reviews Immunology - 2004
Seventeen-colour
flow cytometry: unravelling the immune system.
Perfetto SP, Chattopadhyay PK, Roederer M.
Nat Rev Immunol. 2004 Aug;4(8):648-55.
Journal of Virology- 2004
Vbeta14(+)
T cells mediate the vaccine-enhanced disease induced by immunization
with respiratory syncytial virus (RSV) G glycoprotein but
not with formalin-inactivated RSV.
Johnson TR, Varga SM, Braciale TJ, Graham BS
J Virol. 2004 Aug;78(16):8753-60.
Journal of Antimicrobial Chemotherapy- 2004
Inhibition
of respiratory syncytial virus by RhoA-derived peptides: implications
for the development of improved antiviral agents targeting
heparin-binding viruses.
Budge PJ, Graham BS.
J Antimicrob Chemother. 2004 Aug;54(2):299-302.
America Journal of Respiratory Critical Care Medicine- 2004
Respiratory
syncytial virus in allergic lung inflammation increases Muc5ac and gob-5.
Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson
SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles RS Jr.
Am J Respir Crit Care Med. 2004 Aug 1;170(3):306-12.
Nature Medicine- 2004
Correlates
of immune protection in HIV-1 infection: what we know, what
we don't know, what we should know.
Pantaleo G, Koup RA.
Nat Med. 2004 Aug;10(8):806-10.
Journal of Immunology- 2004
Absence
of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive,
HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.
Ferrari G, Neal W, Ottinger J, Jones AM, Edwards BH, Goepfert
P, Betts MR, Koup RA, Buchbinder S, McElrath MJ, Tartaglia J, Weinhold KJ.
J Immunol. 2004 Aug 1;173(3):2126-33.
AIDS Research and Human Retroviruses - 2004
Macaque
Dendritic Cells Infected with SIV-Recombinant Canarypox ex
Vivo Induce SIV-Specific Immune Responses in Vivo.
Villamide-Herrera L, Ignatius R, Eller MA, Wilkinson K, Griffin
C, Mehlhop E, Jones J, Han SY, Lewis MG, Parrish S, Vancott
TC, Lifson JD, Schlesinger S, Mascola JR, Pope M.
AIDS Res Hum Retroviruses . 2004 Aug;20(8):871-84.
Journal of Infectious Diseases - 2004
Safety
and immunogenicity of an HIV subtype B and E prime-boost vaccine
combination in HIV-negative Thai adults.
Nitayaphan S, Pitisuttithum P, Karnasuta C, Eamsila C, de
Souza M, Morgan P, Polonis V, Benenson M, VanCott T, Ratto-Kim
S, Kim J, Thapinta D, Garner R, Bussaratid V, Singharaj P,
el-Habib R, Gurunathan S, Heyward W, Birx D, McNeil J, Brown
AE; Thai AIDS Vaccine Evaluation Group.
J Infect Dis. 2004 Aug 15;190(4):702-6.
2004
July 2004
Journal of Antimicrobial Chemotherapy- 2004
Inhibition
of respiratory syncytial virus by RhoA-derived peptides: implications
for the development of improved antiviral agents targeting
heparin-binding viruses.
Budge PJ, Graham BS.
J Antimicrob ChemotherInfect Dis. 2004 Jul 14 [Epub ahead of print]
Journal of Infectious Diseases- 2004
Safety
and Immunogenicity of an HIV Subtype B and E Prime-Boost Vaccine
Combination in HIV-Negative Thai Adults.
Nitayaphan S, Pitisuttithum P, Karnasuta C, Eamsila C, De
Souza M, Morgan P, Polonis V, Benenson M, VanCott T, Ratto-Kim
S, Kim J, Thapinta D, Garner R, Bussaratid V, Singharaj P,
El Habib R, Gurunathan S, Heyward W, Birx D, McNeil J, Brown
AE; Thai AIDS Vaccine Evaluation Group.
J Infect Dis. 2004 Aug 15;190(4):702-6.
Journal of Immunology- 2004
Absence
of immunodominant anti-Gag p17 (SL9) responses among Gag CTL-positive,
HIV-uninfected vaccine recipients expressing the HLA-A*0201 allele.
Ferrari G, Neal W, Ottinger J, Jones AM, Edwards BH, Goepfert
P, Betts MR, Koup RA, Buchbinder S, McElrath MJ, Tartaglia J, Weinhold KJ.
J Immunol. 2004 Aug 1;173(3):2126-33.
June 2004
Clinical Infectious Diseases- 2004
Modified
vaccinia ankara: potential as an alternative smallpox vaccine.
McCurdy LH, Larkin BD, Martin JE, Graham BS.
Clin Infect Dis. 2004 38(12):1749-53.
Journal of Virology-June 2004
pH-dependent
entry of severe acute respiratory syndrome coronavirus is
mediated by the spike glycoprotein and enhanced by dendritic
cell transfer through DC-SIGN.
Yang ZY, Huang Y, Ganesh L, Leung K, Kong WP, Schwartz O,
Subbarao K, Nabel GJ.
J Virol. 2004 Jun;78(11):5642-50.
Journal of Virology-June 2004
Respiratory
syncytial virus (RSV) G glycoprotein is not necessary for
vaccine-enhanced disease induced by immunization with formalin-inactivated RSV.
Johnson TR, Teng MN, Collins PL, Graham BS.
J Virol. 2004 Jun;78(11):6024-32.
Blood-June 2004
High
prevalence of autoreactive, neuroantigen-specific CD8+ T cells
in multiple sclerosis revealed by novel flow cytometric assay.
Crawford MP, Yan SX, Ortega SB, Mehta RS, Hewitt RE, Price
DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.
Blood. 2004 Jun 1;103(11):4222-31
Blood-June 2004
Unusual
Immunophenotype of CD8+ T-cells in Familial Hemophagocytic
Lymphohistiocytosis.
Karandikar NJ, Kroft SH, Yegappan S, Rogers BB, Aquino VM,
Lee KM, Kumar V, Guenaga FJ, Jaffe ES, Douek DC, McKenna RW.
Blood. 2004 Jun 17
2004
May 2004
Journal of Immunology-May 2004
A
Immunogenicity of recombinant adenovirus serotype 35 vaccine
in the presence of pre-existing anti-Ad5 immunity.
Barouch DH, Pau MG, Custers JH, Koudstaal W, Kostense S, Havenga
MJ, Truitt DM, Sumida SM, Kishko MG, Arthur JC, Korioth-Schmitz
B, Newberg MH, Gorgone DA, Lifton MA, Panicali DL, Nabel GJ,
Letvin NL, Goudsmit J.
J Immunol 2004 May 172(10):6290-7.
American Journal of Respiratory and Critical Care
Medicine-May 2004
Respiratory
Syncytial Virus in Allergic Lung Inflammation Increases Muc5ac and gob-5.
A Hashimoto K, Graham BS, Ho SB, Adler KB, Collins RD, Olson
SJ, Zhou W, Suzutani T, Jones PW, Goleniewska K, O'Neal JF, Peebles Jr RS.
Am J Respir Crit Care Med. 2004 May 6 (Epub ahead of print).
Journal of Virology-May 2004
RhoA-derived
peptide dimers share mechanistic properties with other polyanionic
inhibitors of respiratory syncytial virus (RSV), including
disruption of viral attachment and dependence on RSV G.
Budge PJ, Li Y, Beeler JA, Graham BS.
J Virol. 2004 May;78(10):5015-22.
Journal of Immunology-May 2004
The
functional profile of primary human antiviral CD8+ T cell
effector activity is dictated by cognate peptide concentration.
Betts MR, Price DA, Brenchley JM, Lore K, Guenaga FJ, Smed-Sorensen
A, Ambrozak DR, Migueles SA, Connors M, Roederer M, Douek DC, Koup RA.
J Immunol. 2004 May 15;172(10):6407-17.
Journal of Immunology-May 2004
Adult
human liver contains CD8(pos) T cells with naive phenotype,
but is not a site for conventional alphabeta T cell development.
Golden-Mason L, Douek DC, Koup RA, Kelly J, Hegarty JE, O'Farrelly C.
J Immunol. 2004 May 15;172(10):5980-5.
Journal of Virology-May 2004
Migration
of antigen-specific T cells away from CXCR4-binding human
immunodeficiency virus type 1 gp120.
Brainard DM, Tharp WG, Granado E, Miller N, Trocha AK, Ren
XH, Conrad B, Terwilliger EF, Wyatt R, Walker BD, Poznansky MC.
J Virol. 2004 May;78(10):5184-93.
Journal of Virology-May 2004
Effects
of antibody on viral kinetics in simian/human immunodeficiency
virus infection: implications for vaccination.
Zhang L, Ribeiro RM, Mascola JR, Lewis MG, Stiegler G, Katinger
H, Perelson AS, Davenport MP.
J Virol. 2004 May;78(10):5520-2.
Journal of Virology-May 2004
Immunogenicity
of constrained monoclonal antibody A32-human immunodeficiency
virus (HIV) Env gp120 complexes compared to that of recombinant
HIV type 1 gp120 envelope glycoproteins.
Liao HX, Alam SM, Mascola JR, Robinson J, Ma B, Montefiori
DC, Rhein M, Sutherland LL, Scearce R, Haynes BF.
J Virol. 2004 May;78(10):5270-8.
2004
April 2004
Nature-April 2004
DNA
vaccine induces SARS coronavirus neutralization and protective immunity in mice.
Yang ZY, Kong WP, Huang Y, Roberts A, Murphy BR, Subbarao K, Nabel GJ.
Nature 2004 Apr 1;428(6982):561-4.
Journal of Virology-April 2004
Selective
modification of variable loops alters tropism and enhances
immunogenicity of human immunodeficiency virus type 1 envelope.
Yang ZY, Chakrabarti BK, Xu L, Welcher B, Kong WP, Leung K,
Panet A, Mascola JR, Nabel GJ.
J Virol 2004 Apr;78(8):4029-36.
Journal of Experimental Medicine-April 2004
Immediate
Cytotoxicity But Not Degranulation Distinguishes Effector
and Memory Subsets of CD8+ T Cells.
Wolint P, Betts MR, Koup RA, Oxenius A.
J Exp Med. 2004 Apr 5;199(7):925-36
Blood-April 2004
Identification
and in vitro expansion of CD4+ and CD8+ T cells specific for
human neutrophil elastase.
Fujiwara H, El Ouriaghli F, Grube M, Price DA, Rezvani K,
Gostick E, Sconocchia G, Melenhorst J, Hensel N, Douek DC, Barrett AJ.
Blood. 2004 Apr 15;103(8):3076-83.
Current HIV/AIDS Reports-April 2004
Current Advances in HIV Vaccines
D'Souza, MP, Allen M, Sheets R, Johnston MI
Current HIV/AIDS Reports 2004. April 1:18-24
March 2004
Journal of Virology-March 2004
The
V3 Loop Is Accessible on the Surface of Most Human Immunodeficiency
Virus Type 1 Primary Isolates and Serves as a Neutralization Epitope.
Gorny MK, Revesz K, Williams C, Volsky B, Louder MK, Anyangwe
CA, Krachmarov C, Kayman SC, Pinter A, Nadas A, Nyambi PN,
Mascola JR, Zolla-Pazner S.
J Virol. 2004 Mar 1;78(5):2394-2404
Journal of Virology-March 2004
Treatment
with anti-LFA-1 delays the CD8+ cytotoxic-T-lymphocyte response
and viral clearance in mice with primary respiratory syncytial virus infection.
Rutigliano JA, Johnson TR, Hollinger TN, Fischer JE, Aung S, Graham BS.
J Virol 2004 Mar;78(6):3014-3023.
Nature Immunology-March 2004
HIV
vaccine design and the neutralizing antibody problem.
Burton DR, Desrosiers RC, Doms RW, Koff WC, Kwong PD, Moore
JP, Nabel GJ, Sodroski J, Wilson IA, Wyatt RT.
Nat Immunol. 2004 Mar;5(3):233-6. No abstract available.
February 2004
Blood-February 2004
High
Prevalence of Autoreactive Neuroantigen-Specific CD8+ T Cells
in Multiple Sclerosis Revealed by Novel Flow Cytometric Assay.
Crawford MP, Yan SX, Ortega S, Mehta RS, Hewitt RE, Price
DA, Stastny P, Douek DC, Koup RA, Racke MK, Karandikar NJ.
Blood. 2004 Epub ahead of print
Journal of Immunology-February 2004
HIV-infected
Langerhans cells preferentially transmit virus to proliferating
autologous CD4(+) memory T cells located within Langerhans
cell-T cell clusters.
Sugaya M, Lore K, Koup RA, Douek DC, Blauvelt A.
J Immunol. 2004 Feb 15;172(4):2219-24.
Journal of Virology-February 2004
T-cell
subsets that harbor human immunodeficiency virus (HIV) in
vivo: implications for HIV pathogenesis.
Brenchley JM, Hill BJ, Ambrozak DR, Price DA, Guenaga FJ,
Casazza JP, Kuruppu J, Yazdani J, Migueles SA, Connors M,
Roederer M, Douek DC, Koup RA.
J Virol. 2004 Feb;78(3):1160-8
Journal of Immunology-February 2004
HLA
class II polymorphisms determine responses to bacterial superantigens.
Llewelyn M, Sriskandan S, Peakman M, Ambrozak DR, Douek DC,
Kwok WW, Cohen J, Altmann DM.
J Immunol. 2004 Feb 1;172(3):1719-26.
Journal of AIDS-February 2004
Immunoprophylaxis
to prevent mother-to-child transmission of HIV-1.
Safrit JT, Ruprecht R, Ferrantelli F, Xu W, Kitabwalla M,
Van Rompay K, Marthas M, Haigwood N, Mascola JR, Luzuriaga
K, Jones SA, Mathieson BJ, Newell ML; Ghent IAS Working Group
on HIV in Women Children.
J Acquir Immune Defic Syndr. 2004 Feb 1;35(2):169-77
Journal of Immunology-February 2004
Ontogeny
of gammadelta T cells in humans.
De Rosa SC, Andrus JP, Perfetto SP, Mantovani JJ, Herzenberg
LA, Herzenberg LA, Roederer M.
J Immunol. 2004 Feb 1;172(3):1637-45
Nature Medicine-February 2004
Genetic,
cellular and immune approaches to disease therapy: past and future.
Nabel GJ
Nat Med. 2004 Feb;10(2): 135-41.
Proceedings of the National Academy of Sciences-February 2004
Structural
basis of tyrosine sulfation and VH-gene usage in antibodies
that recognize the HIV type 1 coreceptor-binding site on gp120.
Huang CC, Venturi M, Majeed S, Moore MJ, Phogat S, Zhang MY,
Dimitrov DS, Hendrickson WA, Robinson J, Sodroski J, Wyatt
R, Choe H, Farzan M, Kwong PD.
Proc Natl Acad Sci U S A. 2004 Feb 23 [Epub ahead of print]
Structure-February 2004
The
447-52D Antibody: Hitting HIV-1.
Kwong PD.
Structure 2004 Feb;12(2):173-4.
January 2004
EMBO Journal-January 2004
A
novel role for XIAP in copper homeostasis through regulation of MURR1.
Burstein E, Ganesh L, Dick RD, Van De Sluis B, Wilkinson JC,
Klomp LW, Wijmenga C, Brewer GJ, Nabel GJ, Duckett CS
EMBO J. 23(1): 244-54.
Journal of Virology-January 2004
Incorporation
of pol into human immunodeficiency virus type 1 Gag virus-like
particles occurs independently of the upstream Gag domain in Gag-pol.
Cen S, Niu M, Saadatmand J, Guo F, Huang Y, Nabel GJ, Kleiman L.
J Virol. 2004 Jan; 78(2): 1042-9
Pediatric Infectious Disease Journal-January 2004
Contribution
of respiratory syncytial virus G antigenicity to vaccine-enhanced
illness and the implications for severe disease during primary
respiratory syncytial virus infection.
Johnson TR, Graham BS.
Pediatr Infect Dis J. 2004 Jan; 23(1): S46-S57.
AIDS-January 2004
T-cell
dynamics during acute SIV infection.
Mattapallil JJ, Letvin NL, Roederer M.
AIDS. 2004 Jan 2;18(1):13-23.
2003
December 2003
Journal of Virology-December 2003
Immunogenicity
of multiple gene and clade human immunodeficiency virus type 1 DNA vaccines.
Kong WP, Huang Y, Yang ZY, Chakrabarti BK, Moodie Z, Nabel GJ.
J Virol 77(23): 12764-72.
Nature-December 2003
The
gene product Murr1 restricts HIV-1 replication in resting CD4+ lymphocytes.
Ganesh L, Burstein E, Guha-Niyogi A, Louder MK, Mascola JR,
Klomp LW, Wijmenga C, Duckett CS, Nabel GJ.
Nature 426(6968): 853-7.
Blood-December 2003
Identification
and in vitro expansion of CD4+ and CD8+ T cells specific for
human neutrophil elastase.
Fujiwara H, El Ouriaghli F, Grube M, Price DA, Rezvani K,
Gostick E, Sconocchia G, Melenhorst J, Hensel N, Douek DC, Barrett AJ.
Blood. 2003
November 2003
AIDS-November 2003
Diverse
HIV-1 subtypes and clinical, laboratory and behavioral factors
in a recently infected US military cohort.
Brodine SK, Starkey MJ, Shaffer RA, Ito SI, Tasker SA, Barile
AJ, Tamminga CL, Stephan KT, Aronson NE, Fraser SL, Wallace
MR, Wegner SA, Mascola JR, McCutchan FE.
AIDS 17(17):2521-27.
Antimicrobial Agents and Chemotherapy-November 2003
Antiviral
activity of RhoA-derived peptides against respiratory syncytial
virus is dependent on formation of peptide dimers.
Budge PJ, Lebowitz J, Graham BS.
Antimicrobial Agents and Chemotherapy (11):3470-7.
October 2003
Blood-October 2003
Functional
leukemia-associated antigen-specific memory CD8+ T cells exist
in healthy individuals and in patients with chronic myelogenous
leukemia before and after stem cell transplantation.
Rezvani K, Grube M, Brenchley JM, Sconocchia G, Fujiwara H,
Price DA, Gostick E, Yamada K, Melenhorst J, Childs R, Hensel
N, Douek DC, Barrett AJ.
Blood 102 (8) 2892-900
Immunology Letters-October 2003
Low T cell receptor excision circle
levels in patients thymectomized 25-54 years ago.
Storek J, Douek DC, Keesey JC, Boehmer L, Storer B, Maloney DG
Immunol Lett. 89(2-3):91-2.
Journal of Immunological Methods-October 2003
Sensitive and viable identification
of antigen-specific CD8+ T cells by a flow cytometric assay
for degranulation.
Betts MR, Brenchley JM, Price DA, De Rosa SC, Douek DC, Roederer M, Koup RA.
Journal of Immunological Methods 281 (1-2):65-78.
Journal of Immunology-October 2003
Toll-Like
Receptor Ligands Modulate Dendritic Cells to Augment Cytomegalovirus-
and HIV-1-Specific T Cell Responses.
Lore K, Betts MR, Brenchley JM, Kuruppu J, Khojasteh, Perfetto
S, Mario M, Seder RA, Koup RA
J Immunol 171(8):4320-8.
Journal of Virology-October 2003
Access
of Antibody Molecules to the Conserved Coreceptor Binding
Site on Glycoprotein gp120 Is Sterically Restricted on Primary
Human Immunodeficiency Virus Type 1.
Labrijn AF, Poignard P, Raja A, Zwick MB, Delgado K, Franti
M, Binley J, Vivona V, Grundner C, Huang CC, Venturi M, Petropoulos
CJ, Wrin T, Dimitrov DS, Robinson J, Kwong PD, Wyatt RT, Sodroski J, Burton DR.
J Virol. 2003 Oct 1;77(19):10557-10565.
Journal of Virology-October 2003
Cellular immunity elicited by human immunodeficiency virus
type 1/ simian immunodeficiency virus DNA vaccination does
not augment the sterile protection afforded by passive infusion
of neutralizing antibodies.
Mascola JR, Lewis MG, VanCott TC, Stiegler G, Katinger H,
Seaman M, Beaudry K, Barouch DH, Korioth-Schmitz B, Krivulka
G, Sambor A, Welcher B, Douek DC, Montefiori DC, Shiver JW,
Poignard P, Burton DR, Letvin NL.
J Virol 77(19):10348-56.
Nature Medicine-October 2003
Ex
vivo identification, isolation and analysis of tumor-cytolytic T cells.
Rubio V, Stuge TB, Singh N, Betts MR, Weber JS, Roederer M, Lee PP.
Nat Med. 2003 Oct 5 [Epub ahead of print]
Virology-October 2003
Epitope
mapping and characterization of a novel CD4-induced human
monoclonal antibody capable of neutralizing primary HIV-1 strains.
Xiang S-H, Wang L, Abreu M, Huang C, Kwong PD, Rosenberg E,
Robinson JE and Sodroski J.
Virology, 325:124-134.
September 2003
British Journal of Haematology-September 2003
Early
reconstitution of the T-cell repertoire after non-myeloablative
peripheral blood stem cell transplantation is from post-thymic
T-cell expansion and is unaffected by graft-versus-host disease
or mixed chimaerism.
Bahceci E, Epperson D, Douek DC, Melenhorst JJ, Childs RC, Barrett AJ
Br J Haematol 122(6):934-43.
Infectious Immunology-September 2003
Coinjection
with CpG-containing immunostimulatory oligodeoxynucleotides
reduces the pathogenicity of a live vaccine against cutaneous
Leishmaniasis but maintains its potency and durability.
Mendez S, Tabbara K, Belkaid Y, Bertholet S, Verthelyi D,
Klinman D, Seder RA, Sacks DL.
Infect Immun. 71(9):5121-9.
Journal of Immunology- September 2003
Prime-boost
vaccination with HIV-1 Gag protein and cytosine phosphate
guanosine oligodeoxynucleotide, followed by adenovirus, induces
sustained and robust humoral and cellular immune responses.
Tritel M, Stoddard AM, Flynn BJ, Darrah PA, Wu CY, Wille U,
Shah JA, Huang Y, Xu L, Betts MR, Nabel GJ, Seder RA.
J Immunol. 2003 Sep 1;171(5):2538-47.
Journal of Virology-September 2003
Ebola
virus pathogenesis: implications for vaccines and therapies.
Sullivan N, Yang ZY, Nabel GJ.
J Virol. 2003 Sep;77(18):9733-7.
Journal of Virology-September 2003
Enhanced
mucosal immunoglobulin a response of intranasal adenoviral
vector human immunodeficiency virus vaccine and localization
in the central nervous system.
Lemiale F, Kong WP, Akyurek LM, Ling X, Huang Y, Chakrabarti
BK, Eckhaus M, Nabel GJ.
J Virol. 2003 Sep;77(18):10078-87.
Nature Immunology-September 2003
Similarities
and differences in CD4+ and CD8+ effector and memory T cell generation.
Seder RA, Ahmed R.
Nat Immunol 4(9):835-42.
Structure-September 2003
Enhancing
Protein Crystallization through Precipitant Synergy.
Majeed S, Ofek G, Belachew A, Huang C, Zhou T, Kwong PD.
Structure (Camb). 2003 Sep;11(9):1061-70.
Virology-September 2003
Structure-based,
Targeted Deglycosylation of HIV-1 gp120 and Effects on Neutralization
Sensitivity and Antibody Recognition.
Kock M, Pancera M, Kwong PD, Kolchinsky P, Grundner C, Wang
L, Hendrickson WA, Sodroski J and Wyatt R. (2003)
Virology, 313: 387-400.
August 2003
Current Opinion in Immunology-August 2003
DNA vaccination: the answer to stable,
protective T-cell memory?
Kirman JR, Seder RA.
Curr Opin Immunol. 15(4):471-6.
Journal of Immunology Methods-August 2003
Optimized
lymphocyte isolation methods for analysis of chemokine receptor expression.
Berhanu D, Mortari F, De Rosa SC, Roederer M.
J Immunol Methods 279(1-2):199-207.
Nature-August 2003
Accelerated
vaccination for Ebola virus haemorrhagic fever in non-human primates.
Sullivan NJ, Geisbert TW, Geisbert JB, Xu
L, Yang ZY, Roederer M, Koup RA, Jahrling PB, Nabel GJ.
Nature. 2003 Aug 7;424(6949):681-4.
July 2003
Cell-July 2003
Tyrosine
sulfation of human antibodies contributes to recognition of
the CCR5 binding region of HIV-1 gp120. Choe H, Li W,
Wright PL, Vasilieva N, Venturi M, Huang CC, Grundner C, Dorfman
T, Zwick MB, Wang L, Rosenberg ES, Kwong PD, Burton DR, Robinson
JE, Sodroski JG, Farzan M.
Cell. 2003 Jul 25;114(2):161-70.
Journal of Experimental Medicine-July 2003
Dendritic
Cells Are Responsible for the Capacity of CpG Oligodeoxynucleotides
to Act as an Adjuvant for Protective Vaccine Immunity Against
Leishmania major in Mice.
Shah JA, Darrah PA, Ambrozak DR, Turon TN, Mendez S, Kirman
J, Wu CY, Glaichenhaus N, Seder RA.
J Exp Med. 2003 Jul 21;198(2):281-91.
June 2003
Journal of Clinical Microbiology-June 2003
Herpesvirus
DNA is consistently detected in lungs of patients with idiopathic
pulmonary fibrosis.
Tang YW, Johnson JE, Browning PJ, Cruz-Gervis RA, Davis A,
Graham BS, Brigham KL, Oates JA Jr, Loyd JE, Stecenko AA.
J Clin Microbiol 41(6):2633-40
May 2003
Current Molecular Medicine-May 2003
Defining
the protective antibody response for HIV-1.
Mascola JR.
Curr Mol Med. 2003 May;3(3):209-16.
April 2003
Cytometry-April 2003
Measuring
containment of viable infectious cell sorting in high velocity cell sorters
Perfetto SP, DR Ambrozak, RA Koup, and M Roederer
Cytometry 52A (2): 122-130
Nature Medicine-April, 2003
HIV-1:
nature's master of disguise.
Mascola JR, Montefiori DC.
Nat Med. 2003 9(4): 393-4.
Viral Immunology-April 2003
The
complex relationship between respiratory syncytial virus and
allergy in lung disease.
Peebles RS Jr, Hashimoto K, Graham BS.
Viral Immunol 16(1):25-34
Virus Research-April 2003
Vaccine
for AIDS and Ebola virus infection.
Nabel GJ.
Virus Res. 2003 Apr;92(2):213-7. Review.
March 2003
Immunity-March 2003
Non-pathogenic
simian immunodeficiency virus infection of sooty mangabey
monkeys is characterized by limited bystander immunopathology
and preserved immune regenerative capacity despite chronic
high level virus replication.
Silvestri G, DL Sodora, RA Koup, SP O'Neil, HM McClure, SI
Staprans, and MB Feinberg.
Immunity 18 (3): 441-52
Journal of Immunological Methods-March 2003
Optimized
determination of T cell epitope responses
Roederer M, and RA Koup.
J. Immunol. Methods 274 (1-2): 221-228
Nature-March 2003
Antibody
neutralization and escape by HIV-1.
Wei X, Decker JM, Wang S, Hui H, Kappes JC, Wu X, Salazar-Gonzalez
JF, Salazar MG, Kilby JM, Saag MS, Komarova NL, Nowak MA,
Hahn BH, Kwong PD, Shaw GM.
Nature 2003 Mar 20;422(6929):307-12.
February 2003
Journal of Immunology-February 2003
IL-13
is sufficient for respiratory syncytial virus G glycoprotein-induced
eosinophilia after respiratory syncytial virus challenge.
Johnson TR, Parker RA, Johnson JE, Graham BS.
J Immunol. 2003 Feb 15;170(4):2037-45.
Journal of Virology-February 2003
Role
of plasma membrane lipid microdomains in respiratory syncytial virus filament formation.
McCurdy LH, Graham BS.
J Virol 2003 Feb;77(3):1747-56.
PNAS-February 2003
Definitive
separation of graft-versus-leukemia- and graft-versus-host-specific
CD4+ T cells by virtue of their receptor beta loci sequences.
J. Mich�lek, R. H. Collins, H. P. Durrani, P. V�clavkov�,
L. E. Ruff, D. C. Douek, and E. S. Vitetta.
Proc Natl Acad Sci U S A. 2003 Feb 4;100(3):1180-1184.
January 2003
Immunology-January 2003
T
Cell Dynamics in HIV-1 Infection.
Douek DC, Picker LJ, Koup RA.
Annu Rev Immunol 2003 Jan 8.
Infection and Immunity-January 2003
Enhanced
Immunogenicity to Mycobacterium tuberculosis by Vaccination
with an Alphavirus Plasmid Replicon Expressing Antigen 85A
Kirman JR, Turon T, Su H, Li A, Kraus C, Polo JM, Belisle
J, Morris S, Seder RA.
Infect Immun 2003 Jan;71(1):575-9.
Journal of Virology-January 2003
CD4
Binding Site Antibodies Inhibit Human Immunodeficiency Virus
gp120 Envelope Glycoprotein Interaction with CCR5.
Raja A, Venturi M, Kwong P, Sodroski J.
J Virol 2003 Jan 1;77(1):713-718.
Journal of Virology-January 2003
Overcoming
Immunity to a Viral Vaccine by DNA Priming before Vector Boosting.
Yang ZY, Wyatt LS, Kong WP, Moodie Z, Moss B, Nabel GJ.
J Virol 2003 Jan 1;77(1):799-803.
Nature Medicine-January 2003
Beyond
six colors: A new era in flow cytometry.
De Rosa SC, Brenchley JM, Roederer M.
Nat Med 2003 Jan;9(1):112-7.
2003
Handbook of Cell Signaling-2003
HIV-1 Receptor Interactions.
Kwong PD.
Handbook of Cell Signaling, (Eds. Bradshaw RA and
Dennis EA, Elsevier Adademic Press).
2002
December 2002
Clinical & Experimental Immunology-December 2002
Expansion
of activated human naive T-cells precedes effector function.
Brenchley JM, Douek DC, Ambrozak DR, Chatterji M, Betts MR, Davis LS, Koup RA.
Clin Exp Immunol 2002 Dec;130(3):432-40
Journal of Immunological Methods-December 2002
Quantification
of T-cell receptor excision circle DNA using fluorescence
resonance energy transfer and the LightCycler system.
Loeffler J, Bauer R, Hebart H, Douek DC, Rauser G, Bader P, Einsele H.
J Immunol Methods 2002 Dec 20;271(1-2):167-75.
Nature-December 2002
HIV-1
evades antibody-mediated neutralization through conformational
masking of receptor-binding sites.
Kwong PD, Doyle ML, Casper DJ, Cicala C, Leavitt SA, Majeed
S, Steenbeke TD, Venturi M, Chaiken I, Fung M, Katinger H,
Parren PW, Robinson J, Van Ryk D, Wang L, Burton DR, Freire
E, Wyatt R, Sodroski J, Hendrickson WA, Arthos J.
Nature 2002 Dec 12;420(6916):678-82
November 2002
Blood-November 2002
Expression
of CD57 defines replicative senescence and antigen-induced
apoptotic death of CD8+ T cells.
Brenchley JM, Karandikar NJ, Betts MR, Ambrozak DR, Hill BJ,
Crotty LE, Casazza JP, Kuruppu J, Migueles SA, Connors M,
Roederer M, Douek DC, Koup RA.
Blood 2002 Nov 14
October 2002
Journal of Infectious Diseases-October 2002
Preparation
of Clinical-Grade Recombinant Canarypox-Human Immunodeficiency
Virus Vaccine-Loaded Human Dendritic Cells
Marovich MA, Mascola JR, Eller MA, Louder MK, Caudrelier PA,
El-Habib R, Ratto-Kim S, Cox JH, Currier JR, Levine BL, June
CH, Bernstein WB, Robb ML, Schuler-Thurner B, Steinman RM,
Birx DL, Schlesinger-Frankel S.
J Infect Dis 2002 Nov; 186(9):1242-52
Journal of Virology-October 2002
Mutagenic
stabilization and/or disruption of a CD4-bound state reveals
distinct conformations of the human immunodeficiency virus
type 1 gp120 envelope glycoprotein.
Xiang SH, Kwong PD, Gupta R, Rizzuto CD, Casper DJ, Wyatt
R, Wang L, Hendrickson WA, Doyle ML, Sodroski J.
J Virol 2002 Oct;76(19):9888-99
Journal of Virology-October 2002
Decreased
levels of recent thymic emigrants in peripheral blood of simian
immunodeficiency virus-infected macaques correlate with alterations within the thymus.
Sodora DL, JM Milush, F Ware, A Wozniakowski, L Montgomery,
HM McClure, AA Lackner, M Marthas, V Hirsch, RP Johnson, DC Douek, and RA Koup.
J. Virol. 76 (19): 9981-9990
September 2002
DNA Cell Biology-September 2002
Optimal
antigens for HIV vaccines based on CD8+ T response, protein
length, and sequence variability
Betts MR, K Yusim, and RA Koup
DNA Cell Biol. 21(9): 665-670
August 2002
Journal of Immunology-August 2002
Direct
ex vivo analysis of human CD4(+) memory T cell activation
requirements at the single clonotype level
Bitmansour AD, Douek DC, Maino VC, Picker LJ.
J Immunol 169(3):1207-18
Molecular Cell-August 2002
The
Assembly of Ebola Virus Nucleocapsid Requires Virion-Associated
Proteins 35 and 24 and Posttranslational Modification of Nucleoprotein
Yue Huang, Ling Xu, Yongnian Sun, and Gary J. Nabel
Molecular Cell 2002;10:307-316.
Nature Immunology-August 2002
Distinct
lineages of T(H)1 cells have differential capacities for memory
cell generation in vivo
Wu CY, Kirman JR, Rotte MJ, Davey DF, Perfetto SP, Rhee EG,
Freidag BL, Hill BJ, Douek DC, Seder RA.
Nat Immunol 2002 Aug 12
New England Journal of Medicine-August 2002
Antiretroviral-drug
resistance among patients recently infected with HIV.
Little SJ, Holte S, Routy JP, Daar ES, Markowitz M, Collier
AC, Koup RA, Mellors JW, Connick E, Conway B, Kilby M, Wang
L, Whitcomb JM, Hellmann NS, Richman DD.
N Engl J Med 347(6):385-94
July 2002
AIDS Research and Human Retroviruses-July 2002
Demonstration
of de novo HIV type 1 production by detection of multiply
spliced and unspliced HIV type 1 RNA in paraffin-embedded tonsils.
Brachtel EF, Mascola JR, Wear DJ, Ehrenberg PK, Dayhoff DE,
Sanders-Buell E, Michael NL, Frankel SS
AIDS Res and Hum Retrovirsues 18:785-790
European Molecular Biology Organization-July 2002
A
growth factor-dependent nuclear kinase phosphorylates p27Kip1
and regulates cell cycle progression
Boehm M, Yoshimoto T, Crook MF, Nallamshetty S, True A, Nabel GJ, Nabel EG.
The EMBO Journal, 21;13:3390-3401.
Journal of Dermatological Science-July 2002
Injection
of human herpesvirus-8 in human skin engrafted on SCID mice
induces Kaposi's sarcoma-like lesions
Foreman KE, Friborg J, Chandran B, Katano H, Sata T, Mercader
M, Nabel GJ, Nickoloff BJ
J. Dermatol. Sci. 26(3):182-193
Journal of Virology-July 2002
The
mannose-dependent epitope for the neutralizing antibody 2G12
on human immunodeficiency virus type 1 glycoprotein gp120
Rogier W. Sanders, Miro Venturi, Linnea Schiffner, Roopa Kalyanaraman,
Hermann Katinger, Kenneth O. Lloyd, Peter D. Kwong, John P. Moore.
J Virol 2002 Jul;76(14):7293-305
June 2002
Journal of Experimental Medicine-June 2002
Vaccination
with heat-killed leishmania antigen or recombinant leishmanial
protein and CpG oligodeoxynucleotides induces long-term memory
CD4+ and CD8+ T cell responses and protection against leishmania major infection
Rhee EG, Mendez S, Shah JA, Wu CY, Kirman JR, Turon TN, Davey
DF, Davis H, Klinman DM, Coler RN, Sacks DL, Seder RA.
J Exp Med 2002 Jun 17;195(12):1565-73
Journal of Virology-June 2002
Modifications
of the human immunodeficiency virus envelope glycoprotein
enhance immunogenicity for genetic immunization
Chakrabarti BK, Kong WP, Wu BY, Yang ZY, Friborg J, Ling X,
King SR, Montefiori DC, Nabel GJ.
J Virol 2002 Jun;76(11):5357-68.
Nature Immunology-June 2002
Role
of BCR affinity in T cell dependent antibody responses in vivo
Yang Shih TA, Meffre E, Roederer M, Nussenzweig MC.
Nat Immunol 3: 570-5.
Science-June 2002
HIV-1
diversity and vaccine development
Nabel G, Makgoba W, Esparza J.
Science 2002 Jun 28;296(5577):2335
May 2002
Journal of the American Medical Association-May 2002
Hemorrhagic
Fever Viruses as Biological Weapons
Borio L, Inglesby T, Peters CJ, Schmaljohn AL, Hughes JM,
Jahrling PB, Ksiazek T, Johnson KM, Meyerhoff A, O'Toole T,
Ascher MS, Bartlett J, Breman JG, Eitzen EM Jr, Hamburg M,
Hauer J, Henderson DA, Johnson RT, Kwik G, Layton M, Lillibridge
S, Nabel GJ, Osterholm MT, Perl TM, Russell P, Tonat K; The
Working Group on Civilian Biodefense.
JAMA 2002 287;(18):2391-405.
Journal of Virology-May 2002
Human
immunodeficiency virus type 1 neutralization measured by flow
cytometric quantitation of single-round infection of primary human T cells
Mascola JR, Louder MK, Winter C, Prabhakara R, De Rosa SC,
Douek DC, Hill BJ, Gabuzda D, Roederer M.
J Virol 2002;76:4810-21
Journal of Virology-May 2002
Highly
Stable Trimers Formed by Human Immunodeficiency Virus Type
1 Envelope Glycoproteins Fused with the Trimeric Motif of
T4 Bacteriophage Fibritin
Xinzhen Yang, Juliette Lee, Erin M. Mahony, Peter D. Kwong,
Richard Wyatt, and Joseph Sodroski
J. Virol. 2002 76: 4634-4642.
Journal of Virology-May 2002
NK
T cells contribute to expansion of CD8(+) T cells and amplification
of antiviral immune responses to respiratory syncytial virus
Johnson TR, Hong S, Van Kaer L, Altman JD, Koezuka Y, Graham BS.
Journal of Virology 2002; 76:4294-4303.
Nature-May 2002
HIV
preferentially infects HIV-specific CD4+ T cells
Douek DC, Brenchley JM, Betts MR, Ambrozak DR, Hill BJ, Okamoto
Y, Casazza JP, Kuruppu J, Kunstman K, Wolinsky S, Grossman
Z, Dybul M, Oxenius A, Price DA, Connors M, Koup RA.
Nature 2002 May 2;417(6884):95-8
Vaccine-May 2002
HIV
vaccine strategies
Nabel GJ.
Vaccine 2002 May 6;20(15):1945-7.
Vaccine-May 2002
Passive
Transfer Studies to Elucidate the Role of Antibody-mediated Protection Against HIV-1
Mascola JR.
Vaccine 2002;20:1922-25
April 2002
American Journal of Respiratory and Critical Care Medicine-April 2002
Selective
cyclooxygenase-1 and -2 inhibitors each increase allergic
inflammation and airway hyperresponsiveness in mice
Peebles RS, Hashimoto K, Morrow JD, Dworski R, Collins RD,
Jarzecka K, Mitchell DB, Graham BS, Sheller JR. American
Journal of Respiratory and Critical Care Medicine 2002; 165:1154-1160.
Accompanying editorial: Peters-Golden M. Open mind, open airways:
Broadening the paradigm of prostaglandins and allergic airway
inflammation. AJRCCM 2002; 165:1035-1036.
AIDS-April 2002
Immune
reconstitution in HIV-1-infected children on antiretroviral
therapy: role of thymic output and viral fitness
Ometto L, De Forni D, Patiri F, Trouplin V, Mammano F, Giacomet
V, Giaquinto C, Douek D, Koup R, De Rossi A.
AIDS 2002 Apr 12;16(6):839-49
Blood-April 2002
Effects
of exogenous interleukin-7 on human thymus function
Okamoto Y, Douek DC, McFarland RD, Koup RA.
Blood 2002 Apr 15;99(8):2851-8
Journal of Infectious Diseases-April 2002
Illness
severity, virus shedding, and antibody responses in patients
hospitalized with bronchiolitis caused by respiratory syncytial
virus - Article in PDF format (PDF/Adobe
Acrobat Information and Help).
Wright PF, Gruber WC, Peters M, Reed G, Zhu YW, Robinson F,
Coleman-Dockery S, Graham BS.
Journal of Infectious Diseases 2002; 185:1011-1018.
Journal of Virology-April 2002
Solid-phase
proteoliposomes containing human immunodeficiency virus envelope glycoproteins.
Grundner C, Mirzabekov T, Sodroski J, Wyatt R.
J Virol 2002 Apr;76(7):3511-21
Nature Immunology-April 2002
Role
of antigen receptor affinity in T cell-independent antibody responses in vivo
Shih TA, Roederer M, Nussenzweig MC
Nat Immunol 3: 399-406.
March 2002
Cancer Research-March 2002
Cellular
localization and function of Fas ligand (CD95L) in tumors
Kurooka M, Nuovo GJ, Caligiuri MA, Nabel GJ.
Cancer Res 2002 Mar 1;62(5):1261-5.
Journal of Clinical Investigation-March 2002
Glatiramer
acetate (Copaxone) therapy induces CD8(+) T cell responses
in patients with multiple sclerosis
Karandikar NJ, Crawford MP, Yan X, Ratts RB, Brenchley JM,
Ambrozak DR, Lovett-Racke AE, Frohman EM, Stastny P, Douek
DC, Koup RA, Racke MK.
J Clin Invest 2002 Mar;109(5):641-9
Journal of Acquired Immune Deficiency
Syndrome-March 2002
Safety
and immunogenicity of a high-titered canarypox vaccine in
combination with rgp120 in a diverse population of HIV-1-uninfected
adults: AIDS Vaccine Evaluation Group Protocol 022A
Gupta K, Hudgens M, Corey L, McElrath MJ, Weinhold K, Montefiori
DC, Gorse GJ, Frey SE, Keefer MC, Evans TG, Dolin R, Schwartz
DH, Harro C, Graham B, Spearman PW, Mulligan M, Goepfert P.
Journal of Acquired Immune Deficiency Syndrome 2002; 29:254-261.
Journal of Immunology-March 2002
A
novel approach to the analysis of specificity, clonality,
and frequency of HIV-specific T cell responses reveals a potential
mechanism for control of viral escape
Douek DC, Betts MR, Brenchley JM, Hill BJ, Ambrozak DR, Ngai
KL, Karandikar NJ, Casazza JP, Koup RA.
J Immunol 2002 Mar 15;168(6):3099-104
Journal of Immunology-March 2002
The
role of interferon in RSV pathogenesis
Durbin J, Johnson TR, Durbin RK, Mertz S, Peebles RS, Jr., Graham BS.
Journal of Immunology 2002; 168:2944-2951.
February 2002
Blood-February 2002
A
broad T-cell repertoire diversity and an efficient thymic
function indicate a favorable long-term immune reconstitution
after cord blood stem cell transplantation.
Talvensaari K, Clave E, Douay C, Rabian C, Garderet L, Busson
M, Garnier F, Douek D, Gluckman E, Charron D, Toubert A.
Blood 99(4):1458-64
Journal of Immunology-February 2002
CpG
oligodeoxynucleotides as vaccine adjuvants in primates
Verthelyi D, Kenney RT, Seder RA, Gam AA, Friedag B, Klinman DM.
J Immunol 2002 Feb 15;168(4):1659-63
Virology-February 2002
Respiratory
Syncytial Virus Immunobiology and Pathogenesis - Article
in PDF format (PDF/Adobe
Acrobat Information and Help).
Graham BS, Rutigliano JA, Johnson TR.
Virology 2002.
January 2002
Journal of Virology-January 2002
Effects
of antigen and genetic adjuvants on immune responses to human
immunodeficiency virus DNA vaccines in mice
Moore AC, Kong WP, Chakrabarti BK, Nabel GJ.
J Virol 2002 Jan;76(1):243-50
Thorax-January 2002
Suppression
of airway hyperresponsiveness induced by ovalbumin sensitisation
and RSV infection with Y-27632, a Rho kinase inhibitor
Hashimoto K, Peebles RS, Sheller JR, Jarzecka K, Furlong J,
Mitchell DB, Graham BS.
Thorax 2002; (in press).
2002
Annual Review
Advances
in Experimental Biology and Medicine-2002
IL-7,
the thymus and na�ve T cells
Okamoto Y, Douek DC, McFarland RD, Koup RA
Adv Exp Med Biol 512:81-90
Annual
Review of Medicine-2002
Clinical
Trials of HIV Vaccines
Graham BS.
Annual Review of Medicine 2002; 53:207-221.
Current Protocols in Immunology-2002
Multiparameter FACS Analysis
Roederer, M., Coligan, J. E., Margulies, D. H., Shevach, E.
M., Strober, W., Coico, R. and Kruisbeek, A. (ed.),
John Wiley & Sons, Inc, New York, (in press).
2001
December 2001
Journal of Immunology-December 2001
Evidence
for increased T cell turnover and decreased thymic output in HIV infection
Douek DC, Betts MR, Hill BJ, Little SJ, Lempicki R, Metcalf
JA, Casazza J, Yoder C, Adelsberger JW, Stevens RA, Baseler
MW, Keiser P, Richman DD, Davey RT, Koup RA.
J Immunol 2001 Dec 1;167(11):6663-8
Journal of Virology-December 2001
Analysis
of total human immunodeficiency virus (HIV)-specific CD4(+)
and CD8(+) T-cell responses: relationship to viral load in
untreated HIV infection.
Betts MR, Ambrozak DR, Douek DC, Bonhoeffer S, Brenchley JM,
Casazza JP, Koup RA, Picker LJ.
J Virol 75(24):11983-91
Cytometry-December 2001
Compensation
is not dependent on signal intensity nor on the number of parameters (letter)
Roederer, M. (2001).
Cytometry 46, 357.
Immunity-December 2001
Increased
CD95/Fas-Induced Apoptosis of HIV-Specific CD8+ T Cells
Mueller, Y. M., Hutton, J. A., Rosa, S. D., Roederer, M.,
Witek, J., Altman, J. D. and Katsikis, P. D. (2001).
Immunity 15, 871-882.
Journal of Investigative Dermatology-December 2001
Human
Dendritic Cells as Targets of Dengue Virus Infection
Marovich, MM, Grouard-Vogel G, Louder M, Eller M, Sun W, Birx
D, Hayes C, Frankel S and Mascola JR.
J Invest Derm 2001;6(3):219-24.
November 2001
Immunology Letters-November 2001
Monitoring
HIV-specific CD8+ T cell responses by intracellular cytokine production.
Betts MR, Casazza JP, Koup RA.
Immunol Lett 79:117-125.
October 2001
Cytometry-October 2001
Spectral
compensation for flow cytometry: visualization artifacts, limitations and caveats
Roederer, M. (2001).
Cytometry 45, 194-205.
Immunity-October 2001
HIV-1
actively replicates in naive CD4+ T cells residing within human lymphoid tissues
Eckstein, D. A., Penn, M. L., Korin, Y. D., Scripture-Adams,
D. D., Zack, J. A., Kreisberg, M. P., Roederer, M., Sherman,
M. P., Chin, P. S. and Goldsmith, M. A. (2001).
Immunity 15, 671-82.
Journal of Leukocyte Biology-October 2001
Vdelta1
and Vdelta2 gammadelta T cells express distinct surface markers
and might be developmentally distinct lineages
DeRosa, S., Mitra, D., Watanabe, N., Herzenberg, L. A., Herzenberg,
L. A. and Roederer, M. (2001).
J. Leuk. Biol. 70, 518-26.
September 2001
AIDS-September 2001
Poor
CD4+ T cell restoration after suppression of HIV-1 replication
may reflect lower thymic function
Teixeira L, H Valdez, JM McCune, RA Koup, AD Badley, MK Hellerstein,
LA Napolitano, DC Douek, G Mbisa, S Deeks, JM Harris, JD Barbour,
BH Gross, IR Francis, R Halvorsen, R Asaad, and MM Lederman
AIDS 15 (14):1749-1756
National Academy of Sciences-September 2001
Naive
CD4 T cells inhibit CD28-costimulated R5-tropic HIV replication in memory CD4 T cells
Mengozzi, M., Malipatlolla, M., De Rosa, S. C., Herzenberg,
L. A., Herzenberg, L. A. and Roederer, M. (2001).
Proc Natl Acad Sci, USA 98, 11644-9.
Virology-September 2001
Adaptation
to blockade of human immunodeficiency virus type 1 entry imposed
by the anti-CCR5 MAb 2D7
Aarons EJ, SA Beddows, T Willingham, L Wu, and RA Koup
Virology 287 (2) :382-390
August 2001
Current Opinion in Immunology-August 2001
Vaccines
for the prevention of HIV-1 disease
Mascola JR, Nabel GJ.
Curr Opin Immunol 2001 Aug;13(4):489-95
Cytometry-August 2001
Frequency
Difference Gating: A Multivariate Method for Identifying Subsets
that Differ Between Samples
Roederer, M. and Hardy, R. R. (2001).
Cytometry 45, 56-64.
Cytometry-August 2001
Probability
Binning Comparison: A Metric for Quantitating Multivariate
Distribution Differences
Roederer, M., Moore, W., Treister, A. S., Hardy, R. R. and
Herzenberg, L. A. (2001).
Cytometry 45, 47-55.
Cytometry-August 2001
Probability
Binning Comparison: A Metric for Quantitating Univariate Distribution Differences
Roederer, M., Treister, A., Moore, W. and Herzenberg, L. A. (2001).
Cytometry 45, 37-46.
Cytometry-August 2001
PE-APC:
A Resonance Energy Transfer Fluorochrome for Immunofluorescence
Tjioe, I., Legerton, T., Wegstein, J., Herzenberg, L. A. and
Roederer, M. (2001).
Cytometry, 44, 24-9.
Journal of Infectious Diseases-2001
Immune
interaction between respiratory syncytial virus infection
and allergen-sensitization critically depends on timing of challenges
Peebles RS, Hashimoto K, Collins RD, Jarzecka K, Furlong J,
Mitchell DB, Sheller JR, Graham BS.
Journal of Infectious Diseases 2001; 184: 1374-1379.
July 2001
Journal of Virology-July 2001
Decay
kinetics of Human Immunodeficiency Virus-specific CD8+ T cells
in peripheral blood after initiation of highly active antiretroviral therapy
Casazza JP, MR Betts, LJ Picker, and RA Koup
J. Virol. 75 (14): 6508-6516
June 2001
Journal of Infectious Diseases-June 2001
RANTES
production from CD4+ lymphocytes correlates with host genotype
and rates of human immunodeficiency virus type 1 disease progression
Paxton WA, AU Neuman, S Kang, L Deutch, RC Brown, RA Koup, and SM Wolinsky.
J. Infect. Dis. 183 (11):1678-1681
Nature Medicine-June 2001
Heme
oxygenase-1 protects against vascular constriction and proliferation
Duckers HJ, Boehm M, True AL, Yet SF, San H, Park JL, Clinton
Webb R, Lee ME,Nabel GJ, Nabel EG
Nat. Med. 7(6):693-698
Respiratory Research-June 2001
Viruses,
dendritic cells, and the lung
Peebles RS, Graham BS
Respiratory Research 2001; 2:245-249.
May 2001
Cytometry-May 2001
Phycoerythrin-allophycocyanin:
a resonance energy transfer fluorochrome for immunofluorescence
Tjioe I, Legerton T, Wegstein J, Herzenberg LA, Roederer M.
Cytometry 44(1):24-9
Journal of Virology-May 2001
Human
immunodeficiency virus type 1-specific immunity after genetic
immunization is enhanced by modification of Gag and Pol expression
Huang Y, Kong WP, Nabel GJ.
J Virol 2001 May;75(10):4947-51
Molecular Therapy-May 2001
Coexpression
of guanylate kinase with thymidine kinase enhances prodrug
cell killing in vitro and suppresses vascular smooth muscle
cell proliferation in vivo
Akyurek LM, Nallamshetty S, Aoki K, San H, Yang ZY, Nabel GJ, Nabel EG.
Mol. Ther. 2001 3(5 Pt. 1):779-786
April 2001
Nature-April 2001
Challenges
and opportunities for development of an AIDS vaccine
Gary J. Nabel
Nature, Vol 410, 19 April 2001
Nature Immunology-April 2001
Extracellular
matrix interacts with soluble CD95L: retention and enhancement of cytotoxicity
Aoki K, Kurooka M, Chen JJ, Petryniak J, Nabel EG, Nabel GJ
Nat Immunol 2001 Apr; 2(4): 333-7
Nature Medicine-April 2001
A
new latent HIV reservoir
Koup RA
Nat Med (4):404-5
March 2001
Blood-March 2001
Factors
affecting thymic function after allogeneic hematopoietic stem
cell transplantation
Weinberg K, Blazar BR, Wagner JE, Agura E,
Hill BJ, Smogorzewska M, Koup RA, Betts MR, Collins RH, Douek DC.
Blood 97 (5):1458-1466
Viral Immunology-March 2001
Direct
functional analysis of epitope-specific CD8+ T cells in peripheral blood
He, X. S., Rehermann, B., Boisvert, J., Mumm, J., Maecker,
H. T., Roederer, M., Wright, T. L., Maino, V. C., Davis, M.
M. and Greenberg, H. B. (2001).
Viral Immunol 14, 59-69.
February 2001
Clinical Laboratory Medicine-February 2001
11-color
Flow Cytometry: a Powerful Tool for Elucidation of the Complex Immune System
DeRosa, S. and Roederer, M. (2001).
Clinical Laboratory Medicine 2001; 21:697-712
Journal of Immunology-February 2001
Effect
of thymectomy on human peripheral blood T cell pools in Myasthenia
Sempowski GD, JR Thomasch, ME Gooding, LP Hale, LJ Edwards,
E Ciafaloni, DB Sanders, JM Massey, DC Douek, RA Koup, and BF Haynes Gravis.
J. Immunol. 166 (4) :2808-2817
Nature Medicine-February 2001
11
color, 13 parameter Flow Cytometry: Identification of human
naive T cells by phenotype, function, and T cell receptor diversity
DeRosa, S. C., Herzenberg, L. A., Herzenberg, L. A. and Roederer, M. (2001).
Nature Medicine 7, 245-8.
January 2001
Current Opinion in Investigational Drugs-January 2001
Vaccines:
Ideal drugs for the 21st Century?
Rappuoli R, Nabel GJ
Curr. Op. Invest. Drugs 2001 2(1):45-46
Virology-January 2001
Direct
Measurement of CD4+ and CD8+ T Cell Responses to CMV in HIV-1-Infected Subjects
Komanduri, K. V., Donahoe, S. M., Schmidt, D. K., Gillespie,
G., Ogg, G. S., Roederer, M., Nixon, D. F. and McCune, J. M. (2001).
Virology 279, 459-70.
2001 Annual Review
Trans Am Clin Climatol-2001
The
Gordon Wilson lecture: viruses and human disease
Nabel GJ
Trans. Am. Clin. Climatol. Assoc. 112:79-84
2000
December 2000
Trends in Microbiology-December 2000
Viral
replication and the coactivators p300 and CBP
Hottiger MO, Nabel GJ
Trends Microbiol. 8(12):560-565
November 2000
Molecular Medicine-November 2000
SM22a
promoter targets gene expression to vascular smooth muscle
cells in vitro and in vivo
Akyurek LM, Yang Z-Y, Aoki K, San H, Nabel GJ, Parmacek MS, Nabel EG
Mol. Med. 6:983-991
Nature-November 2000
Development
of a preventive vaccine for Ebola virus infection in primates
Sullivan NJ, Sanchez A, Rollin PE, Yang ZY, Nabel GJ.
Nature 2000 Nov 30;408(6812):605-9.
Proceedings of the National Academy
of Science U S A-November 2000
Regulation
of beta -catenin transformation by the p300 transcriptional coactivator
Sun Y, Kolligs FT, Hottiger MO, Mosavin R, Fearon ER, Nabel GJ.
Proceedings of the National Academy of Science U S A 2000
Nov 7;97(23):12613-8.
October 2000
European Journal of Clinical Investigation-October 2000
N-acetylcysteine
(NAC) replenishes glutathione in HIV infection
DeRosa, S. C., Zaretsky, M. D., Dubs, J. G., Roederer, M.,
Anderson, M., Green, A., Mitra, D., Watanabe, N., Nakamura,
H., Tjioe, I., Deresinski, S. C., Moore, W. A., Ela, S. W.,
Parks, D., Herzenberg, L. A. and Herzenberg, L. A. (2000).
Eur. J. Clin. Invest. 30, 915-29.
Science-October 2000
Control
of Viremia and prevention of clinical AIDS in Rhesus monkeys
by cytokine-augmented DNA vaccination
Barouch DH, Santra S, Schmitz J, Kuroda M, Fu T, Wagner W,
Bilska M, Craiu A, Zheng XX, Krivulka G, Beaudry K, Lifton
M, Nickerson C, Trigona W, Punt K, Freed D, Guan L, Dubey
S, Casimiro D, Simon A, Davies ME, Chastain M, Strom T, Gelman
R, Montefiori D, Lewis M, Emini E, Shiver J, and Letvin N.
Science 2000 Oct;290:486-492.
New England Journal of Medicine-October 2000
Clinical
implications of basic research: Antibodies and resistance
to natural HIV infection
Nabel GJ and Sullivan NJ
N. Engl. J. Med. 343(17):1263-1265, 2000
September 2000
Journal of Immunological Methods-September 2000
A
practical approach to multicolor flow cytometry for immunophenotyping
Baumgarth, N. and Roederer, M. (2000).
J. Immunol. Meth 243, 77-97.
August 2000
Nature Medicine-August 2000
Identification
of the Ebola virus glycoprotein as the main viral determinant
of vascular cell cytotoxicity and injury
Yang ZY, Duckers HJ, Sullivan NJ, Sanchez A, Nabel EG, Nabel GJ.
Nature Medicine 2000 Aug;6(8):886-9.
June 2000
Molecular Therapy-June 2000
Restricted
expression of an adenoviral vector encoding Fas ligand (CD95L)
enhances safety for cancer gene therapy
Aoki K, Akyurek LM, San H, Leung K, Parmacek MS, Nabel EG, Nabel GJ.
Molecular Therapy 2000 Jun;1(6):555-65
May 2000
Circulation-May 2000
Differential
effects of the cyclin-dependent kinase inhibitors p27 (Kip1), p21 (Cip1),
and p16 (Ink4) on vascular smooth muscle cell proliferation
Tanner FC, Boehm M, Aky�rek LM, San H, Yang Z-Y, Tashiro J,
Nabel GJ and Nabel EG
Circulation, 101(17):2022-2025
April 2000
Human Gene Therapy-April 2000
Human
gene marker/therapy clinical protocols
Rosenberg SA, Blaese RM, Brenner MK, Deisseroth AB, Ledley
FD, Lotze MT, Wilson
JM, Nabel GJ, Cornetta K, Economou JS, Freeman SM, Riddell
SR, Brenner M, Oldfield E,
Gansbacher B, Dunbar C, Walker RE, Schuening FG, Roth JA,
Crystal RG, Welsh MJ, Culver K,
Heslop HE, Simons J, Wilmott RW, Boucher RC, Siegler HF, Barranger
JA, Karlsson S, Kohn D,
Galpin JE, Raffel C, Hesdorffer C, Ilan J, Cassileth P, O'Shaughnessy
J, Kun LE, Das TK, Wong
Staal F, Sobol RE, Haubrich R, Sznol M, Rubin J, Sorcher EJ,
Rosenblatt J, Walker R, Brigham K,
Vogelzang N, Hersh E, Eck SL.
Hum. Gene Ther. 11(6):919-979
March 2000
Journal of Immunotherapy-March 2000
CD95-mediated
tumor recognition by CD4+ effector cells in a murine mammary model
Aruga E, Tanigawa K, Aruga A, Arai H, Smith JW II, Nickoloff
BJ, Nabel GJ, and Chang AE
J. Immunother. 23(2):225-34
February 2000
Immunology Today-February 2000
How
much longer will tumour cells fool the immune system?
Ferrone S, Finerty JF, Jaffee EM, Nabel GJ.
Immunol. Today 21(2):70-72
January 2000
Journal of Immunology-January 2000
Ebola
virus secretory glycoprotein (sGP) diminishes FcgammaRIIIB-to-CR3
proximity on neutrophils
J. Immunol. 164: 953-958
2000
Annual Review
HIV Molecular Immunology Database-2000
Clinical
Trials of HIV Vaccines in HIV Molecular Immunology Database Compendium
Graham BS, Korber BTM, Moore JP, Brander C, Walker BD, Haynes
BF, Koup R, editors.
Los Alamos National Laboratory: Theoretical Biology and Biophysics,
Los Alamos, NM, 2000, pages I-20 - I-38.
1999
December 1999
Nature-December 1999
p53
inhibition by the LANA protein of KSHV protects against cell death
Friborg J Jr, Kong W, Hottiger MO, and Nabel GJ.
Nature. 402(6764):889-894, 1999.
June 1999
New England Journal of Medicine-June 1999
Naturally
attenuated HIV-lessons for AIDS vaccines and treatment
Collins KL, Nabel GJ
N. Engl. J. Med. 340(22):1756-1757
April 1999
Nature Medicine-April 1999
Surviving
Ebola virus infection
Nabel GJ
Nat. Med. 5(4):373-374
February 1999
Nature - February 1999
A
transformed view of cyclosporine
Nabel GJ
Nature 397(6719):471-472
January 1999
Proceedings of the National Academies of Science-January 1999
Development
of optimized vectors for gene therapy
Nabel GJ
Proc. Natl. Acad. Sci. U.S.A. 96(2):324-326
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