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Current Bibliographies in Medicine 94-1


Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes




CBM  94-1



Effect of Corticosteroids for Fetal Maturation on Perinatal Outcomes


January 1985 through December 1993, plus selected earlier citations

715 Citations




Prepared by


Karen Patrias, M.L.S., National Library of Medicine

Linda L. Wright, M.D., National Institute of Child Health and
Human Development

Gerald Merenstein, M.D., University of Colorado Health
Sciences Center









U.S. DEPARTMENT OF HEALTH
AND HUMAN SERVICES
Public Health Service
National Institutes of Health


National Library of Medicine
Reference Section
8600 Rockville Pike
Bethesda, Maryland  20894


1994



SERIES  NOTE


Current Bibliographies in Medicine (CBM) is a continuation in part of
the National Library of Medicine's Literature Search Series, which
ceased in 1987 with No. 87-15.  In 1989 it also subsumed the
Specialized Bibliography Series.  Each bibliography in the new series
covers a distinct subject area of biomedicine and is intended to fulfill a
current awareness function.  Citations are usually derived from
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MEDLINE, AVLINE, BIOETHICSLINE, CANCERLIT, CATLINE,
HEALTH, POPLINE, and TOXLINE.  The only criterion for the
inclusion of a particular published work is its relevance to the topic
being presented; the format, ownership, or location of the material is
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Current Bibliographies in Medicine
Reference Section
National Library of Medicine
Bethesda, MD  20894
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Use of funds for printing this periodical has been approved by the
Director of the Office of Management and Budget through September
30, 1994.  EFFECT OF CORTICOSTEROIDS FOR FETAL MATURATION
ON PERINATAL OUTCOMES

Preterm delivery is a major cause of infant mortality and morbidity. 
Approximately 500,000 premature infants are born each year in the
United States, many of whom require treatment in newborn intensive
care units for complications of their prematurity.  The survival and
health status of premature infants is directly proportional to their
maturity and weight at birth.  Preterm infants account for 74 per cent of
neonatal deaths; those born before 28 weeks of gestation, instead of the
normal 40 weeks, account for 50 per cent of neonatal deaths.

Corticosteroid treatment of pregnant women delivering prematurely
was first introduced in 1972 to enhance fetal lung maturity.  A recent
meta-analysis* concluded that antenatal corticosteroid administration
prior to anticipated preterm delivery is associated with substantial
reduction in the incidence of early neonatal death, as well as in
respiratory distress syndrome, intraventricular hemorrhage, and
necrotizing enterocolitis.

Despite evidence of beneficial effects from both experimental models
and randomized controlled trials in humans, few women delivered
prematurely receive antenatal steroid treatment.  In reports from
approximately 500 perinatal centers, only 12 to 18 per cent of women
who deliver preterm infants 501-1500 grams are treated with antenatal
steroids.  Many patients are not treated because of concerns about the
efficacy of corticosteroid in subpopulations and the potential
complications of treatment.  There are also questions about the need
for corticosteroid therapy since the advent of artificial surfactant
therapy.

This bibliography was prepared in support of the National Institutes of
Health Consensus Development Conference on the Effect of
Corticosteroid for Fetal Maturation on Perinatal Outcomes held
February 28-March 2, 1994 in Bethesda, Maryland.  Because the
literature on antenatal steroids is large, the bibliography is necessarily
selective.  It emphasizes journal articles in the English language
published between 1985 and the present, selected earlier literature, and
conference papers published from 1992 through 1993.  Preference was
given to articles dealing with human subjects, although relevant articles
describing prenatal animal models are also included.  Selected general
articles on outcome of premature infants, surfactant treatment,
physiologic hormone levels, and the economics of care were included
as background.  The bibliography is arranged in five subject categories
with subheadings; citations may be listed in more than one category.

______________________________
*Crowley P, Chalmers I, Keirse MJ.  The effects of corticosteroid
administration before preterm delivery: an overview of the evidence
from controlled trials.  Br J Obstet Gynaecol 1990 Jan;97(1):11-25.



SEARCH  STRATEGY

A variety of online databases are usually searched in preparing
bibliographies in the CBM series.  To assist you in updating or
otherwise manipulating the material in this search, the strategy used for
the NLM's MEDLINE database is given below.  Please note that the
search strategies presented here differ from individual demand searches
in that they are generally broadly formulated and irrelevant citations
edited out prior to printing.


SS 1 = ADRENAL CORTEX HORMONES OR EXP GLUCOCORTICOIDS OR 
EXP GLUCOCORTICOIDS, SYNTHETIC OR PULMONARY SURFACTANTS

SS 2 = 1 AND INFANT, NEWBORN OR 1 AND INFANT, PREMATURE OR
1 AND ANIMALS, NEWBORN

SS 3 = 1 AND EXP A16 OR 1 AND EMBRYOLOGY (SH)

SS 4 = EXP INFANT, LOW BIRTH WEIGHT OR 
EXP INFANT, PREMATURE, DISEASES OR 
PRENATAL EXPOSURE DELAYED EFFECTS

SS 5 = EXP FETAL DEVELOPMENT OR EXP FETAL DISEASES OR 
EXP FETAL DEATH OR EXP FETAL HEART

SS 6 = EXP PREGNANCY OR EXP PREGNANCY COMPLICATIONS OR 
PRENATAL CARE

SS 7 = 4 OR 5 OR 6

SS 8 = 1 AND 7 OR 2 OR 3

SS 9 = (TF) ALL GLUCOCORTICOID: OR ALL CORTICOSTEROID: OR 
ALL BETAMETHASONE: OR ALL DEXAMETHASONE: OR 
ALL HYDROCORTISONE: OR ADRENAL AND CORTEX AND 
ALL HORMONE#

SS 10 = (TF) ALL PRETERM: OR ALL ANTENAT: OR ALL PERINAT: OR 
ALL PRENAT:

SS 11 = 9 AND 10

SS 12 = 8 AND NOT ALL TRANSPLANT: (MHF)

SS 13 = 11 OR 12


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the back of this bibliography.


SAMPLE  CITATION

Citations in this bibliographic series are formatted according to the
rules established for Index Medicus*.  A sample journal citation
appears below.  For journal articles written in a foreign language, the
English translation of the title is placed in brackets.  The language of
publication is shown by a three letter abbreviation appearing at the end
of the citation.



Journal Article:

Authors               Article Title

Anlar Y, Annar B.  The effect of dexamethasone...
Early Hum Dev 1987 Sep;15(5):265-8.  

Abbreviated Journal  Date Volume Issue Pages
Title







_________________________________

*For details of the formats used for references, see the following
publication:

Patrias, Karen. National Library of Medicine recommended formats for
bibliographic citation.  Bethesda (MD):  The Library; 1991 Apr. 
Available from: NTIS, Springfield, VA; PB91-182030.



TABLE  OF  CONTENTS


NEWBORN

Cardiovascular Effects
Central Nervous System Effects
Endocrine Effects
Gastrointestinal Effects (incl. Bilirubin)
Immunology and Infection
Outcome
Pharmacology
Pulmonary Effects
Renal Function

MATERNAL

Adverse Effects
Combination Therapy
High-Risk Pregnancies
Pharmacology

ECONOMICS

META-ANALYSIS

ANIMAL MODELS

Behavior
Cardiovascular Effects
Central Nervous System Effects
Combination Therapy
Endocrine Effects
Gastrointestinal Effects
Pharmacology
Pulmonary Effects
Renal Function


NEWBORN


Cardiovascular Effects


Arduini D, Rizzo G, Parlati E, Giorlandino C, Valensise H, Dell'Acqua
S, Romanini C.   Modifications of ultradian and circadian rhythms of
fetal heart rate after fetal-maternal adrenal gland suppression: a double
blind study.  Prenat Diagn 1986 Nov-Dec;6(6):409-17.

Clyman RI, Ballard PL, Sniderman S, et al.   Prenatal administration of
betamethasone for prevention of patent ductus arteriosus.  J Pediatr
1981 Jan;98(1):123-6.

Clyman RI, Mauray F, Roman C, Rudolph AM, Heymann MA.  
Glucocorticoids alter the sensitivity of the lamb ductus arteriosus to
prostaglandin E2.  J Pediatr 1981 Jan;98(1):126-8.

Edwards CR, Benediktsson R, Lindsay RS, Seckl JR.   Dysfunction of
placental glucocorticoid barrier: link between fetal environment and
adult hypertension?  Lancet 1993 Feb 6;341(8841):355-7.  Comment
in: Lancet 1993 Mar 27;341(8848):827; Lancet 1993 Mar
27;341(8848):827-8.

Eronen M, Kari A, Pesonen E, Hallman M.   The effect of antenatal
dexamethasone administration on the fetal and neonatal ductus
arteriosus. A randomized double-blind study.  Am J Dis Child 1993
Feb;147(2):187-92.

Fauser A, Pohlandt F, Bartmann P, Gortner L.   Rapid increase of
blood pressure in extremely low birth weight infants after a single dose
of dexamethasone.  Eur J Pediatr 1993 Apr;152(4):354-6.

Heyman E, Ohlsson A, Shennan AT, Heilbut M, Coceani F.  Closure of
patent ductus arteriosus after treatment with dexamethasone.  Acta
Paediatr Scand 1990 Jun-Jul;79(6-7):698-700.

Leung A, Neale E, Rogers M.   Transient improvement of umbilical
arterial waveform after maternal steroid administration. Case report. 
Br J Obstet Gynaecol 1991 May;98(5):492-3.

Ohlsson A, Heyman E.   Dexamethasone-induced bradycardia [letter]. 
Lancet 1988 Nov 5;2(8619):1074.

Quiel V.   [Conservative treatment of HELLP syndrome].  Zentralbl
Gynakol 1993;115(8):378-80. (Ger).

Sabin S, Diss E, Porreco RP.   Betamethasone TRH treatment of
preterm fetuses alters the appearance of fetal heart rate tracings 
[abstract].  Am J Obstet Gynecol 1993;168(1 Pt 2):337.

Wasserstrum N, Huhta JC, Mari G, Sharif DS, Willis R, Neal NK.  
Betamethasone and the human fetal ductus arteriosus.  Obstet Gynecol
1989 Dec;74(6):897-900.


Central Nervous System Effects


Amato M, Huppi P, Markus D, Herschkowitz N.   Neurological
function of immature babies after surfactant replacement therapy. 
Neuropediatrics 1991 Feb;22(1):43-4.

Clark CE, Clyman RI, Roth RS, et al.   Risk factor analysis of
intraventricular hemorrhage in low birthweight infants.  J Pediatr 1981
Oct;99(4):625-8.

Cordella L.   [Stress, glucocorticoids, and handicap: Prenatal and
perinatal data].  Ital J Intellective Impair 1989 Jun;2(1):75-83.  (Ita).

de Zegher F, de Vries L, Pierrat V, Daniels H, Spitz B, Casaer P,
Devlieger H, Eggermont E.   Effect of prenatal
betamethasone/thyrotropin releasing hormone treatment on
somatosensory evoked potentials in preterm newborns.  Pediatr Res
1992 Aug;32(2):212-4.

Doyle LW, Kitchen WH, Ford GW, Rickards AL, Lissenden JV, Ryan
MM.   Effects of antenatal steroid therapy on mortality and morbidity
in very low birth weight infants.  J Pediatr 1986 Feb; 108(2):287-92.

Fazzi E, Bianchini L, Ometto A, Piazza F, Rondini G, Lanzi G.  
[Infantile cerebral palsy and neuromotor development in very low birth
weight infants].  Minerva Pediatr 1990 Jun;42(6):219-25. (Ita).

Fazzi E, Orcesi S, Spinillo A, Stronati M, Telesca C, Farinotti L.  
[Neuropsychologic development of small for gestational age preterm
infants: follow up at 12-36 months of age].  Pediatr Med Chir 1992
Jul-Aug;14(4):403-7. (Ita).

Fernandez-Carrocera LA, Patino-Felix F, Udaeta-Mora E, Garza
Morales S, Ibarra-Reyes MP, Rodriguez-Perez L.   [Subependymal/
intraventricular hemorrhage in preterm newborn infants.
Neurodevelopmental course during the first year of life].  Bol Med
Hosp Infant Mex 1993 Apr;50(4):241-7. (Spa).

Forslund M, Bjerre I.   Follow-up of preterm children. I. Neurological
assessment at 4 years of age.  Early Hum Dev 1989 Sep;20(1):45-66.

Garite TJ, Freeman RK, Linzey EM, et al.   Prospective randomized
study of corticosteroids in the management of premature rupture of the
membranes and the premature gestation.  Am J Obstet Gynecol
1981;141:508-15.

Copper RL.   Neonatal periventricular- intraventricular hemorrhage
after maternal beta-sympathomimetic tocolysis. The March of Dimes
Multicenter Study Group.  Am J Obstet Gynecol 1992 Oct;167(4 Pt
1):873-9.

Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L.  
Very low birth weight outcomes of the National Institute of Child
Health and Human Development Neonatal Network.  Pediatrics 1991
May;87(5):587-97.  Comment in: Pediatrics 1992 Feb;89(2):357;
discussion 357-8.

Halsey CL, Collin MF, Anderson CL.   Extremely low birth weight
children and their peers: a comparison of preschool performance. 
Pediatrics 1993 Apr;91(4):807-11.

Jarvenpaa AL, Vlrtanen M, Pohjavuori M.   The outcome of extremely
low birthweight infants.  Ann Med 1991 Dec;23(6):699-704.

Katz M, Meizner I, Holcberg G, Mazor M, Hagay ZJ, Insler V.  
Reduction or cessation of fetal movements after administration of
steroids for enhancement of lung maturation. I. Clinical evaluation.  Isr
J Med Sci 1988 Jan;24(1):5-9.

Kitchen WH, Doyle LW, Rickards AL, Ford G, Kelly E, Callanan C.  
Survivors of extreme prematurity--outcome at 8 years of age.  Aust N
Z J Obstet Gynaecol 1991 Nov;31(4):337-9.

Kitchen WH, Rickards AL, Doyle LW, Ford GW, Kelly EA, Callanan
C.   Improvement in outcome for very low birthweight children:
apparent or real?  Med J Aust 1992 Aug 3;157(3):154-8.

Klein NK, Hack M, Breslau N.   Children who were very low birth
weight: development and academic achievement at nine years of age.  J
Dev Behav Pediatr 1989 Feb;10(1):32-7.

Lee H, Barratt MS.   Cognitive development of preterm low birth
weight children at 5 to 8 years old.  J Dev Behav Pediatr 1993
Aug;14(4):242-9.

Leviton A, Kuban KC, Pagano M, Allred EN, Van Marter L.  
Antenatal corticosteroids appear to reduce the risk of postnatal
germinal matrix hemorrhage in intubated low birth weight newborns. 
Pediatrics 1993 Jun;91(6):1083-8.

Lipper EG, Ross GS, Auld PA, Glassman MB.   Survival and outcome
of infants weighing less than 800 grams at birth.  Am J Obstet Gynecol
1990 Jul;163(1 Pt 1):146-50.  Comment in: Am J Obstet Gynecol 1991
Aug;165(2):482-3;  Am J Obstet Gynecol 1991 Oct;165(4 Pt
1):1159-60.

MacArthur B, Howie RN, DeZoete A, Elkins J, Liang AY.   Long-term
follow-up of children exposed to betamethasone in utero.  In: Tejani N,
editor.  Obstetrical events and developmental sequelae.  Boca Raton
(FL): CRC Press; 1990.  p. 81-9.

MacArthur BA, Howie RN, Dezoete JA, Elkins J.   Cognitive and
psychosocial development of 4-year-old children whose mothers were
treated antenatally with betamethasone.  Pediatrics 1981
Nov;68(5):638-43.

MacArthur BA, Howie RN, Dezoete JA, Elkins J.   School progress
and cognitive development of 6-year-old children whose mothers were
treated antenatally with betamethasone.  Pediatrics 1982
Jul;70(1):99-105.

Maher J, Goldenberg RL.  Outcomes of very-low-birth-weight infants
after maternal corticosteroid therapy before 28 weeks' gestation 
[letter].  Am J Obstet Gynecol 1993 Nov;169(5):1363-4.

Marlow N, Roberts L, Cooke R.   Outcome at 8 years for children with
birth weights of 1250 g or less.  Arch Dis Child 1993 Mar;68(3 Spec
No):286-90.

McCormick MC.   Has the prevalence of handicapped infants increased
with improved survival of the very low birth weight infant?  Clin
Perinatol 1993 Mar;20(1):263-77.

McCormick MC, Brooks-Gunn J, Workman-Daniels K, Turner J,
Peckham GJ.   The health and developmental status of very
low-birth-weight children at school age.  JAMA 1992 Apr 22-29;
267(16):2204-8.

Meizner I, Katz M, Holcberg G, Insler V.   Reduction or cessation of
fetal movements after steroid administration for enhancement of lung
maturation. II: Analysis of blood flow velocimetry.  Isr J Med Sci 1989
Oct;25(10):556-9.

Msall ME, Buck GM, Rogers BT, Merke D, Catanzaro NL, Zorn WA.  
Risk factors for major neurodevelopmental impairments and need for
special education resources in extremely premature infants.  J Pediatr
1991 Oct;119(4):606-14. Published erratum appears in J Pediatr 1992
May;120(5):838.

Pryds O, Trojaborg W, Carlsen J, Jensen J.   Determinants of visual
evoked potentials in preterm infants.  Early Hum Dev
1989;19(2):117-26.

Ross G, Lipper EG, Auld PA.   Educational status and school-related
abilities of very low birth weight premature children.  Pediatrics 1991
Dec;88(6):1125-34.

Saigal S, Szatmari P, Rosenbaum P, Campbell D, King S.   Cognitive
abilities and school performance of extremely low birth weight children
and matched term control children at age 8 years: a regional study.  J
Pediatr 1991 May;118(5):751-60.

Schmand B, Neuvel J, Smolders-de Haas H, Hoeks J, Treffers PE,
Koppe JG.   Psychological development of children who were treated
antenatally with corticosteroids to prevent respiratory distress
syndrome.  Pediatrics 1990 Jul;86(1):58-64.

Veen S, Ens-Dokkum MH, Schreuder AM, Verloove-Vanhorick SP,
Brand R, Ruys JH.   Impairments, disabilities, and handicaps of very
preterm and very-low-birthweight infants at five years of age. The
Collaborative Project on Preterm and Small for Gestational Age Infants
(POPS) in The Netherlands.  Lancet 1991 Jul 6;338(8758):33-6. 
Comment in: Lancet 1991 Aug 24; 338(8765):511-2.

White AD, Andrews ED, Weinberg JM, Wold DE, Long WA.   The
Exosurf Neonatal TIND Study Group.  Factors associated with
intraventricular hemorrhage (IVH) in the exosurf neonatal treatment
IND (TIND)  [abstract].  Pediatr Res 1992;31:263A.


Endocrine Effects

Ametov AS, Chechkova OB, Samsygina GA, Chernukha VA,
Kazakova LE.   [Hypophyseal, thyroid and adrenal cortical hormone
levels in the blood serum of newborn infants in the early neonatal
period].  Pediatriia 1985 Sep;(9):20-2. (Rus).

Arduini D, Rizzo G, Parlati E, Giorlandino C, Valensise H, Dell'Acqua
S, Romanini C.   Modifications of ultradian and circadian rhythms of
fetal heart rate after fetal-maternal adrenal gland suppression: a double
blind study.  Prenat Diagn 1986 Nov-Dec;6(6):409-17.

Bacigalupo G, Langner K, Schmidt S, Saling E.   Plasma
immunoreactive beta-endorphin, ACTH and cortisol concentrations in
mothers and their neonates immediately after delivery--their
relationship to the duration of labor.  J Perinat Med 1987;15(1):45-52.

Bagnoli F, Bruchi S, Garosi G, Caniggia I, Inaudi PA.   [Phenomenon
of neonatal adaptation: progesterone, ACTH and cortisol during the 1st
24 hours of life].  Boll Soc Ital Biol Sper 1988 Apr;64(4):317-22. (Ita).

Ballard PL, Ballard RA, Creasy RK, Padbury J, Polk DH, Bracken M,
Moya FR, Gross I.   Plasma thyroid hormones and prolactin in
premature infants and their mothers after prenatal treatment with
thyrotropin-releasing hormone.  Pediatr Res 1992 Dec;32(6):673-8.

Branchaud CL, Goodyer CG, Shore P, Lipowski LS, Lefebvre Y.  
Functional zonation of the midgestation human fetal adrenal cortex:
fetal versus definitive zone use of progesterone for cortisol synthesis. 
Am J Obstet Gynecol 1985 Jan 15;151(2):271-7.

Broide E, Bistritzer T, Livne M, Neuman M, Goldberg M, Aladjem M.  
The effect of prenatal administration of dexamethasone and ritodrine on
cord blood cortisol and glucose concentrations in premature infants
with respiratory distress syndrome.  J Perinat Med 1992;20(4):289-95.

Chan EC, Smith R, Lewin T, Brinsmead MW, Zhang HP, Cubis J,
Thornton K, Hurt D.   Plasma corticotropin-releasing hormone,
beta-endorphin and cortisol inter-relationships during human
pregnancy.  Acta Endocrinol (Copenh) 1993 Apr;128(4):339-44.

Charnvises S, Fencl MD, Osathanondh R, Zhu MG, Underwood R,
Tulchinsky D.   Adrenal steroids in maternal and cord blood after
dexamethasone administration at midterm.  J Clin Endocrinol Metab
1985 Dec;61(6):1220-2.

Chernukha EA, Komissarova LM, Malysheva VA, Abubakirova AM,
Galstian AA.   [Cortisol contents in maternal and umbilical artery blood
during delivery of low birth weight fetuses].  Akush Ginekol (Mosk)
1989 Jan;(1):26-30. (Rus).

de Graeff-Meeder ER, Wit JM.   [Glucocorticoids in pregnancy: effects
on the fetus and newborn infant].  Ned Tijdschr Geneeskd 1986 Nov
29;130(48):2168-71. (Dut).

Dorr HG, Sippell WG, Versmold HT, Bidlingmaier F, Knorr D.  
Plasma mineralocorticoids, glucocorticoids, and progestins in
premature infants: longitudinal study during the first week of life. 
Pediatr Res 1988 May;23(5):525-9.

Endoh A.   Trend analysis of serum progesterone, deoxycorticosterone,
deoxycorticosterone sulfate, cortisol, corticosterone,
18-hydroxydeoxycorticosterone and estradiol in early neonates. 
Endocrinol Jpn 1989 Dec;36(6):851-8.

Farquharson RG, Dyas J, Pierrepoint CG.   Cortisol concentrations in
the umbilical artery and vein of breech-presenting infants at term in
relation to the method of delivery.  Br J Obstet Gynaecol 1985
Oct;92(10):1040-3.

Ferrari S, Zaccháe G, Zanini F, Rosignoli R, Corgnati A, Rossi L,
Gaioni L.   [Controlled study on the prevention of respiratory distress
syndrome with betamethasone in pregnancy and ACTH and cortisol
levels in the premature newborn infant].  Pediatr Med Chir 1985
Mar-Apr;7(2):279-82. (Ita).

Franklin RC, Purdie GL, O'Grady CM.   Neonatal thyroid function:
prematurity, prenatal steroids, and respiratory distress syndrome.  Arch
Dis Child 1986 Jun;61(6):589-92.

Fustinana C, Cernandas JC, Lopez N, Rodriquez D.   Somatic growth
in VLBW infants prenatally treated with betamethasone  plus TRH 
[abstract].  Pediatr Res 1993;33(4 Pt 2):260a.

Goland RS, Conwell IM, Warren WB, Wardlaw SL.   Placental
corticotropin-releasing hormone and pituitary-adrenal function during
pregnancy.  Neuroendocrinology 1992;56(5):742-9.

Goland RS, Wardlaw SL, Blum M, Tropper PJ, Stark RI.   Biologically
active corticotropin-releasing hormone in maternal and fetal plasma
during pregnancy.  Am J Obstet Gynecol 1988;159(4):884-90.

Hanes RC Jr.   Adrenocorticotropic hormone: adrenocortical steroids
and their synthetic analogs; inhibitors of the synthesis and actions of
adrenocortical hormones.  In: Gilman AG, et al., editors.  Goodman
and Gilman's the pharmacological basis of therapeutics.  8th ed.  New
York: Pergamon Press; 1990.  p. 1431-59. 

Haning RV Jr, Curet LB, Poole WK, Boehnlein LM, Kuzma DL, Meier
SM.   Effects of fetal sex and dexamethasone on preterm maternal
serum concentrations of human chorionic gonadotropin, progesterone,
estrone, estradiol, and estriol.  Am J Obstet Gynecol 1989 Dec;161(6
Pt 1):1549-53.

Hanna CE, Keith LD, Colasurdo MA, Buffkin DC, Laird MR, Mandel
SH, Cook DM, LaFranchi SH, Reynolds JW.   Hypothalamic pituitary
adrenal function in the extremely low birth weight infant.  J Clin
Endocrinol Metab 1993 Feb;76(2):384-7.

Hercz P.   Quantitative changes in steroid and peptide hormones in the
maternal-fetoplacental system between the 28th-40th weeks of
pregnancy.  Acta Med Hung 1985;42(1-2):29-39.

Hercz P, Siklos P, Ungar L.   Serum cortisol level changes in the
maternal-fetoplacental unit between the 28th-40th weeks of pregnancy. 
Acta Physiol Hung 1987;69(2):161-5.

Hercz P, Siklos P, Ungar L.   Serum dehydroepiandrosterone and
cortisol concentration in the maternal-fetoplacental hormonal system in
elective caesarean section and spontaneous vaginal delivery in the 28th
to 36th and 40th weeks of pregnancy.  Gynecol Obstet Invest
1990;29(2):112-4.

Homoki J, Limmer G, Teller WM.   Influence of maternal antenatal
treatment with betamethasone on the postnatal adrenal status in
preterm infants.  In: Gorog S, editor. Advances in steroid analysis '90.
4th Symposium of the Analysis on Steroids; 1990 Apr 24-26; Pecs,
Hungary. Budapest: Akademiai Kiado: 1991.  p. 333-8.

Honour JH, Wickramaratne K, Valman HB.   Adrenal function in
preterm infants.  Biol Neonate 1992;61(4):214-21.

Ipsiroglu OS, Semmelrock J, Gmoser G, Stockler S, Rosegger H.  
[The value of umbilical cord blood cortisol].  Gynakol Rundsch
1990;30 Suppl 1:197-8. (Ger).

Jaskiewicz J, Szafran Z, Szafran H, Sztefko K, Sucharski P.   The
relation between growth hormone, cortisol and insulin and plasma
levels of free fatty acids and glucose in healthy mothers at delivery and
their newborn children.  Endokrynol Pol 1985;36(4):205-13.

Jones SA, Brooks AN, Challis JR.   Steroids modulate
corticotropin-releasing hormone production in human fetal membranes
and placenta.  J Clin Endocrinol Metab 1989 Apr;68(4):825-30.

Kairalla AB.   Hypothalamic-pituitary-adrenal axis function in
premature neonates after extensive prenatal treatment with
betamethasone: a case history.  Am J Perinatol 1992
Sep-Nov;9(5-6):428-30.

Kraiem Z, Sack J, Brish M.   Serum cortisol levels: the first 10 days in
full-term and preterm infants.  Isr J Med Sci 1985 Feb;21(2):170-2.

Kubota T, Tsuzuki H, Saito M.   Determination of prolactin, growth
hormone, beta-endorphin, and cortisol in both maternal plasma and
amniotic fluid during human gestation.  Acta Endocrinol (Copenh)
1989 Aug;121(2):297-303.

Kuznetsova LV.   [Adrenal glucocorticoid function and its regulation in
human prenatal ontogeny and in the 1st week of life].  Biull Eksp Biol
Med 1987 Jul;104(7):11-3. (Rus).

Lao TT, Panesar NS.   The effect of labour on prolactin and cortisol
concentrations in the mother and the fetus.  Eur J Obstet Gynecol
Reprod Biol 1989 Mar;30(3):233-8.

Lauterbach R, Szafran H, Szafran Z.   Blood glucose concentration and
the levels of cortisol, growth hormone and insulin in women at labour
and their healthy neonates born by vaginal delivery and cesarean
section.  Endokrynol Pol 1988;39(4):169-79.

Lopez Bernal A, MacKenzie IZ.   Corticosteroid levels in human fetal
blood at midgestation and at term.  Am J Obstet Gynecol 1987
Jan;156(1):112-3.

Lopez Bernal A, Turnbull AC.   Cortisol metabolism in human placenta
and decidua is resistant to anoxia.  Horm Metab Res 1985
Mar;17(3):167.

Mendelson CR, Snyder JM.   Role of prolactin, cortisol, and insulin in
the regulation of surfactant synthesis by the human fetal lung.  Pediatr
Pulmonol 1985 May-Jun;1(3 Suppl):S91-8.

Murphy BE, Clark SJ, Donald IR, Pinsky M, Vedady D.   Conversion
of maternal cortisol to cortisone during placental transfer to the human
fetus.  Am J Obstet Gynecol 1974 Feb 15;118(4):538-41.

Nahoul K, Daffos F, Forestier F, Chartier M, Scholler R.   Plasma
corticosteroid patterns in the fetus.  J Steroid Biochem 1988
Jun;29(6):635-40.

Nahoul K, Daffos F, Forestier F, Dehennin L.   Corticosteroid sulfates
in fetus plasma.  J Steroid Biochem 1989 Oct;33(4A):613-9.

Nahoul K, Daffos F, Forestier F, Scholler R.   Cortisol, cortisone and
dehydroepiandrosterone sulfate levels in umbilical cord and maternal
plasma between 21 and 30 weeks of pregnancy.  J Steroid Biochem
1985 Oct;23(4):445-50.

Neri A, Merlob P, Kaplan B, Ovadia Y, Kaufman H.   Maternal and
cord plasma cortisol and aldosterone levels at delivery, in various ethnic
groups in Israel. Preliminary report.  Isr J Med Sci 1986
Jul-Aug;22(7-8):576-8.

Okamoto E, Takagi T, Makino T, Sata H, Iwata I, Nishino E, Mitsuda
N, Sugita N, Otsuki Y, Tanizawa O.   Immunoreactive corticotropin-
releasing hormone, adrenocorticotropin and cortisol in human plasma
during pregnancy and delivery and postpartum.  Horm Metab Res 1989
Oct;21(10):566-72.

Partsch CJ, Sippell WG, MacKenzie IZ, Aynsley-Green A.   The
steroid hormonal milieu of the undisturbed human fetus and mother at
16-20 weeks gestation.  J Clin Endocrinol Metab 1991;73(5):969-74.

Pohjavuori M, Rovamo L, Laatikainen T.   Plasma immunoreactive
beta-endorphin and cortisol in the newborn infant after elective
caesarean section and after spontaneous labour.  Eur J Obstet Gynecol
Reprod Biol 1985 Feb;19(2):67-74.

Procianoy RS, Cecin SKG.   The influence of labor and delivery on
preterm fetal adrenal function.  Acta Paediatr Scand 1985;74(3):400-4.

Procianoy RS, Cecin SK.   Umbilical cord dehydroepiandrosterone
sulfate and cortisol levels in preterm infants born to pre-eclamptic
mothers.  Acta Paediatr Scand 1986 Mar;75(2):279-82.

Rennie JM, Baker B, Lucas A.   Does dexamethasone suppress the
ACTH response in preterm babies?  Arch Dis Child 1989
Apr;64(4):612-3.  Comment in: Arch Dis Child 1989
Oct;64(10):1514-5.

Reynolds GJ, Yu VY, Doery J.   Does dexamethasone suppress the
ACTH response in preterm babies? [letter].  Arch Dis Child 1989
Oct;64(10):1514-5.  Comment on: Arch Dis Child 1989 Apr;64(4):
612-3.

Robinson BG, Emanuel RL, Frim DM, Majzoub JA.   Glucocorticoid
stimulates expression of corticotropin-releasing hormone gene in
human placenta.  Proc Natl Acad Sci U S A 1988 Jul; 85(14):5244-8.

Ruth V, Hallman M, Laatikainen T.   Corticotropin- releasing hormone
and cortisol in cord plasma in relation to gestational age, labor, and
fetal distress.  Am J Perinatol 1993 Mar;10(2):115-8.

Saito K, Nishijima M, Horiuchi S.   [Changes in glucocorticoid
receptor in human placentas: correlation with cortisol levels in maternal
and umbilical cord plasma].  J Iwatw Med Assoc 1990; 42(6):837-46.
(Jpn).

Siamopoulou-Mavridou A, Mavridis AK, Vizandiadis A, Harsoulis P.  
Free urinary cortisol immunoreactive levels in premature and full term
infants.  Acta Paediatr Scand 1986 Nov;75(6):919-22.

Suzuki A, Hashino M, Chiba H, Saito H, Notake Y, Yanaihara T,
Nakayama T.   [Correlation between the levels of catecholamines
(noradrenaline, adrenaline) and adrenal steroids (DHA-S, cortisol) in
maternal and fetal blood during pregnancy and labor].  Nippon
Naibunpi Gakkai Zasshi 1989 Aug 20;65(8):704-14. (Jpn).

Teramo K, Hallman M, Raivio KO.   Maternal glucocorticoid in
unplanned premature labor. Controlled study on the effects of
betamethasone phosphate on the phospholipids of the gastric aspirate
and on the adrenal cortical function of the newborn infant.  Pediatr Res
1980 Apr;14(4 Pt 1):326-9.

Tropper PJ, Warren WB, Jozak SM, Conwell IM, Stark RI, Goland
RS.   Corticotropin releasing hormone concentrations in umbilical cord
blood of preterm fetuses.  J Dev Physiol 1992 Aug;18(2):81-5.

Wittekind CA, Arnold JD, Leslie GI, Luttrell B, Jones MP.  
Longitudinal study of plasma acth and cortisol in very low birth weight
infants in the first 8 weeks of life.  Early Hum Dev
1993;33(3):191-200.


Gastrointestinal Effects (including
Bibilrubin)


Arsenault P, Menard D.   Influence of hydrocortisone on human fetal
small intestine in organ culture.  J Pediatr Gastroenterol Nutr 1985
Dec;4(6):893-901.

Bauer CR, Morrison JC, Poole WK, Korones SB, Boehm JJ, Rigatto
H, Zachman RD.   Decreased incidence of necrotizing enterocolitis
after prenatal glucocorticoid therapy.  Pediatrics 1984
May;73(5):682-8.

Halac E, Halac J, Begue EF, Casanas JM, Indiveri DR, Petit JF,
Figueroa MJ, Olmas JM, Rodriguez LA, Obregon RJ, et al.   Prenatal
and postnatal corticosteroid therapy to prevent neonatal necrotizing
enterocolitis: a controlled trial.  J Pediatr 1990 Jul;117(1 Pt 1):132-8.

Morriss FH Jr, Moore M, Weisbrodt NW, West MS.   Ontogenic
development of gastrointestinal motility IV. Duodenal contractions in
preterm infants.  Pediatrics 1986;78(6):1106-13.

Rokicki W, Krasnodebski J.   Antenatal glucocorticoid administration
and neonatal glycemia.  Dev Pharmacol Ther 1987;10(4):307-11.

Villa M, Menard D, Semenza G, Mantei N.   The expression of lactase
enzymatic activity and mRNA in human fetal jejunum: effect of organ
culture and of treatment with hydrocortisone.  FEBS Lett
1992;301(2):202-6.


Immunology and Infection


Anlar Y, Anlar B.   The effect of dexamethasone on neutrophil
adherence in umbilical cord blood.  Early Hum Dev 1987
Sep;15(5):265-8.

Barak M, Cohen A, Herschkowitz S.   Total leukocyte and neutrophil
count changes associated with antenatal betamethasone administration
in premature infants.  Acta Paediatr 1992 Oct;81(10):760-3.

Frtizsching K, Strobauch P.   [Neonatal leukocytosis caused by
corticoid administration].  Kinderarztl Prax 1985 Sep;53(9):449-51.
(Ger).

Fuenfer MM, Herson VC, Raye JR, Woronick CL, Eisenfeld L,
Ingardia CJ, Block CF, Krause PJ.   The effect of betamethasone on
neonatal neutrophil chemotaxis.  Pediatr Res 1987 Aug;22(2):150-3.

Khairullin RM, Khlystova ZS, Kuznetsova LV.   [Kinetics of
T-lymphocytes and cortisol in the blood of the human fetus].  Akush
Ginekol (Mosk) 1987 Jan;(1):60-1. (Rus).

Lazzarin A, Luerti M, Capsoni F, Galli M, Uberti-Foppa C, Zavattini
G, Corbella E.   A study of cellular immunity in newborns after
prevention of respiratory distress syndrome (RDS).  Int J Tissue React
1986;8(2):157-65.

Martell M, Oehninger C, Scotti C, Delgado L, Martinez M, Korc I.  
Influence of glucocorticoid and betamimetic therapy on milk secretory
IgA concentration produced by mothers delivering preterm infants.  J
Perinat Med 1985;13(2):61-5.

Schmidt PL, Sims ME, Strassner HT, Paul RH, Mueller E, McCart D.  
Effect of antepartum glucocorticoid administration upon neonatal
respiratory distress syndrome and perinatal infection.  Am J Obstet
Gynecol 1984 Jan 15;148(2):178-86.

Taeusch HW Jr.   Glucocorticoid prophylaxis for respiratory distress
syndrome: a review of potential toxicity.  J Pediatr 1975;87:617-23.

Taeusch HW Jr, Frigoletto F, Kitzmiller J, Avery ME, Hehre A,
Fromm B, Lawson E, Neff RK.   Risk of respiratory distress syndrome
after prenatal dexamethasone treatment.  Pediatrics 1979
Jan;63(1):64-72.

Zachman RD, Bauer CR, Boehm J, Korones SB, Rigatto H, Rao AV.  
Effect of antenatal dexamethasone on neonatal leukocyte count.  J
Perinatol 1988 Spring;8(2):111-3.

Zykh I, Dorachinski G, Zykh M.   [Effect of preventive use of
dexamethasone on various indicators of humoral immunity in mothers
and newborn infants].  Akush Ginekol (Mosk) 1990 Jun;(6):54-5.
(Rus).


Outcome


Agfalvi R, Darvay S, Bodankzky H, Gacs G.   A longitudinal study of
the growth of infants with low birth weight: growth and development
of infants appropriate for gestational age and of infants small for
gestational age.  Arztl Jugendkd 1990;81(5): 344-7.

Andrews EB, White AD, Weinberg JM, Layne R, Long WA.  
Antenatal steroids and neonatal outcomes in infants receiving
surfactants in the Exosurf treatment IND  [abstract].  Pediatr Res
1992;31: 241A.

Atkinson AM, Gaudier F, Cliver SP, et al.  The interaction of the
maternal corticosteroids and tocolytic treatment on morbidity and
mortality rates in very low birth weight infants  [abstract].   Am J
Obstet Gynecol 1994;170:386. 

Avery ME.   The argument for prenatal administration of
dexamethasone to prevent respiratory distress syndrome [editorial].  J
Pediatr 1984 Feb;104(2):240.

Aylward GP, Pfeiffer SI, Wright A, Verhulst SJ.   Outcome studies of
low birth weight infants published in the last decade: a metaanalysis.  J
Pediatr 1989 Oct;115(4):515-20.  Comment in: J Pediatr 1990
Jul;117(1 Pt 1):167-8;  J Pediatr 1990 Sep;117(3):511-2.

Benesova O, Pavlik A.   Behavioural teratogenic risk of perinatal
glucocorticoid treatment. 21st Interdisciplinary Conference on
Experimental and Clinical Study of Higher Nervous Functions (1985,
Olomouc, Czechoslovakia).  Act Nerv Super 1986 Sep;28(3):197-8.

Blackman JA.   Neonatal intensive care: is it worth it? Developmental
sequelae of very low birthweight.  Pediatr Clin North Am 1991
Dec;38(6):1497-511.

Block MF, Kling OR, Crosby WM.   Antenatal glucocorticoid therapy
for the prevention of respiratory distress syndrome in the premature
infant.  Obstet Gynecol 1977 Aug;50(2):186-90.

Boyle MH, Torrance GW, Sinclair JC, Horwood SP.   Economic
evaluation of neonatal intensive care of very-low-birth-weight infants. 
N Engl J Med 1983 Jun 2;308(22):1330-7.

Bregman J, Kimberlin LV.   Developmental outcome in extremely
premature infants. Impact of surfactant.  Pediatr Clin North Am 1993
Oct;40(5):937-53.

Caspi E, Schreyer P, Weinraub Z, Reif R, Levi I, Mundel G.  
Prevention of the respiratory distress syndrome in premature infants by
antepartum glucocorticoid therapy.  Br J Obstet Gynaecol 1976
Mar;83(3):187-93.

Coccia C, Pezzani M, Moro GE, Minoli I.   Management of extremely
low-birth-weight infants.  Acta Paediatr 1992 Oct;81 Suppl 382:10-2.

Cohen I, Altaras M, Jaffe R, Aderet NB.   Perinatal factors influencing
outcome of very-low-birth weight infants.  Isr J Med Sci
1986;22(6):430-4.

Cooke RW.   Annual audit of neonatal morbidity in preterm infants. 
Arch Dis Child 1992 Oct;67(10 Spec No):1174-6.

Cooke RW.   Annual audit of three year outcome in very low
birthweight infants.  Arch Dis Child 1993 Sep;69(3 Spec No):295-8.

Cordella L.   [Stress, glucocorticoids, and handicap: Prenatal and
perinatal data].  Ital J Intellective Impair 1989 Jun;2(1):75-83. (Ita).

Couser RJ, Ferrara TB, Wheeler W, McNamara J, Falde B, Johnson K,
Hoekstra RE.   Pulmonary follow-up 2.5 years after a randomized,
controlled, multiple dose bovine surfactant study of preterm newborn
infants.  Pediatr Pulmonol 1993 Mar;15(3):163-7.

de Zegher F, de Vries L, Pierrat V, Daniels H, Spitz B, Casaer P,
Devlieger H, Eggermont E.   Effect of prenatal
betamethasone/thyrotropin releasing hormone treatment on
somatosensory evoked potentials in preterm newborns.  Pediatr Res
1992 Aug;32(2):212-4.

Dluholucky S, Babic J, Taufer I.   Reduction of incidence and mortality
of respiratory distress syndrome by adminstration of hydrocortisone to
mother.  Arch Dis Child 1976 Jun;51(6):420-3.

Doyle LW, Kitchen WH, Ford GW, Rickards AL, Kelly EA.  
Antenatal steroid therapy and 5-year outcome of extremely low birth
weight infants.  Obstet Gynecol 1989 May;73(5 Pt 1):743-6.

Doyle LW, Kitchen WH, Ford GW, Rickards AL, Lissenden JV, Ryan
MM.   Effects of antenatal steroid therapy on mortality and morbidity
in very low birth weight infants.  J Pediatr 1986 Feb; 108(2):287-92.

Doyle LW, Permezel MJ, Kitchen WH.   Is there a lower limit for
birth-weight/gestational age and antenatal steroid therapy?  Aust N Z J
Obstet Gynaecol 1992 Aug;32(3):193-5.  Comment in: Aust N Z J
Obstet Gynaecol 1993 Feb;33(1):103-5.

Dunn MS, Shennan AT, Hoskins EM, Lennox K, Enhorning G.  
Two-year follow-up of infants enrolled in a randomized trial of
surfactant replacement therapy for prevention of neonatal respiratory
distress syndrome.  Pediatrics 1988 Oct;82(4):543-7.

Effect of antenatal dexamethasone administration on the prevention of
respiratory distress syndrome.  Am J Obstet Gynecol 1981 Oct
1;141(3):276-87.

Effects of antenatal dexamethasone administration in the infant:
long-term follow-up.  J Pediatr 1984 Feb;104(2):259-67.

Ens-Dokkum MH, Schreuder AM, Veen S, Verloove-Vanhorick SP,
Brand R, Ruys JH.   Evaluation of care for the preterm infant: review
of literature on follow-up of preterm and low birthweight infants. 
Report from the collaborative Project on Preterm and Small for
Gestational Age Infants (POPS) in the Netherlands.  Paediatr Perinat
Epidermiol 1992 Oct;6(4):434-59.

Escobar GJ, Littenberg B, Petitti DB.   Outcome among surviving very
low birthweight infants: a meta-analysis.  Arch Dis Child 1991
Feb;66(2):204-11.

Fazzi E, Bianchini L, Ometto A, Piazza F, Rondini G, Lanzi G.  
[Infantile cerebral palsy and neuromotor development in very low birth
weight infants].  Minerva Pediatr 1990 Jun;42(6):219-25. (Ita).

Fazzi E, Orcesi S, Spinillo A, Stronati M, Telesca C, Farinotti L.  
[Neuropsychologic development of small for gestational age preterm
infants: follow up at 12-36 months of age].  Pediatr Med Chir 1992
Jul-Aug;14(4):403-7. (Ita).

Fernandez-Carrocera LA, Patino-Felix F, Udaeta-Mora E, Garza
Morales S, Ibarra-Reyes MP, Rodriguez-Perez L.   [Subependymal/
intraventricular hemorrhage in preterm newborn infants.
Neurodevelopmental course during the first year of life].  Bol Med
Hosp Infant Mex 1993 Apr;50(4):241-7. (Spa).

Ferrara TB, Hoekstra RE, Gaziano E, Knox GE, Couser RJ, Fangman
JJ.   Changing outcome of extremely premature infants (less than or
equal to 26 weeks' gestation and less than or equal to 750 gm): survival
and follow-up at a tertiary center.  Am J Obstet Gynecol 1989
Nov;161(5):1114-8.

Forslund M, Bjerre I.   Follow-up of preterm children. I. Neurological
assessment at 4 years of age.  Early Hum Dev 1989 Sep;20(1):45-66.

Fustinana C, Cernandas JC, Lopez N, Rodriquez D.   Somatic growth
in VLBW infants prenatally treated with betamethasone plus TRH 
[abstract].  Pediatr Res 1993;33(4 Pt 2):260a.

Georgieff MK, Mills MM, Zempel CE, Chang PN.   Catch-up growth,
muscle and fat accretion, and body proportionality of infants one year
after newborn intensive care.  J Pediatr 1989 Feb; 114(2):288-92.

Groome LJ, Goldenberg RL, Cliver SP, Davis RO, Copper RL.  
Neonatal periventricular- intraventricular hemorrhage after maternal
beta-sympathomimetic tocolysis. The March of Dimes Multicenter
Study Group.  Am J Obstet Gynecol 1992 Oct;167(4 Pt 1):873-9.

Hack M, Breslau N, Fanaroff AA.   Differential effects of intrauterine
and postnatal brain growth failure in infants of very low birth weight. 
Am J Dis Child 1989 Jan;143(1):63-8.

Hack M, Horbar JD, Malloy MH, Tyson JE, Wright E, Wright L.  
Very low birth weight outcomes of the National Institute of Child
Health and Human Development Neonatal Network.  Pediatrics 1991
May;87(5):587-97.  Comment in: Pediatrics 1992 Feb;89(2):357;
discussion 357-8.

Halsey CL, Collin MF, Anderson CL.   Extremely low birth weight
children and their peers: a comparison of preschool performance. 
Pediatrics 1993 Apr;91(4):807-11.

Horbar JD, Onstad L, Wright E.   Predicting mortality risk for infants
weighing 501 to 1500 grams at birth: a National Institutes of Health
Neonatal Research Network report.  Crit Care Med 1993
Jan;21(1):12-8.  Comment in: Crit Care Med 1993 Jan;21(1):2-3.

Horbar JD, Wright EC, Onstad L.   Decreasing mortality associated
with the introduction of surfactant therapy: an observational study of
neonates weighing 601 to 1300 grams at birth. The Members of the
National Institute of Child Health and Human Development Neonatal
Research Network.  Pediatrics 1993 Aug;92(2):191-6.

Huel G, Keller E, Gueguen S, Robert C, Bouyer J, Papiernik E,
Mamelle N, Laumon B, Munoz F, Collin D, et al.   Effective prevention
of preterm birth: the French experience measured at Haguenau.  Birth
Defects 1989;25(1):1-234.

Hutson JM, Driscoll JM, Fox HE, Driscoll YT, Steir ME.   The effect
of obstetric management on neonatal mortality and morbidity for
infants weighing 700-1000 grams.  Am J Perinatol 1986
Jul;3(3):255-61.

Improvement of outcome for infants of birth weight under 1000 g. The
Victorian Infant Collaborative Study Group.  Arch Dis Child 1991
Jul;66(7 Spec No):765-9.

Jarvenpaa AL, Vlrtanen M, Pohjavuori M.   The outcome of extremely
low birthweight infants.  Ann Med 1991 Dec;23(6):699-704.

Jobe AH, Mitchell BR, Gunkel JH.   Beneficial effects of the combined
use of prenatal corticosteroids and postnatal surfactant on preterm
infants.  Am J Obstet Gynecol 1993 Feb;168(2):508-13.

Johnson DE, Munson DP, Thompson TR.   Effect of antenatal
administration of dexamethasone on hospital cost and survival of
premature infants.  Pediatrics 1981;68:633-7.

Kari MA, Hallman M, Eronon M, Teramo K, Virtanen M, Koivisto N,
Ikonen RS.  Prenatal dexamethasone treatment in conjunction with
rescue therapy of human surfactant - a randomized placebo-controlled
multicenter study.  Pediatrics.  Forthcoming 1994.

Kari MA, Hallman M, Eronen M, Teramo K, Virtanen M, Koivisto M,
Ikonen RS.   Prenatal steroid in conjunction with human surfactant
therapy: a randomized multicenter study  [abstract].  Pediatr Res
1993;33:217A.

Kitchen WH, Bowman E, Callanan C, Campbell NT, Carse EA,
Charlton M, Doyle LW, Drew J, Ford GW, Gore J, et al.   The cost of
improving the outcome for infants of birthweight 500-999 g in Victoria.
The Victorian Infant Collaborative Study Group.  J Paediatr Child
Health 1993 Feb;29(1):56-62.

Kitchen WH, Doyle LW, Rickards AL, Ford G, Kelly E, Callanan C.  
Survivors of extreme prematurity--outcome at 8 years of age.  Aust N
Z J Obstet Gynaecol 1991 Nov;31(4):337-9.

Kitchen WH, Rickards AL, Doyle LW, Ford GW, Kelly EA, Callanan
C.   Improvement in outcome for very low birthweight children:
apparent or real?  Med J Aust 1992 Aug 3;157(3):154-8.

Klein NK, Hack M, Breslau N.   Children who were very low birth
weight: development and academic achievement at nine years of age.  J
Dev Behav Pediatr 1989 Feb;10(1):32-7.

Konishi M, Chida S, Shimada S, Kasai T, Murakami Y, Cho K, Fujii Y,
Maeta H, Fujiwara T.   Surfactant replacement therapy in premature
babies with respiratory distress syndrome: factors affecting the
response to surfactant and comparison of outcome from 1982-86 and
1987-91.  Acta Paediatr Jpn 1992 Dec;34(6):617-30.

Lee H, Barratt MS.   Cognitive development of preterm low birth
weight children at 5 to 8 years old.  J Dev Behav Pediatr 1993
Aug;14(4):242-9.

Lenclen R, Paupe A, Carbajal R, Blanc P, Hoenn E, Olivier-Martin M.  
[The fate of very early premature babies. Mortality, morbidity and
2-year follow-up in a population of 96 very early premature babies]. 
Rev Fr Gynecol Obstet 1992 Nov;87(11):533-9. (Fre).

Leonard CH, Clyman RI, Piecuch RE, Juster RP, Ballard RA, Behle
MB.   Effect of medical and social risk factors on outcome of
prematurity and very low birth weight.  J Pediatr 1990
Apr;116(4):620-6.

Levin S, Robinson A, Zakut H.   The psychomotor development of full
term infants whose mothers were treated with glucocorticosteroids
during pregnancy.  Padiatr Padol 1986;21(3):233-9.

Liggins GC.   Obstetric and paediatric collaboration to reduce
morbidity after preterm birth.  Br J Obstet Gynaecol 1990
Jan;97(1):1-3.  Comment on: Br J Obstet Gynaecol 1990
Jan;97(1):11-25.

Lipper EG, Ross GS, Auld PA, Glassman MB.   Survival and outcome
of infants weighing less than 800 grams at birth.  Am J Obstet Gynecol
1990 Jul;163(1 Pt 1):146-50.  Comment in: Am J Obstet Gynecol 1991
Aug;165(2):482-3;  Am J Obstet Gynecol 1991 Oct;165(4 Pt
1):1159-60.

Litt R, Seidman DS, Gross-Tsur V, Dollberg S, Gale R.   A 2-year
prospective study of very low birthweight infants.  Isr J Med Sci 1992
Nov;28(11):783-8.

Lya den Ouden A, Hille ET, Bauer L, Verloove-Vanhorick SP.  
School performance in very preterm children [letter].  Lancet 1993 Aug
28;342(8870):550-1.

MacArthur B, Howie RN, DeZoete A, Elkins J, Liang AY.   Long-term
follow-up of children exposed to betamethasone in utero.  In: Tejani N,
editor.  Obstetrical events and developmental sequelae.  Boca Raton
(FL): CRC Press; 1990.  p. 81-9. 

MacArthur BA, Howie RN, Dezoete JA, Elkins J.   Cognitive and
psychosocial development of 4-year-old children whose mothers were
treated antenatally with betamethasone.  Pediatrics 1981
Nov;68(5):638-43.

MacArthur BA, Howie RN, Dezoete JA, Elkins J.   School progress
and cognitive development of 6-year-old children whose mothers were
treated antenatally with betamethasone.  Pediatrics 1982
Jul;70(1):99-105.

Manzke H.   [Unpreventable effects of neonatal intensive care on the
later development of extremely small premature infants].  Z
Geburtshilfe Perinatol 1992 Jul-Aug;196(4):165-72. (Ger).

Marlow N, Roberts L, Cooke R.   Outcome at 8 years for children with
birth weights of 1250 g or less.  Arch Dis Child 1993 Mar;68(3 Spec
No):286-90.

McCormick MC.   Has the prevalence of handicapped infants increased
with improved survival of the very low birth weight infant?  Clin
Perinatol 1993 Mar;20(1):263-77.

McCormick MC, Brooks-Gunn J, Workman-Daniels K, Turner J,
Peckham GJ.   The health and developmental status of very
low-birth-weight children at school age.  JAMA 1992 Apr 22-29;
267(16):2204-8.

Morley CJ, Morley R.   Follow up of premature babies treated with
artificial surfactant (ALEC).  Arch Dis Child 1990 Jul;65(7 Spec
No):667-9.

Msall ME, Buck GM, Rogers BT, Catanzaro NL.   Kindergarten
readiness after extreme prematurity.  Am J Dis Child 1992
Nov;146(11):1371-5.

Msall ME, Buck GM, Rogers BT, Merke D, Catanzaro NL, Zorn WA.  
Risk factors for major neurodevelopmental impairments and need for
special education resources in extremely premature infants.  J Pediatr
1991 Oct;119(4):606-14. Published erratum appears in J Pediatr 1992
May;120(5):838.

Needelman HW.   Developmental follow-up of the low birth weight
NICU graduate.  Nebr Med J 1992 Dec;77(12):343-4.

Nwaesei CG, Young DC, Byrne JM, Vincer MJ, Sampson D, Evans
JR, Allen AC, Stinson DA.   Preterm birth at 23 to 26 weeks' gestation:
is active obstetric management justified?  Am J Obstet Gynecol 1987
Oct;157(4 Pt 1):890-7.

Oberklaid F, Sewell J, Sanson A, Prior M.   Temperament and behavior
of preterm infants: a six-year follow-up.  Pediatrics 1991
Jun;87(6):854-61.

Oosterbaan HP, Swaab DF.   [Glucocorticoids in pregnancy: effect on
the fetus and neonate (letter)].  Ned Tijdschr Geneeskd 1987 Jan
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effects of Oradexon and Ambroxol pretreatment on the oxidative
sensitivity of the red blood cells in preterm infants.  Clin Chim Acta
1989;182(3):241-6.


Renal Function


al-Dahan J, Stimmler L, Chantler C, Haycock GB.   The effect of
antenatal dexamethasone administration on glomerular filtration rate
and renal sodium excretion in premature infants.  Pediatr Nephrol 1987
Apr;1(2):131-5.

MacKintosh D, Baird-Lambert J, Drage D, Buchanan N.   Effects of
prenatal glucocorticoids on renal maturation in newborn infants.  Dev
Pharmacol Ther 1985;8(2):107-14.

Zanardo V, Giacobbo F, Zambon P, Trevisanuto D, Griffith P, Grella
P, Zacchello G.   Antenatal aminophylline and steroid exposure effects
on glomerular filtration rate and renal sodium excretion in preterm
newborns.  J Perinat Med 1990;18(4):283-8.



MATERNAL

Adverse Effects


Beer P, Passweg D.   [Maternal pulmonary edema as an anesthesia
complication after intravenous tocolysis and stimulating of lung
maturation].  Gynakol Geburtshilfliche Rundsch 1992;32(2):100-3.
(Ger).

Benedetti TJ.   Maternal complications of parenteral
beta-sympathomimetic therapy for premature labor.  Am J Obstet
Gynecol 1983 Jan 1;145(1):1-6.

Bernstein IM, Catalano PM.   Ketoacidosis in pregnancy associated
with the parenteral administration of terbutaline and betamethasone.  A
case report.  J Reprod Med 1990 Aug;35(8): 818-20.

Cunningham DS, Evans EE.   The effects of betamethasone on
maternal cellular resistance to infection.  Am J Obstet Gynecol 1991
Sep;165(3):610-5.

Curet LB, Morrison JC, Rao AV.   Antenatal therapy with
corticosteroids and postpartum complications.  Am J Obstet Gynecol
1985 May 1;152(1):83-4.

Depp R, Boehm JJ, Nosek JA, Dooley SL, Hobart JM.   Antenatal
corticosteroids to prevent neonatal respiratory distress syndrome: risk
versus bebefit considerations.  Am J Obstet Gynecol 1980;137:338-47.

Dudenhausen JW.   Alternatives to the antenatal glucocorticoid
treatment for the prevention of respiratory distress syndrome.  J Perinat
Med 1987;15(5):453-9.

Elliott HR, Abdulla U, Hayes PJ.   Pulmonary oedema associated with
ritodrine infusion and betamethasone administration in premature
labour.  Br Med J 1978 Sep 16;2(6140):799-800.

Elliott JP, O'Keeffe DF, Greenberg P, Freeman RK.   Pulmonary edema
associated with magnesium sulfate and betamethasone administration. 
Am J Obstet Gynecol 1979 Jul 15;134(6):717-9.

Finley J, Katz M, Rojas-Perez M, Roberts JM, Creasy RK, Schiller NB. 
Cardiovascular consequences of beta-agonist tocolysis: an
echocardiographic study.  Obstet Gynecol 1984 Dec;64(6):787-91.

Guller S, Wozniak R, Krikun G, Burnham JM, Kaplan P, Lockwood
CJ.   Glucocorticoid suppression of human placental fibronectin
expression: implications in uterine-placental adherence.  Endocrinology
1993 Sep;133(3):1139-46.

Hankins GD.   Complications of beta-sympathomimetic tocolytic
agents.  In: Clark SL, et al., editors.  Critical care obstetrics.  2nd ed. 
Boston: Blackwell Scientific Publications; 1991.  p. 231. 

Heytmanek G, Salzer H, Vityska-Binstorfer E, Genger H, Metka M,
Pfersmann R, Wolff F, Weidinger H.  [Ambroxol versus betamethasone
for the promotion of antepartum lung maturity in pathological
pregnancies].  Wien Klin Wochenschr 1990 Aug 3; 102(15):443-8.
(Ger).

Katz M, Robertson PA, Creasy RK.   Cardiovascular complications
associated with terbutaline treatment for preterm labor.  Am J Obstet
Gynecol 1981 Mar 1;139(5):605-8.

Krenek M, Starka L.   [Steroid hormones and glucose tolerance in
pregnancy].  Cesk Gynekol 1989 Feb;54(1):28-36. (Cze).

Kuhn RJ, Speirs AL, Pepperell RJ, Eggers TR, Doyle LW, Hutchison
A.   Betamethasone, albuterol, and threatened premature delivery:
benefits and risks. Study of 469 pregnancies.  Obstet Gynecol 1982
Oct;60(4):403-8.

Martell M, Oehninger C, Scotti C, Delgado L, Martinez M, Korc I.  
Influence of glucocorticoid and betamimetic therapy on milk secretory
IgA concentration produced by mothers delivering preterm infants.  J
Perinat Med 1985;13(2):61-5.

Morrison JC, Whybrew WD, Bucovaz ET, Schneider JM.   Injection of
corticosteroids into mother to prevent neonatal respiratory distress
syndrome.  Am J Obstet Gynecol 1978 Jun 15;131(4):358-66.

Ohlsson A, Heyman E.   Dexamethasone-induced bradycardia [letter]. 
Lancet 1988 Nov 5;2(8619):1074.

Philipsen T, Eriksen PS, Lynggard F.   Pulmonary edema following
ritodrine-saline infusion in premature labor.  Obstet Gynecol 1981
Sep;58(3):304-8.

Prober CG.   The risk of dexamethasone in pregnant women with a
history of recurrent genital herpes.  Pediatr Infect Dis J 1991
Jan;10(1):82-3.

Puntis JW, Morgan ME, Durbin GM.   Dexamethasone-induced
bradycardia [letter].  Lancet 1988 Dec 10;2(8624):1372.

Robertson PA, Herron M, Katz M, Creasy RK.   Maternal morbidity
associated with isoxsuprine and terbutaline tocolysis.  Eur J Obstet
Gynecol Reprod Biol 1981 May;11(6):371-8.

Russi EW, Spaetling L, Gmur J, Schneider H.   High permeability
pulmonary edema (ARDS) during tocolytic therapy--a case report.  J
Perinat Med 1988;16(1):45-9.

Salzer H, Weidinger H, Simbruner G, Vytiska-Binstorfer E.  
[Ambroxol versus betamethasone for stimulating antepartal lung
maturity--a multicenter study].  Z Geburtshilfe Perinatol 1986
Feb-Mar;190(1):49-59. (Ger).

Schmidt PL, Sims ME, Strassner HT, Paul RH, Mueller E, McCart D.  
Effect of antepartum glucocorticoid administration upon neonatal
respiratory distress syndrome and perinatal infection.  Am J Obstet
Gynecol 1984 Jan 15;148(2):178-86.

Spatling L, Staisch KJ, Huch R, Huch A.   Effect of ritodrine and
betamethasone on metabolism, respiration, and circulation.  Am J
Perinatol 1986 Jan;3(1):41-6.

Stubblefield PG.   Pulmonary edema occurring after therapy with
dexamethasone and terbutaline for premature labor: a case report.  Am
J Obstet Gynecol 1978 Oct 1;132(3):341-2.

Wolff F, Carstens V, Fischer JH, Behrenbeck D, Bolte A.  
Cardiopulmonary effects of betamimetic tocolytic and glucocorticoid
therapy in pregnant women.  Arch Gynecol 1986;239(1):49-58.

Yusuf S, Peto R, Lewis J, Collins R, Sleight P.   Beta blockade during
and after myocardial infarction: an overview of the randomized trials. 
Prog Cardiovasc Dis 1985 Mar-Apr;27(5):335-71.

Zavodsky A, Velcevsky J.   [Risks in the administration of
glucocorticoids in pregnancy].  Cesk Gynekol 1990 Jul;55(6):439-40.
(Cze).

Zykh I, Dorachinski G, Zykh M.   [Effect of preventive use of
dexamethasone on various indicators of humoral immunity in mothers
and newborn infants].  Akush Ginekol (Mosk) 1990 Jun;(6):54-5.
(Rus).


Combination Therapy


Adam K, Ou CN, Cotton DB.   Combined effect of terbutaline and
betamethasone on glucose homeostasis  in preterm labor.  Fetal Diagn
Ther 1993;8(3):187-94.

Arias F, Knight AB, Tomich PB.   A retrospective study on the effects
of steroid administration and prolongation of the latent phase in
patients with preterm premature rupture of the membranes.  Am J
Obstet Gynecol 1986 May;154(5):1059-63.

Atkinson AM, Gaudier F, Cliver SP, et al.  The interaction of the
maternal corticosteroids and tocolytic treatment on morbidity and
mortality rates in very low birth weight infants  [abstract].   Am J
Obstet Gynecol 1994;170:386.

Baillie P, Malan AF, Saunders MC, Davey DA.  The active
management of pre-term labour and its effects on fetal outcome.  Aust
N Z J Obstet Gynaecol 1976 May;16(2):94-9.

Ballard PL.   Combined hormonal treatment and lung maturation. 
Semin Perinatol 1984;8:23.

Ballard RA, Ballard PL, Creasy RK, Padbury J, Polk DH, Bracken M,
Moya FR, Gross I.   Respiratory disease in very-low-birthweight infants
after prenatal thyrotropin-releasing hormone and glucocorticoid. TRH
Study Group.  Lancet 1992 Feb 29;339(8792):510-5. Comment in:
Lancet 1992 Apr 18;339(8799):990-1; Lancet 1992 Jun
6;339(8806):1417.

Barkai G, Reichman B, Lusky A, Dan U, Sack J, Goldman B, Mashiach
S.   The effect of thyroxine and corticosteroids upon amniotic fluid
fluorescence polarization: a randomized controlled study.  J Perinat
Med 1992;20(6):459-64.

Beer P, Passweg D.   [Maternal pulmonary edema as an anesthesia
complication after intravenous tocolysis and stimulating of lung
maturation].  Gynakol Geburtshilfliche Rundsch 1992;32(2):100-3.
(Ger).

Benedetti TJ.   Maternal complications of parenteral
beta-sympathomimetic therapy for premature labor.  Am J Obstet
Gynecol 1983 Jan 1;145(1):1-6.

Bernstein IM, Catalano PM.   Ketoacidosis in pregnancy associated
with the parenteral administration of terbutaline and betamethasone.  A
case report.  J Reprod Med 1990 Aug;35(8): 818-20.

Broide E, Bistritzer T, Livne M, Neuman M, Goldberg M, Aladjem M.  
The effect of prenatal administration of dexamethasone and ritodrine on
cord blood cortisol and glucose concentrations in premature infants
with respiratory distress syndrome.  J Perinat Med 1992;20(4):289-95.

Chapman MG.   Salbutamol-induced acidosis in pregnant diabetics
[letter].  Br Med J 1977 Mar 5;1(6061):639-40.

Cohen I, Altaras M, Jaffe R, Aderet NB.   Perinatal factors influencing
outcome of very-low-birth weight infants.  Isr J Med Sci
1986;22(6):430-4.

Cosmi EV.   Prenatal prevention of respiratory distress syndrome: new
pharmacologic approaches.  Early Hum Dev 1992
Jun-Jul;29(1-3):283-6.

Cosmi EV, Di Renzo GC.   Prevention and treatment of fetal lung
immaturity.  Fetal Ther 1989;4 Suppl 1:52-62.

de Zegher F, de Vries L, Pierrat V, Daniels H, Spitz B, Casaer P,
Devlieger H, Eggermont E.   Effect of prenatal
betamethasone/thyrotropin releasing hormone treatment on
somatosensory evoked potentials in preterm newborns.  Pediatr Res
1992 Aug;32(2):212-4.

Dudenhausen JW.   Alternatives to the antenatal glucocorticoid
treatment for the prevention of respiratory distress syndrome.  J Perinat
Med 1987;15(5):453-9.

Elliott HR, Abdulla U, Hayes PJ.   Pulmonary oedema associated with
ritodrine infusion and betamethasone administration in premature
labour.  Br Med J 1978 Sep 16;2(6140):799-800.

Elliott JP, O'Keeffe DF, Greenberg P, Freeman RK.   Pulmonary edema
associated with magnesium sulfate and betamethasone administration. 
Am J Obstet Gynecol 1979 Jul 15;134(6):717-9.

Eriksen NL, Blanco JD.   The role of corticosteroids in the
management of patients with preterm premature rupture of the
membranes.  Clin Obstet Gynecol 1991 Dec;34(4):694-701.

Franklin RC, Purdie GL, O'Grady CM.   Neonatal thyroid function:
prematurity, prenatal steroids, and respiratory distress syndrome.  Arch
Dis Child 1986 Jun;61(6):589-92.

Groome LJ, Goldenberg RL, Cliver SP, Davis RO, Copper RL.  
Neonatal periventricular- intraventricular hemorrhage after maternal
beta-sympathomimetic tocolysis. The March of Dimes Multicenter
Study Group.  Am J Obstet Gynecol 1992 Oct;167(4 Pt 1):873-9.

Gunston KD, Davey DA.   Effects of prenatal fenoterol,
phenobarbitone and dexamethasone administration on the total
phospholipid content of amniotic fluid.  S Afr Med J 1978 Dec
30;54(27):1141-3.

Hankins GD.   Complications of beta-sympathomimetic tocolytic
agents.  In: Clark SL, et al., editors.  Critical care obstetrics.  2nd ed. 
Boston: Blackwell Scientific Publications; 1991.  p. 231. 

Heyborne KD, Burke MS, Porreco RP.   Prolongation of premature
gestation in women with hemolysis, elevated liver enzymes and low
platelets. A report of five cases.  J Reprod Med 1990 Jan;35(1):53-7.

Kattner E, Metze B, Waiss E, Obladen M.   Accelerated lung
maturation following maternal steroid treatment in infants born before
30 weeks gestation.  J Perinat Med 1992;20(6):449-57.

Katz M, Robertson PA, Creasy RK.   Cardiovascular complications
associated with terbutaline treatment for preterm labor.  Am J Obstet
Gynecol 1981 Mar 1;139(5):605-8.

King JF, Grant A, Keirse MJ, Chalmers I.   Beta-mimetics in preterm
labour: an overview of the randomized controlled trials.  Br J Obstet
Gynaecol 1988 Mar;95(3):211-22.

Kwong MS, Egan EA.   Reduced incidence of hyaline membrane
disease in extremely premature infants following delay of delivery in
mother with preterm labor: use of ritodrine and betamethasone. 
Pediatrics 1986 Nov;78(5):767-74.

Lamont RF.   The management of preterm labour.  Clin Obstet
Gynaecol 1986 Jun;13(2):231-46.

Liggins GC.   Can the benefits of antepartum corticosteroid treatment
be improved?  Eur J Obstet Gynecol Reprod Biol 1989
Oct;33(1):25-30.

Liggins GC.   Obstetric and paediatric collaboration to reduce
morbidity after preterm birth.  Br J Obstet Gynaecol 1990
Jan;97(1):1-3.  Comment on: Br J Obstet Gynaecol 1990
Jan;97(1):11-25.

Miodovnik M, Peros N, Holroyde JC, Siddiqi TA.   Treatment of
premature labor in insulin-dependent diabetic women.  Obstet Gynecol
1985 May;65(5):621-7.

Morales WJ, Angel JL, O'Brien WF, Knuppel RA.   Use of ampicillin
and corticosteroids in premature rupture of membranes: a randomized
study.  Obstet Gynecol 1989 May;73(5 Pt 1):721-6.

Morales WJ, Diebel ND, Lazar AJ, Zadrozny D.   The effect of
antenatal dexamethasone administration on the prevention of
respiratory distress syndrome in preterm gestations with premature
rupture of membranes.  Am J Obstet Gynecol 1986 Mar; 154(3):591-5.

Morales WJ, O'Brien WF, Angel JL, Knuppel RA, Sawai S.   Fetal lung
maturation: the combined use of corticosteroids and
thyrotropin-releasing hormone.  Obstet Gynecol 1989 Jan;73(1):111-6.

Morales WJ, Talley T.   Premature rupture of membranes at < 25
weeks: a management dilemma.  Am J Obstet Gynecol 1993
Feb;168(2):503-7.

Moya FR, Gross I.   Prevention of respiratory distress syndrome. 
Semin Perinatol 1988 Oct;12(4):348-58.

Nelson LH, Meis PJ, Hatjis CG, Ernest JM, Dillard R, Schey HM.  
Premature rupture of membranes: a prospective, randomized evaluation
of steroids, latent phase, and expectant management.  Obstet Gynecol
1985 Jul;66(1):55-8.

Ogburn PL Jr, Julian TM, Williams PP, Thompson TR.  The use of
magnesium sulfate for tocolysis in preterm labor complicated by twin
gestation and betamimetic-induced pulmonary edema.  Acta Obstet
Gynecol Scand 1986;65(7):793-4.

Papageorgiou A, Stern L.   Antenatal prevention of the neonatal
respiratory distress syndrome: benefits and potential risks for the
mother and the infant.  J Perinat Med 1986;14(2):75-86.

Papageorgiou AN, Doray J-L, Ardilis R, Kunos I.   Reduction of
mortality, morbidity and respiratory distress syndrome in infants
weighing less than 1,000 grams by treatment with betamethasone and
ritodrine.  Pediatrics 1989;83:493-7.

Parsons MT, Sobel D, Cummiskey K, Constantine L, Roitman J.  
Steroid, antibiotic and tocolytic versus no steroid, antibiotic and
tocolytic management in patients with preterm rupture PROM at 25-32
weeks.  Paper presented at: 8th Annual Meeting of the Society of
Perinatal Obstetricians;1988 Feb 4-6; Las Vegas, Nevada.

Philipsen T, Eriksen PS, Lynggard F.   Pulmonary edema following
ritodrine-saline infusion in premature labor.  Obstet Gynecol 1981
Sep;58(3):304-8.

Phuapradit W, Pongthai S, Chaturachinda K.   A five-year experience
with terbutaline for preterm labor.  J Med Assoc Thail
1986;69(4):224-8.

Robertson PA, Herron M, Katz M, Creasy RK.   Maternal morbidity
associated with isoxsuprine and terbutaline tocolysis.  Eur J Obstet
Gynecol Reprod Biol 1981 May;11(6):371-8.

Russi EW, Spaetling L, Gmur J, Schneider H.   High permeability
pulmonary edema (ARDS) during tocolytic therapy--a case report.  J
Perinat Med 1988;16(1):45-9.

Sabin S, Diss E, Porreco RP.   Betamethasone TRH treatment of
preterm fetuses alters the appearance of fetal heart rate tracings 
[abstract].  Am J Obstet Gynecol 1993;168(1 Pt 2):337.

Salzer H, Lohninger A, Sevelda P, Legenstein E.   [Stimulation of fetal
lung maturation with carnitine].  Gynaekol Rundsch 1985;25(2):72-85.
(Ger).

Schellenberg JC, Liggins GC.   New approaches to hormonal
acceleration of fetal lung maturation.  J Perinat Med
1987;15(5):447-52.

Schutte MF, Treffers PE, Koppe JG, Breur W.   The influence of
betamethasone and orciprenaline on the incidence of respiratory
distress syndrome in the newborn after preterm labour.  Br J Obstet
Gynaecol 1980 Feb;87(2):127-31.

Spatling L, Staisch KJ, Huch R, Huch A.   Effect of ritodrine and
betamethasone on metabolism, respiration, and circulation.  Am J
Perinatol 1986 Jan;3(1):41-6.

Stubblefield PG.   Pulmonary edema occurring after therapy with
dexamethasone and terbutaline for premature labor: a case report.  Am
J Obstet Gynecol 1978 Oct 1;132(3):341-2.

Szczurowicz A, Witczak A, Rumistrzewicz E.   [Effect of
glucocorticoids, tocolytics and oxytocin on the status and fate of
premature infants].  Wiad Lek 1988 Sep 15;41(18):1197-203. (Pol).

Van Dorsten JP, Horger EO 3d, Miller MC.   Preterm rupture of the
membranes: combination therapy.  Am J Obstet Gynecol 1985 Sep
15;153(2):147-53.

Wilkins I, Creasy RK.   Preterm labor.  Clin Obstet Gynecol 1990
Sep;33(3):502-14.

Wolff F, Carstens V, Fischer JH, Behrenbeck D, Bolte A.  
Cardiopulmonary effects of betamimetic tocolytic and glucocorticoid
therapy in pregnant women.  Arch Gynecol 1986;239(1):49-58.


High-Risk Pregnancies


Alba E, Proserpio D.   [Premature rupture of the membranes. Therapy
and materno-neonatal prognosis. Our case series].  Minerva Ginecol
1987 Nov 11;39(11):727-35. (Ita).

Arias F, Knight AB, Tomich PB.   A retrospective study on the effects
of steroid administration and prolongation of the latent phase in
patients with preterm premature rupture of the membranes.  Am J
Obstet Gynecol 1986 May;154(5):1059-63.

Baillie P, Malan AF, Saunders MC, Davey DA.  The active
management of pre-term labour and its effects on fetal outcome.  Aust
N Z J Obstet Gynaecol 1976 May;16(2):94-9.

Barrett JM, Boehm FH.   Comparison of aggressive and conservative
management of premature rupture of fetal membranes.  Am J Obstet
Gynecol 1982 Sep 1;144(1):12-6.

Berclaz G, Gyr T, Bratschi HU, Markus D, Schneider H.   [Induction
of lung maturation in the early stage of premature rupture of fetal
membranes].  Gynakol Rundsch 1991;31 Suppl 2:108-10. (Ger).

Bibbo M, Gill WB, Azizi F, Blough R, Fang VS, Rosenfield RL,
Schumacher GF, Sleeper K, Sonek MG, Wied GL.   Follow-up study
of male and female offspring of DES-exposed mothers.  Obstet
Gynecol 1977 Jan;49(1):1-8.

Bryan H, Hawrylyshyn P, Hogg-Johnson S, Inwood S, Finley A,
D'Costa M, Chipman M.   Perinatal factors associated with the
respiratory distress syndrome.  Am J Obstet Gynecol 1990
Feb;162(2):476-81.

Burkart W, Dame WR, Holzgreve W, Schneider HP.   [Significance of
hormones in the amniotic fluid. II. STH and corticoids].  Geburtshilfe
Frauenheilkd 1985 Nov;45(11):809-12. (Ger).

Burkett G, Bauer CR, Morrison JC, Curet LB.   Effect of prenatal
dexamethasone administration on prevention of respiratory distress
syndrome in twin pregnancies.  J Perinatol 1986;6:304-8.

Capeless EL, Mead PB.   Management of preterm premature rupture of
membranes: lack of a national consensus.  Am J Obstet Gynecol 1987
Jul;157(1):11-2.

Chalmers I, Hetherington J, Newdick M, Mutch L, Grant A, Enkin M,
Enkin E, Dickersin K.   The Oxford Database of Perinatal Trials:
developing a register of published reports of controlled trials. 
Controlled Clin Trials 1986 Dec;7(4):306-24.

Chapman MG.   Salbutamol-induced acidosis in pregnant diabetics
[letter].  Br Med J 1977 Mar 5;1(6061):639-40.

Collins R, Yusuf S, Peto R.   Overview of randomised trials of diuretics
in pregnancy.  Br Med J (Clin Res Ed) 1985 Jan 5;290(6461):17-23.

Creasy RK.   Preterm birth prevention: where are we?  Am J Obstet
Gynecol 1993 Apr;168(4):1223-30.

Crowley P.   Corticosteroids after preterm premature rupture of
membranes.  Obstet Gynecol Clin North Am 1992 Jun;19(2):317-26.

Cunningham FG, MacDonald PC, Gant NF, Leveno KJ, Gilstrap LC.  
Preterm and postterm pregnancy and fetal growth retardation.  In:
Cunningham FG, et al., editors.  Williams obstetrics.  19th ed. 
Norwalk (CN): Appleton & Lange; 1993.  p. 868-70. 

Eriksen NL, Blanco JD.   The role of corticosteroids in the
management of patients with preterm premature rupture of the
membranes.  Clin Obstet Gynecol 1991 Dec;34(4):694-701.

Farrag OA.   Prospective study of 3 metabolic regimens in pregnant
diabetics.  Aust N Z J Obstet Gynaecol 1987 Feb;27(1):6-9.

Finley J, Katz M, Rojas-Perez M, Roberts JM, Creasy RK, Schiller NB. 
Cardiovascular consequences of beta-agonist tocolysis: an
echocardiographic study.  Obstet Gynecol 1984 Dec;64(6):787-91.

Garite TJ, Freeman RK, Linzey EM, et al.   Prospective randomized
study of corticosteroids in the management of premature rupture of the
membranes and the premature gestation.  Am J Obstet Gynecol
1981;141:508-15.

Gjerdingen DK.   Premature labor, Part II: Management.  J Am Board
Fam Pract 1992 Nov-Dec;5(6):601-15.

Hays PM, Smeltzer JS.   Multiple gestation.  Clin Obstet Gynecol 1986
Jun;29(2):264-85.

Heyborne KD, Burke MS, Porreco RP.   Prolongation of premature
gestation in women with hemolysis, elevated liver enzymes and low
platelets. A report of five cases.  J Reprod Med 1990 Jan;35(1):53-7.

Heytmanek G, Salzer H, Vityska-Binstorfer E, Genger H, Metka M,
Pfersmann R, Wolff F, Weidinger H.  [Ambroxol versus betamethasone
for the promotion of antepartum lung maturity in pathological
pregnancies].  Wien Klin Wochenschr 1990 Aug 3; 102(15):443-8.
(Ger).

Hornnes PJ, Kuhl C.   Gastrointestinal hormones and cortisol in normal
pregnant women and women with gestational diabetes.  Acta
Endocrinol Suppl (Copenh) 1986;277:24-6.

Howie RN, Liggins GC.   Clinical trial of antepartum betamethasone
therapy for prevention of respiratory distress in pre-term infants.  In:
Anderson AB, et al., editors.  Pre-term labour.  Proceedings of the 5th
Study Group of the Royal College of Obstetricians and Gynaecologists;
1977 Oct 5-6.  London: Royal College of Obstetricians and
Gynaecologists; 1977.  p. 281-9. 

Huch A.   [Clinical management of premature rupture of fetal
membranes to the 35th week].  Arch Gynecol 1985;238(1-4):241-50.
(Ger).

Huel G, Keller E, Gueguen S, Robert C, Bouyer J, Papiernik E,
Mamelle N, Laumon B, Munoz F, Collin D, et al.   Effective prevention
of preterm birth: the French experience measured at Haguenau.  Birth
Defects 1989;25(1):1-234.

Hutson JM, Driscoll JM, Fox HE, Driscoll YT, Steir ME.   The effect
of obstetric management on neonatal mortality and morbidity for
infants weighing 700-1000 grams.  Am J Perinatol 1986
Jul;3(3):255-61.

Hwang JL, Hsu MC, Yang YS, Lee TY.   Hypertensive disorders in
pregnancy: analysis of 100 cases.  J Formosan Med Assoc
1989;88(6):572-8.

Iams JD, Talbert ML, Barrows H, Sachs L.   Management of preterm
prematurely ruptured membranes: a prospective randomized
comparison of observation versus use of steroids and timed delivery. 
Am J Obstet Gynecol 1985 Jan 1;151(1):32-8.

Ikeno N, Takahashi K.   [Studies on changes in serum estrone,
estradiol, estriol, DHA-S, and cortisol and urinary estriol excretion]. 
Nippon Sanka Fujinka Gakkai Zasshi 1985 Jan;37(1):99-106. (Jpn).

James D.   Preterm prelabour rupture of membranes.  Arch Dis Child
1991 Jul;66(7 Spec No):812-5.

Kaibara M.   [Management of premature rupture of the membranes]. 
Nippon Sanka Fujinka Gakkai Zasshi 1987 Sep;39(9):1659-64. (Jpn).

Kappy KA, Cetrulo CL, Knuppel RA, Ingardia CJ, Sbarra AJ, Scerbo
JC, Mitchell GW.   Premature rupture of the membranes: a
conservative approach.  Am J Obstet Gynecol 1979 Jul
15;134(6):655-61.

Kari MA, Hallman M, Eronon M, Teramo K, Virtanen M, Koivisto N,
Ikonen RS.  Prenatal dexamethasone treatment in conjunction with
rescue therapy of human surfactant - a randomized placebo-controlled
multicenter study.  Pediatrics.  Forthcoming 1994.

Keirse MJ, Ohlsson A, Treffers PE, Kanhai HH.   Prelabour rupture of
the membranes preterm.  In:  Chalmers I, Enkin M, Keirse MJ, editors. 
Effective care in pregnancy and childbirth.  New York: Oxford
University Press; 1989.  p. 666-93. 

Kennedy KA, Clark SL.   Premature rupture of the membranes:
management controversies.  Clin Perinatol 1992 Jun;19(2):385-97.

King JF, Grant A, Keirse MJ, Chalmers I.   Beta-mimetics in preterm
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Leigh J, Garite TJ.   Amniocentesis and the management of premature
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Lewis PJ, de Swiet M, Boylan P, Bulpitt CJ.   How obstetricians in the
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Magann EF, Graves GR, Roberts WE, Blake PG, Morrison JC, Martin
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Maher J, Goldenberg RL.  Outcomes of very-low-birth-weight infants
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Morrison JC, Schneider JM, Whybrew WD, Bucovaz ET.   Effect of
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Parsons MT, Sobel D, Cummiskey K, Constantine L, Roitman J.  
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Prober CG.   The risk of dexamethasone in pregnant women with a
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Simpson GF, Harbert GM Jr.   Use of beta-methasone in management
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Spinnato JA.   Infrequency of pulmonary immaturity in an indigent
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Taslimi MM, Sibai BM, Amon E, Taslimi CK, Herrick CN.   A national
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Theunissen I, van Lierde M.   Preterm premature rupture of the
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Tubman TR, Rollins MD, Patterson C, Halliday HL.   Increased
incidence of respiratory distress syndrome in babies of hypertensive
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Van Dorsten JP, Horger EO 3d, Miller MC.   Preterm rupture of the
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Weitzel HK, Lorenz U, Kipper B.   Clinical aspects of antenatal
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Wilkins I, Creasy RK.   Preterm labor.  Clin Obstet Gynecol 1990
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Wulf KH, Emmrich P, Graeff H, Huch A, Kunzel W, Ludwig H, Wulf
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Ziokowski K, Godziejewski J, Turowski J, Zaucka K.   [Method of
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1985 May-Jun;56(5-6):348-52. (Pol).


Pharmacology


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Bagramian ER, Fanchenko ND, Malysheva VA.   [Plasma levels of
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Ballard PL, Ballard RA, Creasy RK, Padbury J, Polk DH, Bracken M,
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Brien TG.   Pathophysiology of free cortisol in plasma.  Ann N Y Acad
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Chan EC, Smith R, Lewin T, Brinsmead MW, Zhang HP, Cubis J,
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Charnvises S, Fencl MD, Osathanondh R, Zhu MG, Underwood R,
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Chernukha EA, Komissarova LM, Malysheva VA, Abubakirova AM,
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Darne FJ, McGarrigle HH, Lachelin GC.   Diurnal variation of plasma
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Davies DP.   Placental insufficiency and its effect on the fetus and adult
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Dorr HG, Heller A, Versmold HT, Sippell WG, Herrmann M,
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Dorr HG, Sippell WG, Versmold HT, Bidlingmaier F, Knorr D.  
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Dorr HG, Versmold HT, Sippell WG, Bidlingmaier F, Knorr D.  
Antenatal betamethasone therapy: effects on maternal, fetal, and
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1986 Jun;108(6):990-3.

Goland RS, Conwell IM, Warren WB, Wardlaw SL.   Placental
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Goland RS, Wardlaw SL, Blum M, Tropper PJ, Stark RI.   Biologically
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Goretzlehner G, Wodrig W, Goretzlehner U.   [Sex-specific differences
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Hanes RC Jr.   Adrenocorticotropic hormone: adrenocortical steroids
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Haning RV Jr, Curet LB, Poole WK, Boehnlein LM, Kuzma DL, Meier
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Hercz P.   Quantitative changes in steroid and peptide hormones in the
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Hercz P, Siklos P, Ungar L.   Serum cortisol level changes in the
maternal-fetoplacental unit between the 28th-40th weeks of pregnancy. 
Acta Physiol Hung 1987;69(2):161-5.

Hercz P, Siklos P, Ungar L.   Serum dehydroepiandrosterone and
cortisol concentration in the maternal-fetoplacental hormonal system in
elective caesarean section and spontaneous vaginal delivery in the 28th
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1990;29(2):112-4.

Hornnes PJ, Kuhl C.   Gastrointestinal hormones and cortisol in normal
pregnant women and women with gestational diabetes.  Acta
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Hustead VA, Zachman RD.   The effect of antenatal dexamethasone on
maternal and fetal retinol-binding protein.  Am J Obstet Gynecol 1986
Jan;154(1):203-5.

Ikeno N, Takahashi K.   [Studies on changes in serum estrone,
estradiol, estriol, DHA-S, and cortisol and urinary estriol excretion]. 
Nippon Sanka Fujinka Gakkai Zasshi 1985 Jan;37(1):99-106. (Jpn).

Jaskiewicz J, Szafran Z, Szafran H, Sztefko K, Sucharski P.   The
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their newborn children.  Endokrynol Pol 1985;36(4):205-13.

Kono H, Furuhashi N, Shinkawa O, Takahashi T, Tsujiei M, Yajima A. 
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Kubota T, Tsuzuki H, Saito M.   Determination of prolactin, growth
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Lao TT, Panesar NS.   The effect of labour on prolactin and cortisol
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Lauterbach R, Szafran H, Szafran Z.   Blood glucose concentration and
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Murphy BE, Clark SJ, Donald IR, Pinsky M, Vedady D.   Conversion
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Nahoul K, Daffos F, Forestier F, Scholler R.   Cortisol, cortisone and
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Neri A, Merlob P, Kaplan B, Ovadia Y, Kaufman H.   Maternal and
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Neumark J, Hammerle AF, Biegelmayer C.   Effects of epidural
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Noguchi M.   [Changes in human serum corticosterone and cortisol
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Okamoto E, Takagi T, Makino T, Sata H, Iwata I, Nishino E, Mitsuda
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Partsch CJ, Sippell WG, MacKenzie IZ, Aynsley-Green A.   The
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Petersen MC, Nation RL, Ashley JJ, McBride WG.   The placental
transfer of betamethasone.  Eur J Clin Pharmacol 1980
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Phocas I, Sarandakou A, Rizos D.   Maternal serum total cortisol levels
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Prendiville W, Elbourne D, Chalmers I.   The effects of routine
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an overview of the evidence from controlled trials.  Br J Obstet
Gynaecol 1988 Jan;95(1):3-16.

Pschera H, Persson B, Lunell NO.   Amniotic fluid C-peptide and
cortisol in normal and diabetic pregnancies and pregnancies
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Jan;3(1):16-21.

Radikov N, Lyutakova E.   A study of the effect of corticosteroids on
the serum concentration of specific beta 1-glycoprotein.  Folia Med
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Saito K, Nishijima M, Horiuchi S.   [Changes in glucocorticoid
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Tropper PJ, Goland RS, Wardlaw SL, Fox HE, Frantz AG.   Effects of
betamethasone on maternal plasma corticotropin releasing factor,
ACTH and cortisol during pregnancy.  J Perinat Med
1987;15(3):221-5.

Vleugels MP, Eling WM, Rolland R, de Graaf R.   Cortisol levels in
human pregnancy in relation to parity and age.  Am J Obstet Gynecol
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Welshons WV, Lieberman ME, Gorski J.   Nuclear localization of
unoccupied oestrogen receptors.  Nature 1984 Feb
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Westphal U.   Steroid-protein interactions II.  Monogr Endocrinol
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Zheng SH.   [Cortisol levels in maternal and cord blood and amniotic
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1986 Mar;21(2):72-5, 125. (Chi).



ECONOMICS


Boyle MH, Torrance GW, Sinclair JC, Horwood SP.   Economic
evaluation of neonatal intensive care of very-low-birth-weight infants. 
N Engl J Med 1983 Jun 2;308(22):1330-7.

Egberts J.   Estimated costs of different treatments of the respiratory
distress syndrome in a large cohort of preterm infants of less than 30
weeks of gestation.  Biol Neonate 1992;61 Suppl 1:59-65.

Eidelman AI.   Economic consequences of surfactant therapy.  J
Perinatol 1993 Mar-Apr;13(2):137-9.

Ewald U.   What is the actual cost of neonatal intensive care?  Int J
Technol Assess Health Care 1991;7 Suppl 1:155-61.

Hope P.   Exogenous surfactants [editorial].  BMJ 1991 Oct
5;303(6806):799-800.

Huel G, Keller E, Gueguen S, Robert C, Bouyer J, Papiernik E,
Mamelle N, Laumon B, Munoz F, Collin D, et al.   Effective prevention
of preterm birth: the French experience measured at Haguenau.  Birth
Defects 1989;25(1):1-234.

Johnson DE, Munson DP, Thompson TR.   Effect of antenatal
administration of dexamethasone on hospital cost and survival of
premature infants.  Pediatrics 1981;68:633-7.

Kitchen WH, Bowman E, Callanan C, Campbell NT, Carse EA,
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improving the outcome for infants of birthweight 500-999 g in Victoria.
The Victorian Infant Collaborative Study Group.  J Paediatr Child
Health 1993 Feb;29(1):56-62.

Maniscalco WM, Kendig JW, Shapiro DL.   Surfactant replacement
therapy: impact on hospital charges for premature infants with
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Merritt TA, Hallman M, Vaucher Y, McFeeley E, Tubman TR.  
Impact of surfactant treatment on cost of neonatal intensive care: a
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Mugford M, Piercy J, Chalmers I.   Cost implications of different
approaches to the prevention of respiratory distress syndrome.  Arch
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Paneth N, Guillemin J, Harrison H, Campbell N, Mercier CE.  
Roundtable: survival and outcome of the extremely low-birthweight
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Sinclair JC.   Economic evaluation of neonatal intensive care. Which
variables have to be known?  Int J Technol Assess Health Care 1991;7
Suppl 1:146-50.

State of Florida Hospital Containment Board.   Neonatal intensive care
study.  Tallahassee (FL): The Board; 1987 Jan. 

Stevenson RC, Pharoah PO, Cooke RW, Sandhu B.   Predicting costs
and outcomes of neonatal intensive care for very low birthweight
infants.  Public Health 1991 Mar;105(2):121-6.

Storch TG.   The unkindest cut [editorial].  Am J Dis Child 1990
May;144(5):533.

Tubman TR, Halliday HL, Normand C.   Cost of surfactant
replacement treatment for severe neonatal respiratory distress
syndrome: a randomised controlled trial.  BMJ 1990 Oct
13;301(6756):842-5.  Published erratum appears in BMJ 1991 Jan
5;302(6767):27.

Tubman TR, Halliday HL, Normand C.   Economic impact of porcine
surfactant replacement (Curosurf) for severe neonatal respiratory
distress syndrome.  J Perinat Med 1991;19 Suppl 1:403-7.



META-ANALYSIS


Agency for Health Care Policy and Research.   Clinical classifications
for health policy research: discharge statistics by principal diagnosis and
procedure.  Rockville (MD): The Agency; 1993 Aug.  (AHCPR Pub.
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Aylward GP, Pfeiffer SI, Wright A, Verhulst SJ.   Outcome studies of
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Pediatr 1989 Oct;115(4):515-20.  Comment in: J Pediatr 1990
Jul;117(1 Pt 1):167-8;  J Pediatr 1990 Sep;117(3):511-2.

Chalmers I, Hetherington J, Elbourne D, et al.   Matherials and
methods used in synthesizing evidence to evaluate the effects of care
during pregnancy and childbirth.  In: Chalmers I, Enkin M, Keirse MJ,
editors.  Effective care in pregnancy and childbirth.  New York: Oxford
University Press; 1989.  p. 39-65. 

Crowley P, Chalmers I, Keirse MJ.   The effects of corticosteroid
administration before preterm delivery: an overview of the evidence
from controlled trials.  Br J Obstet Gynaecol 1990 Jan;97(1):11-25. 
Comment in: Br J Obstet Gynaecol 1990 Jan;97(1):1-3.

Dickersin K, Hewitt P, Mutch L, Chalmers I, Chalmers TC.   Perusing
the literature: comparison of MEDLINE searching with a perinatal
trials database.  Controlled Clin Trials 1985 Dec;6(4): 306-17.

Escobar GJ, Littenberg B, Petitti DB.   Outcome among surviving very
low birthweight infants: a meta-analysis.  Arch Dis Child 1991
Feb;66(2):204-11.

Gortner L.   Natural surfactant for neonatal respiratory distress
syndrome in very  premature infants: a 1992 update.  J Perinat Med
1992;20(6):409-19.

Hetherington J, Dickersin K, Chalmers I, Meinert CL.   Retrospective
and prospective identification of unpublished controlled trials: lessons
from a survey of obstetricians and pediatricians.  Pediatrics 1989
Aug;84(2):374-80.

Kattner E, Metze B, Waiss E, Obladen M.   Accelerated lung
maturation following maternal steroid treatment in infants born before
30 weeks gestation.  J Perinat Med 1992;20(6):449-57.

Ohlsson A.   Treatment of preterm premature rupture of membranes: a
meta-analysis.  Am J Obstet Gynecol 1989;160:890-906.

Peto R, Pike MC, Armitage P, Breslow NE, Cox DR, Howard SV,
Mantel N, McPherson K, Peto J, Smith PG.   Design and analysis of
randomized clinical trials requiring prolonged observation of each
patient. I. Introduction and design.  Br J Cancer 1976
Dec;34(6):585-612.

State of Florida Hospital Containment Board.   Neonatal intensive care
study.  Tallahassee (FL): The Board; 1987 Jan. 



ANIMAL MODELS

Behavior


Benesova O, Pavlik A.   Behavioural teratogenic risk of perinatal
glucocorticoid treatment. 21st Interdisciplinary Conference on
Experimental and Clinical Study of Higher Nervous Functions (1985,
Olomouc, Czechoslovakia).  Act Nerv Super 1986 Sep;28(3):197-8.

Benesova O, Pavlik A.   Perinatal treatment with glucocorticoids and
the risk of maldevelopment of the brain.  Neuropharmacology 1989
Jan;28(1):89-97.

Dygalo NN.   [Emotional reactivity of rats and of their progeny after
hormonal modification of the intrauterine development].  Zh Vyssh
Nerv Deiat 1988 Jul-Aug;38(4):710-4. (Rus).

Fujii T, Horinaka M, Hata M.   Functional effects of glucocorticoid
exposure during fetal life.  Prog Neuropsychopharmacol Biol
Psychiatry 1993 Mar;17(2):279-93.

Schapiro S, Salas M, Vukovich K.   Hormonal effects on ontogeny of
swimming ability in the rat: assessment of central nervous system
development.  Science 1970 Apr 3;168(927):147-50.


Cardiovascular Effects


Benediktsson R, Lindsay RS, Noble J, Seckl JR, Edwards CR.  
Glucocorticoid exposure in utero: new model for adult hypertension . 
Lancet 1993 Feb 6;341(8841):339-41.  Published erratum appears in
Lancet 1993 Feb 27;341(8844):572.  Comment in: Lancet 1993 Mar
27;341(8848):828.

Bian X, Briggs MM, Schachat FH, Seidler FJ, Slotkin TA.  
Glucocorticoids accelerate the ontogenetic transition of cardiac
ventricular myosin heavy-chain isoform expression in the rat:
promotion by prenatal exposure to a low dose of dexamethasone.  J
Dev Physiol 1992 Jul;18(1):35-42.

Bian X, Seidler FJ, Olsen C, Raymond JR, Slotkin TA.   Effects of fetal
dexamethasone exposure on postnatal control of cardiac adenylate
cyclase: beta-adrenergic receptor coupling to Gs regulatory protein. 
Teratology 1993 Aug;48(2):169-77.

Bian X, Seidler FJ, Slotkin TA.   Fetal dexamethasone exposure
interferes with establishment of cardiac noradrenergic innervation and
sympathetic activity.  Teratology 1993 Feb;47(2):109-17.

Bian XP, Seidler FJ, Bartolome J, Kavlock RJ, Bartolome M, Slotkin
TA.   Dose-dependent effect of prenatal dexamethasone treatment on
beta-adrenergic receptor coupling to ornithine decarboxylase and cyclic
AMP.  J Dev Physiol 1990 Sep;14(3):125-30.

Bian XP, Seidler FJ, Slotkin TA.   Promotional role for glucocorticoids
in the development of intracellular signalling: enhanced cardiac and
renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic
stimuli after low-dose fetal dexamethasone exposure.  J Dev Physiol
1991 Dec;16(6):331-9.

Bian XP, Seidler FJ, Slotkin TA.   Promotional role for glucocorticoids
in the development of intracellular signalling: enhanced cardiac and
renal adenylate cyclase reactivity to beta-adrenergic and non-adrenergic
stimuli after low-dose fetal dexamethasone exposure.  J Dev Physiol
1992 Jun;17(6):289-97.

Hou QC, Slotkin TA.   Effects of prenatal dexamethasone or
terbutaline exposure on development of neural and intrinsic control of
heart rate.  Pediatr Res 1989 Dec;26(6):554-7.

Matsubara H, Hirata Y, Yoshimi H, Takata S, Takagi Y, Iida T,
Yamane Y, Umeda Y, Nishikawa M, Inada M.   Effects of steroid and
thyroid hormones on synthesis of atrial natriuretic peptide by cultured
atrial myocytes of rat.  Biochem Biophys Res Commun 1987 May
29;145(1):336-43.

Matsubara H, Hirata Y, Yoshimi H, Takata S, Takagi Y, Yamane Y,
Umeda Y, Nishikawa M, Inada M.   Ventricular myocytes from
neonatal rats are more responsive to dexamethasone than atrial
myocytes in synthesis of atrial natriuretic peptide.  Biochem Biophys
Res Commun 1987 Nov 13;148(3):1030-8.

Momma K, Takao A.   Increased constriction of the ductus arteriosus
with combined administration of indomethacin and betamethasone in
fetal rats.  Pediatr Res 1989 Jan;25(1):69-75.

Navarro HA, Kudlacz EM, Slotkin TA.   Control of adenylate cyclase
activity in developing rat heart and liver: effects of prenatal exposure to
terbutaline or dexamethasone.  Biol Neonate 1991;60(2):127-36.

Slotkin TA, Seidler FJ, Kavlock RJ, Bartolome JV.   Fetal
dexamethasone exposure impairs cellular development in neonatal rat
heart and kidney: effects on DNA and protein in whole tissues. 
Teratology 1991 Apr;43(4):301-6.

Stein HM, Oyama K, Martinez A, Chappell BA, Buhl E, Blount L,
Padbury JF.   Effects of corticosteroids in preterm sheep on adaptation
and sympathoadrenal mechanisms at birth.  Am J Physiol 1993
May;264(5 Pt 1):E763-9.

Tangalakis K, Lumbers ER, Moritz KM, Towstoless MK, Wintour
EM.   Effect of cortisol on blood pressure and vascular reactivity in the
ovine fetus.  Exp Physiol 1992 Sep;77(5):709-17.

Tsai MY, Brown DM.   Effect of dexamethasone on fetal lung
15-hydroxy-prostaglandin dehydrogenase: possible mechanism for the
prevention of patent ductus arteriosus by maternal dexamethasone
therapy.  Prostaglandins Leukot Med 1987 May; 27(2-3):237-45.

Wood CE.   Negative-feedback inhibition of fetal ACTH secretion by
maternal cortisol.  Am J Physiol 1987 Apr;252(4 Pt 2):R743-8.

Wood CE.   Sensitivity of cortisol-induced inhibition of ACTH and
renin in fetal sheep.  Am J Physiol 1986 May;250(5 Pt 2):R795-802.

Wood CE, Cheung CY, Brace RA.   Fetal heart rate, arterial pressure,
and blood volume responses to cortisol infusion.  Am J Physiol 1987
Dec;253(6 Pt 2):R904-9.


Central Nervous System Effects


Almazan G, Honegger P, Du Pasquier P, Matthieu JM. 
Dexamethasone stimulates the biochemical differentiation of fetal
forebrain cells in reaggregating cultures.  Dev Neurosci
1986;8(1):14-23.

Anderson DJ.   Cell fate determination in the peripheral nervous
system: the sympathoadrenal progenitor.  J Neurobiol 1993
Feb;24(2):185-98.

Benesova O, Pavlik A.   Perinatal treatment with glucocorticoids and
the risk of maldevelopment of the brain.  Neuropharmacology 1989
Jan;28(1):89-97.

Bian X, Seidler FJ, Slotkin TA.   Fetal dexamethasone exposure
interferes with establishment of cardiac noradrenergic innervation and
sympathetic activity.  Teratology 1993 Feb;47(2):109-17.

Bohn MC, Goldstein M, Black IB.   Expression and development of
phenylethanolamine N-methyltransferase (PNMT) in rat brain stem:
studies with glucocorticoids.  Dev Biol 1986 Mar;114(1):180-93.

Carlos RQ, Seidler FJ, Lappi SE, Slotkin TA.   Fetal dexamethasone
exposure affects basal ornithine decarboxylase activity in developing rat
brain regions and alters acute responses to hypoxia and maternal
separation.  Biol Neonate 1991;59(2):69-77.

Carlos RQ, Seidler FJ, Slotkin TA.   Fetal dexamethasone exposure
alters macromolecular characteristics of rat brain development: a
critical period for regionally selective alterations?  Teratology 1992
Jul;46(1):45-59.

Carlos RQ, Seidler FJ, Slotkin TA.   Fetal dexamethasone exposure
sensitizes neonatal rat brain to hypoxia: effects on protein and DNA
synthesis.  Brain Res Dev Brain Res 1991 Dec 17; 64(1-2):161-6.

Chumas PD, Del Bigio MR, Drake JM, Tuor UI.   A comparison of the
protective effect of dexamethasone to other potential prophylactic
agents in a neonatal rat model of cerebral hypoxia-ischemia.  J
Neurosurg 1993 Sep;79(3):414-20.

Cintra A, Solfrini V, Bunnemann B, Okret S, Bortolotti F, Gustafsson
JA, Fuxe K.   Prenatal development of glucocorticoid receptor gene
expression and  immunoreactivity in the rat brain and pituitary gland: a
combined in-situ hybridization and immunocytochemical analysis. 
Neuroendocrinology 1993 Jun;57(6):1133-47.

Cosi C, Spoerri PE, Comelli MC, Guidolin D, Skaper SD.  
Glucocorticoids depress activity-dependent expression of BDNF
mRNA in hippocampal neurones.  Neuroreport 1993 May;4(5):527-30.

Dygalo NN.   [Emotional reactivity of rats and of their progeny after
hormonal modification of the intrauterine development].  Zh Vyssh
Nerv Deiat 1988 Jul-Aug;38(4):710-4. (Rus).

Dygalo NN, Milova AA, Shishkina GT.   [The ontogeny of the alpha 2-
and beta-adrenoreceptors in the brain following exposure to
corticosterone during intrauterine development].  Ontogenez 1991
Nov-Dec;22(6):606-11. (Rus).

Dygalo NN, Naumenko EV.   [Hydrocortisone modification during
intrauterine development of the activity of brain tyrosine hydroxylase in
adult white rats].  Ontogenez 1988 May-Jun;19(3):319-22. (Rus).

Dygalo NN, Shishkina GT, Milova AA.   [The beta-adrenoreceptors of
the cerebral cortex in rat pups after exposures altering the
noradrenaline level].  Ontogenez 1993 May-Jun;24(3):93-7. (Rus).

Fujii T, Horinaka M, Hata M.   Functional effects of glucocorticoid
exposure during fetal life.  Prog Neuropsychopharmacol Biol
Psychiatry 1993 Mar;17(2):279-93.

Garina IA, Zhukov DA, Rakitskaia VV, Shaliapina VG.  Receptor
binding of corticosterone in some rat brain structures following
neonatal blockade of the hypophyseoadrenal system.  Neurosci Behav
Physiol 1986 Sep-Oct;16(5):448-51.

Garina IA, Zhukov DA, Rakitskaia VV, Shaliapina VG.  [Receptor
binding of corticosterone in various structures of the rat brain after
neonatal blockade of the hypophyseal-adrenal system].  Probl
Endokrinol (Mosk) 1985 Jul-Aug;31(4):46-9. (Rus).

Gudoshnikov VI, Fedotov VP.   The heightened sensitivity of
hypophyseal cells of neonatal rats to corticosteroids.  Neurosci Behav
Physiol 1993 Mar-Apr;23(2):107-11.

Hill CE, McLennan IS, Hendry IA.   Development of sympathetic
neurones in vivo: an investigation of the possible role of
glucocorticosteroids in regulating transmitter type.  Aust J Exp Biol
Med Sci 1985 Aug;63(Pt 4):439-49.

Juanes MC, Arizmendi C, Medina JM.   Attenuation of postnatal
hypoxia in the premature newborn rat by maternal treatment with
dexamethasone: its relationship with lung phospholipid content.  Biol
Neonate 1986;50(6):337-44.

Navarro HA, Lachowicz J, Bartolome J, Whitmore WL, Slotkin TA.  
Effects of prenatal dexamethasone on development of ornithine
decarboxylase activity in brain and peripheral tissues of rats.  Pediatr
Res 1988 Oct;24(4):465-9.

Rodriguez MP, Sosenko IR, Antigua MC, Frank L.   Prenatal hormone
treatment with thyrotropin releasing hormone and with thyrotropin
releasing hormone plus dexamethasone delays antioxidant enzyme
maturation but does not inhibit a protective antioxidant enzyme
response to hyperoxia in newborn rat lung.  Pediatr Res 1991
Dec;30(6):522-7.

Scully JL, Otten U.   Glucocorticoid modulation of neurotrophin
expression in immortalized mouse hippocampal neurons.  Neurosci Lett
1993 May 28;155(1):11-4.

Slotkin TA, Lappi SE, McCook EC, Tayyeb MI, Eylers JP, Seidler FJ.  
Glucocorticoids and the development of neuronal function: effects of
prenatal dexamethasone exposure on central noradrenergic activity. 
Biol Neonate 1992;61(5):326-36.

Slotkin TA, Lappi SE, Tayyeb MI, Seidler FJ.   Dose-dependent
glucocorticoid effects on noradrenergic synaptogenesis in rat brain:
ontogeny of [3H]desmethylimipramine binding sites after fetal exposure
to dexamethasone.  Res Commun Chem Pathol Pharmacol 1991
Jul;73(1):3-19.

Slotkin TA, McCook EC, Seidler FJ.   Glucocorticoids regulate the
development of intracellular signaling  enhanced forebrain adenylate
cyclase catalytic subunit activity after fetal dexamethasone exposure. 
Brain Res Bull 1993;32(4):359-64.

Tuor UI, Simone CS, Arellano R, Tanswell K, Post M.  Glucocorticoid
prevention of neonatal hypoxic-ischemic damage: role of hyperglycemia
and antioxidant enzymes.  Brain Res 1993 Feb 26;604(1-2):165-72.

Tuor UI, Simone CS, Barks JD, Post M.   Dexamethasone prevents
cerebral infarction without affecting cerebral blood flow in neonatal
rats.  Stroke 1993 Mar;24(3):452-7.

Uno H, Lohmiller L, Thieme C, Kemnitz JW, Engle MJ, Roecker EB,
Farrell PM.   Brain damage induced by prenatal exposure to
dexamethasone in fetal rhesus macaques. I. Hippocampus.  Brain Res
Dev Brain Res 1990 May 1;53(2):157-67.

Velazquez PN, Romano MC.   Corticosterone therapy during
gestation: effects on the development of rat cerebellum.  Int J Dev
Neurosci 1987;5(3):189-94.

Zahalka EA, Seidler FJ, Slotkin TA.   Dexamethasone treatment in
utero enhances neonatal cholinergic nerve terminal development in rat
brain.  Res Commun Chem Pathol Pharmacol 1993 Aug;81(2): 191-8.


Combination Therapy


Anceschi MM, Petrelli A, Zaccardo G, Barbati A, Di Renzo GC, Cosmi
EV, Hallman M.   Inositol and glucocorticoid in the development of
lung stability in male and female rabbit fetuses.  Pediatr Res 1988
Nov;24(5):617-21.

Barker PM, Markiewicz M, Parker KA, Walters DV, Strang LB.  
Synergistic action of triiodothyronine and hydrocortisone on
epinephrine-induced reabsorption of fetal lung liquid.  Pediatr Res 1990
Jun;27(6):588-91.

Barker PM, Walters DV, Markiewicz M, Strang LB.   Development of
the lung liquid reabsorptive mechanism in fetal sheep: synergism of
triiodothyronine and hydrocortisone.  J Physiol (Lond) 1991
Feb;433:435-49.

Devaskar U, Church JC, Chechani V, Sadiq F.   Effect of simultaneous
administration of betamethasone and triiodothyronine (T3) on the
development of functional pulmonary maturation in fetal rabbit. 
Biochem Biophys Res Commun 1987 Jul 31;146(2): 524-9.

Devaskar SU, Grim PF 3d, Devaskar UP.   A differential effect of
thyroxine and glucocorticoids on fetal brain and heart insulin receptor. 
Pediatr Res 1985 Feb;19(2):192-8.

Ekelund L, Enhorning G.   Glucocorticoids and
beta-adrenergic-receptor agonists: their combined effect on fetal rabbit
lung surfactant.  Am J Obstet Gynecol 1985 Aug 15;152(8):1063-7.

ElKady T, Jobe A.   Corticosteroids and surfactant increase lung
volumes and decrease rupture pressures of preterm rabbit lungs.  J Appl
Physiol 1987 Oct;63(4):1616-21.

ElKady T, Jobe A.   Maternal treatments with corticosteroids and/or
T3 change lung volumes and rupture pressures in preterm rabbits.  Biol
Neonate 1988;54(4):203-10.

Gallaher KJ, Rannels DE, Rannels SR.   Vitamin K-dependent
carboxylase activity in fetal rat lung: developmental effects of
dexamethasone and triiodothyronine.  Pediatr Res 1989 May;25(5):
530-4.

Gladstone IM, Mercurio MR, Devenny SG, Jacobs HC.  Antenatal
steroids, postnatal surfactant, and pulmonary function in premature
rabbits.  J Appl Physiol 1989 Oct;67(4):1377-82.

Hill MD, Abramson FP.   The effect of phenobarbital and
dexamethasone on hepatic cytochrome P-450 and alpha 1-acid
glycoprotein in maternal and fetal guinea pigs.  Res Commun Chem
Pathol Pharmacol 1990 Jul;69(1):33-48.

Ikegami M, Jobe AH, Pettenazzo A, Seidner SR, Berry DD, Ruffini L.  
Effects of maternal treatment with corticosteroids, T3, TRH, and their
combinations on lung function of ventilated preterm rabbits with and
without surfactant treatments.  Am Rev Respir Dis 1987
Oct;136(4):892-8.

Ikegami M, Jobe AH, Seidner S, Yamada T.   Gestational effects of
corticosteroids and surfactant in ventilated rabbits.  Pediatr Res 1989
Jan;25(1):32-7.

Ikegami M, Jobe AH, Tabor BL, Rider ED, Lewis JF.   Lung albumin
recovery in surfactant-treated preterm ventilated lambs.  Am Rev
Respir Dis 1992 May;145(5):1005-8.

Ikegami M, Polk D, Tabor B, Lewis J, Yamada T, Jobe A.  
Corticosteroid and thyrotropin-releasing hormone effects on preterm
sheep lung function.  J Appl Physiol 1991 May;70(5):2268-78.

Karp WB, Robertson AF, Kanto WP Jr.   The effect of hydrocortisone,
thyroxine, and phenobarbital on diamine oxidase activity in newborn rat
intestine.  Pediatr Res 1987 Apr;21(4):368-70.

Liggins GC, Schellenberg JC, Manzai M, Kitterman JA, Lee CC.  
Synergism of cortisol and thyrotropin-releasing hormone in lung
maturation in fetal sheep.  J Appl Physiol 1988 Oct;65(4):1880-4.

Lohninger A, Krieglsteiner HP, Salzer H, Vytiska-Binstorfer E, Riedl
W, Erhardt W.   Studies on the effects of betamethasone, L-carnitine,
and betamethasone-L-carnitine combinations on the dipalmitoyl
phosphatidylcholine content and phosphatidylcholine species
composition in foetal rat lungs.  J Clin Chem Clin Biochem 1986
Jun;24(6):361-8.

O'Brodovich H, Canessa C, Ueda J, Rafii B, Rossier BC, Edelson J.  
Expression of the epithelial Na+ channel in the developing rat lung. 
Am J Physiol 1993 Aug;265(2 Pt 1):C491-6.

Orlowski J, Lingrel JB.   Thyroid and glucocorticoid hormones regulate
the expression of multiple Na,K-ATPase genes in cultured neonatal rat
cardiac myocytes.  J Biol Chem 1990 Feb 25;265(6): 3462-70.

Oulton M, Rasmusson MG, Yoon RY, Fraser M.  
Gestation-dependent effects of the combined treatment of
glucocorticoids and thyrotropin-releasing hormone on surfactant
production by fetal rabbit lung.  Am J Obstet Gynecol 1989
Apr;160(4):961-7.

Polk D, Ikegami M, Jobe AH, Newnham J, Kelly R, Cohen R, Sly P.  
Combined antenatal thyroid hormone and betamethasone therapy and
postnatal pulmonary function in the preterm lamb: effects of a single 
fetal im dose  [abstract].  Pediatr Res 1993;33(4 Pt 2):341a.

Pope TS, Smart DA, Rooney SA.   Hormonal effects on fatty-acid
synthase in cultured fetal rat lung; induction by dexamethasone and
inhibition of activity by triiodothyronine.  Biochim Biophys Acta 1988
Mar 25;959(2):169-77.

Rodriguez MP, Sosenko IR, Antigua MC, Frank L.   Prenatal hormone
treatment with thyrotropin releasing hormone and with thyrotropin
releasing hormone plus dexamethasone delays antioxidant enzyme
maturation but does not inhibit a protective antioxidant enzyme
response to hyperoxia in newborn rat lung.  Pediatr Res 1991
Dec;30(6):522-7.

Rodriguez-Pierce M, Sosenko IR, Frank L.   Prenatal thyroid releasing
hormone and thyroid releasing hormone plus dexamethasone lessen the
survival of newborn rats during prolonged high O2 exposure.  Pediatr
Res 1992 Oct;32(4):407-11.

Rooney SA, Gobran LI, Chu AJ.   Thyroid hormone opposes some
glucocorticoid effects on glycogen content and lipid synthesis in
developing fetal rat lung.  Pediatr Res 1986 Jun;20(6):545-50.

Seidner S, Rider E, Jobe A, Yamada T, Ikegami M.   Effects of
antenatal thyrotropin-releasing hormone, antenatal corticosteroids, and
postnatal ventilation on surfactant mobilization in premature rabbits. 
Am J Obstet Gynecol 1992 May;166(5):1551-9.

Tabor BL, Ikegami M, Jobe AH, Yamada T, Oetomo SB.   Dose
response of thyrotropin-releasing hormone on pulmonary maturation in
corticosteroid-treated preterm rabbits.  Am J Obstet Gynecol 1990
Aug;163(2):669-76.

Walther FJ, Ikegami M, Warburton D, Polk DH.   Corticosteroids,
thyrotropin-releasing hormone, and antioxidant enzymes in preterm
lamb lungs.  Pediatr Res 1991 Dec;30(6):518-21.

Warburton D, Parton L, Buckley S, Cosico L, Enns G, Saluna T.  
Combined effects of corticosteroid, thyroid hormones, and beta-agonist
on surfactant, pulmonary mechanics, and beta-receptor binding in fetal
lamb lung.  Pediatr Res 1988 Aug;24(2):166-70.

Ward SM, Caritis SN, Chiao JP, Moore JJ.   Dexamethasone effects on
ritodrine-induced changes in myometrial contractility and
beta-adrenergic receptor function.  Am J Obstet Gynecol 1988 Dec;
159(6):1461-6.


Endocrine Effects


Inczefi-Gonda A, Csaba G.   Prolonged influence of a single neonatal
steroid (dexamethasone) treatment on thymocytic steroid binding.  Exp
Clin Endocrinol 1985 Jun;85(3):358-60.

Rodriguez-Pierce M, Sosenko IR, Frank L.   Prenatal thyroid releasing
hormone and thyroid releasing hormone plus dexamethasone lessen the
survival of newborn rats during prolonged high O2 exposure.  Pediatr
Res 1992 Oct;32(4):407-11.

Wood CE.   Negative-feedback inhibition of fetal ACTH secretion by
maternal cortisol.  Am J Physiol 1987 Apr;252(4 Pt 2):R743-8.

Wood CE.   Sensitivity of cortisol-induced inhibition of ACTH and
renin in fetal sheep.  Am J Physiol 1986 May;250(5 Pt 2):R795-802.


Gastrointestinal Effects


Barnard JA, Ghishan FK.   Methylprednisolone accelerates the
ontogeny of sodium-taurocholate cotransport in rat ileal brush border
membranes.  J Lab Clin Med 1986 Dec;108(6):549-55.

Bate LA, Ireland W, Connell BJ, Grimmelt B.   Development of the
small intestine of piglets in response to prenatal elevation of
glucocorticoids.  Histol Histopathol 1991 Apr;6(2):207-16.

Beck JC, Lipkowitz MS, Abramson RG.   Ontogeny of sodium proton
antiporter activity in rabbit renal brush border membrane vesicles.  J
Clin Invest 1991;87(6):2067-76.

Bujanover Y, Amarri S, Lebenthal E, Petell JK.   The effect of
dexamethasone and glucagon on the expression of hepatocyte plasma
membrane proteins during development.  Hepatology 1988 Jul-Aug;
8(4):722-7.

Burchell A, Leakey JE.   Development of the rat hepatic microsomal
glucose-6-phosphatase system and its glucocorticoid inducibility.  Biol
Neonate 1988;54(2):107-15.

Engelhard EL, Beggs JC, Neu J.   Maturation of antioxidant enzymes in
rat small intestine: lack of glucocorticoid stimulation.  J Pediatr 1987
Sep;111(3):459-63.

Franke H, Dargel R.   Morphometric studies on lipoprotein particles in
developing rat liver and their corticosteroid-induced changes during the
late gestational period.  Cell Tissue Res 1985;242(3):661-7.

Heitkemper MM, Marotta SF.   Effects of corticosterone and
metyrapone on gastrointestinal neurotransmitter enzyme activities.  Res
Commun Chem Pathol Pharmacol 1986 Oct;54(1):47-64.

Hill MD, Abramson FP.   The effect of phenobarbital and
dexamethasone on hepatic cytochrome P-450 and alpha 1-acid
glycoprotein in maternal and fetal guinea pigs.  Res Commun Chem
Pathol Pharmacol 1990 Jul;69(1):33-48.

Horvath K, Blochin B, Hill I, Verma R, Lu RB, Lebenthal E.   The pre-
and postnatal development of Na+/K(+)-ATPase in gastrointestinal
organs of the rat: effect of betamethasone treatment.  J Pediatr
Gastroenterol Nutr 1993 May;16(4):412-8.

Huang DP, Cote GJ, Massari RJ, Chiu JF.   Dexamethasone inhibits
alpha-fetoprotein gene transcription in neonatal rat liver and isolated
nuclei.  Nucleic Acids Res 1985 Jun 11;13(11):3873-90.

Israel EJ, Schiffrin EJ, Carter EA, Frieberg E, Walker WA.   Cortisone
strengthens the intestinal mucosal barrier in a rodent necrotizing
enterocolitis model.  Adv Exp Med Biol 1991;310:375-80.

Israel EJ, Schriffrin EJ, Carter EA, Freiberg E, Walker WA.  
Prevention of necrotizing enterocolitis in the rat with prenatal
cortisone.  Gastroenterology 1990;99(5):1333-8.

James PS, Smith MW, Tivey DR, Wilson TJ.   Dexamethasone
selectively increases sodium-dependent alanine transport across
neonatal piglet intestine.  J Physiol (Lond) 1987 Dec; 393:569-82.

Johnston NE, Stewart JA.   The effect of glucocorticoids and
prematurity on absorption of colostral immunoglobulin in the calf. 
Aust Vet J 1986 Jun;63(6):191-2.

Karp WB, Robertson AF, Kanto WP Jr.   The effect of hydrocortisone,
thyroxine, and phenobarbital on diamine oxidase activity in newborn rat
intestine.  Pediatr Res 1987 Apr;21(4):368-70.

Leakey JE, Althaus ZR, Bailey JR, Slikker W Jr.   Dexamethasone
increases UDP- glucuronyltransferase activity towards bilirubin,
oestradiol and testosterone in foetal liver from rhesus monkey during
late gestation.  Biochem J 1985 Jan 1;225(1):183-8.

Lee PC, Struve MF, Werlin SL.   Modulation of lingual lipase
development by glucocorticoid in the rat.  Pediatr Res 1991
Jan;29(1):46-9.

Leung YK, Jirapinyo P, Lebenthal E, Lee PC.   Effect of
hydrocortisone on the maturation of cholecystokinin (CCK) binding
and CCK stimulated amylase release in pancreatic acini of neonatal rats. 
Pancreas 1987;2(1):73-8.

Li J, Saunders JC, Gilmour RS, Silver M, Fowden AL.  Insulin-like
growth factor-II messenger ribonucleic acid expression in fetal tissues
of the sheep during late gestation: effects of cortisol.  Endocrinology
1993 May;132(5):2083-9.

Linder MW, Prough RA.   Developmental aspects of glucocorticoid
regulation of polycyclic aromatic hydrocarbon-inducible enzymes in rat
liver.  Arch Biochem Biophys 1993 Apr;302(1):92-102.

Navarro HA, Kudlacz EM, Slotkin TA.   Control of adenylate cyclase
activity in developing rat heart and liver: effects of prenatal exposure to
terbutaline or dexamethasone.  Biol Neonate 1991;60(2):127-36.

Neu J, Ozaki CK, Angelides KJ.   Glucocorticoid- mediated alteration
of fluidity of brush border membrane in rat small intestine.  Pediatr Res
1986 Jan;20(1):79-82.

Nishida N, Takeuchi T.   Effect of dexamethasone on the adenylate
cyclase system of cultured hepatocytes of fetal rats.  Biol Neonate
1987;52(1):33-9.

Pang KY, Newman AP, Udall JN, Walker WA.   Development of
gastrointestinal mucosal barrier. VII. In utero maturation of microvillus
surface by cortisone.  Am J Physiol 1985 Jul;249(1 Pt 1):G85-91.

Rudolph CD, Roman C, Rudolph AM.   Effect of cortisol on hepatic
gluconeogenesis in the fetal sheep.  J Dev Physiol 1989
Apr;11(4):219-23.

Wallin R, Hutson SM.   Dexamethasone stimulates vitamin
K-dependent carboxylase activity in neonatal rats and cultured fetal
hepatocytes.  Pediatr Res 1991 Sep;30(3):281-5.

Yeoh GC, Brighton VJ, Angus DA, Kraemer M, Vassy J, Chalemeau
MT.   The effect of dexamethasone on albumin production by fetal rat
hepatocytes in culture.  Eur J Cell Biol 1985 Jul;38(1):157-64.


Pharmacology


Akagi K, Berdusco ET, Challis JR.   Cortisol inhibits ACTH but not
the AVP response to hypoxaemia in fetal lambs at days 123-128 of
gestation.  J Dev Physiol 1990 Dec;14(6):319-24.

Althaus ZR, Bailey JR, Leakey JE, Slikker W Jr.   Transplacental
metabolism of dexamethasone and cortisol in the late gestational age
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1986;9(5):332-49.

Antolovich GC, McMillen IC, Robinson PM, Silver M, Young IR,
Perry RA.   Effect of cortisol infusion on the pituitary-adrenal axis of
the hypothalamo-pituitary-disconnected fetal sheep. 
Neuroendocrinology 1992 Sep;56(3):312-9.

Aszterbaum M, Feingold KR, Menon GK, Williams ML.  
Glucocorticoids accelerate fetal maturation of the epidermal
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Bocking AD, McMillen IC, Harding R, Thorburn GD.   Effect of
reduced uterine blood flow on fetal and maternal cortisol.  J Dev
Physiol 1986 Aug;8(4):237-45.

Cabello G, Wrutniak C.   Pituitary-thyroid axis sensitivity and neonatal
changes in plasma iodothyronine, thyreostimulin and cortisol levels in
the preterm lamb: comparison of two experimental models.  J Dev
Physiol 1989 Jul;12(1):15-9.

Coulter CL, Martin MC, Voytek CC, Hofmann JI, Jaffe RB.  
Response to hemorrhagic stress in the rhesus monkey fetus in utero:
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May;76(5):1234-40.

Dalle M, Pradier P, Delost P.   The regulation of glucocorticosteroid
secretion during the perinatal period.  Reprod Nutr Dev
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Darbeida H, Naaman E, Durand P.   Glucocorticoid induction of the
maturation of ovine fetal adrenocortical cells.  Biochem Biophys Res
Commun 1987 Jun 30;145(3):999-1005.

Devaskar SU, Grim PF 3d, Devaskar UP.   A differential effect of
thyroxine and glucocorticoids on fetal brain and heart insulin receptor. 
Pediatr Res 1985 Feb;19(2):192-8.

Fowden AL, Comline RS, Silver M.   The effects of cortisol on the
concentration of glycogen in different tissues in the chronically
catheterized fetal pig.  Q J Exp Physiol 1985 Jan;70(1):23-35.

Fraser M, Liggins GC.   The effect of cortisol on thyroid hormone
kinetics in the ovine fetus.  J Dev Physiol 1989 Apr;11(4):207-11.

Geevarghese SK, Chytil F.   Dexamethasone enhances perinatal
pulmonary maturation in fetal rats via  manipulation of retinoids 
[abstract].  Pediatr Res 1993;33(4 Pt 2):302a.

Graf R, Gossrau R, Frank HG.   Placental toxicity in rats after
administration of synthetic glucocorticoids. A morphological,
histochemical and immunohistochemical investigation.  Anat Embryol
(Berl) 1989;180(2):121-30.

Hargrave BY, Rose JC.   By 95 days of gestation CRF increases
plasma ACTH and cortisol in ovine fetuses.  Am J Physiol 1986
Apr;250(4 Pt 1):E422-7.

Harvey LM, Gilbert RD, Longo LD, Ducsay CA.   Changes in ovine
fetal adrenocortical responsiveness after long-term hypoxemia.  Am J
Physiol 1993 May;264(5 Pt 1):E741-7.

Heller CL, Weisenberg LS, Ortâi E, De Nicola AF.   Steps of
glucocorticoid action in normal and diabetic rat placenta.  J Steroid
Biochem 1988 Jul;31(1):119-23.

Hill CE, McLennan IS, Hendry IA.   Development of sympathetic
neurones in vivo: an investigation of the possible role of
glucocorticosteroids in regulating transmitter type.  Aust J Exp Biol
Med Sci 1985 Aug;63(Pt 4):439-49.

Inczefi-Gonda A, Csaba G.   Prolonged influence of a single neonatal
steroid (dexamethasone) treatment on thymocytic steroid binding.  Exp
Clin Endocrinol 1985 Jun;85(3):358-60.

Jefferies AL.   Effect of hormones on clearance of fetal lung liquid after
birth in preterm rabbits  [abstract].  Pediatr Res 1993;33(4 Pt 2):330a.

Klepac R.   Effect of dexamethasone on glycogen deposition in
pregnant rats and their fetuses.  Exp Clin Endocrinol 1985
Dec;86(3):305-9.

Leeper LL, Schroeder R, Henning SJ.   Kinetics of circulating
corticosterone in infant rats.  Pediatr Res 1988 Nov;24(5):595-9.

Leung P, Gidari AS.   Effect of dexamethasone on fetal liver erythroid
colony-forming cells in vivo.  Exp Hematol 1985 Oct;13(9):906-11.

Li J, Saunders JC, Gilmour RS, Silver M, Fowden AL.  Insulin-like
growth factor-II messenger ribonucleic acid expression in fetal tissues
of the sheep during late gestation: effects of cortisol.  Endocrinology
1993 May;132(5):2083-9.

Linder MW, Prough RA.   Developmental aspects of glucocorticoid
regulation of polycyclic aromatic hydrocarbon-inducible enzymes in rat
liver.  Arch Biochem Biophys 1993 Apr;302(1):92-102.

Lund J, Faucher DJ, Ford SP, Porter JC, Waterman MR, Mason JI.  
Developmental expression of bovine adrenocortical steroid
hydroxylases. Regulation of P-450(17 alpha) expression leads to
episodic fetal cortisol production.  J Biol Chem 1988 Nov
5;263(31):16195-201.

McCoy SJ, Shirley BA.   Effects of prenatal administration of
testosterone and cortisone on the reproductive system of the female rat. 
Life Sci 1992;50(9):621-8.

Momma K, Takao A.   Increased constriction of the ductus arteriosus
with combined administration of indomethacin and betamethasone in
fetal rats.  Pediatr Res 1989 Jan;25(1):69-75.

Nagel MD, Nagel J.   Development of erythroid colony-forming cells in
rat fetal spleen: apparent lack of sensitivity to an in vivo corticosteroid
excess as compared to fetal liver.  Development 1987
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Nichols KV, Floros J, Dynia DW, Veletza SV, Wilson CM, Gross I.  
Regulation of surfactant protein A mRNA by hormones and butyrate in
cultured fetal rat lung.  Am J Physiol 1990 Dec;259(6 Pt 1): L488-95.

Oberg KC, Carpenter G.   Dexamethasone acts as a negative regulator
of epidermal growth factor receptor synthesis in fetal rat lung cells. 
Mol Endocrinol 1989 Jun;3(6):915-22.

Pepe GJ, Albrecht ED.   Fetal regulation of transplacental
cortisol-cortisone metabolism in the baboon.  Endocrinology
1987;120(6):2529-33.

Pepe GJ, Waddell BJ, Stahl SJ, Albrecht ED.   The regulation of
transplacental cortisol-cortisone metabolism by estrogen in pregnant
baboons.  Endocrinology 1988 Jan;122(1):78-83.

Pope TS, Smart DA, Rooney SA.   Hormonal effects on fatty-acid
synthase in cultured fetal rat lung; induction by dexamethasone and
inhibition of activity by triiodothyronine.  Biochim Biophys Acta 1988
Mar 25;959(2):169-77.

Randhawa P, Hass M, Frank L, Massaro D.   Dexamethasone increases
superoxide dismutase activity in serum-free rat fetal lung organ
cultures.  Pediatr Res 1986 Sep;20(9):895-8.

Rider ED, Jobe AH, Ikegami M, Yamada T, Seidner S.  Antenatal
betamethasone dose effects in preterm rabbits studied at 27 days
gestation.  J Appl Physiol 1990 Mar;68(3):1134-41.

Rooney SA, Smart DA, Weinhold PA, Feldman DA.   Dexamethasone
increases the activity but not the amount of choline-phosphate
cytidylyltransferase in fetal rat lung.  Biochim Biophys Acta 1990 Jun
14;1044(3):385-9.

Rudolph CD, Roman C, Rudolph AM.   Effect of cortisol on hepatic
gluconeogenesis in the fetal sheep.  J Dev Physiol 1989
Apr;11(4):219-23.

Shishkina GT.   [The sexual system of fetal and adult male rats of 2
strains after prenatal exposure to glucocorticoids].  Ontogenez 1990
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Shishkina GT, Bykova TS.   [The postnatal development of the genital
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Shishkina GT, Dygalo NN, Iudin NS, Borodin PM, Naumenko EV.  
[The prenatal genotype-dependent modification by glucocorticoids of
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Tabor BL, Rider ED, Ikegami M, Jobe AH, Lewis JF.   Dose effects of
antenatal corticosteroids for induction of lung maturation in preterm
rabbits.  Am J Obstet Gynecol 1991 Feb;164(2):675-81.


Pulmonary Effects


Adamson IY, King GM.   Epithelial-interstitial cell interactions in fetal
rat lung development accelerated by steroids.  Lab Invest 1986
Aug;55(2):145-52.

Adamson IY, King GM.   Postnatal development of rat lung following
retarded fetal lung growth.  Pediatr Pulmonol 1988;4(4):230-6.

Anceschi MM, Petrelli A, Zaccardo G, Barbati A, Di Renzo GC, Cosmi
EV, Hallman M.   Inositol and glucocorticoid in the development of
lung stability in male and female rabbit fetuses.  Pediatr Res 1988
Nov;24(5):617-21.

Asayama K, Hayashibe H, Dobashi K, Uchida N, Kato K.   Effect of
dexamethasone on antioxidant enzymes in fetal rat lungs and kidneys. 
Biol Neonate 1992;62(2-3):136-44.

Austin SD, Polk DH, Jobe AH, Ikegami M.   Dose response of fetal
betamethasone therapy for surfactant protein mRNA expression in
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Ballard PL.   Glucocorticoid regulation of lung maturation.  Mead
Johnson Symp Perinat Dev Med 1987;(30):22-7.

Ballard PL.   Hormonal regulation of pulmonary surfactant.  Endocr
Rev 1989 May;10(2):165-81.

Ballard PL.   Hormones and lung maturation.  Monogr Endocrinol
1986;28:1-354.

Barker PM, Markiewicz M, Parker KA, Walters DV, Strang LB.  
Synergistic action of triiodothyronine and hydrocortisone on
epinephrine-induced reabsorption of fetal lung liquid.  Pediatr Res 1990
Jun;27(6):588-91.

Barker PM, Walters DV, Markiewicz M, Strang LB.   Development of
the lung liquid reabsorptive mechanism in fetal sheep: synergism of
triiodothyronine and hydrocortisone.  J Physiol (Lond) 1991
Feb;433:435-49.

Boggaram V, Mendelson CR.   Transcriptional regulation of the gene
encoding the major surfactant protein (SP-A) in rabbit fetal lung.  J
Biol Chem 1988 Dec 15;263(35):19060-5.

Boshier DP, Holloway H, Liggins GC, Marshall RJ.   Morphometric
analyses of the effects of thyrotrophin releasing hormone and cortisol
on the lungs of fetal sheep.  J Dev Physiol 1989 Jul; 12(1):49-54.

Clerch LB, Iqbal J, Massaro D.   Perinatal rat lung catalase gene
expression: influence of corticosteroid and hyperoxia.  Am J Physiol
1991 Jun;260(6 Pt 1):L428-33.

Connelly IH, Hammond GL, Harding PG, Possmayer F.   Levels of
surfactant-associated protein messenger ribonucleic acids in rabbit lung
during perinatal development and after hormonal treatment. 
Endocrinology 1991 Nov;129(5):2583-91.

Cott GR, Rao AK.   Hydrocortisone promotes the maturation of
Na(+)-dependent ion transport across the fetal pulmonary epithelium. 
Am J Respir Cell Mol Biol 1993 Aug;9(2):166-71.

Davis JM, Whitin J.   Prophylactic effects of dexamethasone in lung
injury caused by hyperoxia and hyperventilation.  J Appl Physiol 1992
Apr;72(4):1320-5.

Dayer AM, Kapanci Y, Rademakers A, Rusy LM, De Mey J, Will JA.  
Increased numbers of neuroepithelial bodies (NEB) in lungs of fetal
rhesus monkeys following maternal dexamethasone treatment.  Cell
Tissue Res 1985;239(3):703-5.

Devaskar U, Church JC, Chechani V, Sadiq F.   Effect of simultaneous
administration of betamethasone and triiodothyronine (T3) on the
development of functional pulmonary maturation in fetal rabbit. 
Biochem Biophys Res Commun 1987 Jul 31;146(2): 524-9.

Ekelund L, Enhorning G.   Glucocorticoids and
beta-adrenergic-receptor agonists: their combined effect on fetal rabbit
lung surfactant.  Am J Obstet Gynecol 1985 Aug 15;152(8):1063-7.

ElKady T, Jobe A.   Corticosteroids and surfactant increase lung
volumes and decrease rupture pressures of preterm rabbit lungs.  J Appl
Physiol 1987 Oct;63(4):1616-21.

ElKady T, Jobe A.   Maternal treatments with corticosteroids and/or
T3 change lung volumes and rupture pressures in preterm rabbits.  Biol
Neonate 1988;54(4):203-10.

Fiascone JM, Jacobs HC, Moya FR, Mercurio MR, Lima DM.  
Betamethasone increases pulmonary compliance in part by
surfactant-independent mechanisms in preterm rabbits.  Pediatr Res
1987 Dec;22(6):730-5.

Fiascone JM, Mercurio MR, Lima DM, Jacobs HC.   Corticosteroids
and intratracheal surfactant both alter the distribution between the
airways and lung tissue of intratracheally administered radiolabeled
phosphatidylcholine in the preterm rabbit.  Exp Lung Res 1990
Jul-Aug;16(4):311-21.

Fisher JH, McCormack F, Park SS, Stelzner T, Shannon JM, Hofmann
T.   In vivo regulation of surfactant proteins by glucocorticoids.  Am J
Respir Cell Mol Biol 1991 Jul;5(1):63-70.

Floros J.   Sixty years of surfactant research.  Am J Physiol 1990
Apr;258(4 Pt 1):L238-40.

Floros J, Gross I, Nichols KV, Veletza SV, Dynia D, Lu HW, Wilson
CM, Peterec SM.   Hormonal effects on the surfactant protein B
(SP-B) mRNA in cultured fetal rat lung.  Am J Respir Cell Mol Biol
1991 May;4(5):449-54.

Floros J, Phelps DS, Smith BT.   2-dimensional gel electrophoretic of
dexamethasone-induced organ-specific developmental proteins FSA
FSB in rat lung fibroblasts.  Electrophoresis 1985;6(5):238-41.

Frank L.   Prenatal dexamethasone treatment improves survival of
newborn rats during prolonged high O2 exposure.  Pediatr Res 1992
Aug;32(2):215-21.

Frank L, Lewis PL, Sosenko IR.   Dexamethasone stimulation of fetal
rat lung antioxidant enzyme activity in parallel with surfactant
stimulation.  Pediatrics 1985 Mar;75(3):569-74.

Fraser M, Liggins GC.   The effect of cortisol on thyroid hormone
kinetics in the ovine fetus.  J Dev Physiol 1989 Apr;11(4):207-11.

Fraslon C, Batenburg JJ.   Pre-translational regulation of lipid
synthesizing enzymes and surfactant proteins in fetal rat lung in explant
culture.  FEBS Lett 1993 Jul 5;325(3):285-90.

Fraslon C, Lacaze-Masmonteil T, Zupan V, Chailley-Heu B, Bourbon
JR.   Fetal rat lung type II cell differentiation in serum-free isolated cell
culture: modulation and inhibition.  Am J Physiol 1993 May;264(5 Pt
1):L504-16.

Gallaher KJ, Rannels DE, Rannels SR.   Vitamin K-dependent
carboxylase activity in fetal rat lung: developmental effects of
dexamethasone and triiodothyronine.  Pediatr Res 1989 May;25(5):
530-4.

Geevarghese SK, Chytil F.   Dexamethasone enhances perinatal
pulmonary maturation in fetal rats via  manipulation of retinoids 
[abstract].  Pediatr Res 1993;33(4 Pt 2):302a.

Gewolb IH, Warshaw JB.   Fetal and maternal corticosterone and
corticosteroid binding globulin in the diabetic rat gestation.  Pediatr Res
1986 Feb;20(2):155-60.

Gladstone IM, Mercurio MR, Devenny SG, Jacobs HC.  Antenatal
steroids, postnatal surfactant, and pulmonary function in premature
rabbits.  J Appl Physiol 1989 Oct;67(4):1377-82.

Gross I, Wilson CM, Floros J, Dynia DW.   Initiation of fetal rat lung
phospholipid and surfactant-associated protein A mRNA synthesis. 
Pediatr Res 1989 Mar;25(3):239-44.

Hallman M, Teramo K, Sipinen S, Raivio K.   Effects of betamethasone
and ritodrine on the fetal secretion of lung surfactant.  J Perinat Med
1985;13(1):23-9.

Honig LS, Smith BT, Slavkin HC, Donahue HG.   Influence of the
major histocompatibility complex h-2 on glucocorticoid-stimulated
pulmonary surfactant synthesis in 2 congenic mouse strains.  Proc Soc
Exp Biol Med 1984;176(4):419-25.

Iannuzzi DM, Ertsey R, Ballard PL.   Biphasic glucocorticoid
regulation of pulmonary SP-A: characterization of inhibitory process. 
Am J Physiol 1993 Mar;264(3 Pt 1):L236-44.

Ikegami M, Berry D, elKady T, Pettenazzo A, Seidner S, Jobe A.  
Corticosteroids and surfactant change lung function and protein leaks
in the lungs of ventilated premature rabbits.  J Clin Invest 1987
May;79(5):1371-8.

Ikegami M, Jobe A, Pettenazzo A, Seidner S.   Effect of maternal
hormone treatment on lung protein leakage and lung function of
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Ikegami M, Jobe AH, Pettenazzo A, Seidner SR, Berry DD, Ruffini L.  
Effects of maternal treatment with corticosteroids, T3, TRH, and their
combinations on lung function of ventilated preterm rabbits with and
without surfactant treatments.  Am Rev Respir Dis 1987
Oct;136(4):892-8.

Ikegami M, Jobe AH, Seidner S, Yamada T.   Gestational effects of
corticosteroids and surfactant in ventilated rabbits.  Pediatr Res 1989
Jan;25(1):32-7.

Ikegami M, Jobe AH, Tabor BL, Rider ED, Lewis JF.   Lung albumin
recovery in surfactant-treated preterm ventilated lambs.  Am Rev
Respir Dis 1992 May;145(5):1005-8.

Ikegami M, Polk D, Tabor B, Lewis J, Yamada T, Jobe A.  
Corticosteroid and thyrotropin-releasing hormone effects on preterm
sheep lung function.  J Appl Physiol 1991 May;70(5):2268-78.

Jefferies AL.   Effect of hormones on clearance of fetal lung liquid after
birth in preterm rabbits  [abstract].  Pediatr Res 1993;33(4 Pt 2):330a.

Johnson JW, Mitzner W, Beck JC, London WT, Sly DL, Lee PA,
Khouzami VA, Cavalieri RL.   Long-term effects of betamethasone on
fetal development.  Am J Obstet Gynecol 1981 Dec 15;
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Juanes MC, Arizmendi C, Medina JM.   Attenuation of postnatal
hypoxia in the premature newborn rat by maternal treatment with
dexamethasone: its relationship with lung phospholipid content.  Biol
Neonate 1986;50(6):337-44.

Keeney SE, Mathews MJ, Rassin DK.   Antioxidant enzyme responses
to hyperoxia in preterm and term rats after prenatal dexamethasone
administration.  Pediatr Res 1993 Feb;33(2):177-80.

Kendall JZ, Lakritz J, Plopper CG, Richards GE, Randall GC,
Nagamani M, Weir AJ.   The effects of hydrocortisone on lung
structure in fetal lambs.  J Dev Physiol 1990 Mar;13(3):165-72.

Kotas RV, Avery ME.   Accelerated appearance of pulmonary
surfactant in the fetal rabbit.  J Appl Physiol 1971 Mar;30(3):358-61.

Kotas RV, Mims LC, Hart LK.   Reversible inhibition of lung cell
number after glucocorticoid injection into fetal rabbits to enhance
surfactant appearance.  Pediatrics 1974 Mar;53(3):358-61.

Kresch MJ, Gross I.   The biochemistry of fetal lung development.  Clin
Perinatol 1987 Sep;14(3):481-507.

Kudlacz EM, Navarro HA, Kavlock RJ, Slotkin TA.   Regulation of
postnatal beta-adrenergic receptor/adenylate cyclase development by
prenatal agonist stimulation and steroids: alterations in rat kidney and
lung after exposure to terbutaline or dexamethasone.  J Dev Physiol
1990 Nov;14(5):273-81.

Kudlacz EM, Navarro HA, Slotkin TA.   Phosphatidic acid
phosphatase in neonatal rat lung: effects of prenatal dexamethasone or
terbutaline treatment on basal activity and on responsiveness to beta
adrenergic stimulation.  J Pharmacol Exp Ther 1989 Jul;250(1):236-40.

Kudlacz EM, Slotkin TA.   Regulation of neonatal rat lung compliance
by beta-adrenergic receptor stimulation: effects of prenatal exposure to
terbutaline or dexamethasone.  J Dev Physiol 1990 Dec;14(6):307-10.

Liggins GC.   Premature delivery of foetal lambs infused with
glucocorticoids.  J Endocrinol 1969 Dec;45(4):515-23.

Liggins GC, Schellenberg JC, Manzai M, Kitterman JA, Lee CC.  
Synergism of cortisol and thyrotropin-releasing hormone in lung
maturation in fetal sheep.  J Appl Physiol 1988 Oct;65(4):1880-4.

Lohninger A, Krieglsteiner HP, Salzer H, Erhardt E, Kaiser E.   Role of
L carnitine in perinatal metabolism and effects of L carnitine
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Carnitine: its role in lung and heart disorders. Satellite symposium,
Central European Congress for Anesthesiology; 1985 Sep 13; Graz,
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Lohninger A, Krieglsteiner HP, Salzer H, Vytiska-Binstorfer E, Riedl
W, Erhardt W.   Studies on the effects of betamethasone, L-carnitine,
and betamethasone-L-carnitine combinations on the dipalmitoyl
phosphatidylcholine content and phosphatidylcholine species
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Jun;24(6):361-8.

Lortie C, King GM, Adamson IY.   Effects of dexamethasone on
macrophages in fetal and neonatal rat lung.  Pediatr Pulmonol
1990;8(3):138-44.

Maniscalco WM, Finkelstein JN, Parkhurst AB.   Dexamethasone
increases de novo fatty acid synthesis in fetal rabbit lung explants. 
Pediatr Res 1985 Dec;19(12):1272-7.

Massaro GD, Massaro D.   Formation of alveoli in rats: postnatal effect
of prenatal dexamethasone.  Am J Physiol 1992 Jul;263(1 Pt
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Mendelson CR, Chen C, Boggaram V, Zacharias C, Snyder JM.  
Regulation of the synthesis of the major surfactant apoprotein in fetal
rabbit lung tissue.  J Biol Chem 1986 Jul 25;261(21):9938-43.

Mendelson CR, Snyder JM.   Effect of cortisol on the synthesis of
lamellar body glycerophospholipids in fetal rabbit lung tissue in vitro. 
Biochim Biophys Acta 1985 Mar 27;834(1):85-94.

Navarro HA, Kudlacz EM, Eylers JP, Slotkin TA.   Prenatal
dexamethasone administration disrupts the pattern of cellular
development in rat lung.  Teratology 1989 Nov;40(5):433-8.

Nichols KV, Floros J, Dynia DW, Veletza SV, Wilson CM, Gross I.  
Regulation of surfactant protein A mRNA by hormones and butyrate in
cultured fetal rat lung.  Am J Physiol 1990 Dec;259(6 Pt 1): L488-95.

Nielsen HC.   The development of surfactant synthesis in fetal rabbit
lung organ culture exhibits a sex dimorphism.  Biochim Biophys Acta
1986 Sep 4;883(2):373-9.

Nielsen HC, Torday JS.   Sex differences in avian embryo pulmonary
surfactant production: evidence for sex chromosome involvement. 
Endocrinology 1985 Jul;117(1):31-7.

O'Brodovich H, Canessa C, Ueda J, Rafii B, Rossier BC, Edelson J.  
Expression of the epithelial Na+ channel in the developing rat lung. 
Am J Physiol 1993 Aug;265(2 Pt 1):C491-6.

Oberg KC, Carpenter G.   Dexamethasone acts as a negative regulator
of epidermal growth factor receptor synthesis in fetal rat lung cells. 
Mol Endocrinol 1989 Jun;3(6):915-22.

Ogasawara Y, Kuroki Y, Tsuzuki A, Ueda S, Misaki H, Akino T.  
Pre- and postnatal stimulation of pulmonary surfactant protein D by in
vivo dexamethasone treatment of rats.  Life Sci 1992;50(23):1761-7.

Orlowski J, Lingrel JB.   Thyroid and glucocorticoid hormones regulate
the expression of multiple Na,K-ATPase genes in cultured neonatal rat
cardiac myocytes.  J Biol Chem 1990 Feb 25;265(6): 3462-70.

Oulton M, Rasmusson MG, Yoon RY, Fraser M.  
Gestation-dependent effects of the combined treatment of
glucocorticoids and thyrotropin- releasing hormone on surfactant
production by fetal rabbit lung.  Am J Obstet Gynecol 1989
Apr;160(4):961-7.

Patterson CE, Davis KS, Beckman DE, Rhoades RA.   Fatty acid
synthesis in the fetal lung: relationship to surfactant lipids.  Biochim
Biophys Acta 1986 Aug 14;878(1):110-26.

Phelps DS, Floros J.   Dexamethasone in vivo raises surfactant protein
B mRNA in alveolar and bronchiolar epithelium.  Am J Physiol 1991
Feb;260(2 Pt 1):L146-52.

Polk D, Ikegami M, Jobe AH, Newnham J, Kelly R, Cohen R, Sly P.  
Combined antenatal thyroid hormone and betamethasone therapy and
postnatal pulmonary function in the preterm lamb: effects of a single
fetal im dose  [abstract].  Pediatr Res 1993;33(4 Pt 2):341a.

Post M.   Maternal administration of dexamethasone stimulates
choline-phosphate cytidylyltransferase in fetal type II cells.  Biochem J
1987 Jan 1;241(1):291-6.

Post M, Barsoumian A, Smith BT.   The cellular mechanism of
glucocorticoid acceleration of fetal lung maturation.
Fibroblast-pneumonocyte factor stimulates choline-phosphate
cytidylyltransferase activity.  J Biol Chem 1986 Feb 15;261(5):2179-84.

Randhawa P, Hass M, Frank L, Massaro D.   Dexamethasone increases
superoxide dismutase activity in serum-free rat fetal lung organ
cultures.  Pediatr Res 1986 Sep;20(9):895-8.

Rider ED, Jobe AH, Ikegami M, Yamada T, Seidner S.  Antenatal
betamethasone dose effects in preterm rabbits studied at 27 days
gestation.  J Appl Physiol 1990 Mar;68(3):1134-41.

Robert MF, Bator AT, Taeusch HW Jr.   Pulmonary pressure- volume
relationships after corticotropin (ACTH) and salin injections in fetal
rabbits.  Pediatr Res 1975 Oct;9(10):760-2.

Roberts JM, Jacobs MM, Cheng JB, Barnes PJ, O'Brien AT, Ballard
PJ.   Fetal pulmonary beta-adrenergic receptors: characterization in the
human and in vitro modulation by glucocorticoids in the rabbit.  Pediatr
Pulmonol 1985 May-Jun;1(3 Suppl):S69-76.

Rooney SA, Gobran L, Gross I, Wai-lee TS, Nardone LL, Motoyama
EK.   Studies on pulmonary surfactant. Effects of cortisol
administration to fetal rabbits on lung phospholipid content,
composition and biosynthesis.  Biochim Biophys Acta 1976 Nov
19;450(2):121-30.

Rooney SA, Gobran LI, Chu AJ.   Thyroid hormone opposes some
glucocorticoid effects on glycogen content and lipid synthesis in
developing fetal rat lung.  Pediatr Res 1986 Jun;20(6):545-50.

Rooney SA, Gobran LI, Marino PA, Maniscalco WM, Gross I.  
Effects of betamethasone on phospholipid content, composition and
biosynthesis in the fetal rabbit lung.  Biochim Biophys Acta 1979 Jan
29;572(1):64-76.

Rooney SA, Smart DA, Weinhold PA, Feldman DA.   Dexamethasone
increases the activity but not the amount of choline-phosphate
cytidylyltransferase in fetal rat lung.  Biochim Biophys Acta 1990 Jun
14;1044(3):385-9.

Schellenberg JC, Liggins GC, Stewart AW.   Growth, elastin
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Renal Function


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Bian XP, Seidler FJ, Slotkin TA.   Promotional role for glucocorticoids
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Celsi G, Wang ZM, Akusjarvi G, Aperia A.   Sensitive periods for
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Hill KJ, Lumbers ER, Elbourne I.   The actions of cortisol on fetal renal
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Kudlacz EM, Navarro HA, Kavlock RJ, Slotkin TA.   Regulation of
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Scholle S, Braunlich H.   Effects of prenatally administered thyroid
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Slotkin TA, Seidler FJ, Kavlock RJ, Gray JA.   Fetal dexamethasone
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Last updated: 31 December 1996