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| Current Bibliographies in Medicine | |
Current Bibliographies in Medicine 2002-2
Trimethylaminuria and the Flavin Monooxygenases
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Table of Contents Series Note PDF Version of This CBM Sample Citations Introduction Bibliography: Trimethylamine, Trimethylamine N-Oxide, Trimethylamine Dehydrogenase Flavin Monooxygenases and the Flavin Monooxygenase System Dimethylglycine and Dimethylamine Appendix: Sources of Information on Trimethylaminuria |
January 1999 through August 2001 163 Citations Prepared by 2002 March U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES National Library of Medicine Each bibliography in the Current Bibliographies in Medicine (CBM) series covers a distinct subject area of biomedicine and fulfills a current awareness function. Online databases and the Internet are the primary sources for citations in these bibliographies. Relevance to the subject is the only criterion for inclusion of works in a CBM; the format, ownership, or location of the material are not considered. Other publications in the Current Bibliographies in Medicine series are available through the Library's World Wide Web site at http://www.nlm.nih.gov/pubs/resources.html. Comments and suggestions on this series may be addressed to: Karen Patrias, Editor PubMed®, LocatorPlus®, and the NLM Gateway The Library offers three interfaces to its databases; all are available on the World Wide Web. PubMed provides access primarily to the journal literature; LocatorPlus is an online catalog of the books, journal titles, and audiovisuals held by the Library; and the NLM Gateway serves as an entry point for a variety of databases and other Library products. Further information on PubMed, LocatorPlus, and the NLM Gateway may be found at http://www.nlm.nih.gov/nlmhome.html. To view this bibliography in Portable Document Format (PDF), download it from http://www.nlm.nih.gov/pubs/cbm/trimethylaminuria_update.pdf. Note that PDF documents require the use of the Adobe® Acrobat® Reader, which can be downloaded from Adobe's Web site at no charge. Citations are formatted according to the rules established for Index Medicus®*. Sample journal and conference paper citations appear below. For journal articles written in a foreign language, the English translation of the title is displayed in brackets and the language of publication is shown by a three-letter abbreviation appearing at the end of the citation. Note also for journal articles than an availability statement follows many citations. This statement contains an Internet hyperlink to the citation in the NLM PubMed retrieval system. The PubMed record includes an abstract for most articles and may also provide a link to the publisher's Internet site. Journal Article: Example: Order, with separating punctuation: Conference Papers Presented: Example:Cha YN, Park CS, Lee KH, Chung WG. N-demethylation of caffeine by recombinant human flavin-containing monooxygenases. Paper presented at: 38th Annual Meeting of the Society of Toxicology; 1999 Mar 14-18; New Orleans, LA. Order, with separating punctuation: * For details of the formats used for references, see the following publications: Patrias, Karen. National Library of Medicine recommended formats for bibliographic citation. Supplement: Internet formats. Bethesda (MD): The Library; 2001 Jul. Available from: http://www.nlm.nih.gov/pubs/formats/internet.pdf |
Trimethylaminuria and the Flavin Monooxygenases
Trimethylaminuria (TMAU) is a metabolic disorder that produces pronounced body odors resulting from the systemic accumulation of an excessive amount of unoxidized trimethylamine that is then excreted in the breath, sweat, and urine. The biochemical deficit causing this condition is the inability to completely metabolize trimethyamines (TMA) to TMA-oxide (TMAO) in the liver. Many researchers believe that there are several types of TMAU caused by a "spectrum" of changes in the gene which controls the formation of the flavin-containing monooxygenase 3 (FMO3) enzyme. In humans, this is an important liver enzyme that controls the metabolism of substances such as TMA. The most severe form of TMAU appears to be caused by mutations in the FMO3 gene; these mutations appear inherited in an autosomal recessive fashion. Studies are leading many researchers to conclude that the less severe forms of TMAU are caused by several non-benign genetic polymorphisms in the FMO3 gene. Genetic polymorphisms are changes in the gene structure that may be fairly common in the population; however, for reasons, which are not well understood, these changes lead to TMAU-symptoms in certain individuals.
It is estimated that as much as one percent of the U.S. population may suffer from TMAU, but its true incidence is not yet known. But whether it is one or one-tenth of one percent, we know that the condition affects people of both sexes and of all ages and races from around the world. Currently there are more than 300 people with a malodor disorder on the Trimethylaminuria Support Group's mailing list, with many more preferring to remain anonymous because of the often-associated stigma, negative and harassing behaviors targeted at some, and the general lack of medical and other support.
This bibliography was prepared in support of the Second Workshop on Trimethylaminuria held at the National Institutes of Health (NIH) on March 15-16, 2002, in Bethesda, Maryland. The Workshop was sponsored by the NIH Office of Rare Diseases. Co-sponsors of the meeting included: the National Human Genome Research Institute; the National Center for Research Resources; the National Institute of Diabetes and Digestive and Kidney Diseases; the National Library of Medicine; and the Trimethylaminuria Support Group, Inc. (TSG). It was organized by TSG, Inc., and co-chaired by John Cashman, Ph.D., and Eileen Treacy, M.D. This meeting marked the first time large numbers of people with TMAU came together to get the critical facts needed to better understand its mechanisms and treatment options, and to learn how to manage life with TMAU. Goals of the meeting included educating people with TMAU, increasing general awareness, and stimulating new research into this life-disrupting condition.
Candidate citations for this bibliography were obtained from searching a wide of variety of online databases for the period January 1999 through August 2001. Although the search strategy was not limited by language or types of material, the resulting final bibliography consists primarily of citations to English-language journal articles and conference papers. Both human and animal studies have been included. Citations have been arranged into six broad categories; a citation appears in only one category. This publication also updates the bibliography prepared for the First International Workshop on Trimethylaminuria (Fish-Malodor Syndrome) held at the NIH in March 1999:
Patrias, Karen; Pikus, Anita; McConnell, Harry; Mitchell, Steve, compilers. Trimethylaminuria (Fish- Malodor Syndrome) and the flavin monooxygenases [bibliography on the Internet]. Bethesda (MD): National Library of Medicine; 1999 Mar. (Current bibliographies in medicine; no. 99-2). 430 citations from January 1966 through December 1998. Available from: http://www.nlm.nih.gov/pubs/cbm/trimethylaminuria.html
The compilers which to thank Patti DeWild, Marcia Tucker, and Ed Hamilton for their valuable assistance in reviewing this updated bibliography.
This publication is not copyrighted and may be freely reproduced. However any reproductions of this bibliography, in whole or in part, should include all credits. If you wish to cite this bibliography, the correct format is:
Patrias, Karen; Ahmed, Terry T.; Lambert, Debby, compilers. Trimethylaminuria and the flavin monooxygenases [bibliography on the Internet]. Bethesda (MD): National Library of Medicine (US); 2002 Mar [insert cited year month day]. (Current bibliographies in medicine; no. 2002-2). 163 citations from January 1999 through August 2001. Available from: http://www.nlm.nih.gov/pubs/cbm/trimethylaminuria_update.html
Trimethylaminuria
Basarab T, Ashton GH, Du H, Menage P, McGrath JA. Sequence variations in the flavin-containing mono-oxygenase 3 gene (FMO3) in fish odour syndrome. Br J Dermatol. 1999 Jan;140(1):164-7. Available from: PubMed; PMID 10215790
Basran J, Sutcliffe MJ, Scrutton NS. Deuterium isotope effects during carbon-hydrogen bond cleavage by trimethylamine dehydrogenase. implications for mechanism and vibrationally assisted hydrogen tunneling in wild-type and mutant enzymes. J Biol Chem. 2001 Jul 6;276(27):24581-7. Available from: PubMed; PMID 11304539
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Burks RL, Jeppesen E, Lodge DM. Responses of pelagic macrozooplankton to littoral habitat in the presence and/or only fish odor in experimental mesocosms. Paper presented at: 47th Annual Meeting of the North American Benthological Society; 1999 May 25-28; Duluth, MN.
Crook M, Griffiths W, Eldridge P. Fishing for a diagnosis? Cpd Bull Clin Biochem. 2000;2(1):27.
Dolphin CT, Janmohamed A, Smith RL, Shephard EA, Phillips IR. Compound heterozygosity for missense mutations in the flavin-containing monooxygenase 3 (FM03) gene in patients with fish-odour syndrome. Pharmacogenetics. 2000;10(9):799-807. Available from: PubMed; PMID 11191884
Forrest SM, Knight M, Akerman BR, Cashman JR, Treacy EP. A novel deletion in the flavin-containing monooxygenase gene (FMO3) in a Greek patient with trimethylaminuria. Pharmacogenetics. 2001 Mar;11(2):169-74. Available from: PubMed; PMID 11266081
Forrest SM, Knight MA, Akerman BR, Treacy EP. Analysis of the flavin-containing monooxygenase (FMO3) gene for mutations in Australia identifies a high carrier frequency for TMAURIA and a novel deletion in a Greek patient [abstract]. Am J Hum Genet. 1999;65(4):A235. Paper presented at the Annual Meeting of the American Society of Human Genetics.
Guarducci S, Lapi E, Cecconi A, Giovannucci UM. Smith-Magenis Syndrome: fish diagnosis and natural history in an adult patient [abstract]. Eur J Hum Genet. 1999;7 Suppl 1:57. Paper presented at the 31st Annual Meeting of the European Society of Human Genetics.
Kashyap AS, Kashyap S. Fish odour syndrome. Postgrad Med J. 2000 May;76(895):318-9. Available from: PubMed; PMID 10858113
Lambert DM, Mamer OA, Akerman BR, Choiniere L, Gaudet D, Hamet P, Treacy EP. In vivo variability of tma oxidation is partially mediated by polymorphisms of the FMO3 gene. Mol Genet Metab. 2001 Jul;73(3):224-9. Available from: PubMed; PMID 11461189
Lee CW, Tomlinson B, Yeung JHK, Lin G, Damani LA. Distribution of the N-oxidation of dietary-derived trimethylamine in a male Chinese population. Pharmacogenetics. 2000 Dec;10(9):829-31. Available from: PubMed; PMID 11191887
Mayatepek E, Quak E, Wevers R, Kohlmueller D, Meissner T, Hoffmann GF, Zschocke J. Molecular defects in primry trimethylaminuria. Paper presented at: 37th Annual Meeting of the Society for Study of Inborn Errors of Metabolism; 1999 Sep 7-10; Geneva.
Mitchell SC. Trimethylaminuria: susceptibility of heterozygotes. Lancet. 1999 Dec 18-25;354(9196):2164-5. Available from: PubMed; PMID 10609842
Mitchell SC, Smith RL. Trimethylaminuria: The fish malodor syndrome. Drug Metab Dispos. 2001 Apr;29(4 Pt 2):517-21. Available from: PubMed; PMID 11259343
Murphy HC, Dolphin CT, Janmohamed A, Holmes HC, Michelakakis H, Shephard EA, Chalmers RA, Phillips IR, Iles RA. A novel mutation in the flavin-containing monooxygenase 3 gene, FM03, that causes fish-odour syndrome: activity of the mutant enzyme assessed by proton NMR spectroscopy. Pharmacogenetics. 2000 Jul;10(5):439-51. Available from: PubMed; PMID 10898113
Rehman HU. Fish odor syndrome. Postgrad Med J. 1999 Aug;75(886):451-2. Available from: PubMed; PMID 10646019
Tomas Carmona I, Limeres Posse J, Diz Dios P, Fernandez Feijoo J, Vazquez Garcia E. [Extraoral etiology of halitosis]. Med Oral. 2001;6(1):40-7. Available from: PubMed; PMID 11488130 (Spa).
Treacy EP, Lambert DM, Gaudet D, Akerman BR, Choiniere L, Hamet P, Mamer OA. Measurement of trimethylamine and trimethylamine n-oxide ratios as a marker of variant FMO3 mediated metabolism [abstract]. J Inherit Metab Dis. 2000;23 Suppl 1:282. Paper presented at the 8th International Conference on Inborn Errors of Metabolism.
Yi HG, Park CS, Kang JS, Kang JH, Chung WG, Pie JE, Ryu SD, Choi W, Cha YN. Over production of nitric oxide and peroxynitrite in patients with liver cirrhosis and cancer suppresses flavin - containing monooxygenase (FMO) activity and causes trimethylaminuria (TMAU) [abstract]. Faseb J. 2001;15(4):A576. Paper presented at the 2001 Annual Meeting of the Federation of American Societies for Experimental Biology.
Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek E. Mild fish odour syndrome caused by common variants in the FMO3 gene. Paper presented at: 37th Annual Meeting of the Society for Study of Inborn Errors of Metabolism; 1999 Sep 7-10; Geneva.
Zschocke J, Kohlmueller D, Quak E, Meissner T, Hoffmann GF, Mayatepek E. Mild trimethylaminuria caused by common variants in FMO3 gene. Lancet. 1999 Sep 4;354(9181):834-5. Available from: PubMed; PMID 10485731
Trimethylamine, Trimethylamine N-Oxide, Trimethylamine Dehydrogenase
Anderson RF, Jang MH, Hille R. Radiolytic studies of trimethylamine dehydrogenase. Spectral deconvolution of the neutral and anionic flavin semiquinone, and determination of rate constants for electron transfer in the one-electron reduced enzyme. J Biol Chem. 2000 Oct 6;275(40):30781-6. Available from: PubMed; PMID 10859304
Bai C, Biwersi J, Verkman AS, Matthay MA. A mouse model to test the in vivo efficacy of chemical chaperones. J Pharmacol Toxicol Methods. 1998 Jul;40(1):39-45. Available from: PubMed; PMID 9920533
Boskou G, Debevere J. Shelf-life extension of cod fillets with an acetate buffer spray prior to packaging under modified atmospheres. Food Addit Contam. 2000 Jan;17(1):17-25. Available from: PubMed; PMID 10793851
Buc J, Santini C-L, Giordani R, Czjzek M, Wu L-F, Giordano G. Enzymatic and physiological properties of the tungsten-substituted molybdenum TMAO reductase from Escherichia coli. Mol Microbiol. 1999 Apr;32(1):159-68. Available from: PubMed; PMID 10216869
Garrod S, Humpher E, Connor SC, Connelly JC, Spraul M, Nicholson JK, Holmes E. High-resolution (1)H NMR and magic angle spinning NMR spectroscopic investigation of the biochemical effects of 2-bromoethanamine in intact renal and hepatic tissue. Magn Reson Med. 2001 May;45(5):781-90. Available from: PubMed; PMID 11323804
Gon S, Giudici-Orticoni MT, Mejean V, Iobbi-Nivol C. Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase in Escherichia coli. J Biol Chem. 2001 Apr 13;276(15):11545-51. Available from: PubMed; PMID 11056172
Hall ME, Shrewsbury RP, Chen SY, Elkins AL, Burnham BS, Spielvogel BF, Hall IH. The disposition and tissue distribution of trimethylamine-(sup 1sup 4C)carboxyborane and trimethylamine-(sup 1sup 4C)carboxymethoxyborane in CFinf 1 mice. Pharm Sci. 1997;3(9):473-8.
Hashimoto Y, Nakayama Y, Mitsubayashi K. Development of a biosensor for trimethylamine. Chem Sens. 1999;15 Suppl B:49-51.
Hirata T, Yoshimatsu K. [The effect on the fish odor by the vegetable, fruit, mashroom and seaweed, respectively]. Bull Yamaguchi Agric Exp Stn. 1999;(50):50-3. (Jpn).
Holmes HC, Burns SP, Michelakakis H, Kordoni V, Bain MD, Chalmers RA, Rafter JEM, Iles RA. Choline and L-carnitine as precursors of trimethylamine [abstract]. Biochem Soc Trans. 1997;25(1):96S.
Iles RA, Burns SP, Rafter JE, Bain MD, Chalmers RA. L-carnitine catabolism in organic acidurias - consequences for oral therapy [abstract]. J Inherit Metab Dis. 1998;21 Suppl 2:72. Paper presented at the 36th Annual Symposium of the Society for the Study of Inborn Errors of Metabolism.
Jang MH, Basran J, Scrutton NS, Hille R. The reaction of trimethylamine dehydrogenase with trimethylamine. J Biol Chem. 1999 May 7;274(19):13147-54. Available from: PubMed; PMID 10224069
Jang MH, Scrutton NS, Hille R . Formation of W(3)A(1) electron-transferring flavoprotein (ETF) hydroquinone in the trimethylamine dehydrogenase center dot ETF protein complex. J Biol Chem. 2000 Apr 28;275(17):12546-52. Available from: PubMed; PMID 10777543
Kleber H-P. Bacterial carnitine metabolism. FEMS Microbiol Lett. 1997 Feb 1;147(1):1-9. Available from: PubMed; PMID 9037756
Mamer OA, Choiniere L, Treacy EP. Measurement of trimethylamine and trimethylamine N-oxide independently in urine by fast atom bombardment mass spectrometry. Anal Biochem. 1999 Dec 15;276(2):144-9. Available from: PubMed; PMID 10603236
Marzo A, Curti S. L-Carnitine moiety assay: An up-to-date reappraisal covering the commonest methods for various applications. J Chromatogr B Biomed Sci Appl. 1997 Nov 21;702(1-2):1-20. Available from: PubMed; PMID 9449551
Mills GA, Walker V, Mughal H. Quantitative determination of trimethylamine in urine by solid-phase microextraction and gas chromatography-mass spectrometry. J Chromatog B Biomed Sci Appl. 1999 Feb 19;723(1-2):281-5. Available from: PubMed; PMID 10080656
Mitchell S, Ayesh R, Barrett T, Smith R. Trimethylamine and foetor hepaticus. Scand J Gastroenterol. 1999 May;34(5):524-8. Available from: PubMed; PMID 10423071
Mitsubayashi K, Hashimoto Y. Development of a gas-phase biosensor for trimethylamine using a flavin-containing monooxygenase 3. Electrochemistry. 2000 Nov;68(11):901-3.
Mitsubayashi K, Hashimoto Y, Nakayama Y, Montesinos T, Noguer T, Marty JL. Gas-sensors with high selectivity using a biological catalytic system. J Adv Sci. 2000;12(3):211-6.
Niizeki N, Daikoku T, Sakaguchi M. Biosynthesis of trimethylamine oxide from choline in the Teleost Tilapia Oreochromis niloticus [abstract]. Comp Biochem Physiol A. 1999;124 Suppl:S137. Paper presented at the 5th International Congress of Comparative Physiology and Biochemistry.
Raymond JA, DeVries AL. Elevated concentrations and synthetic pathways of trimethylamine oxide and urea in some teleost fishes of McMurdo Sound, Antarctica. Fish Physiol Biochem. 1998 Jun;18(4):387-98.
Reid E, Cole J, Eaves DJ. The Escherichia coli CcmG protein fulfils a specific role in cytochrome c assembly. Biochem J. 2001 Apr 1;355(1):51-8. Available from: PubMed; PMID 11256948
Rey-Mansilla M, Sotelo CG, Gallardo JM. Decomposition of trimethylamine oxide during iced storage of blue whiting (Micromesistius poutassou). Z Lebensm Untersforsch A. 1999;208(4):267-9.
Rey-MM, Sotelo CG, Gallardo JM. Decomposition of trimethylamine oxide during iced storage of blue whiting (Micromesistius poutassou). Z Lebensm Untersforsch A. 1999;209(5):372. Erratum to document cited in Chemical Abstracts, vol. 131, abstract no. 31244.
Roberts P, Basran J, Wilson EK, Hille R, Scrutton NS. Redox cycles in trimethylamine dehydrogenase and mechanism of substrate inhibition. Biochemistry. 1999 Nov 9;38(45):14927-40. Available from: PubMed; PMID 10555975
Roberts P, Basran J, Wilson EK, Hille R, Scrutton NS. Redox cycles in trimethylamine dehydrogenase and mechanism of substrate inhibition. Biochemistry. 2000;39(3):625. Available from: PubMed; PMID 10642189
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Zhang AQ, Mitchell SC, Smith RL. Dietary precursors of trimethylamine in man: A pilot study. Food Chem Toxicol. 1999 May;37(5):515-20. Available from: PubMed; PMID 10456680
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Flavin Monooxygenases and the Flavin Monooxygenase System
Adali O, Carver GC, Philpot RM. The effect of arginine-428 mutation on modulation of activity of human liver flavin monooxygenase 3 (FMO3) by imipramine and chlorpromazine. Exp Toxicol Pathol. 1999 Jul;51(4-5):271-6. Available from: PubMed; PMID 10445381
Adali O, Philpot RM. Characterization and structure-function studies of human liver flavin monooxygenase isoenzyme 3 (FMO3). Turk J Zool. 1999;23(1):45-52.
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Akerman BR, Lemass H, Chow LM, Lambert DM, Greenberg C, Bibeau C, Mamer OA, Treacy EP. Trimethylaminuria is caused by mutations of the FMO3 gene in a North American cohort. Mol Genet Metab. 1999 Sep;68(1):24-31. Available from: PubMed; PMID 10479479
Barber M, Conrad ME, Umbreit JN, Barton JC, Moore EG. Abnormalities of flavin monooxygenase as an etiology for sideroblastic anemia. Am J Hematol. 2000 Oct;65(2):149-53. Available from: PubMed; PMID 10996833
Barber M, Conrad ME, Umbreit JN, Barton JC, Moore EG. Abnormalities of flavin monooxygenase as an etiology of sideroblastic anemia [abstract]. Blood. 1999;94(10 Suppl 1 Pt 1):413a. Paper presented at the 41st Annual Meeting of the American Society of Hematology.
Cashman JR. Human flavin-containing monooxygenase: substrate specificity and role in drug metabolism. Curr Drug Metab. 2000 Sep;1(2):181-91. Available from: PubMed; PMID 11465082
Cashman JR, Akerman BR, Forrest SM, Treacy EP. Population-specific polymorphisms of the human FMO3 gene: significance for detoxication. Drug Metab Dispos. 2000 Feb;28(2):169-73. Available from: PubMed; PMID 10640514
Cashman JR, Xiong Y, Lin J, Verhagen H, Van Poppel G, Van Bladeren PJ, Larsen-Su S, Williams DE. In vitro and in vivo inhibition of human flavin-containing monooxygenase form 3 (FMO3) in the presence of dietary indoles. Biochem Pharmacol. 1999 Sep 15;58(6):1047-55. Available from: PubMed; PMID 10509757
Cashman JR, Xiong YN, Xu L, Janowsky A. N-oxygenation of amphetamine and methamphetamine by the human flavin- containing monooxygenase (form 3): Role in bioactivation and detoxication. J Pharmacol Exp Ther. 1999 Mar;288(3):1251-60. Available from: PubMed; PMID 10027866
Cha YN, Kang JH, Park CS, Chung WG. Inhibition of flavin-containing monooxygenase and CYP1A2 activities in human by grapefruit juice. Paper presented at: 39th Annual Meeting of the Society of Toxicology; 2000 Mar 19-23; Philadelphia.
Cha YN, Lee KH, Chung WG, Park CS, Kang JH, Baek HM, Kang JS, Roh HK. Correlation between phenotypes of FMO obtained by ranitidine n-oxidation and genotypes of FMO3 in a Korean population [abstract]. Clin Pharmacol Ther. 1999;65(2):183. Paper presented at the 100th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics.
Cha YN, Park CS, Lee KH, Chung WG. N-demethylation of caffeine by recombinant human flavin-containing monooxygenases. Paper presented at: 38th Annual Meeting of the Society of Toxicology; 1999 Mar 14-18; New Orleans, LA.
Charon CM, Dolphin CT. Sequence variation in the human flavin-containing monooxygenase 3 gene (FMO3): Identification by denaturing-high performance liquid chromatography (DHPLC) [abstract]. Biochem Soc Trans. 2000;28(5):A435. Paper presented at the 18th International Congress of Biochemistry and Molecular Biology.
Chiapella C, Radovan RD, Moreno JA, Casares L, Barbe J, Llagostera M. Plant activation of aromatic amines mediated by cytochromes P450 and flavin-containing monooxygenases. Mutat Res. 2000 Oct 31;470(2):155-60. Available from: PubMed; PMID 11027970
Chung WG, Kang JH, Park CS, Cho MH, Cha YN. Effect of age and smoking on in vivo CYP1A2, flavin-containing monooxygenase, and xanthine oxidase activities in Koreans: determination by caffeine metabolism. Clin Pharmacol Ther. 2000 Mar;67(3):258-66. Available from: PubMed; PMID 10741629
Chung WG, Park CS, Roh HK, Lee WK, Cha YN. Oxidation of ranitidine by isozymes of flavin-containing monooxygenase and cytochrome P450. Jpn J Pharmacol. 2000 Oct;84(2):213-20. Available from: PubMed; PMID 11128045
Chung WG, Ryu SD, Park CS, Cha YN. Inhibition of liver microsomal flavin-containing monooxygenase activities by flavonoids. Paper presented at: 39th Annual Meeting of the Society of Toxicology; 2000 Mar 19-23; Philadelphia.
Chung WG, Ryu SD, Park CS, Lee KH, Cha YN. Activation of rat liver microsomal flavin-containing monooxygenase by deprenyl, an inhibitor of monoamine oxidase B. Paper presented at: 38th Annual Meeting of the Society of Toxicology; 1999 Mar 14-18; New Orleans, LA.
Clement B, Behrens D, Moller W, Cashman JR. Reduction of amphetamine hydroxylamine and other aliphatic hydroxylamines by benzamidoxime reductase and human liver microsomes. Chem Res Toxicol. 2000 Oct;13(10):1037-45. Available from: PubMed; PMID 11080052
Code EL, McNamara J, Crespi CL. Quantitation of human flavin-containing monooxygenases on immunoblots. Paper presented at: 38th Annual Meeting of the Society of Toxicology; 1999 Mar 14-18; New Orleans, LA.
Eichhorn E, van der Ploeg JR, Leisinger T. Characterization of a two-component alkanesulfonate monooxygenase from Escherichia coli. J Biol Chem. 1999 Sep 17;274(38):26639-46. Available from: PubMed; PMID 10480865
El-Alfy A, Schlenk D. Distribution of flavin-containing monooxygenase gene expression in several teleost fish species using a cDNA sequence from the teleost rainbow trout (Oncorhynchus mykiss). Mar Environ Res. 2000;50(1-5):72.
El-Alfy A, Schlenk D. Isolation of a flavin-containing monooxygenase cDNA sequence from the teleost rainbowtrout (Oncorhynchus mykiss). Paper presented at: 38th Annual Meeting of the Society of Toxicology; 1999 Mar 14-18; New Orleans, LA.
Fang J. Metabolism of clozapine by rat brain: The role of flavin-containing monooxygenase (FMO) and cytochrome P450 enzymes. Eur J Drug Metab Pharmacokinet. 2000 Apr-Jun;25(2):109-14. Available from: PubMed; PMID 11112091
Fang J, Gorrod JW. Metabolism, pharmacogenetics, and metabolic drug-drug interactions of antipsychotic drugs. Cell Mol Neurobiol. 1999 Aug;19(4):491-510. Available from: PubMed; PMID 10379422
Hamman MA, Haehner-Daniels BD, Wrighton SA, Rettie AE, Hall SD. Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases: Comparison of human liver and kidney microsomes and mammalian enzymes. Biochem Pharmacol. 2000 Jul 1;60(1):7-17. Available from: PubMed; PMID 10807940
Hartmann S, Hultschig C, Eisenreich W, Fuchs G, Bacher A, Ghisla S. NIH shift in flavin-dependent monooxygenation: mechanistic studies with 2-aminobenzoyl-CoA monooxygenase/reductase. Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):7831-6. Available from: PubMed; PMID 10393907
He M, Rettie AE, Neal J, Trager WF. Metabolism of sulfinpyrazone sulfide and sulfinpyrazone by human liver microsomes and cDNA-expressed cytochrome P450s. Drug Metab Dispos. 2001;29(5):701-11. Available from: PubMed; PMID 11302937
Hines RN, Luo Z. Identification of tissue-selective transcription factors controlling rRabbit FMO1 expression [abstract]. Faseb J. 2001;15(4):A574. Paper presented at the 2001 Annual Meeting of the Federation of American Societies for Experimental Biology.
Hines RN, Luo Z, Cresteil T, Ding X, Prough RA, Fitzpatrick JL, Ripp SL, Falkner KC, Ge NL, Levine A, Elferink CJ. Molecular regulation of genes encoding xenobiotic-metabolizing enzymes: Mechanisms involving endogenous factors. Drug Metab Dispos. 2001 May;29(5):623-33. Available from: PubMed; PMID 11302926
Hines RN, Luo Z, McNally K. Molecular mechanisms controlling flavin-containing monooxygenase tissue-specific expression. Faseb J. 2000 May 11;14(8):C3.
Hodgson E, Cherrington NJ, Philpot RM, Rose RL. Biochemical aspects of flavin-containing monooxygenases (FMOs). NATO ASI Ser Ser A. 1999;303:55-70.
Hodgson E, Rose RL, Cao Y, Dehal SS, Kupfer D. Flavin-containing monooxygenase isoform specificity for the N-oxidation of tamoxifen determined by product measurement and NADPH oxidation. J Biochem Mol Toxicol. 2000;14(2):118-20. Available from: PubMed; PMID 10630426
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Iles RA, Murphy HC, Dolphin CT, Janmohamed A, Holmes HC, Michelakakis H, Shephard EA, Chalmers RA, Phillips IR. Characterization and enzyme expression analysis of FMO3 mutations in trimethylaminuria using proton NMR spectroscopy [abstract]. J Inherit Metab Dis. 2000;23 Suppl 1:281. Paper presented at the 8th International Conference on Inborn Errors of Metabolism.
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Dimethylglycine and Dimethylamine
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Choline
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Malodors
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Marczylo T, Ioannides C. Evidence for the presence of a microsomal NADH-dependent enzyme system that can bioactivate aromatic amines in the liver of rats and mice. Toxicology. 1999 Jun 15;134(2-3):127-41. Available from: PubMed; PMID 10403632
Appendix: Sources of Information on Trimethylaminuria
P.O. Box 3361
Grand Central Station
New York, NY 10163
212-678-2506
E-mail: Trimeth411@aol.com
P.O. Box 8126
Gaithersburg, MD 20898-8126
1-888-205-2311
TTY: 1-888-205-3223
Fax: 202-966-5689
E-mail: Gardinfo@nih.gov
National Institutes of Health
31 Center Drive, MSC 2084
Building 31, Room 1B-19
Bethesda, MD 20892-2084
Telephone: 301-402-4336
Fax: 301-480-9655
E-mail: hh70f@nih.gov
http://rarediseases.info.nih.gov/
P.O. Box 8923
New Fairfield, CT 06812-8923
Phone: 203-746-6518; 1-800-999-6673
Fax: 203-746-6481
http://www.rarediseases.org/
Last updated: 27 November 2002