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Diagnostic Study of Quantitative Imaging and Spectroscopy in Patients With Multiple Sclerosis
This study is currently recruiting patients.
Sponsored by: | National Center for Research Resources (NCRR) University of Pennsylvania
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Information provided by: | Office of Rare Diseases (ORD) |
Purpose
OBJECTIVES: I. Determine by quantitative magnetic resonance imaging measurements the change in the total volume of brain parenchyma as well as its gray and white matter, T2 and enhanced T1 lesion volume, and the magnetization transfer ratio histogram parameters, and correlate these measurements with clinical measures of disability in patients with multiple sclerosis. II. Measure the quantity of whole brain N-acetylaspartate in patients with multiple sclerosis and compare these values to those from age matched controls. III. Determine the correlation between specific neuropsychological tests which assess global cognitive functioning and the quantitative measurements taken in these patients in this study.
Condition | Treatment or Intervention |
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Multiple Sclerosis |
Drug: standard gadolinium contrast |
MedlinePlus related topics: Multiple Sclerosis
Study Type: Observational
Study Design: Screening
Expected Total Enrollment: 100
Study start: April 1999
PROTOCOL OUTLINE: Patients undergo magnetic resonance imaging and spectroscopy with standard gadolinium contrast followed by neuropsychological testing every 6 months for 5 years. An equal number of age and sex matched healthy patients act as a control group and undergo magnetic resonance imaging and spectroscopy without standard gadolinium contrast every 6 months for 5 years.
Eligibility
Ages Eligible for Study: 20 Years - 70 Years, Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
--Prior/Concurrent Therapy--
--Patient Characteristics--
Location and Contact Information
More Information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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