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Improving Memory in Patients with Multiple Sclerosis
This study is currently recruiting patients.
Sponsored by: | National Institute of Child Health and Human Development (NICHD) Department of Education
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Information provided by: | National Institute of Child Health and Human Development (NICHD) |
Purpose
People with multiple sclerosis (MS) suffer from cognitive and other brain problems. This study will examine the effectiveness of the drug donepezil and of sugar water for enhancing memory in individuals with MS. Donepezil (also known as Aricept) has been FDA approved for improving memory and learning in individuals with Alzheimer’s disease.
Condition | Treatment or Intervention | Phase |
---|---|---|
Multiple Sclerosis |
Drug: donepezil Drug: glucose |
Phase III |
MedlinePlus related topics: Multiple Sclerosis
Study Type: Interventional
Study Design: Treatment, Randomized, Double-Blind, Placebo Control, Parallel Assignment, Efficacy Study
Official Title: Interventions to Improve Memory in Patients with Multiple Sclerosis
Expected Total Enrollment: 60
Study start: September 1999;
Study completion: August 2002
Cognitive dysfunction is one of the leading causes of disability in people with MS. Memory involving specific words (verbal memory) is particularly affected in individuals with MS. Attempts to rehabilitate cognitive dysfunction in MS have had only limited success.
This study will determine the efficacy of donepezil therapy and glucose administration for enhancing verbal memory functioning in individuals with MS. The study will also measure secondary outcomes assessing other areas of cognitive dysfunction (i.e., nonverbal memory, conceptual thinking, processing speed) which may improve with intervention.
Forty participants with MS will be randomly assigned to receive either donepezil or placebo for 24 weeks. Participants will complete memory and cognitive tests at the beginning and end of the 24 week period.
Twenty participants with MS will be randomly assigned to drink a beverage sweetened with either glucose or saccharin (placebo). Participants will then complete memory and other cognitive tests. Two weeks later, participants will drink a beverage sweetened with the alternative sweetener and again complete the memory and cognitive tests.
Eligibility
Ages Eligible for Study: 18 Years - 56 Years, Genders Eligible for Study: Both
Criteria
Inclusion Criteria
Exclusion Criteria
Location and Contact Information
More Information
Publications
Wild KV, Lezak MD,Whitman RH, Bourdette DN: Psychosocial impact of cognitive impairment in the multiple sclerosis patient. J Clin Exp Neuropsychology 415: 685-691, 1991
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