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Potent antitumor activity of 2-methoxyestradiol in human pancreatic cancer cell lines.
Schumacher G, Kataoka M, Roth JA, Mukhopadhyay T.
Department of General Surgery and Transplantation, Charite Campus Virchow Klinikum, Berlin, Germany.
We examined the effect of 2-methoxyestradiol (2-ME) on the growth and tumorigenesis of human pancreatic cancer cells. 2-ME inhibited the growth of these cell lines (50-90%) in a dose- and time-dependent fashion, and terminal deoxynucleotidyl transferase staining showed that it induced apoptotic cell death. Flow cytometric analysis indicated that 2-ME-sensitive cells showed a prolonged S phase after 48 h of treatment. We used a mouse model for in vivo studies of lung metastasis and injected MIA PaCa-2 cells into the tail veins of nu/nu mice; lung colonies were formed. Mice given oral 2-ME showed 60% inhibition in the number of lung colonies compared with control, untreated animals. These results suggest that 2-ME may have clinical application for the treatment of pancreatic cancer.
PMID: 10100698 [PubMed - indexed for MEDLINE]
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