Description
What is AIDS-related lymphoma?
What is AIDS-related lymphoma?
AIDS-related lymphoma is a disease in which cancer (malignant) cells are found
in the lymph system in patients who have AIDS (acquired immunodeficiency
syndrome). AIDS is caused by the human immunodeficiency virus (HIV) which
attacks and weakens the immune system. Infections and other diseases can then
invade the body, and the immune system cannot fight against them.
The lymph system is made up of thin tubes that branch, like blood vessels, into
all parts of the body. Lymph vessels carry lymph, a colorless, watery fluid
that contains white blood cells called lymphocytes. Along the network of
vessels are groups of small, bean-shaped organs called lymph nodes. Clusters
of lymph nodes make and store infection-fighting cells. The spleen (an organ
in the upper abdomen that makes lymphocytes and filters old blood cells from
the blood), the thymus (a small organ beneath the breastbone), and the tonsils
(an organ in the throat) are also part of the lymph system. Because there is
lymph tissue in many parts of the body, the cancer can spread to almost any of
the body’s organs or tissues including the liver, bone marrow (the spongy
tissue inside the large bones of the body that makes blood cells), spleen, or
brain.
Lymphomas are divided into two general types, Hodgkin’s lymphomas and
non-Hodgkin’s lymphomas, which are classified by the way their cells look under
a microscope. This determination is called the histology. Histology is also
used to determine the type of non-Hodgkin’s lymphoma.
The types of non-Hodgkin’s lymphomas are classified by how quickly they
spread: aggressive lymphomas grow and spread faster than indolent lymphomas.
Both major types of lymphoma, Hodgkin’s lymphoma and non-Hodgkin’s lymphoma, may
occur in AIDS patients. Also, the aggressive types of non-Hodgkin’s lymphoma are more commonly found in AIDS patients. Both types of
lymphomas can also occur in adults and in children. (Refer to the PDQ summaries
on Adult Hodgkin’s Lymphoma Treatment; Childhood Hodgkin’s Lymphoma Treatment;
Adult Non-Hodgkin’s Lymphoma Treatment; Childhood Non-Hodgkin’s Lymphoma
Treatment; and Primary CNS Lymphoma Treatment for more information.)
A doctor should be seen if any of the following symptoms persist for longer
than 2 weeks: painless swelling in the lymph nodes in the neck, underarm, or
groin; fever; night sweats; tiredness; weight loss without dieting; or itchy
skin.
If a patient has AIDS and symptoms of lymphoma, a doctor will carefully check
for swelling or lumps in the neck, underarms, and groin. If the lymph nodes
don’t feel normal, the doctor may need to cut out a small piece of tissue and
look at it under the microscope to see if there are any cancer cells. This
procedure is called a biopsy.
In general, patients with AIDS-related lymphoma respond to treatment
differently than patients with lymphoma who do not have AIDS. AIDS-related
lymphoma usually grows faster and spreads outside the lymph nodes and to other
parts of the body more often than lymphoma that is not related to AIDS.
Because therapy can damage weak immune systems even further, patients who have
AIDS-related lymphoma are generally treated with lower doses of drugs than
patients who do not have AIDS.
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