Model System for Collecting, Analyzing and Disseminating Information on Genetic Tests

Office of Genomics and Disease Prevention,CDC

In September 2000, the Office of Genomics and Disease Prevention, CDC, funded a new cooperative agreement with the Foundation for Blood Research (FBR).  FBR is a nonprofit research organization with expertise in clinical and laboratory investigation.  They have carried out a wide array of studies evaluating test performance, quality control, and effectiveness. The current project is to develop a model system for assembling, analyzing, disseminating and updating existing data on the safety and effectiveness of DNA-based genetic tests and testing algorithms. (More detail about the process and definitions of terms can be found at ACCE Project).

Over a 3-year period, five tests for different disorders will be evaluated from the standpoint of analytical validity, clinical validity, clinical utility, and related ethical/legal/social issues. The goal of this effort is to facilitate the appropriate transition of genetic tests from investigational settings to use in clinical and public health practice. This goal is consistent with preliminary recommendations of the Department of Health and Human Services Secretary's Advisory Committee on Genetic Testing.

View Draft Genetic Test Reviews
Draft Genetic Test Reviews or sections of reviews have been posted online for viewing.  The matrix below indicates which review, by disorder, is currently available in Acrobat PDF and/or HTML formats.  Click on the corresponding check mark icon to view.  Additional HTML sections will be added as they become available.  For those sections available in PDF format, you will need free Adobe Acrobat software.

Readers are welcome to e-mail comments to FBR at fbrinfo@fbr.org.  Please indicate the title of the Genetic Test Review in the subject heading of your e-mail.

Cystic Fibrosis Hemochromatosis Venous Thromboembolism Breast & Ovarian Cancer Colorectal Cancer Introduction (Genetic Test Brief) not yet available not yet available not yet available not yet available Disorder & Setting not yet available Analytic Validity   not yet available Clinical Validity not yet available Clinical Utility not yet available not yet available Ethical, Legal & Social Issues not yet available not yet available not yet available not yet available not yet available Master Reference List and Glossary not yet available not yet available not yet available not yet available

Use the Genomics and Disease Prevention Information System (GDPInfo)to find relevant documents on genetic testing or the above disorders. Create a search in GDPInfo by topic (use check boxes), by disease (use disease menu) or a combination of both criteria.   Search now.