Question
1: Based on this study, what is the
magnitude of the overall association between C677T and rheumatoid
arthritis? between ImmuneBlast and rheumatoid arthritis? Show
calculations in terms of relative risks and population attributable
fractions.
Your
answer:
Question
2: Is there
evidence of gene-environment interaction in this case-control study?
Compute the effects of the exposure alone, the genotype alone and
the combination. Show
calculations in terms of relative risks and population attributable
fractions.
Your answer:
Question
3: Discuss
the etiologic inference of the authors in terms of causal criteria
including
comment on study design and analysis.
Your answer:
Question
4: If
the authors did not have a control group, what kind of inference on
gene-environment interaction could they obtain from a case only
analysis? Is this a valid result?
Discuss pros and cons of this approach compared to a standard
case-control analysis.
Your answer:
Question
5: Can
you comment on the recommendations of the authors to test the
general population for the RA gene before taking ImmuneBlast?
Your answer:
**The above case study was totally
fictitious scenario and had been constructed for educational
purposes only. The journal, the gene, the exposures and all the
numbers were all made up.**
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