| HuGE
Net fact sheets are designed to be a quick and simple response to
new gene discoveries and associated diseases. Please fill out the
following template providing current, updated information on what is now
known about this gene, its' variants, associations, etc.
Title
Gene/Disease (i.e. APOE/Alzheimer Disease)
Gene
Identify the gene being reviewed and provide a brief review of its
chromosome location, the gene product and its function, if known. (ONE
SENTENCE)
Gene
variants
List known allelic variants and summarize known information on the
frequency of homozygosity and heterozygosity of these variants in
different populations and ethnic groups. (A FEW SENTENCES)
Disease(s)
Identify the disease(s), disorders this gene is associated with.
Briefly summarize the descriptive epidemiology and confirmed and
suspected risk factors (including other genes).(Brief)
Associations
Summarize the magnitude of the association between the allelic
variants and various diseases-absolute, relative and attributable
risks in different populations. Comment on the quality and methodology
of studies. (Brief)
Interactions
Discuss whether the allelic variants of this interact with any of the
disease known risk factors including other genes and environmental
factors. Summarize the magnitude of such interactions.(Brief)
Laboratory
tests
Summarize the sensitivity, specificity, and predictive values of
different tests available for this gene, including biochemical,
molecular, and other tests in different populations. (more info)
Status
of Laboratory Testing
Summarize the public health activities and locations where this testing
is conducted.
You
may contact us by e-mail at genetics@cdc.gov.
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