The use of genetic markers will make epidemiology both more complex and
more powerful. In 20 years, collection of data on individual genetic
profiles will be an integral component of all epidemiologic studies.
Molecular genetics is providing insight into the pathogenesis of disease,
e.g., in an inherited colorectal cancer, researchers found defects in a gene
prevented a protein product from recognizing and repairing mistakes
made during DNA replication.
A better understanding of the molecular biology of protein function and
drug interactions will facilitate drug development.
Emerging genetic technologies for use in clinical practice include
chip-based testing, micro-arrays, and high-pressure liquid chromotography.
Future improved screening methods will be available for all known mutations.
Someday, DNA chips will generate customized risk analyses with the ability
to test for many genes, independent of an individual’s ethnicity.
Microsatellite Instability Testing (MSI) is a testing strategy for genes
in tumor tissue. If the test is positive, then DNA is tested for mutations.
If a mutation is found, testing may be offered to other family members.
Genetic information can be used to identify people susceptible to specific
diseases so that medical, behavioral, or environmental interventions can be used
to reduce the likelihood of developing disease.
Genetic screening for disease prevention must address informed
decision-making by consumers, determination of the health benefits of taking
the test, test quality, and ability to interpret test results.
Before offering widespread testing, health professionals will need to
address the psychosocial issues of testing
asymptomatic people.
Treatment
Identifying subsets of particular diseases on the basis of genetic
information
promises to lead to more effective therapeutic regimens for populations with
those subtypes.
New approaches in the development of vaccines and drugs will lead to
interventions that more effectively reduce the health impact of environmental
and biological exposures.
New technologies and clinical trials will be costly. Society and industry
face difficult choices when balancing patient demand with the cost of research
and development.
The CDC Office of Genomics and Disease Prevention
makes
this information available as a public service only. Providing this information does not constitute endorsement by the CDC.