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 Public Health Perspectives

  

Genetics and Obesity References

  1. Troiano RP and Flegal KM. Overweight prevalence among youth in the United States:  why so many different numbers? International Journal of Obesity and Related Metabolic Disorders 1999;2:S22-7

  2. National Task Force on the Prevention and Treatment of Obesity. Overweight,  Obesity, and Health Risk. Archives of Internal Medicine 2000;160:898-904

  3. Bjorntorp, P.  Thrifty genes and human obesity.  Are we chasing ghosts?  Lancet 2001;258:1006-8

  4. Neel JV. Diabetes Mellitus; a “thrifty” genotype rendered detrimental by progress? American Journal of Human Genetics 1962;14:353-63

  5. Neel JV. Diabetes mellitus: a “thrifty genotype rendered detrimental by “progress”? Bulletin of the World Health Organization 1999; 77:694-703

  6. Neel JV. The “thrifty genotype” in 1998. Nutrition Reviews 1999;57:S2-9

  7. Maes HHM, Neale MC, Eaves LJ. Genetic and environmental factors in relative body weight and human adiposity. Behavior Genetics 1997;27(4):325-51

  8. Bouchard C, Tremblay A, Despres JP, et al. The response to long-term overfeeding in identical twins. New England Journal of Medicine 1990;322:1477-82

  9. Bouchard C and Tremblay A. Genetic influences on the response of body fat and fat distribution to positive and negative energy balances in human identical twins. Journal of Nutrition 1997;127:943S-7S

  10. Hainer V, Stunkard A, Kunesova M, et al. A twin study of weight loss and metabolic efficiency.  International Journal of Obesity 2001;533-7

  11. Stunkard AJ, Sorensen TIA, Hanis C, et al. An adoption study of human obesity. New England Journal of Medicine 1986;314;193-8

  12. Sorensen TIA, Price RA. Stunkard AJ, et al. Genetics of obesity in adult adoptees and their biological siblings. British Medical Journal 1989;298:87-90

  13. Sorensen TI and Stunkard AJ. Does obesity run in families because of genes?  An adoption study using silhouettes as a measure of obesity. Acta Psychiatry Scandinavia Supplement 1993;370:67-72

  14. Lee JH, Reed DR and Price RA. Familial risk ratios for extreme obesity: implications for mapping human obesity genes.  International Journal of Obesity and Related Metabolic Disorders 1997;21:935-40

  15. Van der Sande MAB, Walrave GEL, Milligan PJM, et al. Family history:  an opportunity for early interventions and improved control of hypertension, obesity and diabetes.  Bulletin of the World Health Organization 2001;79(4):321-328

  16. Barash GS, Farooqi IS, O’Rahilly S. Genetics of body-weight regulation.  Nature 2000;404:644-51

  17. Friedman JM and Halaas JL. Leptin and the reulation of body weight in mammals. Nature 1998;395:763-70

  18. Auwerx J and Staels B. Leptin. The Lancet 1998;351:737-39

  19. Montague CT, Farooqi IS, Whitehead JP, et al. Congenital leptin deficiency is associated with sever early-onset obesity in humans. Nature 1997;387:903-8

  20. Farooqi SI, Jebb SA, Langmack, G, et al. Brief Report:  Effects of recombinant leptin therapy in a child with congenital leptin deficiency. New England Journal of Medicine 1999;341:879-84

  21. Strobel A, Issad, T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nature Genetics 1998;18(3):213-5

  22. Clement K, Vaisse C, Lahlou N, et al. A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998;392(6674):398-401

  23. Krude H, Biebermann H, Luck W, et al. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nature Genetics 1998;19:155-7

  24. Chrast R, Scott, HS, Chen H, et al. Cloning of two human homologs of the Drosophila single-minded gene SIM1 on chromosome 6q and SIM2 on 21q within the Down syndrome chromosomal region. Genome Research 1997;7:615-24

  25. Holder JL, Butte NF, Zinn AR. Profound obesity associated with a balanced translocation that disrupts the SIM1 gene. Human Molecular Genetics 2000;9(1):101-8

  26. O’Rahally S, Gray H, Humphreys PJ, et al. Impaired processing of prohormones associated with abnormalities of glucose homeostasis and adrenal function. New England Journal of Medicine 1995;333(21):1386-90

  27. Jackson RS, Creemers JWM, Ohagi S, et al. Obesity and impaired porhormone processing associated with mutations in the human prohormone convertase 1 gene. Nature Genetics 1997;16(3):303

  28. Spiegelman BM and Flier JS. Obesity and the regulation of energy balance.  Cell 2001;104:531-43

  29. Magenis RE, Smith L, Nadeau JH, et al. Mapping of the ACTH, MSH, and neural (MC3 and MC4) melanocortin receptors in the mouse and human. Mammalian Genome 1994;5:503-8

  30. Yeo GSH, Farooqi IS, Aminian S, et al. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nature Genetics 1998;20:111-2

  31. Vaisse C, Clement K, Buy-Grand B, et al. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nature Genetics 1998;20:113-4

  32.  Vaisse C, Clement K, Durand E, et al. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.  Journal of Clinical Investigation 2000;106(2):253-62

  33. Hinney A, Schmidt A, Nottebom K, et al. Several mutations in the melanocortin-4 receptor gene including a nonsense and a frameshift mutation associated with dominantly inherited obesity in humans. Journal of Clinical Endocrinology and Metabolism 1999;84:1483-6

  34. Sina M, Hinney A, Ziegler A, et al. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. American Journal of Human Genetics 1999;65:1501-7

  35. Sina M, Hinney A, Ziegler A, et al. Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene. American Journal of Human Genetics 1999;65:1501-7

  36. Dubern B, Clement K, Pelloux V, et al. Mutational analysis of melanocortin-4 receptor, abouti-related protein, and [alpha]-melanocyte-stimulating hormone genes in severly obese children. Journal of Pediatrics 2001;139(2):204-9

  37. Farooqi IS, Yeo GSH, Keogh JM, et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. Journal of Clinical Investigation 2000;106(2):271-9

  38. Hirsch J and Leibel RL. The genetics of obesity. Hospital Practice 1998;33(3):55-9,62-5,69-70

  39. Perusse L, Chagnon YC, Weisnagel SJ, et al. The human obesity gene map:  the 2000 Update. Obesity Research 2001;9(2):135-69

  40. Feitosa MF, Borecki, IB, Rich SS, et al. Quantitative-trait loci influencing body-mass index reside on chromosomes 7 and 13: the National Health, Lung, and Blood Institute Family Heart Study. American Journal of Human Genetics 2002;70:72-82

  41. Comuzzie AG, Funahashi T, Sonnenberg G, et al. The genetic basis of plasma variation in adiponectin, a global endophenotype for obesity and the metabolic syndrome. Journal of Clinical Endocrinology and Metabolism 2001;86(9):4321-5

  42. Perusse L, Rice, T, Chagnon, YC, et al. A genome-wide scan for abdominal fat assessed by computed tomography in the Quebec Family Study.  Diabetes 2001;50(3):614-21

  43. Hsueh WC, Mitchell BD, Schneider JL, et al. Genome-wide scan of obesity in the Old Order Amish. Journal of Clinical Endocrinology and Metabolism 2001;86(3):1199-205

  44. van der Kallen CJ, Cantor RM, van Greevenbroek MM, et al. Genome scan for adiposity in Dutch dyslipidemic families reveals novel quantitative trait loci for leptin, body mass index and soluble tumor necrosis factor receptor superfamily 1A. International Journal of Obesity and Related Metabolic Disorders 2000;24(11):1381-91

  45. Wolf A and Colditz G. Current estimates of the economic cost of obesity in the United States. Obesity Research 1998;6:97-106

  46. Ravussin E and Bouchard C. Human genomics and obesity: finding appropriate drug targets. European Journal of Pharmacology 2000;410:131-45

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This page last modified on October 05, 2004