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Laboratory:
1. Title: Impact of Lead-Based Paint Abatement on Children's Blood Lead Levels, St. Louis

Publication: Am J Epidemiol 1994; 139: 1016-1026.

Abstract:

In order to evaluate the effectiveness of lead-based paint (LBP) hazard abatement in reducing children's blood lead (PbB) levels, we conducted a retrospective cohort study in St. Louis, Missouri. LBP hazard abatement consists of the removal of peeling and chipping lead-based paint. We reviewed environmental and medical records of the St. Louis City Health Department and abstracted data on children with PbB levels greater than or equal mg/dL during 1989 or 1990. Among 185 children selected, 54 children had not moved or received chelation therapy and had their PbB levels measured 10 to 14 months after diagnosis. The geometric mean (GM) PbB level decreased 23% among children living in abated dwellings (n = 37) and 12% among children in non-abated dwellings (n = 17) (p = 0.07, t-test). The estimated size of the abatement effect was similar using multiple regression (-12%, p = 0.06) and generalized linear models (-5% to -16%, p = 0.003), when adjusted for important covariates. The effect of abatement was much greater among children whose PbB levels at diagnosis were greater than or equal 35 mg/dL.Centers for Disease Control and Prevention.

2. Articles or citations of studies dealing with the importance of nutrition in minimizing the effects of lead exposure in young children:
  • Hu H, Kotha S, Brennan T. The Role of Nutrition in Mitigating Environmental Insults: Policy and Ethical Issues. Environmental Health Perspectives. 103 (Supplement 6): 185-190 (1995).
  • Mahaffey K. Nutrition and Lead: Strategies for Public Health. Environmental Health Perspectives. 103 (Supplement 6): 191-196 (1995).
  • Mahaffey K. Environmental Lead Toxicity: Nutrition as a Component of Intervention. Environmental Health Perspectives. 89: 75-78 (1990).
  • Goyer R. Nutrition and Metal Toxicity. American Journal of Clinical Nutrition. 61 (Supplement): 646S-650S (1995).
  • Sargent J. The Role of Nutrition in the Prevention of Lead Poisoning in Children. Pediatric Annals. 23 (11): 636-642 (1994).
  • Lucas S, Sexton M, Langenberg P. Relationship Between Blood Lead and Nutritional Factors in Preschool Children: A Cross-sectional Study. Pediatrics. 97: 74-78 (1996).
  • Ruff H, Markowitz M, Bijur P, Rosen J. Relationships among Blood Lead Levels, Iron Deficiency, and Cognitive Development in Two-Year-Old Children.  Environmental Health Perspectives. 104 (2): 180-185 (1996).
  • Bruening K, Kemp F, Simone N, Holding Y, Louria D, Bogden J. Dietary Calcium Intakes of Urban Children at Risk of Lead Poisoning. Environmental Health Perspectives. 107 (6): 431-435 (1999).
  • Simon J, Hudes E. Relationship of Ascorbic Acid to Blood Lead Levels. JAMA. 281 (24): 2289-2293 (1999).
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This page last reviewed September 20, 2004

Childhood Lead Poisoning Prevention Branch
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