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Research Project:
Determination of the Molecular Basis for Re-Emergence, Pathogenesis and Host Range of Fmdv
Location:
Project Number: 1940-32000-035-00
Project Type:
Appropriated
Start Date: Oct 01, 2000
End Date: Sep 30, 2005
Objective:
Foot-and-mouth disease (FMD) is the most important foreign animal disease threat to the US. Recent outbreaks have demonstrated that viruses with altered virulence are arising in the field, increasing their dangerousness. Objective 1: Determine the properties of these viruses, focusing on the Pan-Asian lineage viruses which devastated the UK. Objective 2: Develop antiviral therapies that could be used to control FMD, reducing reliance on widespread slaughter to control a US outbreak.
Approach:
To evaluate changes in pathogenic potential of FMD viruses in the field, we will determine complete genome sequences, pathogenic potential, and spread in livestock of selected strains of virus. Since FMDV is known to undergo frequent genetic changes, genetic changes detected will be systematically inserted into genetically engineered viruses to test their significance. Knowledge gained from these studies will provide for development of improved tools to identify & control these viruses if introduced into the US. To develop new FMD therapeutics, we will define, at the molecular level, the first step in host cell/virion interaction, cell receptor binding. Using this information, we will determine if this critical step in virus infection can be utilized to develop antiviral therapies that could reduce virus shedding. We will seek to identify new targets for antiviral therapies by discovering sites of interaction between the virus and cell factors that are critical to viral replication. Information developed in this objective will provide a basis for new therapeutics to control FMD.
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