Project Number: 1275-22000-206-00
Project Type: Appropriated

Start Date: May 02, 2003
End Date: Apr 30, 2008

Objective:
1) Develop novel plant virus-based vectors for expression of foreign gene sequences in plants. 2) Identify genetic elements from plant viruses and viroids to target and enhance foreign gene expression in plants. 3) Evaluate plant gene function in host/pathogen interactions and candidate sequences for plant disease control using viral-based vectors. 4) Develop new strategies and plant expression systems for the production of vaccines and other biomedical products for prevention, treatment, and control of animal diseases using plant viruses as delivery vehicles.

Approach:
1) Develop plant virus-based vectors for fruit and vegetable crops. 2)Mutagenize plant virus-based vectors to reduce or eliminate insect vector transmission. 3) Identify subcellular targeting signals of viroid molecules. 4) Develop viral-based expression strategies to target peptides to specific tissues. 5) Evaluate genes for potential in conferring resistance to cellular and subcellular pathogens. 6) Express single-chain antibodies and evaluate ability to confer resistance to cucumoviruses. 7) Develop epitope display strategy for candidate vaccines for animal pathogens. 8) Develop diagnostic reagents for bovine viral diarrhea virus. BSL-1, Recertified 2/1/03

Project Team

Hammond, Rosemarie Owens, Robert

Project Annual Reports

FY 2003

Related National Programs

Plant Biological and Molecular Processes (302)   Plant Diseases (303)

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DEVELOPMENT OF PLANT-BASED EXPRESSION SYSTEMS FOR THE PRODUCTION OF BIOMEDICALS