RATIONALE: Drugs used in chemotherapy such as gemcitabine use different ways to stop cancer cells from dividing so they stop growing or die. Oblimersen may increase the effectiveness of gemcitabine by making cancer cells more sensitive to the drug.

PURPOSE: Phase I trial to study the effectiveness of combining oblimersen with gemcitabine in treating patients who have metastatic or unresectable solid tumors or lymphoma.

Condition	Treatment or Intervention	Phase
adult Hodgkin's lymphoma adult T-cell leukemia and lymphoma adult non-Hodgkin's lymphoma adult solid tumor Cutaneous T-Cell Lymphoma	Drug: gemcitabine  Drug: oblimersen  Procedure: antisense therapy  Procedure: chemotherapy	Phase I

OBJECTIVES:

• Determine the maximum tolerated dose and dose-limiting toxicity of oblimersen and gemcitabine in patients with advanced solid tumor or lymphoma.
• Determine the effect of oblimersen on the pharmacokinetics and pharmacodynamics of gemcitabine in these patients.
• Determine the toxic effects of this regimen in these patients.

OUTLINE: This is a dose-escalation study.

Patients receive oblimersen IV continuously on days 1-5 and gemcitabine IV over 2-3 hours on day 5. Courses repeat every 2 weeks in the absence of disease progression or unacceptable toxicity.

Cohorts of 3-6 patients receive escalating doses of oblimersen and gemcitabine until the maximum tolerated dose (MTD) is determined. The MTD is defined as the dose preceding that at which 2 of 3 or 2 of 6 patients experience dose-limiting toxicity. Up to 10 additional patients receive treatment at the MTD.

PROJECTED ACCRUAL: Approximately 15 patients will be accrued for this study within 6-8 months.

Ages Eligible for Study:  18 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically confirmed malignancy for which there is no standard or effective curative or palliative therapy
• Solid tumors and lymphoma allowed
• Metastatic or unresectable disease
• Measurable or evaluable nonmeasurable disease
• Evaluable nonmeasurable disease includes ascites, pleural/pericardial effusions, lymphangitis cutis/pulmonis, inflammatory breast disease, abdominal masses not followed by CT scan or MRI, or cystic lesions
• Disease characterized by elevated serum tumor marker alone is allowed
• No known brain metastases

PATIENT CHARACTERISTICS: Age

• Over 18

Performance status

• ECOG 0-2 OR
• Karnofsky 60-100%

Life expectancy

• More than 3 months

Hematopoietic

• Absolute neutrophil count at least 1,500/mm^3
• Platelet count at least 100,000/mm^3

Hepatic

• Bilirubin no greater than 1.5 mg/dL
• AST and ALT no greater than 2.5 times upper limit of normal
• No history of portal hypertension
• No history of cirrhosis or hepatitis
• No radiographic evidence of cirrhosis and/or varices

Renal

• Creatinine normal OR
• Creatinine clearance at least 60 mL/min

Cardiovascular

• No symptomatic congestive heart failure
• No unstable angina pectoris
• No cardiac arrhythmia

Other

• Not pregnant or nursing
• Negative pregnancy test
• Fertile patients must use effective contraception
• No prior allergic reaction attributed to compounds of similar chemical or biological composition to oblimersen or other study agents
• No other concurrent uncontrolled illness that would preclude study participation
• No ongoing or active infection
• No psychiatric illness or social situation that would preclude study compliance

PRIOR CONCURRENT THERAPY: Biologic therapy

• No concurrent prophylactic colony-stimulating factors such as filgrastim (G-CSF) or sargramostim (GM-CSF)
• Concurrent interventional growth factors allowed
• No growth factor administration within 24 hours before study chemotherapy
• Concurrent epoetin alfa allowed

Chemotherapy

• No more than 3 prior chemotherapy regimens
• More than 4 weeks since prior chemotherapy (6 weeks for nitrosoureas or mitomycin)

Endocrine therapy

• More than 2 weeks since prior hormonal therapy
• Concurrent megestrol for anorexia/cachexia allowed

Radiotherapy

• No prior pelvic or whole abdominal radiotherapy
• More than 4 weeks since prior radiotherapy

Surgery

• More than 4 weeks since prior major surgery

Other

• Recovered from prior therapy
• More than 4 weeks since prior investigational therapy
• No prior oblimersen
• No other concurrent investigational agents
• No other concurrent anticancer therapy
• No concurrent combination antiretroviral therapy for HIV-positive patients

California
      Stanford Cancer Center at Stanford University Medical Center, Stanford,  California,  94305-5151,  United States; Recruiting

Study chairs or principal investigators

Branimir Ivan Sikic, MD,  Study Chair,  Stanford University   

Study ID Numbers:  CDR0000299507; SUMC-NCI-5908; NCI-5908
Record last reviewed:  May 2003
Record first received:  May 6, 2003
ClinicalTrials.gov Identifier:  NCT00060112
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2004-11-17