Hereditary defects in one or more of the clotting factors can cause the formation of potentially dangerous blood clots (thrombosis). Approximately 5-8% of the U.S. population has one of these clotting disorders collectively called thrombophilia, a propensity for blood clotting in which a genetic defect can be identified that often results in thrombosis.

More than 60,000 Americans die each year from venous thromboembolism; in addition, nearly half of patients with deep vein clots experience long-term health consequences that adversely affect their quality of life.

Prevention activities

CDC is helping to establish a network of hemostasis and thrombosis centers to promote the management, treatment, and prevention of complications experienced by persons with clotting disorders.

CDC is conducting laboratory work to identify genetic risk factors that predispose persons to thrombophilia. Identifying these factors could help prevent complications that result from clotting.

For more information

Locate a hemostasis and thrombosis center

Publications

Summary of CDC April 2000 meeting on the factor V Leiden mutation (33 KB)

Hooper WC, Evatt BL. The role of activated protein C resistance in the pathogenesis of venous thrombosis. Am J Med Sci 1998;216:120-128.

Organizations

International Society on Thrombosis and Haemostasis

American Thrombosis Association

The Adobe™ Acrobat™ (PDF) file format is viewable only with the free Adobe™ Acrobat™ Reader installed on your computer.

Disclaimer: Links to non-Federal organizations found at this site are provided solely as a service to our users. These links do not constitute an endorsement of these organizations or their programs by CDC or the Federal Government, and none should be inferred. CDC is not responsible for the content of the individual organization webpages found at these links.

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This page was last updated August 05, 2004

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National Center on Birth Defects and Developmental Disabilities

The National Center on Birth Defects and Developmental Disabilities (NCBDDD) promotes the health of babies, children, and adults, and enhances the potential for full, productive living.  Our work includes identifying the causes of birth defects and developmental disabilities, helping children to develop and reach their full potential, and promoting health and well-being among people of all ages with disabilities.