Press Release
For More Information, Contact Tammy McCoy (404) 633-3777
Embargoed for Release at 5:30 PM ET, Friday Oct. 24, 2003
Arthritis News
CHOLESTEROL-LOWERING THERAPY HAS ADDITIONAL BENEFITS FOR PATIENTS WITH
RHEUMATOID ARTHRITIS
ORLANDO, FLORIDA—A
new study shows that patients with rheumatoid arthritis experience
a reduction
in C-reactive protein, an important common blood
test marker for inflammation and cardiovascular
disease, while taking atorvastatin, as well as
lower cholesterol and triglyceride (fat-like
substances) blood levels, according to research
presented this
week at the American College of Rheumatology
Annual Scientific Meeting in Orlando, Florida.
This
is the first study of this or any other lipid-lowering therapy
in a randomized trial
in patients with rheumatoid arthritis, who are
at
increased risk of heart disease because of widespread
inflammation. Those patients who received the
drug showed a significant reduction in C-reactive
protein,
an inflammatory agent associated with rheumatoid
arthritis and predictive of cardiovascular disease,
compared to those who received placebo.
The randomized,
double-blind, placebo-controlled study followed 116 patients
who received medication
or placebo for six months, at the end of which
the DAS 28 (an arthritis activity score used
mainly in Europe for the clinical assessment
of rheumatoid
arthritis; it is similar to the ACR 20, 50, 70
criteria for improvement), and blood concentrations
of C-reactive protein and of other risk factors
for heart disease were measured. Significant
reduction in the DAS 28 score after treatment
with atorvastatin
was observed. Moreover, the study showed significant
reductions in C-reactive protein levels (that
measure inflammation), and lipid profile levels
including
total cholesterol, LDL-cholesterol and triglycerides,
despite the chronic inflammation attendant with
rheumatoid arthritis.
According to the American Heart Association,
cardiovascular disease is the leading cause of
death among adults in the U.S. (nearly 1,000,000
deaths annually), and affects one in five adults.
Patients with rheumatoid arthritis are twice
as likely to develop serious cardiovascular
disease.
“Statins are an exciting therapeutic opportunity
for those of us treating rheumatoid arthritis,” said
Professor Iain McInnes, Professor of Experimental
Medicine and Rheumatology at the Centre for Rheumatic
Diseases in Glasgow, United Kingdom and an investigator
on the study. “Statins have the potential
to reduce not only the increased risk of cardiovascular
disease in rheumatoid arthritis, but also may
have direct effects on the inflammation that
is the
cause of the distressing joint damage and functional
problems in these patients.”
The American
College of Rheumatology is the professional organization
for rheumatologists and health professionals
who share a dedication to healing, preventing
disability and curing arthritis and related rheumatic
and
musculoskeletal diseases. For more information
on the ACR’s annual meeting, see www.rheumatology.org/annual.
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