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Alternative names Return to top
ZygomycosisDefinition Return to top
Mucormycosis is a fungal infection of the sinuses, brain, or lungs that occurs primarily in people with immune disorders.Causes, incidence, and risk factors Return to top
Mucormycosis is caused by common fungi frequently found in the soil and in decaying vegetation. Most individuals are exposed to these fungi on a daily basis -- but people with immune disorders may be more susceptible to infection.
Conditions most commonly associated with mucormycosis include diabetes mellitus, chronic steroid use, metabolic acidosis, organ transplantation, leukemia/lymphoma, treatment with deferoxamine, and AIDS.
Syndromes associated with mucormycosis include:
Symptoms Return to top
Symptoms of rhinocerebral mucormycosis include the following:
Symptoms of pulmonary mucormycosis include the following:
Symptoms of gastrointestinal mucormycosis include the following:
Symptoms of renal mucormycosis include the following:
Symptoms of cutaneous mucormycosis include a single, painful, hardened area of skin that may have a blackened central area.
Signs and tests Return to top
Mucormycosis should be suspected if symptoms appear in individuals with immune disorders such as diabetes or those with weakened immune systems such as transplant recipients. Symptoms of rhinocerebral mucormycosis are most likely to occur among immunosuppressed people.
Depending on the site of involvement, CT scans or MRIs may be performed. Evaluation by an ear-nose-throat specialist is recommended if sinus involvement is suspected.
To definitively diagnose mucormycosis, a tissue specimen must be obtained and analyzed.
Treatment Return to top
The mainstay of treatment for mucormycosis is early surgical intervention to remove all dead and infected tissue, along with intravenous antifungal therapy. Surgical removal of involved tissue is critical and may be disfiguring because it may involve removal of the palate, nasal structures, or eye structures.
However, chances of survival are greatly decreased without this aggressive intervention.
Expectations (prognosis) Return to top
Mucormycosis has an extremely high mortality rate even with aggressive surgical intervention. Death rates range from 25-80% depending on the site involved as well as the underlying immune problems.Complications Return to top
Calling your health care provider Return to top
People with immune disorders (including diabetes) should seek medical attention if they develop fever, headache, sinus pain, eye swelling, or any of the other symptoms listed above.Prevention Return to top
Because the fungi that cause mucormycosis are widespread, the most appropriate preventive measures involve improved control of the underlying illnesses associated with mucormycosis. Update Date: 7/14/2004 Updated by: Daniel Levy, M.D., Ph.D., Infectious Diseases, Greater Baltimore Medical Center, Baltimore, MD. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |