MedlinePlus Medical Encyclopedia: BUN

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BUN

Contents of this page:
Alternative names Definition How the test is performed How to prepare for the test How the test will feel	Why the test is performed Normal Values What abnormal results mean What the risks are Special considerations

Alternative names

Blood urea nitrogen

Definition Return to top

BUN (blood urea nitrogen) is a test that measures the amount of urea nitrogen (a breakdown product of protein metabolism) in the blood.

How the test is performed Return to top

Blood is drawn from a vein, usually from the inside of the elbow or the back of the hand. The puncture site is cleaned with antiseptic, and a tourniquet is placed around the upper arm to apply pressure and restrict blood flow through the vein. This causes veins below the tourniquet to fill with blood.

A needle is inserted into the vein, and the blood is collected in an air-tight vial or a syringe. During the procedure, the tourniquet is removed to restore circulation. Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.

Infant or young child:
The area is cleaned with antiseptic and punctured with a sharp needle or a lancet. The blood may be collected in a pipette (small glass tube), on a slide, onto a test strip, or into a small container. A bandage may be applied to the puncture site if there is any continued bleeding.

How to prepare for the test Return to top

There are no special preparations.

Infants and children:
The preparation you can provide for this or any test or procedure depends on your child's age, previous experiences, and level of trust. For general information regarding how you can prepare your child, see the following topics:

Infant test or procedure preparation (birth to 1 year)
Toddler test or procedure preparation (1 to 3 years)
Preschooler test or procedure preparation (3 to 6 years)
Schoolage test or procedure preparation (6 to 12 years)
Adolescent test or procedure preparation (12 to 18 years)

How the test will feel Return to top

When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.

Why the test is performed Return to top

The BUN test is a somewhat routine test used primarily to evaluate renal (kidney) function. The test is often performed on patients with many different diseases.

Urea is formed in the liver as the end product of protein metabolism. During digestion, protein is broken down to amino acids. Amino acids contain nitrogen, which is removed as NH4+ (ammonium ion), while the rest of the molecule is used to produce energy or other substances needed by the cell. The ammonia is combined with other small molecules to produce urea. The urea makes its way into the blood and it is ultimately eliminated in the urine by the kidneys.

Most renal diseases affect urea excretion so that BUN levels increase in the blood. Patients with dehydration or bleeding into the stomach and/or intestines may also have abnormal BUN levels. Numerous drugs also affect BUN by competing with it for elimination by the kidneys.

Normal Values Return to top

7 to 20 mg/dl

What abnormal results mean Return to top

Greater-than-normal levels may indicate:

Congestive heart failure
Excessive protein catabolism (possibly due to starvation)
Excessive protein ingestion
Gastrointestinal bleeding
Hypovolemia (possibly due to burns or dehydration)
Myocardial infarction (heart attack)
Renal disease (for example, glomerulonephritis, pyelonephritis, and acute tubular necrosis)
Renal failure
Shock
Urinary tract obstruction (for example, tumor, stones, and prostatic hypertrophy)

Lower-than-normal levels may indicate:

Liver failure
Low protein diet
Malnutrition
Over-hydration

Additional conditions under which the test may be performed:

Acute nephritic syndrome
Alport syndrome
Atheroembolic renal disease
Chronic renal failure
Complicated UTI (pyelonephritis)
Dementia due to metabolic causes
Diabetic nephropathy/sclerosis
Digitalis toxicity
End-stage renal disease
Epilepsy
Generalized tonic-clonic seizure
Goodpasture's syndrome
Hemolytic-uremic syndrome (HUS)
Hepatorenal syndrome
IgM mesangial proliferative glomerulonephritis
Interstitial nephritis
Lupus nephritis
Malignant hypertension (arteriolar nephrosclerosis)
Medullary cystic disease
Membranoproliferative GN I
Membranoproliferative GN II
Noninsulin-dependent diabetes mellitus (NIDDM)
Prerenal azotemia
Primary amyloid
Rapidly progressive (crescentic) glomerulonephritis
Secondary systemic amyloid
Wilms' tumor

What the risks are Return to top

Excessive bleeding
Fainting or feeling light-headed
Hematoma (blood accumulating under the skin)
Infection (a slight risk any time the skin is broken)
Multiple punctures to locate veins

Special considerations Return to top

For people with liver disease, the BUN level may be low even if the kidneys are normal.

Some drugs affect BUN levels. Before having this test, make sure the health care provider knows which medications you are taking.

Drugs that can increase BUN measurements include allopurinol, aminoglycosides, cephalosporins, chloral hydrate, cisplatin, furosemide, guanethidine, indomethacin, methotrexate, methyldopa, nephrotoxic drugs (for example, high-dose aspirin, amphotericin B, bacitracin, carbamazepine, colistin, gentamicin, methicillin, neomycin, penicillamine, polymyxin B, probenecid, vancomycin), propranolol, rifampin, spironolactone, tetracyclines, thiazide diuretics, and triamterene.

Drugs that can decrease BUN measurements include chloramphenicol and streptomycin.

Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.

Update Date: 8/7/2003

Updated by: Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.

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