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Alternative names Return to top
Potassium wastingDefinition Return to top
Bartter's syndrome involves a group of symptoms and signs:
There is no elevation of blood pressure with Bartter's syndrome, which usually occurs with kidney disease.
Causes, incidence, and risk factors Return to top
The exact cause of Bartter's syndrome is not known. In some cases, it may be genetic and the condition is present from before birth (congenital).
The condition is thought to be caused by a defect in the kidney's ability to reabsorb potassium. As a result, an excessive amount of potassium is excreted from the body. This is also known as potassium wasting.
Symptoms Return to top
This disease usually occurs in childhood. Symptoms include muscle cramping and weakness, constipation, increased frequency of urination, and growth failure.
Signs and tests Return to top
The diagnosis of Bartter's syndrome is usually made by finding low levels of potassium in the blood. The potassium level is usually less than 2.5 mEq/L. Other signs of this syndrome include:
These same signs and symptoms can also occur in people who have taken excessive amounts of diuretics or laxatives. Urine tests can be done to exclude these causes.
In Bartter's syndrome, a biopsy of the kidney typically shows overgrowth of cells called the juxtaglomerular apparatus. However, this is not found in all patients, especially in young children.
Treatment Return to top
Bartter's syndrome is treated by keeping the blood potassium level above 3.5 mEq/L. This is achieved through a diet rich in potassium. Some patients also require salt and magnesium supplements.Expectations (prognosis) Return to top
The long term prognosis for patients with Bartter's syndrome is not certain. Infants who experience severe growth failure typically grow normally with treatment. Studies are being done to see if these children have decreased mental functioning, which can occur if potassium levels are abnormal for too long. While most patients remain well with ongoing treatment, some develop kidney failure.Complications Return to top
Kidney failure is a possible complication.
Calling your health care provider Return to top
Call your health care provider if your child is not growing well, is urinating frequently, and is having muscle cramps. Update Date: 12/22/2002 Updated by: Philip L. Graham III, M.D., F.A.A.P., Department of Pediatrics, Children's Hospital of New York, Columbia University, New York, NY. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |