Chronic inflammatory polyneuropathy is a common type of damage to nerves outside the brain or spinal cord (peripheral neuropathy) involving multiple nerves (polyneuropathy). An acute form of the disorder is called Guillain-Barre syndrome.

Polyneuropathy implies a widespread process that usually affects both sides of the body equally. The cause of chronic inflammatory polyneuropathy is an abnormal immune response. The specific antigens, immune processes, and triggering factors are variable and in many cases are unknown.

It may occur in association with other conditions such as HIV, inflammatory bowel disease, lupus erythematosis, chronic active hepatitis, and blood cell abnormalities.

• Weakness, usually in the arms and hands or legs and feet
• Facial weakness
• Difficulty walking
• Difficulty using the arms and hands or legs and feet
• Sensation changes (usually of the arms and hands or legs and feet)
  • Pain, burning, tingling, or other abnormal sensations
  • Numbness or decreased sensation

• Swallowing difficulty
• Speech impairment
• Loss of function or feeling in the muscles
• Muscle contractions
• Muscle atrophy
• Uncoordinated movement
• Dysfunctional movement
• Joint pain
• Hoarseness or changing voice
• Fatigue
• Facial paralysis
• Bowel or bladder dysfunction
• Breathing difficulty

A neurological examination shows sensory abnormalities and weakness. Sensation deficits usually occur in a symmetrical pattern, and progress from the extremities to central locations.

Reflexes are usually absent. Muscle weakness or paralysis of the affected area may be present, and muscle atrophy (loss of muscle mass) may be apparent. Nerves may be physically palpable. A nerve biopsy may be necessary to demonstrate an inflammatory cause and to rule out other nerve diseases.

A spinal tap may show elevated CSF total protein or other abnormalities that indicate an inflammatory neurologic process. EMG and nerve conduction tests may indicate loss of the myelin sheath (slow conduction rate) or degeneration of the axon of the nerve cell (normal conduction rate).

The selection of other tests is guided by the suspected cause of the disorder, as suggested by the history, symptoms and pattern of symptom development. The tests may include various X-rays, scans, and blood tests.

• Permanent weakness or paralysis of areas of the body
• Permanent decrease or loss of sensation in areas of the body
• Repeated or unnoticed injury to an area of the body
• Side effects of medications used to treat the disorder (see the specific medication)
• Pain