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Trypsin and chymotrypsin in stool

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Illustrations

Digestive system organs
Digestive system organs

Alternative names    Return to top

Stool - trypsin and chymotrypsin

Definition    Return to top

This test detects the presence of trypsin and chymotrypsin in stool.

How the test is performed    Return to top

There are many ways to collect the samples. Your health care provider will instruct you on how to collect the stool.

You can catch the stool on plastic wrap that is loosely placed over the toilet bowl and held in place by the toilet seat. Then put the sample in a clean container. One type of test kit supplies a special tissue that you use to collect the sample, then put the sample in a clean container.

Infants and young children:
For children wearing diapers, you can line the diaper with plastic wrap. The plastic wrap should be positioned to prevent the mixing of urine and stool.

A drop of emulsified stool is placed on a thin layer of gelatin. If trypsin or chymotrypsin are present, the gelatin will be digested, which will produce a clearing of the gelatin.

How to prepare for the test    Return to top

Your health care provider will provide you with the necessary supplies to collect the stool.

Why the test is performed    Return to top

Trypsin and chymotrypsin are proteolytic enzymes released from the pancreas during normal digestion. This test is a simple screening test sometimes used to test young children suspected of having cystic fibrosis.

Cystic fibrosis causes the formation of mucous plugs that can obstruct the pancreatic ducts that empty into the small intestines.

Normal Values    Return to top

Positive test results are normal.

What abnormal results mean    Return to top

Negative test results suggest the possibility of cystic fibrosis.

Note: This is a screening tool, not a diagnostic test. A diagnosis of cystic fibrosis requires further investigation.

Update Date: 8/18/2003

Updated by: Andrew J. Muir, M.D., M.H.S., Division of Gastroenterology, Duke University Medical Center, Durham, NC. Review provided by VeriMed Healthcare Network.

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