MedlinePlus Medical Encyclopedia: Splenomegaly

Skip navigation


Medical Encyclopedia
Other encyclopedia topics:	A-Ag Ah-Ap Aq-Az B-Bk Bl-Bz C-Cg Ch-Co Cp-Cz D-Di Dj-Dz E-Ep Eq-Ez F G H-Hf Hg-Hz I-In Io-Iz J K L-Ln Lo-Lz M-Mf Mg-Mz N O P-Pl Pm-Pz Q R S-Sh Si-Sp Sq-Sz T-Tn To-Tz U V W X Y Z 0-9

Splenomegaly

Contents of this page:
Illustrations Alternative names Definition Considerations	Common Causes Home Care Call your health care provider if What to expect at your health care provider's office

Illustrations

Splenomegaly

Enlarged spleen

Alternative names Return to top

Spleen enlargement; Enlarged spleen

Definition Return to top

Splenomegaly is an enlargement of the spleen beyond its normal size.

Considerations Return to top

The spleen is an organ involved in the production and maintenance of red blood cells, the production of certain circulating white blood cells, and is a part of the lymph system and the immune system.

Because of its wide variety of functions, the spleen may be affected by many conditions involving the blood or lymph system, and by infection, malignancies, liver disease, and parasites.

Common Causes Return to top

Infections
- Infectious mononucleosis (EBV or CMV)
- Other viral infections
- Parasitic infections
- Cat scratch disease
- Bacterial infections
Diseases involving the liver
- Cirrhosis (portal vein obstruction, portal hypertension)
- Sclerosing cholangitis
- Wilson's disease
- Biliary atresia
- Cystic fibrosis
Hemolytic anemias
- Thalassemia
- Hemoglobinopathies
- Hemolytic anemia due to G6PD deficiency
- Idiopathic autoimmune hemolytic anemia
- Immune hemolytic anemia
Cancer
- Leukemia
- Lymphoma
- Hodgkin's disease
Other causes
- Sarcoidosis
- Sickle cell splenic crisis
- Banti's syndrome
- Felty syndrome

Home Care Return to top

Rupture of the enlarged spleen is particularly possible in infectious mononucleosis and several other causes of splenomegaly. Appropriate limitation of activity, including avoiding contact sports, will help prevent trauma that might cause the spleen to rupture.

Care will be required for the specific condition causing the splenomegaly. Follow the instructions given by your health care provider regarding appropriate care.

Call your health care provider if Return to top

Although often there are no symptoms from an enlarged spleen, you may experience pain in the left upper section of your abdomen. If you do, especially if it is severe or gets worse when you take a deep breath, you should seek attention from your doctor right away.

Other symptoms that you may experience and warrant a call or visit to your doctor depend on the underlying cause of the enlarged spleen. Refer to articles of topics mentioned in the Causes section above for additional information.

What to expect at your health care provider's office Return to top

The physician will ask a series of questions to determine if you have symptoms either from the enlarged spleen or the underlying cause of the large spleen, such as fever or signs of an infectious disease.

The doctor will also perform a thorough exam of your abdomen. To check for an enlarged spleen, he or she will percuss (tap) along the left upper quadrant of your abdomen and palpate (feel) in that same area, especially just under the rib cage.

Diagnostic tests may be required, including:

Blood tests such as a CBC
Tests for suspected causes
Abdominal film or CT scan

Update Date: 6/20/2004

Updated by: Jacqueline A. Hart, M.D., Department of Internal Medicine, Newton-Wellesley Hospital, Newton, Ma., and Senior Medical Editor, A.D.A.M., Inc. and Thomas A. Owens, M.D., Departments of Internal Medicine and Pediatrics, Duke University Medical Center, Durham, NC. Review provided by VeriMed Healthcare Network (7/18/2003).

The information provided herein should not be used during any medical emergency or for the diagnosis or treatment of any medical condition. A licensed physician should be consulted for diagnosis and treatment of any and all medical conditions. Call 911 for all medical emergencies. Links to other sites are provided for information only -- they do not constitute endorsements of those other sites. Copyright 2002 A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited.