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Alternative names Return to top
Keratitis interstitialDefinition Return to top
Interstitial keratitis involves inflammation of the connective tissue structure of the cornea (the clear window on the front of the eye), which can lead to vision loss.Causes, incidence, and risk factors Return to top
Interstitial keratitis is a serious condition in which blood vessels grow into the cornea and can cause loss of the normal transparency. This condition is often caused by infections and may cause severe visual impairment.
Syphilis is the most common cause of interstitial keratitis, but rare causes include leprosy and tuberculosis. Most cases in the developed world occur in patients with fully established systemic infection with the spirochete of syphilis.
In the US, most cases of syphilis are recognized and treated before they reach this stage. However, interstitial keratitis is the most common cause of blindness in the world, with cases caused by trachoma and onchocerciasis (river blindness) being very common in parts of Asia and Africa.
Symptoms Return to top
Signs and tests Return to top
Interstitial keratitis can be easily diagnosed by physical examination of the eyes with slit lamp examination. Blood tests and chest X-rays will usually be needed to confirm the infection causing the condition.
Treatment Return to top
The underlying disease must be treated. Treatment of the cornea with corticosteroid drops may minimize scarring and help preserve the clarity of the cornea.
Expectations (prognosis) Return to top
If interstitial keratitis is diagnosed early and treated effectively, the corneal clarity and thus good vision will be preserved.
Complications Return to top
Once corneal clarity is lost, corneal transplantation is required. The recovery is long and arduous, and corneal transplantation is not as successful for interstitial keratitis as it is for most other corneal diseases. The presence of blood vessels in the diseased cornea brings white blood cells to the newly transplanted cornea and increases the risk of rejection.
Calling your health care provider Return to top
All patients with interstitial keratitis will be closely followed by an ophthalmologist and a medical specialist with expertise in the underlying disease. Any worsening pain, increasing redness or decreasing vision should be evaluated immediately. This is particularly crucial for patients with corneal transplants.
Prevention Return to top
Prevention consists of avoidance of the underlying infection, and if infected, receiving prompt and thorough treatment and follow-up.
Update Date: 7/24/2004 Updated by: Edward B. Feinberg, MD, MPH, Professor and Chair, Department of Ophthalmology, Boston University School of Medicine, Boston, MA. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |