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Alternative names Return to top
Renal tubular acidosis - proximal; Type II RTA; RTA - proximal; Renal tubular acidosis type IIDefinition Return to top
The term "renal" refers to the kidney. The kidney contains over a million functional units called nephrons, which filter your blood and produce urine. Normally, a blood buffer called bicarbonate is reabsorbed into the blood in the proximal tubule of each nephron. When it is not reabsorbed properly, your body is left an acidic state (called acidosis).
Causes, incidence, and risk factors Return to top
When healthy, your body is very slightly alkaline. Acidic substances in the body, such as carbon dioxide, are buffered (counteracted) by alkaline substances, primarily bicarbonate. Your kidneys regulate your body's pH by controlling acids and bicarbonate buffer.
An acidic state in your body can be caused by high carbon dioxide levels (respiratory acidosis). It can also be caused by low bicarbonate levels (metabolic acidosis).
Proximal renal tubular acidosis (Type II RTA) is from poor bicarbonate reabsorption by the proximal tubules. This leads to lower bicarbonate buffer in the blood, causing metabolic acidosis.
Type II RTA is less common than classical Type I RTA. It most commonly occurs during infancy, and may spontaneously resolve.
Many different molecular abnormalities can lead to Type II RTA. It can occur in an isolated form or with general problems with the proximal tubule. (See Fanconi's Syndrome.)
People with Type II RTA tend to reabsorb chloride to compensate, and thus have high blood serum chloride levels. They are also low in potassium.
Symptoms Return to top
Signs and tests Return to top
Treatment Return to top
The goal is to restore the normal pH (acid-base level) and a normal electrolyte balance to the body. This will indirectly correct bone disorders and reduce the risk of osteomalacia and osteopenia in adults. Some adults may need no treatment. All children need alkaline medication to prevent bone disease (rickets in particular) and to permit normal growth. The underlying cause should be corrected if it can be identified.
Alkaline medications include sodium bicarbonate and potassium citrate. They correct the acidic condition of the body and correct low potassium levels. Thiazide diuretics may indirectly decrease bicarbonate loss but may exacerbate the low potassium levels.
Vitamin D and calcium supplements may be needed to aid in the reduction of skeletal deformities resulting from osteomalacia or rickets.
Expectations (prognosis) Return to top
Although the cause of proximal renal tubular acidosis may resolve spontaneously, the effects and complications can be permanent or life-threatening. Treatment is usually successful.Complications Return to top
Calling your health care provider Return to top
Call your health care provider if you have symptoms of proximal renal tubular acidosis.
Call your health care provider if new symptoms develop, including pain in the bones, back, flank, or abdomen; skeletal deformities, increased heart rate or irregular heartbeat, muscle cramps, decreased urine output, bloody urine, or other symptoms.
Get medical help immediately if decreased alertness or orientation, decreased consciousness, or seizures develop.
Prevention Return to top
Most of the disorders that cause proximal renal tubular acidosis are not preventable. Update Date: 11/1/2003 Updated by: Irfan A. Agha, M.D., Department of Medicine, Renal Division, St. Louis University, St. Louis, MO. Review provided by VeriMed Healthcare Network.
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Page last updated: 28 October 2004 |