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Beriberi

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Alternative names   

Thiamine deficiency; Vitamin B1 deficiency

Definition    Return to top

Beriberi is a vitamin deficiency disease caused by inadequate bodily stores of thiamine (vitamin B1). It can damage the heart and nervous system.

Causes, incidence, and risk factors    Return to top

There are two major manifestations of thiamine deficiency: cardiovascular disease (wet beriberi) and nervous system disease ("dry beriberi" and Wernicke-Korsakoff syndrome). Both types are most often caused by excessive alcohol consumption.

Symptoms of dry beriberi include pain, tingling, or loss of sensation in hands and feet (peripheral neuropathy), muscle wasting with loss of function or paralysis of the lower extremities, and potential brain damage and death.

Wet beriberi is characterized by swelling, increased heart rate, lung congestion, and enlarged heart related to congestive heart failure.

Beriberi has become rare in the United States because most foods are now vitamin-enriched, which means that a normal diet contains adequate amounts of thiamine.

As a result, beriberi now occurs primarily in patients who abuse alcohol, because drinking heavily can lead to malnutrition and poor absorption and storage of thiamine. This is the cause of Wernicke-Korsakoff syndrome, which is alcohol-related brain damage affecting language and thinking.

Beriberi can also occur in breast-fed infants when the mother has an inadequate intake of thiamine. It can also affect infants fed unusual formulas with inadequate thiamine supplements.

Others at risk for beriberi include patients undergoing dialysis, patients receiving high doses of diuretics, and people in developing countries with limited diets who consume milled rice.

In addition, there is a rare condition known as genetic beriberi. This is an inherited condition in which affected people lose the ability to absorb thiamine from foods. This can happen slowly over time and manifest as an adult. Since beriberi may not be considered in nonalcoholics, this diagnosis is often missed.

Nervous system symptoms are caused by the degeneration of nerve fibers and their insulation (myelin sheath). Heart failure is the most common cause of death in people with beriberi.

Symptoms    Return to top

Early neurologic symptoms include:

Later neurologic symptoms (Wernicke's encephalopathy) include:

If a patient with Wernicke's encephalopathy receives thiamine replacement, language problems, unusual eye movements, and walking difficulties may subside, but may be replaced by Korsakoff's syndrome, which includes memory loss, impaired ability to learn, and confabulation (making up stories to explain behavior that have little relation to reality).

Heart Failure Symptoms:

Signs and tests    Return to top

A physical examination may show signs of congestive heart failure, including symmetrically swollen lower legs, fluid in the lungs, and elevated neck veins with labored breathing, a rapid heartbeat, and an enlarged heart.

The person with late-stage beriberi may be confused or have memory loss and delusions. Neurological examination may show a loss of vibratory sensation (the person is less able to sense vibration), decreased reflexes, loss of coordination, gait changes, nystagmus, drooping of the eyelids, and inability to move the eye outwards.

Tests include:

Treatment    Return to top

Thiamine can be administered by injection and with pills. Patients should also receive therapeutic doses of other water-soluble vitamins.

Expectations (prognosis)    Return to top

Following thiamine treatment, the symptoms should improve rapidly. Cardiac damage is usually reversible and is not permanent. Full recovery is expected. However, if acute heart failure has already occurred, the outlook is poor.

Nervous system damage is also reversible, if caught early. If not, some symptoms (such as memory loss) may not be completely recovered with treatment.

Untreated, beriberi is often fatal.

Complications    Return to top

Calling your health care provider    Return to top

Beriberi is extremely rare in the United States. However, if you feel your family's diet is inadequate or poorly balanced and you or your children have any of the described symptoms, call your health care provider.

Prevention    Return to top

Adequate intake of thiamine will prevent beriberi. Nursing mothers should make sure that their diet is adequate in all vitamins and be sure that infant formulas contain thiamine. People who drink heavily should try to cut down or quit and supplement their diets with B-vitamins to ensure appropriate intake of thiamine.

Update Date: 8/17/2004

Updated by: Specific sections updated by Jacqueline A. Hart, M.D., Senior Medical Editor, A.D.A.M., Inc. Previously reviewed by Sreeni Jonnalagadda, M.D., Interventional and Pancreatobiliary Endoscopy, Washington University School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network (2/12/2004).

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