Research Type	Secondary Focus Area	Tertiary Focus Area	Project Number	Project Title
Brain & Nervous System
Mechanistic			DoD-92	Traumatic Experiences Persistently Enhance Cue-dependent Learning: Toward an Animal Model of Chronic Stress and Posttraumatic Stress Disorder
Epidemiology Research	Symptoms/General Health		DoD-23	Acute and Long-Term Impact of Deployment to Southwest Asia on the Physical and Mental Health of Soldiers and their Families
Epidemiology Research	Symptoms/General Health		DoD-52	Female Gender and Other Potential Predictors of Functional Health Status Among Persian Gulf War Veterans
Epidemiology Research			DoD-82	Feasibility of Developing a Registry of PTSD Affected Veteran Sib Pairs
Clinical Research	Prevention		DoD-83	Risk for Stress-related Substance Abuse: the Effects of Family History of Alcoholism
Clinical Research	Symptoms/General Health		DoD-84	Psychobiologic Alterations in Persian Gulf War Veterans with and without PTSD
Clinical Research	Treatment	Symptoms/ General Health	DoD-85	CNS Cytokines and CRH in Gulf War Veterans with Multiple Unexplained Symptoms
Clinical Research			DoD-86	Effects of Combat Stress on Structure and Function of the Hippocampus
Epidemiology Research	Prevention		DoD-87	Measurement and Validation of Psychosocial Risk and Resilience Factors Accounting for Physical and Mental Health and Health-Related Quality of Life among PGWVs
Clinical Research	Symptoms/General Health		DoD-89	Limbic Blood Flow and Opiate Receptor PET in Posttraumatic Stress Disorder
Clinical Research			VA-20	Psychological Adjustment in Operation Desert Shield/Storm Veterans
Mechanistic			DoD-91	Neurological and Circadian Substrates of PTSD-like Behaviors
Mechanistic			DoD-80	Molecular Regulation of corticosteroid Receptor Expression in stress-Responsive Cells
Clinical Research	Symptoms/General Health		VA-54	Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress
Clinical Research			VA-12	Psychological Assessment of Operation Desert Storm Returnees
Clinical Research	Symptoms/General Health		VA-7	Desert Storm Reunion Survey
Clinical Research	Symptoms/General Health		VA-4A	Evaluation of Cognitive Functioning of Persian Gulf Veterans
Clinical Research	Symptoms/General Health		VA-4B	Evaluation of Neurological Functioning in Persian Gulf Veterans
Clinical Research	Symptoms/General Health		VA-10	Memory and Attention in PTSD
Clinical Research	Symptoms/General Health		VA-6A	Psychosocial, Neuropsychological and Neurobehavioral Assessment (Project I)
Clinical Research	Diagnosis		VA-4F	Validity of Computerized Tests
Clinical Research			VA-21	A Comparison of PTSD Symptomatology among Three Army Medical Units Involved in ODS
Clinical Research			VA-13	Neurobehavioral Aspects of Persian Gulf Experiences: A Pilot Study
Clinical Research	Treatment		DoD-90	SPECT Benzodiazepine Receptor and MR Imaging in PTSD
Clinical Research			VA-50	Neuropsychological findings in a sample of Operation Desert Storm veterans
Epidemiology Research			VA-36	Stress Symptoms and Their Causal Attribution in Desert Storm Veterans
Clinical Research	Chemical Weapons		DoD-63	PGW Veterans: Epidemiological and Clinical Evidence for Residual Organophosphate Neurotoxicity
Clinical Research	Symptoms/General Health		DoD-41	Evaluation of Muscle Function in Persian Gulf Veterans
Clinical Research	Symptoms/General Health		DoD-40	Psychological and Neurobiological Consequences of the Gulf War Experience
Clinical Research	Symptoms/General Health		DoD-36	Fatigue in Persian Gulf Syndrome-Physiologic Mechanisms
Clinical Research	Symptoms/General Health	Diagnosis	DoD-67	Antibacterial Treatment method based upon the excretion of dead and decaying spherical bacteria
Clinical Research	Symptoms/General Health		VA-51	Psychobiological Assessment of Desert Storm Veterans
Clinical Research	Diagnosis		DoD-32	Neuropsychological Functioning in Persian Gulf Era Veterans
Clinical Research	Symptoms/General Health	Diagnosis	DoD-31	Dysregulation of the Stress Response in the Persian Gulf Syndrome
Clinical Research	Symptoms/General Health		VA-11	Neuropsychological Functioning in Veterans
Clinical Research	Symptoms/General Health		VA-9	Evaluation of Cognitive Functioning in Persian Gulf War Veterans Reporting War-related Health Problems
Mechanistic	Treatment		DoD-6A	Combat Stress Pharmacotherapy
Clinical Research	Diagnosis	Prevention	DoD-6B	Combat Stress Diagnosis, PTSD Prevention
Clinical Research	Symptoms/General Health		HHS-5	Cognitive Function and Symptom Patterns in Persian Gulf Veterans
Chemical Weapons
Clinical Research	Diagnosis		VA-47	Retrospective Verification of Mustard Gas Exposure
Mechanistic	Prevention		DoD-51	Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses
Mechanistic			DoD-50	Toxicokinetics of 0-Ethyl S-(2-Diisopropylaminoethyl) Methylphosphonothioate [(+)-VX] in Rats, Hairless Guinea Pigs and Marmosets - Identification of Metabolic Pathways
Mechanistic	Brain & Nervous System		DoD-53	Long-Term Effects of Subclinical Exposures to Sarin
Mechanistic	Diagnosis		VA-6D	DNA Damage from Chemical Agents and Its Repair (Project IV)
Epidemiology Research			VA/DoD-2DA**	Follow-Up investigation of troops exposed to nerve agents at Aberdeen Proving Ground
Clinical Research	Pyridostigmine Bromide	Prevention	DoD-60	Butyrylcholinesterase Genetic Variants in Persons with Gulf War Illness
Development	Diagnosis		DoD-49	Diagnosis and Dosimetry of Exposure to Sulfur Mustard: Development of Standard Operating Procedures and Exploratory Research on Protein Adducts
Epidemiology Research	Symptoms/General Health		DoD-69	Five Year Follow-Up of arm Personnel Exposed to Chemical Warfare Agents
Depleted Uranium
Mechanistic	Environmental Toxicology		DoD-7B	Carcinogenicity of Depleted Uranium Fragments
Mechanistic	Environmental Toxicology		DoD-7A	Health Risk Assessment of Embedded Depleted Uranium: Behavior, Physiology, Histology, and Biokinetic Modeling
Diagnosis
Clinical Research			DoD-47	Study of Mycoplasmal Infections in Gulf War Veterans
Clinical Research	Symptoms/General Health		HHS-6	Defining Gulf War Illness
Development			DoD-66	Testing for mycoplasmal infection replicability of nucleoprotein gene tracking and forensic polymerase chain reaction
Development			DoD-12	Forward Deployable Diagnostics for Infectious Diseases
Environmental Toxicology
Mechanistic	Prevention		VA-4E	The Aromatic Hydrocarbon Receptor (AhR) as a Biomarker of Susceptibility
Clinical Research	Symptoms/General Health		VA-4D	Evaluation of Respiratory Dysfunction Among Gulf War Veterans
Clinical Research	Brain & Nervous System	Interactions	VA-48	Cross-Sensitization as a CNS Model for Gulf War Chemical Intolerance
Epidemiology Research			VA-4C	Gulf War And Vietnam Veterans Cancer Incidence Surveillance
Development			DoD-16	Kuwait Oil Fire Health Risk Assessment
Development	Interactions		DoD-34	Characterization of Emissions from Heaters Burning Leaded Diesel Fuel in Unvented Tents
Development			DoD-19	Persian Gulf Veterans Health Tracking System
Development			DoD-18	Kuwait Oil Fires Troop Exposure Assessment Model (TEAM)
Epidemiology Research			DoD-13	Effects of Persian Gulf War Service on Military Working Dogs
Mechanistic	Brain & Nervous System	Chemical Weapons	DoD-22	Chronic Organophosphorous Exposure and Cognition
Mechanistic	Prevention		HHS-3	Biomarkers of Susceptibility and Polycyclic Aromatic Hydrocarbon (PAH) Exposure in Urine and blood Cell DNA from U.S. Army Soldiers Exposed to Kuwaiti Oil Well Fires
Immune Function
Mechanistic	Interactions	Environmental Toxicology	HHS-7	Immunotoxicity of Dermal Permethrinand Cis-Urocanic Acid
Clinical Research	Brain & Nervous System		DoD-88	Clinical Relevance of novel Immunological Markers in PTSD
Clinical Research	Symptoms/General Health		VA-17	Immunological Evaluation of Persian Gulf Veterans
Clinical Research	Symptoms/General Health		VA-6B	Clinical and Neuroendocrine Aspects of Fibromyalgia (Project II)
Clinical Research			DoD-48	Assessment of Genomic Instability via Chromosome 7 Inversion Frequency in a Gulf-War Syndrome Cohort vs Selected Control Groups
Clinical Research	Symptoms/General Health	Environmental Toxicology	VA-5C	Effects of Exertion and Chemical Stress on Persian Gulf Veterans
Clinical Research	Brain & Nervous System		VA-5B	Physiological and Psychological Assessments of Persian Gulf Veterans
Interactions
Mechanistic	Pyridostigmine Bromide	Brain & Nervous System	DoD-75	Toxic Interactions of Prophylactic Drugs and Pesticides
Mechanistic	Chemical Weapons	Brain & Nervous System	DoD-72	Long-term Effects of Subchronic Exposure to Sarin, Alone and with Stress or Other Chemicals
Mechanistic	Immune Function	Pyridostigmine Bromide	DoD-81	Immunotoxicity due to Coexposure to DEET, Pyridostigmine, and Stress
Mechanistic	Chemical Weapons	Brain & Nervous System	DoD-78	Experimental Models of Gulf War Syndrome
Mechanistic	Pyridostigmine Bromide	Brain & Nervous System	DoD-2	Physiological and Neurobehavioral Effects in Rodents from Exposure to Pyridostigmine, Fuels, and DEET
Mechanistic	Pyridostigmine Bromide	Immune Function	DoD-76	Evaluations of Immunotoxicity due to Concurrent Exposure to DEET, Pyridostigmine, and JP-8 Jet Fuel
Mechanistic	Chemical Weapons	Pyridostigmine Bromide	DoD-62	Sarin and Pyridostigmine Interaction under Physical Stress: Neurotoxic Effects in Mice
Development	Environmental Toxicology		HHS-8	Strategy to Identify Non-Additive Response to Chemical Mixtures
Mechanistic	Pyridostigmine Bromide	Brain & Nervous System	DoD-37	Neurobehavioral and Immunological Toxicity of Pyridostigmine, Permethrin, and DEET in Male and Female Rats
Mechanistic	Pyridostigmine Bromide		DoD-77	Percutaneous Absorption of Chemical Mixtures Relevant to the Gulf War
Mechanistic	Chemical Weapons	Pyridostigmine Bromide	DoD-61	Neurophysiologic and Neuropathologic Effects in Monkeys of Low Level Exposures to Sarin, Pyridostigmine, Pesticides, and Botulinum Toxoid
Mechanistic	Chemical Weapons	Pyridostigmine Bromide	DoD-56	Low-Level Sarin Neurotoxicity and Its Modulation by Pyridostigmine
Mechanistic	Brain & Nervous System	Chemical Weapons	DoD-54	Assessment of Subchronic Neurobehavioral and Neuropathologic Effects in Rats
Mechanistic	Chemical Weapons	Pyridostigmine Bromide	DoD-55	Low-Level Exposure to GB Vapor in Air: Diagnosis/Dosimetry, Lowest Observable Effect Levels, Performance-Incapacitation, and Possible Delayed Effects
Leishmaniasis
Mechanistic	Prevention		VA-15	Vaccine-Mediated Immunity Against Leishmaniasis
Development	Diagnosis		DoD-8B	Development of a Leishmania Skin Test Antigen (LSTA)
Clinical Research	Diagnosis	Treatment	VA-6E	Clinical and Epidemiology Leishmania Research
Mechanistic	Treatment		DoD-9	Identification of the Genetic Factors Which Control Tropism in Leishmania
Mechanistic	Prevention		VA-16	Protective Immunity in Experimental Visceral Leishmaniasis
Development	Diagnosis		DoD-38	Diagnostic Antigens of Leishmania tropica
Development	Diagnosis		DoD-8A	Serologic Diagnosis of Viscerotropic Leishmaniasis (VTL)
Mortality
Epidemiology Research			VA-1	Mortality Follow-up Study of Persian Gulf Veterans, First Update
Epidemiology Research			DoD-15	Comparative Mortality Among US Military Personnel Worldwide During Operations Desert Shield and Desert Storm
Pyridostigmine Bromide
Mechanistic	Environmental Toxicology		VA-6C	Neurotoxicity of Environmental Pollutants and Warfare Agents (Project III)
Epidemiology Research			DoD-17	Retrospective Studies Involving Military Use of Pyridostigmine as a Pretreatment for Nerve Agent Poisoning
Clinical Research	Brain & Nervous System	Prevention	DoD-64	Individual Differences in Neurobehavioral Effects of Pyridostigmine
Mechanistic	Prevention		DoD-33	Effects of Pyridostigmine in Flinders Line Rats Differing in Cholinergic Sensitivity
Mechanistic	Interactions		DoD-10	Pyridostigmine Synergistic Toxicity Study
Clinical Research			DoD-11	Male/Female Differential Tolerances to Pyridostigmine Bromide
Epidemiology Research	Prevention		DoD-21	Study of Variability In Pyridostigmine Inhibition of Blood Cholinesterases in Healthy Adults and Individuals With Symptoms Following Participation in Operation Desert Storm
Mechanistic	Brain & Nervous System		DoD-59	Pyridostigmine-induced Neurodegeneration: Role of neuronal Apoptosis
Mechanistic	Brain & Nervous System		DoD-79	Time Course of Stress-induced Impairment of Blood Brain Barrier
Mechanistic	Brain & Nervous System		VA-49	Sensitivity to Pyridostigmine Bromide: Persistent Neural Dysfunction
Mechanistic	Interactions		VA-5D	Effects of Genetics and Stress on Responses to Environmental Toxins
Reproductive Health
Epidemiology Research			HHS-4	Suspected Increase of Birth Defects and health Problems Among Children Born to Persian Gulf War Veterans in Mississippi
Epidemiology Research			DoD-1C	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 3: A comparative study of pregnancy outcomes among Gulf War veterans and other active-duty personnel
Epidemiology Research			DoD-1G	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 7: Prevalence of Congenital Anomalies Among Children of Persian Gulf War Veterans
Epidemiology Research			DoD-1D	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 4: Adverse Reproductive Outcomes in Gulf War Veterans
Epidemiology Research			DoD-35	Feasibility of Investigating Whether There is a Relationship Between Birth Defects and Service in the Gulf War.
Clinical Research	Symptoms/General Health	Immunology	DoD-44	Investigation of Seminal Plasma Hypersensitivity Reactions
Symptoms/General Health
Epidemiology Research	Diagnosis		HHS-2	Disease Cluster in a Pennsylvania Air National Guard Unit, EPI-AID 95-18
Epidemiology Research	Reproductive Health		DoD-30	Epidemiological Studies Persian Gulf War Illnesses, PG Women's Health Linkage Study
Epidemiology Research			DoD-46	Exploratory Data Analysis with the CCEP Database
Clinical Research	Brain & Nervous System		DoD-58	Illness Among Persian Gulf War Veterans: Case Validation Studies
Clinical Research	Brain & Nervous System		DoD-57	Physiologic Effects of Stress in Gulf War Veterans
Clinical Research	Immunology	Brain & Nervous System	DoD-42	The Symptomatic Persian Gulf Veterans Protocol: An Analysis of Risk Factors with an Immunologic and Neuropsychiatric Assessment
Clinical Research	Brain & Nervous System	Reproductive Health	DoD-45	Physical and Emotional Health of Gulf War Veterans Women
Clinical Research	Brain & Nervous System		VA-4Core	Boston Environmental Hazards Research Center Program
Clinical Research			VA-40	Musculoskeletal Symptoms in Gulf War Syndrome
Epidemiology Research			VA-46	Diarrhea in Persian Gulf Veterans: An Irritable Bowel-Like Disorder
Epidemiology Research			DoD-39	A Controlled Epidemiological and Clinical Study into the Effect of Gulf War Service on Servicemen and Women of the United Kingdom Armed Forces
Epidemiology Research			DoD-74	Relationship of Stress Exposures to Health in Gulf War Veterans
Clinical Research	Brain & Nervous System		VA-8	Psychological Test Data of Gulf War Veterans Over Time
Epidemiology Research			VA-5A	Health and Exposure Survey of Persian Gulf Veterans
Epidemiology Research			VA-6Core	Core Program: Portland Environmental Hazards Research Center: Environment, Veterans Health and the Gulf War Syndrome.
Epidemiology Research			HHS-1	Health Assessment of Persian Gulf War Veterans from Iowa
Clinical Research			DoD-1A	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 1: A Study of Symptoms Among 1500 Seabees
Epidemiology Research			DoD-1B	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 2: A comparative study of hospitalizations among Active-duty personnel who participated in the Gulf War and similar personnel who did not.
Clinical Research	Brain & Nervous System		VA-5Core	East Orange Environmental Hazards Research Center Program
Epidemiology Research			DoD-1E	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study 5: Seabee Health Study.
Epidemiology Research			DoD-1F	Epidemiologic Studies of Morbidity Among Gulf War Veterans: A Search for Etiologic Agents and Risk Factors; Study6: A Comparison of Nonfederal Hospitalization Experience Among Veterans in California who have separated from active service: PGW vs EV.
Epidemiology Research			DoD-14	Risk Factors Among US Army Soldiers for Enrolling on the Department of Veterans Affairs Gulf War Registry
Epidemiology Research			DoD-71	A Comparison of Post Deployment Hospitalization Between Vietnam and Gulf War Veterans
Epidemiology Research			DoD-4	The General Well-Being of Gulf War Era Service Personnel from the States of Pennsylvania and Hawaii: A Survey
Epidemiology Research			VA/DoD-2DB**	Patterns of Pre-Persian Gulf War Illness and Health Care Seeking, Pilot Study
Epidemiology Research			VA-2	National Health Survey of Persian Gulf Veterans
Epidemiology Research			DoD-73	Post-deployment Morbid Stress, Behavior and Health: Developing a Model for Predicting Morbidity, Mortality, and other Adverse Outcomes
Clinical Research			VA-18	Chronic Gastrointestinal Illness in Persian Gulf Veterans
Epidemiology Research			DoD-70	War Syndromes from 1900 to the Present: Symptom Patterns and Long-term Health Outcomes
Epidemiology Research			VA-2A	VA National Survey of Persian Gulf Veterans - Phase I
Epidemiology Research			VA-2B	VA National Survey of Persian Gulf Veterans - Phase II
Epidemiology Research	Brain & Nervous System	Diagnosis	VA-2C	VA National Survey of Persian Gulf Veterans - Phase III
Epidemiology Research			VA-3	Use of Roster of Veterans Who Served in Persian Gulf Area
Epidemiology Research			VA/DoD-2VB**	Patterns of Pre-Persian Gulf War Illness and Health Care Seeking, Pilot Study
Epidemiology Research			DoD-20	A Statistical Study Correlating the Reported Cases of Gulf War Syndrome to Battlefield Locations of Afflicted US Army Personnel During the Iraq-Kuwait War; Part 1: Method to Related Troop Deployment and the Reported Cases of Gulf War Syndrome and Probable Incidence of Maladies Defined by ICD-9-CM
Treatment
Clinical Research	General Health		VA-55	Antibiotic Treatment of Gulf War Veterans' Illnesses
Clinical Research			DoD-65	Multi-disciplinary Pathophysiologic studies of neurotoxic Gulf War related syndromes leading to diagnosis and treatment
Clinical Research	Symptoms/General Health		VA/DoD-1D**	A Randomized, Multi-Center, Controlled Trial of Multi-Modal Therapy in Veterans with Gulf War Illnesses
Clinical Research	Symptoms/General Health		VA/DoD-1V**	A Randomized, Multi-Center, Controlled Trial of Multi-Modal Therapy in Veterans with Gulf War Illnesses