MedlinePlus Drug Information: Ifosfamide

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Other drug names:	A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9

Ifosfamide

(eye fos' fa mide)

Brand name(s): Ifex
Other name(s): Isophosphamide

Contents of this page:
About your treatment Other uses for this medicine Precautions	Side effects In case of emergency/overdose Special instructions

IMPORTANT WARNING:

Ifosfamide can cause serious urinary side effects. You will be given mesna, a medication to prevent urinary side effects, and be required to either drink liquids or receive hydration intravenously. Follow all directions carefully.Ifosfamide can cause a decrease in the number of blood cells in your bone marrow. Your doctor will order tests before, during, and after your treatment to see if your blood cells are affected by this drug.

About your treatment

Your doctor has ordered the drug ifosfamide to help treat your illness. The drug is given by injection into a vein.

This medication is used to treat:

germ cell testicular cancer
bone and soft tissue sarcomas

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Ifosfamide is in a class of drugs known as alkylating agents; it slows or stops the growth of cancer cells in your body. The length of treatment depends on the types of drugs you are taking, how well your body responds to them, and the type of cancer you have.

Other uses for this medicine

Ifosfamide also is used to treat lung cancer, cervical cancer, and ovarian cancer. Talk to your doctor about the possible risks of using this drug for your condition.

Precautions

Before taking ifosfamide,

tell your doctor and pharmacist if you are allergic to ifosfamide or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially aspirin and vitamins.
tell your doctor if you have or have ever had kidney disease.
you should know that ifosfamide may interfere with the normal menstrual cycle (period) in women and may stop sperm production in men. However, you should not assume that you cannot get pregnant or that you cannot get someone else pregnant. Women who are pregnant or breast-feeding should tell their doctors before they begin taking this drug. You should not plan to have children while receiving chemotherapy or for a while after treatments. (Talk to your doctor for further details.) Use a reliable method of birth control to prevent pregnancy. Ifosfamide may harm the fetus.
while being treated with ifosfamide, drink plenty of fluids because this drug can irritate your kidneys and bladder. This precaution is especially important if you have had chemotherapy before.
do not have any vaccinations (e.g., measles or flu shots) without talking to your doctor.

Side effects

Side effects from ifosfamide are common and include:

thinned or brittle hair
darkened and thickened skin

Tell your doctor if the following symptom is severe or lasts for several hours:

fatigue

If you experience any of the following symptoms, call your doctor immediately:

painful urination or red urine
black, tarry stools
unusual bruising or bleeding
cough
congestion
fever
dizziness
chills
shortness of breath
sore throat
nausea and vomiting
rash
agitation, confusion, or hallucinations

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

Special instructions

Drink plenty of fluids. Drink about 10 eight-ounce glasses of fluid and urinate frequently during the first 24 hours after treatment to keep your kidneys working.

Last Revised - 01/01/2003

American Society of Health-System Pharmacists, Inc. Disclaimer