MedlinePlus Drug Information: Indinavir

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Indinavir

(in din' a veer)

Brand name(s): Crixivan

Contents of this page:
Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow?	What should I do if I forget a dose? What side effects can this medication cause? What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know?

Why is this medication prescribed?

Indinavir is used to treat human immunodeficiency virus (HIV) infection in adults. It belongs to a class of drugs called protease (pro' tee ace) inhibitors, which slow the spread of HIV infection in the body. It is usually taken with other antiviral medications. Indinavir is not a cure and may not decrease the number of HIV-related illnesses. Indinavir does not prevent the spread of HIV to other people.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Indinavir comes as a capsule to take by mouth. It is usually taken every 8 hours (three times a day). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take indinavir exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Continue to take indinavir even if you feel well. Do not stop taking indinavir without talking to your doctor.

Other uses for this medicine

Indinavir is also used in combination with zidovudine (Retrovir, AZT) and lamivudine (Epivir) to treat health-care workers and other individuals exposed to HIV infection after accidental contact with HIV-contaminated blood, tissues, or other body fluids. Talk to your doctor about the possible risks of using this drug for your condition.

What special precautions should I follow?

Before taking indinavir,

tell your doctor and pharmacist if you are allergic to indinavir or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially astemizole (Hismanal), atorvastatin (Lipitor), cerivastatin (Baycol), cisapride (Propulsid), clarithromycin (Biaxin), delavirdine (Rescriptor), dexamethasone (Decadron), efavirenz (Sustiva), fluconazole (Diflucan), isoniazid (INH), itraconazole (Sporanox), ketoconazole (Nizoral), lovastatin (Mevacor), medications for seizures, midazolam (Versed), oral contraceptives, quinidine, rifabutin (Mycobutin), rifampin (Rifadin), sildenafil (Viagra), simvastatin (Zocor), terfenadine (Seldane), and triazolam (Halcion).
tell your doctor what vitamins and herbal products you are taking, especially St. John's wort.
if you are taking didanosine, take it at least one hour before or after indinavir.
tell your doctor if you have or have ever had hemophilia or kidney or liver disease or a history of alcohol abuse.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking indinavir, call your doctor.
tell your doctor if you drink alcohol.

What special dietary instructions should I follow?

Take indinavir on an empty stomach, 1 hour before meals or 2 hours after meals, with plenty of fluids (an 8-ounce glass of water). However, if indinavir upsets your stomach, it may be taken with a light meal, such as dry toast or cornflakes with skim milk. Do not take with grapefruit juice. If you are also taking didanosine (DDI), take 1 hour apart on an empty stomach.

Drink at least 48 ounces (six 8-ounce glasses) of water or other liquids every 24 hours.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Side effects from indinavir are common. Tell your doctor if any of these symptoms are severe or do not go away:

headache
stomach pain
change in the distribution of body fat

If you experience any of the following symptoms, call your doctor immediately:

rash
back pain
pain in the side of your body
blood in urine
muscle pain
upset stomach
excessive tiredness
unusual bleeding or bruising
loss of appetite
pain in the upper right part of your stomach
flu-like symptoms
dark yellow or brown urine
yellowing of the skin or eyes
paleness

Indinavir may increase the sugar level in your blood. If you experience any of the following symptoms, call your doctor immediately:

frequent urination
increased thirst
weakness
dizziness
headache

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. A desiccant (drying agent) is included with your capsules; keep this in your medicine bottle at all times. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to indinavir.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Last Revised - 01/01/2003

American Society of Health-System Pharmacists, Inc. Disclaimer