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Phenothiazines  (Systemic)

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Brand Names

Some commonly used brand names are:

In the U.S.—

  • Chlorpromazine Hydrochloride Intensol1
  • Compazine8
  • Compazine Spansule8
  • Mellaril11
  • Mellaril Concentrate11
  • Mellaril-S11
  • Permitil2
  • Permitil Concentrate2
  • Prolixin2
  • Prolixin Concentrate2
  • Prolixin Decanoate2
  • Prolixin Enanthate2
  • Serentil3
  • Serentil Concentrate3
  • Stelazine12
  • Stelazine Concentrate12
  • Thorazine1
  • Thorazine Spansule1
  • Trilafon6
  • Trilafon Concentrate6
  • Vesprin13

In Canada—

  • Apo-Fluphenazine2
  • Apo-Perphenazine6
  • Apo-Thioridazine11
  • Apo-Trifluoperazine12
  • Chlorpromanyl-201
  • Chlorpromanyl-401
  • Largactil1
  • Largactil Liquid1
  • Largactil Oral Drops1
  • Majeptil10
  • Mellaril11
  • Modecate2
  • Modecate Concentrate2
  • Moditen Enanthate2
  • Moditen HCl2
  • Neuleptil5
  • Novo-Chlorpromazine1
  • Novo-Trifluzine12
  • Novo-Ridazine11
  • Nozinan4
  • Nozinan Liquid4
  • Nozinan Oral Drops4
  • Nu-Prochlor8
  • Piportil L 4 7
  • PMS Fluphenazine2
  • PMS Perphenazine6
  • PMS Prochlorperazine8
  • PMS Thioridazine11
  • PMS Trifluoperazine12
  • Serentil3
  • Stelazine12
  • Stemetil8
  • Stemetil Liquid8

Note:

For quick reference, the following phenothiazines are numbered to match the corresponding brand names.
This information applies to the following medicines:
1.  Chlorpromazine (klor-PROE-ma-zeen)
2.  Fluphenazine (floo-FEN-a-zeen)
3.  Mesoridazine (mez-oh-RID-a-zeen)
4.  Methotrimeprazine (meth-oh-trye-MEP-ra-zeen)*
5.  Pericyazine (pair-ee-SYE-a-zeen)*
6.  Perphenazine (per-FEN-a-zeen)
7.  Pipotiazine (pip-oh-TYE-a-zeen)*
8.  Prochlorperazine (proe-klor-PAIR-a-zeen)
9.  Promazine (PROE-ma-zeen)§*
10.  Thioproperazine (thye-oh-proe-PAIR-a-zeen)*
11.  Thioridazine (thye-oh-RID-a-zeen)
12.  Trifluoperazine (trye-floo-oh-PAIR-a-zeen)
13.  Triflupromazine (trye-floo-PROE-ma-zeen)
‡  Generic name product may be available in the U.S.
§  Generic name product may be available in Canada
*  Not commercially available in the U.S.
†  Not commercially available in Canada

Category


Description

Phenothiazines (FEE-noe-THYE-a-zeens) are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.

Phenothiazines are available only with your doctor's prescription in the following dosage forms:



Before Using This Medicine

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For phenothiazines, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to phenothiazines. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes. Some of the phenothiazine dosage forms contain parabens, sulfites, or tartrazine.

Pregnancy—Although studies have not been done in pregnant women, some side effects, such as jaundice and movement disorders, have occurred in a few newborns whose mothers received phenothiazines during pregnancy. Studies in animals have shown that, when given to the mother during pregnancy, these medicines can decrease the number of successful pregnancies and cause problems with bone development in the offspring. Before taking this medicine, make sure your doctor knows if you are pregnant or if you may become pregnant.

Breast-feeding—Phenothiazines pass into breast milk and may cause drowsiness or unusual muscle movements in the nursing baby. It may be necessary for you to take a different medicine or to stop breast-feeding during treatment. Be sure you have discussed the risks and benefits of the medicine with your doctor.

Children—Certain side effects, such as muscle spasms of the face, neck, and back, tic-like or twitching movements, inability to move the eyes, twisting of the body, or weakness of the arms and legs, are more likely to occur in children, especially those with severe illness or dehydration. Children are usually more sensitive than adults to the effects of phenothiazines.

Older adults—Constipation, trouble urinating, dryness of mouth, confusion, problems with memory, dizziness or fainting, drowsiness, trembling of the hands and fingers, and problems with muscle movement, such as decreased or unusual movements, are especially likely to occur in elderly patients, who are usually more sensitive than younger adults to the effects of phenothiazines.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking phenothiazines, it is especially important that your health care professional know if you are taking any of the following:

Other medical problems—The presence of other medical problems may affect the use of phenothiazines. Make sure you tell your doctor if you have any other medical problems, especially:


Proper Use of This Medicine

For patients taking this medicine by mouth:

For patients using the suppository form of this medicine:

Do not take more or less of this medicine and do not take it more or less often than your doctor ordered. Not taking more than your doctor ordered is particularly important for children or elderly patients, since they may react very strongly to this medicine.

This medicine must be taken for several weeks before its full effect is reached when it is used to treat mental and emotional conditions .

Dosing—

The dose of phenothiazines will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of phenothiazines. If your dose is different, do not change it unless your doctor tells you to do so.

The number of capsules, tablets, or teaspoonfuls of elixir, solution, suspension, or syrup that you take, or the number of injections you receive or suppositories that you use, depends on the strength of the medicine. Also, the number of doses you use each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are taking phenothiazines.

Missed dose—

If you miss a dose of this medicine and your dosing schedule is:

If you have any questions about this, check with your doctor.

Storage—

To store this medicine:


Precautions While Using This Medicine

Your doctor should check your progress at regular visits, especially during the first few months of treatment with this medicine. This will allow your dosage to be changed if necessary to meet your needs.

Do not stop taking this medicine without first checking with your doctor. Your doctor may want you to reduce gradually the amount you are taking before stopping completely. This is to prevent side effects and to keep your condition from becoming worse.

Do not take this medicine within 2 hours of taking antacids or medicine for diarrhea. Taking these products too close together may make this medicine less effective.

This medicine will add to the effects of alcohol and other central nervous system (CNS) depressants (medicines that slow down the nervous system, possibly causing drowsiness). Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; or anesthetics, including some dental anesthetics. Check with your doctor before taking any of the above while you are using this medicine.

Before using any prescription or over-the-counter (OTC) medicine for colds or allergies, check with your doctor. These medicines may increase the chance of developing heatstroke or other unwanted effects, such as dizziness, dry mouth, blurred vision, and constipation, while you are taking a phenothiazine.

Before you have any medical tests, tell the medical doctor in charge that you are taking this medicine. The results of some tests (such as electrocardiogram [ECG or EKG] readings, the gonadorelin test, the metyrapone test, tests for phenylketonurea, and urine bilirubin tests) may be affected by this medicine.

Before having any kind of surgery, dental treatment, or emergency treatment, tell the medical doctor or dentist in charge that you are using this medicine. Taking phenothiazines together with medicines that are used during surgery, dental treatments, or emergency treatments may increase CNS depression or cause low blood pressure.

This medicine may cause some people to become drowsy or less alert than they are normally. Even if this medicine is taken only at bedtime, it may cause some people to feel drowsy or less alert on arising. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.

Phenothiazines may cause blurred vision, difficulty in reading, or other changes in vision, especially during the first few weeks of treatment. Do not drive, use machines, or do anything else that could be dangerous if you are not able to see well. If the problem continues or gets worse, check with your doctor.

Dizziness, lightheadedness, or fainting may occur, especially when you get up from a lying or sitting position. Getting up slowly may help. If the problem continues or gets worse, check with your doctor.

This medicine may make you sweat less, causing your body temperature to increase. Use extra care not to become overheated during exercise or hot weather while you are taking this medicine, since overheating may result in heatstroke. Also, hot baths or saunas may make you feel dizzy or faint while you are taking this medicine.

This medicine also may make you more sensitive to cold temperatures. Dress warmly during cold weather. Be careful during prolonged exposure to cold, such as in winter sports or swimming in cold water.

Phenothiazines may cause dryness of the mouth. For temporary relief, use sugarless candy or gum, melt bits of ice in your mouth, or use a saliva substitute. However, if your mouth continues to feel dry for more than 2 weeks, check with your medical doctor or dentist. Continuing dryness of the mouth may increase the chance of dental disease, including tooth decay, gum disease, and fungus infections.

Phenothiazines may cause your skin to be more sensitive to sunlight than it is normally. Exposure to sunlight, even for brief periods of time, may cause a skin rash, itching, redness or other discoloration of the skin, or a severe sunburn. When you begin taking this medicine:

If you have a severe reaction from the sun, check with your doctor.

Phenothiazines may cause your eyes to be more sensitive to sunlight than they are normally. Exposure to sunlight over a period of time (several months to years) may cause blurred vision, change in color vision, or difficulty in seeing at night. When you go out during the daylight hours, even on cloudy days, wear sunglasses that block ultraviolet (UV) light. Ordinary sunglasses may not protect your eyes. If you have any questions about the kind of sunglasses to wear, check with your medical doctor or eye doctor.

If you are taking a liquid form of this medicine, avoid getting it on your skin or clothing because it may cause a skin rash or other irritation.

If you are receiving this medicine by injection:


Side Effects of This Medicine

Side Effects of This Medicine

Along with their needed effects, phenothiazines can sometimes cause serious unwanted effects. Tardive dyskinesia or tardive dystonia (muscle movement disorders) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia or tardive dystonia include worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, body, arms, or legs. Another possible serious unwanted effect is the neuroleptic malignant syndrome (NMS). Signs and symptoms of NMS include severe muscle stiffness, fever, fast heartbeat, difficult breathing, increased sweating, and loss of bladder control. You and your doctor should discuss the good this medicine will do as well as the risks of taking it.

Stop taking this medicine and check with your doctor immediately if any of the following side effects occur:

Check with your doctor immediately if any of the following side effects occur:

Also, check with your doctor as soon as possible if any of the following side effects occur:

Phenothiazines may cause your urine to be dark. In most cases, this is not a sign of a serious problem. However, if your urine does become dark, discuss it with your doctor.

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this time, check with your doctor if you notice dizziness, nausea and vomiting, stomach pain, trembling of the fingers and hands, or any of the following signs of tardive dyskinesia or tardive dystonia:


Although not all of the side effects listed above have been reported for all of the phenothiazines, they have been reported for at least one of them. However, since all of the phenothiazines are very similar, any of the above side effects may occur with any of these medicines.

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.


Additional Information

Once a medicine has been approved for marketing for a certain use, experience may show that it also is useful for other medical problems. Although these uses are not included in product labeling, phenothiazines are used in certain patients with the following medical conditions:

Other than the above information, there is no additional information relating to proper use, precautions, or side effects for these uses.

Revised: 12/18/2003

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Copyright© 2003 Thomson MICROMEDEX. All rights reserved. USP DI® and Advice for the Patient® are registered trademarks of USP used under license to Micromedex, a business of Thomson Healthcare Inc. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.