MedlinePlus Drug Information: Lansoprazole/clarithromycin/amoxicillin

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Other drug names:	A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9

Lansoprazole/clarithromycin/amoxicillin

(lan soe' pra zole) (kla rith' roe mye sin) (a mox i sil' in)

Brand name(s): Prevpac

Contents of this page:
Why is this medication prescribed? How should this medicine be used? What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?	What side effects can this medication cause? What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know?

Why is this medication prescribed?

Prevpac (lansoprazole, clarithromycin, and amoxicillin) is used to treat Helicobacter pylori infections associated with ulcers. Each daily administration pack contains a single day's dose of lansoprazole, clarithromycin, and amoxicillin.

How should this medicine be used?

Prevpac comes as an individual card containing a single day's dose of lansoprazole (two capsules), clarithromycin (two tablets), and amoxicillin (four capsules). You should take one lansoprazole capsule, one clarithromycin tablet, and two amoxicillin capsules twice a day. The individual dosing cards are supplied in boxes of 14 cards, which will give you a 2-week supply of medication. The tablets and capsules should be taken by mouth. All three medications can be taken at the same time. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take the medication in Prevpac exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

What special precautions should I follow?

Before taking Prevpac,

tell your doctor and pharmacist if you are allergic to amoxicillin, azithromycin (Zithromax), clarithromycin (Biaxin), dirithromycin (Dynabac), erythromycin, lansoprazole (Prevacid), penicillin, or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially allopurinol (Lopurin, Zyloprim), other antibiotics, anticoagulants ('blood thinners') such as warfarin (Coumadin), astemizole (Hismanal), carbamazepine (Tegretol), cisapride (Propulsid), cyclosporine (Neoral, Sandimmune), digoxin (Lanoxin, Lanoxicaps), dihydroergotamine (D.H.E. 45, Migranol), disopyramide (Norpace), ergotamine, felodipine (Plendil), fluconazole (Diflucan), ketoconazole (Nizoral), lovastatin (Mevacor), oral contraceptives, phenytoin (Dilantin), pimozide (Orap), probenecid (Benemid), sucralfate (Carafate), tacrolimus (Prograf), theophylline (Theo-Dur, Slo-Bid, Slo-Phyllin, others), triazolam (Halcion), zidovudine (Retrovir, AZT), and vitamins.
tell your doctor if you have or have ever had asthma; irregular heartbeats; jaundice or yellowing of the skin or eyes; colitis; stomach problems; or liver or kidney disease.
tell your doctor if you are pregnant, plan to become pregnant or are breast-feeding. If you become pregnant while taking the medications in Prevpac, call your doctor.
if you are having surgery, including dental surgery, tell your doctor or dentist that you take Prevpac.

What special dietary instructions should I follow?

Clarithromycin and amoxicillin may cause an upset stomach. Take your medication doses with food or milk.

What should I do if I forget a dose?

Take the missed dose (one lansoprazole capsule, one clarithromycin tablet, and 2 amoxicillin capsules) as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Although side effects from the medications in Prevpac are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

diarrhea
stomach pain or cramps
vomiting
upset stomach
altered taste sensation
headache
dizziness or lightheadedness
sour stomach

If you experience any of the following symptoms, call your doctor immediately:

swelling of the face, eyes, lips, tongue, arms, or legs
difficulty breathing or swallowing
rash
hives
unusual bleeding or bruising
yellowing of the eyes of skin
dark urine
pale stools
unusual tiredness
vaginal infection

What storage conditions are needed for this medicine?

Keep this medication in the daily packets and storage box they came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Do not let anyone else take your medication. Your prescription is probably not refillable. If you still have symptoms after you finish your prescription, call your doctor.

Last Revised - 01/01/2003

American Society of Health-System Pharmacists, Inc. Disclaimer