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In the U.S.—

Calcibind

• Antiurolithic, calcium calculi

Cellulose sodium phosphate (SELL-u-lose SO-dee-um FOS-fate) is used to prevent the formation of calcium-containing kidney stones. It is used in patients whose bodies absorb too much calcium from their food.

Cellulose sodium phosphate works by combining with the calcium and some other minerals in food. This prevents the calcium from reaching the kidneys where the stones are formed.

Cellulose sodium phosphate is available only with your doctor's prescription, in the following dosage form:

Oral
• Powder for oral suspension (U.S.)

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For cellulose sodium phosphate, the following should be considered:

Allergies—Tell your doctor if you have ever had any unusual or allergic reaction to cellulose sodium phosphate. Also tell your health care professional if you are allergic to any other substances, such as foods, preservatives, or dyes.

Diet—Make certain your health care professional knows if you are on any special diet, such as a low-sodium or low-sugar diet. Also tell your health care professional if your diet contains large amounts of milk or other dairy products, spinach (or other dark green leafy vegetables), chocolate, brewed tea, or rhubarb or if you are taking vitamin C or magnesium supplements.

Pregnancy—Studies have not been done in either humans or animals. However, pregnant women usually need more calcium in their diet, and should not take cellulose sodium phosphate unless it is clearly needed. Be sure you have discussed the risks and benefits with your doctor.

Breast-feeding—It is not known whether cellulose sodium phosphate passes into breast milk. However, this medicine has not been reported to cause problems in nursing babies.

Children—Although there is no specific information comparing use of cellulose sodium phosphate in children with use in any other age group, its use is not recommended in children up to 16 years of age because of the increased need for calcium in growing children.

Older adults—Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of cellulose sodium phosphate in the elderly with use in other age groups.

Other medicines—Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking cellulose sodium phosphate, it is especially important that your health care professional know if you are taking any of the following:

• Calcium supplements, or calcium containing antacids or laxatives—Use may lead to too much calcium in the body, preventing the cellulose sodium phosphate from working properly

• Magnesium supplements, or magnesium containing antacids or laxatives—Cellulose sodium phosphate and magnesium should not be taken within 1 hour of each other

Other medical problems—The presence of other medical problems may affect the use of cellulose sodium phosphate. Make sure you tell your doctor if you have any other medical problems, especially:

• Bone disease—Cellulose sodium phosphate may make the condition worse

• Edema or swelling or
• Heart disease—The high sodium content of cellulose sodium phosphate may cause the body to hold water

• Intestinal problems or
• Parathyroid disease or problems—Cellulose sodium phosphate may increase the risk of bone problems

Take this medicine mixed in a full glass (8 ounces) of water, soft drink, or fruit juice. After drinking all the liquid containing the medicine, rinse the glass with a little more liquid. Drink that also to make sure you get all the medicine.

It is very important that you take cellulose sodium phosphate with meals. If this medicine is taken an hour or more after a meal, it will not work properly.

Take cellulose sodium phosphate only as directed. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects.

Drink at least a full glass (8 ounces) of water, a soft drink, or fruit juice every hour while you are awake, unless otherwise directed by your doctor. This also will help prevent kidney stones while you are taking cellulose sodium phosphate.

Dosing—

The dose of cellulose sodium phosphate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of cellulose sodium phosphate. If your dose is different, do not change it unless your doctor tells you to do so.

• To prevent kidney stones:
  • Adults: At first, 10 to 15 grams a day (3.3 to 5 grams three times a day with meals). Then, your doctor may reduce your dose.
  • Children: Use is not recommended.

Missed dose—

If you miss a dose of this medicine, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage—

To store this medicine:

• Keep out of the reach of children.
• Store away from heat and direct light.
• Do not store in the bathroom, near the kitchen sink, or in other damp places. Heat or moisture may cause the medicine to break down.
• Do not keep outdated medicine or medicine no longer needed. Be sure that any discarded medicine is out of the reach of children.

It is important that your doctor check your progress at regular visits. This is to make sure cellulose sodium phosphate is working properly and does not cause unwanted effects.

If you are taking a magnesium supplement, take it at least one hour before or after you take cellulose sodium phosphate. Otherwise, the magnesium may combine with this medicine and keep it from working properly.

Do not take vitamin C, or eat spinach (or other dark green leafy vegetables), chocolate, brewed tea, or rhubarb while you are taking cellulose sodium phosphate. They may increase the chance of kidney stones.

Do not drink milk or eat milk products (for example, cheese, ice cream, and yogurt) while you are taking this medicine, because dairy products are high in calcium. Drinking milk or eating milk products may keep cellulose sodium phosphate from working properly.

While you are taking cellulose sodium phosphate, do not eat salty foods or use extra salt on foods. To do so may increase the chance of unwanted effects.

For patients on a low-sodium diet:

• This medicine contains sodium. If you have any questions about this, check with your health care professional.

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

• With long-term use
  • Convulsions (seizures);  drowsiness;  loss of appetite;  mood or mental changes ;  muscle spasms or twitching;  nausea or vomiting;  trembling;  unusual tiredness or weakness 
  
  

Other side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. However, check with your doctor if any of the following side effects continue or are bothersome:

• More common
  • Abdominal or stomach discomfort;  loose bowel movements or diarrhea 
  
  

Other side effects not listed above may also occur in some patients. If you notice any other effects, check with your doctor.