MedlinePlus Drug Information: Mesoridazine Oral

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Other drug names:	A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9

Mesoridazine Oral

(mez oh rid' a zeen)

Brand name(s): Serentil

Contents of this page:
Why is this medication prescribed? How should this medicine be used? Other uses for this medicine What special precautions should I follow? What special dietary instructions should I follow?	What should I do if I forget a dose? What side effects can this medication cause? What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know?

IMPORTANT WARNING:

Mesoridazine can cause life-threatening irregular heartbeats. You should only take mesoridazine if your schizophrenia has not responded to other medications. If you experience the following symptom, call your doctor immediately: fast, irregular, or pounding heartbeats. Talk to your doctor about the risks of taking mesoridazine.

Why is this medication prescribed?

Mesoridazine is used to treat the symptoms of schizophrenia and reduce restlessness, anxiety, and tension. It also can reduce hyperactivity and uncooperativeness.

How should this medicine be used?

Mesoridazine comes as a tablet and liquid concentrate to take by mouth. It usually is taken two or three times a day. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take mesoridazine exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

The liquid concentrate must be diluted before use. It comes with a specially marked dropper for measuring the dose. Ask your pharmacist to show you how to use the dropper if you have difficulty. To dilute the liquid concentrate, add it to at least 2 ounces of water, orange juice, or grape juice before taking it. If any of the juice gets on the dropper, rinse the dropper with tap water before replacing it in the bottle. Do not allow the liquid concentrate to touch your skin or clothing; it can irritate your skin. If you spill the liquid concentrate on your skin, wash it off immediately with soap and water.

Continue to take mesoridazine even if you feel well. Do not stop taking mesoridazine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor probably will decrease your dose gradually. This drug must be taken regularly for a few weeks before its full effect is felt.

Other uses for this medicine

This medication should not be prescribed for other uses; ask your doctor or pharmacist for more information.

What special precautions should I follow?

Before taking mesoridazine,

tell your doctor and pharmacist if you are allergic to mesoridazine or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially antacids, antihistamines, appetite reducers (amphetamines), benztropine (Cogentin), bromocriptine (Parlodel), carbamazepine (Tegretol), dicyclomine (Bentyl), fluoxetine (Prozac), guanethidine (Ismelin), lithium, medications for colds, medications for depression, meperidine (Demerol), methyldopa (Aldomet), phenytoin (Dilantin), propranolol (Inderal), quinidine, sedatives, trihexyphenidyl (Artane), valproic acid (Depakane), and vitamins.
tell your doctor if you have or have ever had depression; seizures; shock therapy; asthma; emphysema; chronic bronchitis; problems with your urinary system or prostate; glaucoma; history of alcohol abuse; thyroid problems; angina; irregular heartbeat; problems with your blood pressure; blood disorders; or blood vessel, heart, kidney, liver, or lung disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking mesoridazine, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking mesoridazine.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Mesoridazine may make your skin sensitive to sunlight.

What special dietary instructions should I follow?

Mesoridazine may cause an upset stomach. Take mesoridazine with food or milk.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it and take any remaining doses for that day at evenly spaced intervals. However, if you remember a missed dose when it is almost time for your next scheduled dose, skip the missed dose. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Side effects from mesoridazine are common. Your urine may turn pink or reddish-brown; this effect is not harmful. Tell your doctor if any of these symptoms are severe or do not go away:

drowsiness
dry mouth
upset stomach
vomiting
diarrhea
constipation
restlessness
headache
weight gain

If you experience any of the following symptoms or the one listed in the IMPORTANT WARNING section, call your doctor immediately:

dizziness or seizures
lightheadedness or fainting
tremor
jaw, neck, or back muscle spasms
restlessness or pacing
fine worm-like tongue movements
unusual face, mouth, or jaw movements
shuffling walk
slow, jerky movements
seizures or convulsions
difficulty urinating or loss of bladder control
eye pain or discoloration
difficulty breathing or fast breathing
skin rash
yellowing of the skin or eyes

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Protect the liquid from light. Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to mesoridazine.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Last Revised - 01/01/2003

American Society of Health-System Pharmacists, Inc. Disclaimer