MedlinePlus Drug Information: Riluzole

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Other drug names:	A-Am An-Az B C-Ch Ci-Cz D-Dh Di-Dz E F G H I-J K-L M-Mh Mi-Mz N-Nh Ni-Nz O P-Pl Pm-Pz Q-R S-Sn So-Sz T-To Tp-Tz U-V W-Z 0-9

Riluzole

(ril' yoo zole)

Brand name(s): Rilutek

Contents of this page:
Why is this medication prescribed? How should this medicine be used? What special precautions should I follow? What special dietary instructions should I follow? What should I do if I forget a dose?	What side effects can this medication cause? What storage conditions are needed for this medicine? In case of emergency/overdose What other information should I know?

Why is this medication prescribed?

Riluzole is used to slow the progress of amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease). The drug also may delay the need for a tracheostomy (breathing tube), but it is not a cure for ALS.

This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

How should this medicine be used?

Riluzole comes as a tablet to take by mouth. It usually is taken twice a day, every 12 hours. You should take it at the same time each day (usually in the morning and in the evening). Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take riluzole exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Riluzole slows progression of ALS but does not cure it. Continue to take riluzole even if you feel well. Do not stop taking riluzole without talking to your doctor.

What special precautions should I follow?

Before taking riluzole,

tell your doctor and pharmacist if you are allergic to riluzole or any other drugs.
tell your doctor and pharmacist what prescription and nonprescription medications you are taking, especially amitriptyline (Elavil), caffeine-containing products, ciprofloxacin (Cipro), ofloxacin (Floxin), omeprazole (Prilosec), rifampin (Rifadin), theophylline (Theo-Dur), and vitamins.
tell your doctor if you have or have ever had blood disorders or anemia or kidney or liver disease.
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking riluzole, call your doctor.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking riluzole.
you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you.
remember that alcohol can add to the drowsiness caused by this drug.
tell your doctor if you use tobacco products. Cigarette smoking may decrease the effectiveness of this drug.

What special dietary instructions should I follow?

Take riluzole on an empty stomach (1 hour before or 2 hours after meals). Do not drink or eat a lot of caffeine-containing products, such as coffee, tea, cola, or chocolate. Avoid eating charcoal-broiled foods.

What should I do if I forget a dose?

Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.

What side effects can this medication cause?

Although side effects from riluzole are not common, they can occur. Tell your doctor if any of these symptoms are severe or do not go away:

dizziness
tiredness
upset stomach
stomach pain
diarrhea
muscle weakness or aches
loss of appetite
headache

If you experience any of the following symptoms, call your doctor immediately:

difficulty breathing
fever
depression

What storage conditions are needed for this medicine?

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature, away from light and excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

In case of emergency/overdose

In case of overdose, call your local poison control center at 1-800-222-1222. If the victim has collapsed or is not breathing, call local emergency services at 911.

What other information should I know?

Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests to check your response to riluzole.

Riluzole can affect your body's ability to fight infection. If you have any illness, especially one with a fever, call your doctor.

Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription.

Last Revised - 01/01/2003

American Society of Health-System Pharmacists, Inc. Disclaimer