RATIONALE: Nutritional supplements may help prevent loss of appetite, weight loss, and fatigue in patients with advanced cancer.

PURPOSE: Randomized phase III trial to compare the effectiveness of two nutritional supplements in preventing loss of appetite, weight loss, and fatigue in patients who have stage III or stage IV solid tumors.

Condition	Treatment or Intervention	Phase
adult solid tumor Cachexia Lymphoma	Drug: Juven  Procedure: anticachectic therapy  Procedure: biologically based therapies  Procedure: cancer prevention intervention  Procedure: complementary and alternative therapy  Procedure: nutritional supplementation  Procedure: nutritional support  Procedure: supportive care/therapy	Phase III

OBJECTIVES:

• Compare the change in lean body mass of patients treated with Juven® vs a non-Juven® supplement.
• Compare the change in fatigue and quality of life of patients treated with these supplements.
• Compare the results of plethysmography, bioimpedance, and skinfold measurement in patients treated with these supplements.
• Compare the weight change in patients treated with these supplements.

OUTLINE: This is a randomized, double-blind, multicenter study. Patients are stratified according to primary disease site (lung vs others), concurrent chemotherapy (yes vs no), evidence of metastases (yes vs no), and degree of weight loss (2-5% vs 6-10%). Patients are randomized to 1 of 2 treatment arms.

• Arm I: Patients receive oral Juven® supplement twice daily for 8 weeks.
• Arm II: Patients receive oral non-Juven® supplement twice daily for 8 weeks. All patients undergo lean body mass measurement (to include multiple body composition and weight change) and fatigue and quality of life assessments at baseline and then at 4 and 8 weeks.

PROJECTED ACCRUAL: A total of 468 patients (234 per treatment arm) will be accrued for this study within 16 months.

Ages Eligible for Study:  17 Years and above,  Genders Eligible for Study:  Both

Criteria

DISEASE CHARACTERISTICS:

• Histologically or cytologically confirmed solid tumor or lymphoma with no leukemic aspect
• Stage III or IV or any other stage associated with current metastatic disease at presentation
• No primary or metastatic brain tumors
• Weight loss of at least 2% but no more than 10% within the past 3 months
• No ascites

PATIENT CHARACTERISTICS: Age

• 17 and over

Performance status

• Zubrod 0-2

Life expectancy

• At least 3 months

Hematopoietic

• Not specified

Hepatic

• Not specified

Renal

• No hypercalcemia

Cardiovascular

• No persistent moderate or severe peripheral edema
• No uncontrolled congestive heart failure

Gastrointestinal

• No enteric fistula
• No concurrent intestinal obstruction
• Prior intestinal obstruction allowed

Other

• Not pregnant or nursing
• Negative pregnancy test
• No uncontrolled infections
• No other serious medical illness
• No metabolic disorder

PRIOR CONCURRENT THERAPY: Biologic therapy

• Not specified

Chemotherapy

• Concurrent chemotherapy allowed

Endocrine therapy

• No dexamethasone as an appetite stimulant
• Intermittent dexamethasone during concurrent chemotherapy allowed

Radiotherapy

• Concurrent radiotherapy allowed

Surgery

• At least 1 week since prior minor surgery
• At least 3 weeks since prior major surgery

Other

• At least 30 days since prior total parenteral nutrition
• No concurrent parenteral feedings
• No concurrent known appetite stimulants (e.g., megestrol or dronabinol)
• No concurrent omega 3 fatty acids or their congeners (e.g., ProSure™)
• No concurrent amino acid supplements
• Concurrent use of other dietary supplements (e.g., Ensure® or Boost) is allowed
• Concurrent enteral feedings via PEG or nasogastric tube are allowed

Alabama
      Comprehensive Cancer Institute, Huntsville,  Alabama,  35801,  United States; Recruiting
      DCH Cancer Treatment Center, Tuscaloosa,  Alabama,  35401,  United States; Recruiting
      MBCCOP - Gulf Coast, Mobile,  Alabama,  36607,  United States; Recruiting
      Montgomery Cancer Center, Montgomery,  Alabama,  36106-3657,  United States; Recruiting
      University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham,  Alabama,  35294-3300,  United States; Recruiting
Arizona
      Foundation for Cancer Research and Education, Phoenix,  Arizona,  85013,  United States; Recruiting
California
      California Cancer Center at Woodward Park Office, Fresno,  California,  93720,  United States; Recruiting
      CCOP - Bay Area Tumor Institute, Oakland,  California,  94609-3305,  United States; Recruiting
      CCOP - Santa Rosa Memorial Hospital, Santa Rosa,  California,  95403,  United States; Recruiting
      City of Hope Comprehensive Cancer Center, Duarte,  California,  91010-3000,  United States; Recruiting
      David Grant Medical Center, Travis Air Force Base,  California,  94535,  United States; Recruiting
      Huntington Cancer Center at Huntington Hospital, Pasadena,  California,  91105,  United States; Recruiting
      Jonsson Comprehensive Cancer Center, UCLA, Los Angeles,  California,  90095-1714,  United States; Recruiting
      Loma Linda University Cancer Institute at Loma Linda University Medical Center, Loma Linda,  California,  92354,  United States; Recruiting
      Mount Diablo Regional Cancer Center, Concord,  California,  94524-4110,  United States; Recruiting
      Naval Medical Center - San Diego, San Diego,  California,  92134-3202,  United States; Recruiting
      O'Connor Hospital, San Jose,  California,  95128,  United States; Recruiting
      Providence Saint Joseph Medical Center - Burbank, Burbank,  California,  91505,  United States; Recruiting
      Radiation Medical Group, Incorporated, San Diego,  California,  92101,  United States; Recruiting
      Radiation Oncology Centers - Sacramento, Sacramento,  California,  95816,  United States; Recruiting
      Robert and Beverly Lewis Family Cancer Care Center at Pomona Valley Hospital Medical Center, Pomona,  California,  91767,  United States; Recruiting
      Saint Agnes Cancer Center, Fresno,  California,  93720,  United States; Recruiting
      St. Joseph's Regional Cancer Center, Stockton,  California,  95204,  United States; Recruiting
      Sutter Health Western Division Cancer Research Group, Greenbrae,  California,  94904,  United States; Recruiting
      Torrance Memorial Medical Center, Torrance,  California,  90505,  United States; Recruiting
      UCSF Comprehensive Cancer Center, San Francisco,  California,  94115,  United States; Recruiting
      USC/Norris Comprehensive Cancer Center and Hospital, Los Angeles,  California,  90033-0804,  United States; Recruiting
      Veterans Affairs Medical Center - Long Beach, Long Beach,  California,  90822,  United States; Recruiting
Colorado
      Memorial Hospital Cancer Center, Colorado Springs,  Colorado,  80909,  United States; Recruiting
      St. Mary's Regional Cancer Center at St. Mary's Hospital and Medical Center, Grand Junction,  Colorado,  81502-1628,  United States; Recruiting
      University of Colorado Cancer Center at University of Colorado Health Sciences Center, Denver,  Colorado,  80010,  United States; Recruiting
Connecticut
      Hospital of Saint Raphael, New Haven,  Connecticut,  06511,  United States; Recruiting
      Yale Comprehensive Cancer Center, New Haven,  Connecticut,  06520-8040,  United States; Recruiting
Delaware
      CCOP - Christiana Care Health Services, Newark,  Delaware,  19713,  United States; Recruiting
District of Columbia
      Sibley Memorial Hospital, Washington,  District of Columbia,  20016,  United States; Recruiting
Florida
      21st Century Oncology - Fort Myers, Fort Myers,  Florida,  33901-8082,  United States; Recruiting
      Baptist-South Miami Regional Cancer Program, Miami,  Florida,  33176-2197,  United States; Recruiting
      Bay Medical Center, Panama City,  Florida,  32401,  United States; Recruiting
      CCOP - Mount Sinai Medical Center, Miami Beach,  Florida,  33140,  United States; Recruiting
      Florida Radiation Oncology Group, Jacksonville,  Florida,  32207,  United States; Recruiting
      Gulf Coast Cancer Treatment Center, Panama City,  Florida,  32405-4587,  United States; Recruiting
      H. Lee Moffitt Cancer Center and Research Institute, Tampa,  Florida,  33612-9497,  United States; Recruiting
      Holmes Regional Medical Center, Melbourne,  Florida,  32901-3276,  United States; Recruiting
      MD Anderson Cancer Center Orlando, Orlando,  Florida,  32806-2134,  United States; Recruiting
      Sarasota Radiation and Medical Oncology Center, Sarasota,  Florida,  34233,  United States; Recruiting
      Shands Cancer Center at the University of Florida Health Science Center, Gainesville,  Florida,  32610-0385,  United States; Recruiting
      Tallahassee Memorial Hospital, Tallahassee,  Florida,  32308,  United States; Recruiting
      University of Miami Sylvester Comprehensive Cancer Center, Miami,  Florida,  33136,  United States; Recruiting
Georgia
      CCOP - Atlanta Regional, Atlanta,  Georgia,  30342-1701,  United States; Recruiting
      Medical Center/John B. Amos Community Cancer Center, Columbus,  Georgia,  31901,  United States; Recruiting
      Regional Radiation Oncology Center at Rome, Rome,  Georgia,  30165,  United States; Recruiting
      Winship Cancer Institute of Emory University, Atlanta,  Georgia,  30322,  United States; Recruiting
Hawaii
      MBCCOP - Hawaii, Honolulu,  Hawaii,  96813,  United States; Recruiting
Illinois
      Cardinal Bernardin Cancer Center at Loyola University Medical Center, Maywood,  Illinois,  60153,  United States; Recruiting
      CCOP - Central Illinois, Decatur,  Illinois,  62526,  United States; Recruiting
      Ingalls Memorial Hospital, Harvey,  Illinois,  60426,  United States; Recruiting
      Lutheran General Cancer Care Center, Park Ridge,  Illinois,  60068,  United States; Recruiting
      Methodist Medical Center of Illinois, Peoria,  Illinois,  61636,  United States; Recruiting
      Northwest Community Hospital, Arlington Heights,  Illinois,  60005,  United States; Recruiting
      Robert H. Lurie Comprehensive Cancer Center at Northwestern University, Chicago,  Illinois,  60611-3013,  United States; Recruiting
Indiana
      Ball Memorial Hospital Cancer Center, Muncie,  Indiana,  47303-3499,  United States; Recruiting
      Bloomington Hospital, Bloomington,  Indiana,  47402,  United States; Recruiting
      CCOP - Northern Indiana CR Consortium, South Bend,  Indiana,  46601,  United States; Recruiting
      Community Regional Cancer Care, Indianapolis,  Indiana,  46219,  United States; Recruiting
      Methodist Cancer Center at Methodist Hospital, Indianapolis,  Indiana,  46206-1367,  United States; Recruiting
      Oncology Institute of Greater Lafayette, Lafayette,  Indiana,  47904,  United States; Recruiting
      St. John's Cancer Center at St. John's Medical Center, Anderson,  Indiana,  46016,  United States; Recruiting
      Veterans Affairs Medical Center - Indianapolis (Roudebush), Indianapolis,  Indiana,  46202,  United States; Recruiting
Iowa
      Wendt Regional Cancer Center of Finley Hospital, Dubuque,  Iowa,  52001,  United States; Recruiting
Kentucky
      Cancer Center at Lexington Clinic, Lexington,  Kentucky,  40504,  United States; Recruiting
      Central Baptist Hospital, Lexington,  Kentucky,  40503,  United States; Recruiting
      Esther Marie Hatton Cancer Care Center at St. Elizabeth Medical Center, Edgewood,  Kentucky,  41017,  United States; Recruiting
      James Graham Brown Cancer Center at University of Louisville, Louisville,  Kentucky,  40202,  United States; Recruiting
      Louisville Radiation Oncology Center at Caritas Regional Cancer Center, Louisville,  Kentucky,  40215,  United States; Recruiting
      Markey Cancer Center at University of Kentucky Chandler Medical Center, Lexington,  Kentucky,  40536-0293,  United States; Recruiting
      Merle M. Mahr Cancer Center at Regional Medical Center of Hopkins County, Madisonville,  Kentucky,  42431,  United States; Recruiting
Louisiana
      CCOP - Ochsner, New Orleans,  Louisiana,  70121,  United States; Recruiting
      Mary Bird Perkins Cancer Center, Baton Rouge,  Louisiana,  70809,  United States; Recruiting
      MBCCOP - LSU Health Sciences Center, New Orleans,  Louisiana,  70112,  United States; Recruiting
      Tulane Cancer Center at Tulane University Hospital and Clinic, New Orleans,  Louisiana,  70112-2699,  United States; Recruiting
Maine
      Maine Medical Center, Portland,  Maine,  04102,  United States; Recruiting
Maryland
      Cancer Center at Greater Baltimore Medical Center, Baltimore,  Maryland,  21204,  United States; Recruiting
      DeCesaris Cancer Institute at Anne Arundel Medical Center, Annapolis,  Maryland,  21401,  United States; Recruiting
      Greenebaum Cancer Center at University of Maryland Medical Center, Baltimore,  Maryland,  21201,  United States; Recruiting
      Harbor Hospital Center, Baltimore,  Maryland,  21215-1290,  United States; Recruiting
      Peninsula Regional Medical Center, Salisbury,  Maryland,  21801,  United States; Recruiting
      Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore,  Maryland,  21231-2410,  United States; Recruiting
      Sinai Hospital of Baltimore, Baltimore,  Maryland,  21215,  United States; Recruiting
      St. Agnes Cancer Center, Baltimore,  Maryland,  21229,  United States; Recruiting
Massachusetts
      Cancer Research Center at Boston Medical Center, Boston,  Massachusetts,  02118,  United States; Recruiting
      Cape Cod Hospital, Hyannis,  Massachusetts,  02601,  United States; Recruiting
      Dana-Farber/Harvard Cancer Center at Dana Farber Cancer Institute, Boston,  Massachusetts,  02114,  United States; Recruiting
      NSMC Cancer Center, Peabody,  Massachusetts,  01960,  United States; Recruiting
      South Suburban Oncology Center, Quincy,  Massachusetts,  02169,  United States; Recruiting
      Veterans Affairs Medical Center - Boston (Jamaica Plain), Jamaica Plain,  Massachusetts,  02130,  United States; Recruiting
Michigan
      Barbara Ann Karmanos Cancer Institute, Detroit,  Michigan,  48201,  United States; Recruiting
      CCOP - Beaumont, Royal Oak,  Michigan,  48073-6769,  United States; Recruiting
      CCOP - Kalamazoo, Kalamazoo,  Michigan,  49007-3731,  United States; Recruiting
      CCOP - Michigan Cancer Research Consortium, Ann Arbor,  Michigan,  48106,  United States; Recruiting
      Josephine Ford Cancer Center at Henry Ford Health System, Detroit,  Michigan,  48202,  United States; Recruiting
      McLaren Regional Cancer Center, Flint,  Michigan,  48532-3685,  United States; Recruiting
      MidMichigan Medical Center - Midland, Midland,  Michigan,  48670,  United States; Recruiting
      University of Michigan Comprehensive Cancer Center, Ann Arbor,  Michigan,  48109-0010,  United States; Recruiting
      Upper Michigan Cancer Center at Marquette General Hospital, Marquette,  Michigan,  49855,  United States; Recruiting
      William Beaumont Hospital - Royal Oak, Royal Oak,  Michigan,  48073,  United States; Recruiting
      William Beaumont Hospital - Troy, Troy,  Michigan,  48085,  United States; Recruiting
Minnesota
      CCOP - Metro-Minnesota, Saint Louis Park,  Minnesota,  55416,  United States; Recruiting
      Fairview University Medical Center - University Campus, Minneapolis,  Minnesota,  55455,  United States; Recruiting
      Mayo Clinic Cancer Center, Rochester,  Minnesota,  55905-0001,  United States; Recruiting
Missouri
      CCOP - Cancer Research for the Ozarks, Springfield,  Missouri,  65807,  United States; Recruiting
      CCOP - Kansas City, Kansas City,  Missouri,  64131,  United States; Recruiting
      Ellis Fischel Cancer Center at University of Missouri - Columbia, Columbia,  Missouri,  65203,  United States; Recruiting
      Siteman Cancer Center at Barnes-Jewish Hospital, St. Louis,  Missouri,  63110,  United States; Recruiting
      St. Louis University Hospital Cancer Center, Saint Louis,  Missouri,  63110-0250,  United States; Recruiting
Montana
      CCOP - Montana Cancer Consortium, Billings,  Montana,  59101,  United States; Recruiting
Nebraska
      CCOP - Missouri Valley Cancer Consortium, Omaha,  Nebraska,  68106,  United States; Recruiting
      Methodist Hospital Cancer Center at Nebraska Methodist Hospital - Omaha, Omaha,  Nebraska,  68114-4199,  United States; Recruiting
      UNMC Eppley Cancer Center at the University of Nebraska Medical Center, Omaha,  Nebraska,  68198-7521,  United States; Recruiting
Nevada
      CCOP - Southern Nevada Cancer Research Foundation, Las Vegas,  Nevada,  89106,  United States; Recruiting
New Hampshire
      Elliot Regional Cancer Center, Manchester,  New Hampshire,  03103,  United States; Recruiting
      Norris Cotton Cancer Center at Dartmouth-Hitchcock Medical Center, Lebanon,  New Hampshire,  03756-0002,  United States; Recruiting
New Jersey
      Associated Radiologists, P.A. at Warren Radiation Therapy Center, Warren,  New Jersey,  07059,  United States; Recruiting
      Atlantic City Medical Center, Pomona,  New Jersey,  08240,  United States; Recruiting
      Cancer Institute of New Jersey at Robert Wood Johnson University Hospital, New Brunswick,  New Jersey,  08903,  United States; Recruiting
      Community Medical Center, Toms River,  New Jersey,  08755,  United States; Recruiting
      Fox Chase Cancer Center at St. Francis Medical Center, Trenton,  New Jersey,  08629,  United States; Recruiting
      Fox Chase Virtua Health Cancer Program at Virtua Memorial Hospital, Mount Holly,  New Jersey,  08060,  United States; Recruiting
      John F. Kennedy Medical Center, Edison,  New Jersey,  08818,  United States; Recruiting
      Medical Center of Princeton, Princeton,  New Jersey,  08540,  United States; Recruiting
      Monmouth Medical Center, Long Branch,  New Jersey,  07740-6395,  United States; Recruiting
      Newark Beth Israel Medical Center, Newark,  New Jersey,  07112,  United States; Recruiting
      South Jersey Regional Cancer Center, Millville,  New Jersey,  08332,  United States; Recruiting
      Valley Hospital, Ridgewood,  New Jersey,  07450,  United States; Recruiting
      Veterans Affairs Medical Center - East Orange, East Orange,  New Jersey,  07019,  United States; Recruiting
New Mexico
      Radiation Oncology Associates of Albuquerque, Albuquerque,  New Mexico,  87109,  United States; Recruiting
New York
      Beth Israel Medical Center - Philipps Ambulatory Care Center, New York,  New York,  10003,  United States; Recruiting
      CCOP - North Shore University Hospital, Manhasset,  New York,  11030,  United States; Recruiting
      CCOP - Syracuse Hematology-Oncology Associates of Central New York, P.C., East Syracuse,  New York,  13057,  United States; Recruiting
      Champlain Valley Physicians Hospital Medical Center, Plattsburgh,  New York,  12901-1490,  United States; Recruiting
      Finger Lakes Radiation Oncology Center, Clifton Springs,  New York,  14432,  United States; Recruiting
      Herbert Irving Comprehensive Cancer Center at Columbia University, New York,  New York,  10032,  United States; Recruiting
      James P. Wilmot Cancer Center at University of Rochester Medical Center, Rochester,  New York,  14642,  United States; Recruiting
      Lourdes Regional Cancer Center, Binghamton,  New York,  13905,  United States; Recruiting
      Memorial Sloan-Kettering Cancer Center, New York,  New York,  10021,  United States; Recruiting
      New York Methodist Hospital, Brooklyn,  New York,  11215,  United States; Recruiting
      North Shore Radiation Oncology, Setauket,  New York,  11733,  United States; Recruiting
      Riverhill Radiation Oncology, Yonkers,  New York,  10701,  United States; Recruiting
      SUNY Downstate Medical Center, Brooklyn,  New York,  11203,  United States; Recruiting
      University Hospital at State University of New York - Upstate Medical University, Syracuse,  New York,  13210,  United States; Recruiting
North Carolina
      Batte Cancer Center at Northeast Medical Center, Concord,  North Carolina,  28025,  United States; Recruiting
      CCOP - Southeast Cancer Control Consortium, Goldsboro,  North Carolina,  27534-9479,  United States; Recruiting
      Comprehensive Cancer Center at Wake Forest University, Winston Salem,  North Carolina,  27157-1082,  United States; Recruiting
      Leo W. Jenkins Cancer Center of University Health Systems of Eastern Carolina, Greenville,  North Carolina,  27835-6028,  United States; Recruiting
      Lineberger Comprehensive Cancer Center at University of North Carolina - Chapel Hill, Chapel Hill,  North Carolina,  27599-7295,  United States; Recruiting
North Dakota
      Trinity Cancer Care Center, Minot,  North Dakota,  58701,  United States; Recruiting
Ohio
      Akron City Hospital at Summa Health System, Akron,  Ohio,  44304,  United States; Recruiting
      Akron General's McDowell Cancer Center, Akron,  Ohio,  44302,  United States; Recruiting
      Arthur G. James Cancer Hospital at Ohio State University, Columbus,  Ohio,  43210-1240,  United States; Recruiting
      Cancer Center at Christ Hospital, Cincinnati,  Ohio,  45219,  United States; Recruiting
      CCOP - Columbus, Columbus,  Ohio,  43206,  United States; Recruiting
      CCOP - Dayton, Dayton,  Ohio,  45429,  United States; Recruiting
      CCOP - Toledo Community Hospital, Toledo,  Ohio,  43623-3456,  United States; Recruiting
      Charles M. Barrett Cancer Center at University Hospital, Cincinnati,  Ohio,  45219,  United States; Recruiting
      Cleveland Clinic Taussig Cancer Center, Cleveland,  Ohio,  44195,  United States; Recruiting
      Ireland Cancer Center, Cleveland,  Ohio,  44106-5065,  United States; Recruiting
      Parma Community General Hospital, Parma,  Ohio,  44129,  United States; Recruiting
      University Hospitals of Cleveland, Cleveland,  Ohio,  44106,  United States; Recruiting
Oklahoma
      CCOP - Oklahoma, Tulsa,  Oklahoma,  74136,  United States; Recruiting
      Frank C. Love Cancer Institute at St. Anthony Hospital, Oklahoma City,  Oklahoma,  73102,  United States; Recruiting
      LaFortune Cancer Center at St. John Health System, Tulsa,  Oklahoma,  74104,  United States; Recruiting
      Oklahoma University Medical Center, Oklahoma City,  Oklahoma,  73104,  United States; Recruiting
Oregon
      CCOP - Columbia River Oncology Program, Portland,  Oregon,  97225,  United States; Recruiting
Pennsylvania
      Abington Memorial Hospital, Abington,  Pennsylvania,  19001,  United States; Recruiting
      Abramson Cancer Center at University of Pennsylvania Medical Center, Philadelphia,  Pennsylvania,  19104-4283,  United States; Recruiting
      Albert Einstein Cancer Center, Philadelphia,  Pennsylvania,  19141-3098,  United States; Recruiting
      Allegheny General Hospital, Pittsburgh,  Pennsylvania,  15212,  United States; Recruiting
      CCOP - MainLine Health, Wynnewood,  Pennsylvania,  19096,  United States; Recruiting
      Dale and Frances Hughes Cancer Center at Pocono Medical Center, East Stroudsburg,  Pennsylvania,  18301,  United States; Recruiting
      Delaware County Memorial Hospital, Drexel Hill,  Pennsylvania,  19026,  United States; Recruiting
      Fox Chase Cancer Center, Philadelphia,  Pennsylvania,  19111,  United States; Recruiting
      Geisinger Medical Center, Danville,  Pennsylvania,  17822-2001,  United States; Recruiting
      Hillman Cancer Center at University of Pittsburgh Cancer Institute, Pittsburgh,  Pennsylvania,  15236,  United States; Recruiting
      John and Dorothy Morgan Cancer Center at Lehigh Valley Hospital, Allentown,  Pennsylvania,  18105,  United States; Recruiting
      Kimmel Cancer Center at Thomas Jefferson University - Philadelphia, Philadelphia,  Pennsylvania,  19107-5541,  United States; Recruiting
      Mercy Fitzgerald Hospital, Darby,  Pennsylvania,  19023,  United States; Recruiting
      Mercy Hospital Cancer Center - Scranton, Scranton,  Pennsylvania,  18501,  United States; Recruiting
      Mercy Hospital of Pittsburgh, Pittsburgh,  Pennsylvania,  15219,  United States; Recruiting
      Penn State Cancer Institute at Milton S. Hershey Medical Center, Hershey,  Pennsylvania,  17033-0850,  United States; Recruiting
      Reading Hospital and Medical Center, Reading,  Pennsylvania,  19612-6052,  United States; Recruiting
      St. Luke's Hospital Cancer Center, Bethlehem,  Pennsylvania,  18015,  United States; Recruiting
      Wellspan Health - York Cancer Center, York,  Pennsylvania,  17403,  United States; Recruiting
      Western Pennsylvania Hospital, Pittsburgh,  Pennsylvania,  15224,  United States; Recruiting
      Wilkes-Barre General Hospital, Wilkes Barre,  Pennsylvania,  18764-0001,  United States; Recruiting
Rhode Island
      Roger Williams Medical Center, Providence,  Rhode Island,  02908-4735,  United States; Recruiting
South Carolina
      CCOP - Greenville, Greenville,  South Carolina,  29615,  United States; Recruiting
      CCOP - Upstate Carolina, Spartanburg,  South Carolina,  29303,  United States; Recruiting
South Dakota
      Rapid City Regional Hospital, Rapid City,  South Dakota,  57709,  United States; Recruiting
Tennessee
      Vanderbilt-Ingram Cancer Center at Vanderbilt Medical Center, Nashville,  Tennessee,  37232-5671,  United States; Recruiting
      West Tennessee Cancer Center at Jackson-Madison County General Hospital, Jackson,  Tennessee,  38301,  United States; Recruiting
Texas
      Arlington Cancer Center, Arlington,  Texas,  76012,  United States; Recruiting
      CCOP - Scott and White Hospital, Temple,  Texas,  76508,  United States; Recruiting
      Harrington Cancer Center, Amarillo,  Texas,  79106,  United States; Recruiting
      Joe Arrington Cancer Research and Treatment Center, Lubbock,  Texas,  79410-1894,  United States; Recruiting
      University of Texas - MD Anderson Cancer Center, Houston,  Texas,  77030-4009,  United States; Recruiting
      University of Texas Health Science Center at San Antonio, San Antonio,  Texas,  78284-7811,  United States; Recruiting
      University of Texas Medical Branch, Galveston,  Texas,  77555-0209,  United States; Recruiting
      Wilford Hall Medical Center, Lackland Air Force Base,  Texas,  78236-5300,  United States; Recruiting
Utah
      Dixie Regional Medical Center, Saint George,  Utah,  84770,  United States; Recruiting
      LDS Hospital, Salt Lake City,  Utah,  84143,  United States; Recruiting
      University of Utah Health Sciences Center, Salt Lake City,  Utah,  84132,  United States; Recruiting
      Utah Valley Regional Medical Center - Provo, Provo,  Utah,  84604,  United States; Recruiting
Vermont
      Green Mountain Oncology Group, Bennington,  Vermont,  05201,  United States; Recruiting
      Vermont Cancer Center at University of Vermont, Burlington,  Vermont,  05405-0075,  United States; Recruiting
Virginia
      Bon Secours - St. Mary's Hospital, Richmond,  Virginia,  23226,  United States; Recruiting
      Cancer Center at the University of Virginia, Charlottesville,  Virginia,  22908,  United States; Recruiting
      Massey Cancer Center at Virginia Commonwealth University, Richmond,  Virginia,  23298-0058,  United States; Recruiting
      Naval Medical Center, Portsmouth, Portsmouth,  Virginia,  23708-2197,  United States; Recruiting
      RMH Regional Cancer Center, Harrisonburg,  Virginia,  22801,  United States; Recruiting
Washington
      Cancer Institute at Virginia Mason Medical Center, Seattle,  Washington,  98111,  United States; Recruiting
      Deaconess Medical Center, Spokane,  Washington,  99204,  United States; Recruiting
      Yakima Valley Memorial Hospital, Yakima,  Washington,  98902,  United States; Recruiting
West Virginia
      Schiffler Cancer Center at Wheeling Hospital, Wheeling,  West Virginia,  26003,  United States; Recruiting
Wisconsin
      All Saints Cancer Center at All Saints Healthcare, Racine,  Wisconsin,  53405,  United States; Recruiting
      CCOP - Marshfield Clinic Research Foundation, Marshfield,  Wisconsin,  54449,  United States; Recruiting
      CCOP - St. Vincent Hospital Cancer Center, Green Bay, Green Bay,  Wisconsin,  54301,  United States; Recruiting
      Columbia Hospital, Milwaukee,  Wisconsin,  53211,  United States; Recruiting
      Community Memorial Hospital, Menomonee Falls,  Wisconsin,  53051,  United States; Recruiting
      Gundersen Lutheran Cancer Center at Gundersen Lutheran Medical Center, La Crosse,  Wisconsin,  54601,  United States; Recruiting
      Marshfield Clinic, Marshfield,  Wisconsin,  54449,  United States; Recruiting
      Southern Wisconsin Radiotherapy Center, Madison,  Wisconsin,  53713,  United States; Recruiting
      St. Vincent Hospital, Green Bay,  Wisconsin,  54307-3508,  United States; Recruiting
      University of Wisconsin Comprehensive Cancer Center, Madison,  Wisconsin,  53792,  United States; Recruiting
      Veterans Affairs Medical Center - Milwaukee (Zablocki), Milwaukee,  Wisconsin,  53295,  United States; Recruiting
      Vince Lombardi Cancer Clinic at St. Luke's Medical Center, Milwaukee,  Wisconsin,  53215,  United States; Recruiting
      Waukesha Memorial Hospital Regional Cancer Center, Waukesha,  Wisconsin,  53188,  United States; Recruiting
Canada, Alberta
      Cross Cancer Institute, Edmonton,  Alberta,  T6G 1Z2,  Canada; Recruiting
      Tom Baker Cancer Centre - Calgary, Calgary,  Alberta,  T2N 4N2,  Canada; Recruiting
Canada, New Brunswick
      Doctor Leon Richard Oncology Centre, Moncton,  New Brunswick,  E1C 8X3,  Canada; Recruiting
      Saint John Regional Hospital, Saint John,  New Brunswick,  E2L 4L2,  Canada; Recruiting
Canada, Newfoundland and Labrador
      Newfoundland Cancer Treatment and Research Foundation, St. Johns,  Newfoundland and Labrador,  A1B 3V6,  Canada; Recruiting
Canada, Nova Scotia
      Nova Scotia Cancer Centre, Halifax,  Nova Scotia,  B3H 1V7,  Canada; Recruiting
Canada, Ontario
      Cancer Care Ontario-London Regional Cancer Centre, London,  Ontario,  N6A 4L6,  Canada; Recruiting
      Kingston Regional Cancer Centre, Kingston,  Ontario,  K7L 5P9,  Canada; Recruiting
      Margaret and Charles Juravinski Cancer Centre, Hamilton,  Ontario,  L8V 5C2,  Canada; Recruiting
      Northeastern Ontario Regional Cancer Centre at Regional Hospital of Sudbury Regional Hospital, Sudbury,  Ontario,  P3E 5J1,  Canada; Recruiting
      Ottawa Regional Cancer Centre, Ottawa,  Ontario,  K1H 1C4,  Canada; Recruiting
      Princess Margaret Hospital, Toronto,  Ontario,  M5G 2M9,  Canada; Recruiting
      Regional Cancer Care at Thunder Bay Regional Health Sciences Centre, Thunder Bay,  Ontario,  P7B 6V4,  Canada; Recruiting
      Toronto Sunnybrook Regional Cancer Centre, Toronto,  Ontario,  M4N 3M5,  Canada; Recruiting
Canada, Quebec
      Centre Hospitalier de l'Universite de Montreal, Montreal,  Quebec,  H2L 4MI,  Canada; Recruiting
      Centre Hospitalier Universitaire de Quebec, Quebec City,  Quebec,  G1R 2J6,  Canada; Recruiting
      CHUS-Hopital Fleurimont, Fleurimont,  Quebec,  J1H 5N4,  Canada; Recruiting
      McGill Cancer Centre, Montreal,  Quebec,  H2W 1S6,  Canada; Recruiting
Canada, Saskatchewan
      Allan Blair Cancer Centre at Pasqua Hospital, Regina,  Saskatchewan,  S4T 7T1,  Canada; Recruiting
      Saskatoon Cancer Centre, Saskatoon,  Saskatchewan,  S7N 4H4,  Canada; Recruiting

Study chairs or principal investigators

Lawrence B. Berk, MD, PhD,  Study Chair,  CCOP - Columbus   

Study ID Numbers:  CDR0000269100; RTOG-0122
Record last reviewed:  October 2004
Record first received:  January 27, 2003
ClinicalTrials.gov Identifier:  NCT00053053
Health Authority: Unspecified
ClinicalTrials.gov processed this record on 2004-11-17