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ACTN3 Variants and Athletic Performance
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October 6, 2004
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Reviewed by:
Cynthia Moore
National Center on Birth Defects
and Developmental Disabilities
Muin J. Khoury
Office of Genomics and Disease Prevention,
Centers for Disease Control and Prevention
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Table 1. Assocation of Sprint/Power Ability and ACTN3 Variant
RR |
53 |
130 |
5.4 |
RX |
48 |
226 |
2.8 |
XX |
6 |
80 |
1.0 |
Total |
107 |
436 |
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Table 2. Association of Endurance Ability and ACTN3 Variant
RR |
60 |
130 |
0.5 |
RX |
88 |
226 |
0.7 |
XX |
46 |
80 |
1.0 |
Total |
194 |
436 |
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Table 3. Clinical Validity of ACTN3 Variant for Sprint/Power or Endurance Ability
RR |
53 |
60 |
113 |
RX |
48 |
88 |
136 |
XX |
6 |
46 |
52 |
Total |
107 |
194 |
301 |
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Sensitivity of RR for Sprint/Power trait
Specificity of RR for Sprint/Power trait
PPV of RR for Sprint/Power trait
NPV of RX /XX for Sprint/Power trait
Sensitivity of XX for Endurance trait
Specificity of XX for Endurance trait
PPV of XX for Endurance trait
NPV of RR/RX for Endurance trait |
49.5% (53/107)
69.1% (134/194)
46.9% (53/113)
71.2% (134/188)
23.7% (46/194)
94.4% (101/107)
88.5% (46/52)
40.6% (101/249) |
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