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Gemcitabine, Carboplatin, and Dexamethasone With or Without Rituximab in Treating Patients With Relapsed or Primary Refractory Lymphoma
This study is currently recruiting patients.
Sponsored by: | University of Washington |
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Information provided by: | National Cancer Institute (NCI) |
Purpose
RATIONALE: Drugs used in chemotherapy, such as gemcitabine, carboplatin, and dexamethasone, use different ways to stop cancer cells from dividing so they stop growing or die. Monoclonal antibodies, such as rituximab, can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining chemotherapy with monoclonal antibody therapy may kill more cancer cells.
PURPOSE: Phase II trial to study the effectiveness of combining gemcitabine, carboplatin, and dexamethasone with or without rituximab in treating patients who have relapsed or primary refractory lymphoma.
Condition | Treatment or Intervention | Phase |
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Hodgkin's lymphoma adult T-cell leukemia and lymphoma anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma Cutaneous T-Cell Lymphoma Non-Hodgkin's Lymphoma |
Drug: carboplatin Drug: dexamethasone Drug: gemcitabine Drug: rituximab Procedure: antibody therapy Procedure: biological response modifier therapy Procedure: chemotherapy Procedure: monoclonal antibody therapy |
Phase II |
MedlinePlus related topics: Cancer; Cancer Alternative Therapy; Hodgkin's Disease; Immune System and Disorders; Leukemia, Adult Acute; Leukemia, Adult Chronic; Leukemia, Childhood; Lymphatic Diseases; Lymphoma; Viral Infections
Study Type: Interventional
Study Design: Treatment
Official Title: Phase II Pilot Study of Gemcitabine, Carboplatin, and Dexamethasone With or Without Rituximab in Patients With Relapsed or Primary Refractory Lymphoid Malignancy
OBJECTIVES:
OUTLINE: This is a pilot study. Patients are stratified according to CD20 expression (negative vs positive).
Patients are followed every 6 months for 5 years.
PROJECTED ACCRUAL: Approximately 51 patients will be accrued for this study within 2-3 years.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS: Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Other
PRIOR CONCURRENT THERAPY: Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Location and Contact Information
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
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National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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