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Food and Drug Administration Center for Drug Evaluation and Research

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Common Toxicity Criteria - Standard grades for adverse events

Look up tables in summary format

  • National Cancer Institute (NCI) Common Toxicity Criteria - Versions 3, 2 and 1
  • Link to NCI Common Terminology Criteria for Adverse Events Version 3 web site for more information, additional tools, and tables to download
  • Southwestern Oncology Group (SWOG) Toxicity Criteria
  • Radiation Therapy Oncology Group (RTOG) Radiation Morbidity Criteria
  • World Health Organization (WHO) Toxicity Criteria

More resources under development

Performance Status - Rating scales for patient function

  • Karnofsky score
  • Eastern Cooperative Oncology Group (ECOG) or Zubrod score
  • Lansky score - for children

Disease Staging Manual - Standardized descriptions for staging various malignancies

Calculators

  • Dose Calculator
    This calculator will convert a dose in mg/kg or mg/m2 to a total dose. It will also indicate the equivalent dose for several species of animals. The method to convert a dose from one species to another is to set the dose in mg/m2 the same. As an example, a mouse dose of 50 mg/kg is equivalent to a dose of about 150 mg/m2. To find an equivalent human dose, set the dose to 150 mg/m2 and then read that the equivalent human dose is about 3.5 mg/kg. The weight in kilograms can be adjusted to any value to individualize dosing. The basis for the calculations is the formula mg/m5 = (mg/kg x 100 x kga)/K where K is a different value for each animal species. The weights are entered in kilograms. The estimated surface area is based on the formula BSA = (K x kgb)/100 where K is the same K value as in the previous equation and a different value for each animal species
  • Human Fluid and Caloric Requirements
    This calculator will determine the fluid and calorie requirements for a person who is either active or sedentary based on height and weight (more accurate) or weight. Other parameters such as body mass index and estimated body surface area are also calculated. Weights may be entered in kilograms or pounds and heights may be entered in centimeters or inches. Any combination will work. The "ideal" body weights are from insurance actuarial tables based on height and do not constitute a recommendation.

FDA/Center for Drug Evaluation and Research
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