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Enediynes are naturally occurring molecules commonly called biological warheads for their ability to bind to and split tumor's DNA backbones. A team of undergraduate physical, biological, and computational chemists at New York's Hamilton College have been studying this mechanism in the hopes of making this a more viable cancer treatment. Computations were performed on the National Center for Supercomputing Applications (NCSA) SGI Origin2000 supercomputer, purchased primarily with funds from the National Science Foundation. [Structure comes from R.A. Kumar, N. Ikemoto, and D. J. Portel, J. Mol. Biol, 265 173-186 (1997).] [See also,
Model of Esperamicin A1 Image 1
and
Image 3
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