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Study of Energy Expenditure in Infants With Ventricular Septal Defects
This study is currently recruiting patients.
Sponsored by: | National Center for Research Resources (NCRR) Indiana University
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Information provided by: | National Center for Research Resources (NCRR) |
Purpose
OBJECTIVES:
I. Compare the total daily energy expenditure in infants with ventricular septal defects vs healthy control infants.
Condition |
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Heart Septal Defects, Ventricular |
MedlinePlus related topics: Congenital Heart Disease
Study Type: Observational
Study Design: Natural History
Expected Total Enrollment: 20
Study start: August 1994
PROTOCOL OUTLINE:
Height, weight, and vital signs (including oxygen saturation by pulse oximetry) are measured on Day 1. Resting energy expenditure, oxygen consumption (VO2), carbon dioxide production (VCO2), and resting respiratory exchange quotient (RQ) are measured using open circuit respiratory calorimetry on Day 1. Patients undergo assessment of total daily energy expenditure using the doubly labeled water method comprised of oral deuterium and oral oxygen O 18 with the next scheduled feeding on Day 1. Urine samples are collected prior to isotope administration, then serially for approximately 12 hours after isotope administration on Day 1, and then daily on Days 2-7. These samples are analyzed by mass spectrometry. On Day 1, patients also undergo echocardiogram to confirm size of defect and measure the degree of pulmonary/systemic blood flow ratio and pulmonary artery pressures.
Eligibility
Ages Eligible for Study: 3 Months - 4 Months, Genders Eligible for Study: Both
Accepts Healthy Volunteers
Criteria
PROTOCOL ENTRY CRITERIA:
--Disease Characteristics--
Infants with moderate to large ventricular septal defect (VSD) by most recent echocardiogram who meet the following conditions: no other concurrent heart or lung disease; no chromosomal defects or congenital anomalies
OR
Healthy control infants without VSD who meet the following conditions: clinically well; no heart disease; no chromosomal defects or congenital anomalies
--Prior/Concurrent Therapy--
Surgery: VSD infants -- No prior cardiac surgery or palliative procedures; VSD and control infants -- Greater than 6 weeks since other prior surgery
Other: VSD and control infants: Greater than 6 weeks since prior hospitalization
Location and Contact Information
More Information
U.S. National Library of Medicine, Contact NLM Customer Service | ||||||||||||||
National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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