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High-Dose Radiation Therapy Plus Chemotherapy in Treating Patients With Advanced Nose or Throat Cancer
This study is currently recruiting patients.
Sponsored by: | Memorial Sloan-Kettering Cancer Center |
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Information provided by: | National Cancer Institute (NCI) |
Purpose
RATIONALE: Radiation therapy that delivers a high dose of radiation directly to the tumor may kill more tumor cells and cause less damage to normal tissue. Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining high-dose radiation with chemotherapy may kill more tumor cells.
PURPOSE: Phase I/II trial to study the effectiveness of combining high-dose radiation therapy with chemotherapy in treating patients who have newly diagnosed stage II, stage III, or stage IV nasopharyngeal cancer.
Condition | Treatment or Intervention | Phase |
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stage II lymphoepithelioma of the nasopharynx stage II squamous cell carcinoma of the nasopharynx stage III lymphoepithelioma of the nasopharynx stage III squamous cell carcinoma of the nasopharynx stage IV lymphoepithelioma of the nasopharynx stage IV squamous cell carcinoma of the nasopharynx |
Drug: cisplatin Drug: fluorouracil Procedure: adjuvant therapy Procedure: chemotherapy Procedure: radiation therapy |
Phase I Phase II |
MedlinePlus related topics: Cancer; Cancer Alternative Therapy; Head and Neck Cancer; Throat Disorders
Study Type: Interventional
Study Design: Treatment
Official Title: Phase I/II Study of Dose-Painting Using Intensity Modulated Radiotherapy With Chemotherapy in Patients With Stage II-IVB Nasopharyngeal Cancer
OBJECTIVES:
OUTLINE: Cohorts of 10 patients receive the following treatment to assess for dose-limiting toxicity.
Phase I
Phase II
PROJECTED ACCRUAL: Approximately 10-74 patients (10-20 for phase I and 54 for phase II) will be accrued for this study.
Eligibility
Ages Eligible for Study: 18 Years and above, Genders Eligible for Study: Both
Criteria
DISEASE CHARACTERISTICS:
PATIENT CHARACTERISTICS: Age
Performance status
Life expectancy
Hematopoietic
Hepatic
Renal
Other
PRIOR CONCURRENT THERAPY: Biologic therapy
Chemotherapy
Endocrine therapy
Radiotherapy
Surgery
Location and Contact Information
More Information
Clinical trial summary from the National Cancer Institute's PDQ® database
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National Institutes of Health, Department of Health & Human Services | ||||||||||||||
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