This is a preliminary study to evaluate the possible use of transcranial magnetic stimulation (TMS), together with exercise, for rehabilitation of chronic stroke patients. It will identify the optimum stimulation settings (within the limits of current safety guidelines) to be used in a later rehabilitation study and confirm the safety of the procedure at these settings. Some previous studies using TMS to treat movement disorders such as Parkinson's disease have shown improvement in motor function; others have not. The results of this study may provide information to help researchers design better rehabilitation treatments after stroke.

Stroke patients with residual arm function and no history of seizures may be eligible for this study. The stroke must have occurred at least 6 months before entry into the study and must have affected only one side of the brain.

For the TMS procedure, subjects are seated in a comfortable chair with their hands placed on a pillow on their lap. An insulated wire coil is placed on the scalp. A brief electrical current is passed through the coil, creating a magnetic pulse that stimulates the outer part of the brain, called the cortex. This may cause muscle, hand or arm twitching if the coil is near the part of the brain that controls movement, or it may affect movements or reflexes. Subjects are asked to make movements, do simple tasks, or tense muscles. Metal electrodes are taped to the skin over the muscle for computer recording of the electrical activity of the hand and arm muscles activated by the stimulation. The testing lasts 2-3 hours.

Condition	Treatment or Intervention	Phase
Cerebrovascular Accident	Device: rTMS, Magstim	Phase I

Stroke survivors are often left with permanent physical and mental disabilities that create a major social and economic burden. Many of these patients receive different therapies in an attempt to improve their independence and quality of life. However, most of the current strategies are focused on the acute stage after stroke and are of limited influence in improving stroke outcome. One of the main problems of patients who have suffered a stroke is the difficulty in appropriately using the hand contralateral to the lesioned hemisphere; to date we have no successful means to improve the hand function in chronic stages of stroke. This protocol attempts to address this problem.

A promising technique is repetitive transcranial magnetic stimulation (rTMS) that, so far, has produced some effects on motor function on other movement disorders like Parkinson's disease (PD). We hypothesize that rTMS will have a beneficial effect on motor function in chronic stroke patients. Specifically, we propose to look at the effect of 20 and 25 Hz stimulation since these types of stimulation have been shown to increase the excitability of the cerebral cortex. The purpose of this protocol is to investigate the effect of repetitive transcranial stimulation (rTMS) on the motor cortex of chronic stroke patients and motor function. Four different stimulation parameters within the limits of current safety guidelines will be used. We plan to determine; 1) which rTMS stimulation parameters induce more cortex excitability, 2) whether there is any improvement of hand motor function after rTMS, and 3) if the applied stimulation parameters are safe in chronic stroke patients. The optimal parameters will be subsequently proposed for use in an experimental protocol for rehabilitation.

Genders Eligible for Study:  Both

Criteria

INCLUSION CRITERIA:
Fifteen adult and impaired patients (right or left) with residual arm function who have had a single monohemispheric stroke (documented by CT or MRI) at least 6 months before, without severe proprioceptive deficits, independent of previous physical therapy will be included.
They should be able to perform the pinch task.
Their gender or ethnic origin will not provide bias for inclusion to the study.
All subjects will sign an informed consent prior to participation in the trial.
EXCLUSION CRITERIA:
Exclusion criteria for the trial will include any current medical or surgical condition or neurological or psychiatric illness.
Any individual who is on medication with potential influence on nervous system function such as stimulants, anxiolytics, hypnotics, antipsychotics, antiparkinsonians, antidepressants, and anticonvulsants, who has a pacemaker, an implanted medical pump, a metal plate, a metal plate or metal object in the skull or eye (for example after brain surgery) will be excluded.
Also excluded from the study will be: patients with more than one stroke, patients with large cortical, cerebellar, or brainstem lesions, patients unable to extend metacarpophalangeal (MP) joints at least 10-20 degrees, patients unable to extend the wrist at least 20 degrees, patients with substantially recovered motor function, patients with severe depression, poor motivational capacity, or severe language disturbances, particularly of receptive nature, patients with severe spasticity/pain, patients with bilateral motor problems, patients with serious cognitive deficits (defined as equivalent to a mini-mental state exam score of 20 or less), patients with severe uncontrolled medical problems (e.g. cardiovascular disease, severe rheumatoid arthritis, active joint deformity of arthritic origin, active cancer or renal disease, any kind of end-stage pulmonary or cardiovascular disease, or a deteriorated condition due to age, or others).
Patients with any history of seizure will be excluded.
Patients without any history of seizures, but with any sign of increased cerebral activity in the EEG will be excluded.

Maryland
      National Institute of Neurological Disorders and Stroke (NINDS), 9000 Rockville Pike,  Bethesda,  Maryland,  20892,  United States; Recruiting

Study ID Numbers:  030049; 03-N-0049
Record last reviewed:  October 4, 2004
Last Updated:  October 4, 2004
Record first received:  November 21, 2002
ClinicalTrials.gov Identifier:  NCT00050128
Health Authority: United States: Federal Government
ClinicalTrials.gov processed this record on 2004-11-18