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United States National Library of Medicine National Institutes of Health

Finding aid to the Julius Axelrod Papers, 1915-1998

TABLE OF CONTENTS


Descriptive Summary

Biographical Note

Collection Summary

Index Terms

Administrative Information

Restrictions

Other Descriptive Information

Series Descriptions

Series I. Personal and Biographical, 1953-1994,

Series II. Laboratory Notes and Notebooks, 1946-1971,

Series III. Reprints and Research Publications, 1948-1998,

Series IV. Nobel Prize and Other Awards, 1949-1995,

Series V. Professional Activities and Travel, 1962-1997,

Series VI. Photographs, 1915-1996,

Series VII. Audiovisuals, 1990,

Oversize Materials

 

Archives and Modern Manuscripts Program, History of Medicine Division

Processed by: Aaron D. Purcell and David H. Serlin, Ph.D.

Machine-readable finding aid encoded by John P. Rees


Descriptive Summary

Collection Number:MS C 494
CreatorAxelrod, Julius, 1912-
TitleJulius Axelrod Papers
Dates:1915-1998
Quantity:7.4 linear feet, oversize, loose degrees, awards, and posters
Abstract:The collection consists primarily of materials related to Axelrod's scientific career. The bulk of these materials consists of awards, laboratory notebooks, reprints, and photographs. The collection is especially stong in documenting Axelrod's receipt of the Nobel Prize in 1970. There is little correspondence.

Biographical Note

Julius (Julie) Axelrod was born May 20, 1912, on the lower east side of Manhattan in New York City, the son of Polish immigrants Isadore and Molly Axelrod. Julius' father supported the family as a basketmaker. Axelrod attended Seward Park High School, where he quickly developed an interest in history, literature, and science, and set his sights on medical school. In 1929, Axelrod enrolled in New York City University (NYU). After one year, he transferred to the tuition-free City College of New York (CCNY), which Axelrod later described as a "proletarian Harvard." Axelrod graduated with a Bachelor of Science degree in biology in 1933. He applied to several medical schools, but was not admitted. Reflecting on these rejections, he told a newspaper reporter in 1970 that "It was hard in those days for Jews to get into medical school. I wasn't that good a student, but if my name was Bigelow I probably would have gotten in."

Axelrod also found it difficult to find work in his field, especially in the middle of the Depression. After a brief stint as a laboratory technician at the Harriman Research Laboratory at NYU Medical School, Axelrod found a position in 1935 testing vitamin supplements added to food, particularly milk, for the New York City Department of Health's Laboratory of Industrial Hygiene. Axelrod remained in this position until 1946. During this period, he lost his left eye in a laboratory accident. In 1938, Axelrod married Sally Taub, an elementary school teacher. Over the next decade, the couple had two sons, Paul and Alfred. While working for the Department of Health, Axelrod took night classes at NYU and earned his Master of Science degree in chemistry in 1941 with a thesis on the chemical breakdown of enzymes in cancerous tumor tissues.

In 1946, Axelrod began conducting research on the chemistry of analgesic (pain-relieving) medications with Bernard "Steve" Brodie at Goldwater Memorial Hospital on Welfare (now Roosevelt) Island. He continued to work with Brodie, whom he considered to be his mentor, for the next eight years. Their research together laid the foundation for Axelrod's lifelong enthusiasm for pharmacological science. In 1949, Axelrod accepted a position as a research chemist at the National Heart Institute (NHI), a part of the rapidly expanding National Institutes of Health (NIH) in Bethesda, Maryland. From 1949 to 1955, he pursued many new projects at the NHI that built upon his previous work.

Although Axelrod clearly possessed the requisite skill and scientific expertise to carry out his own research, he knew that without a Ph.D. his opportunities for career advancement were limited. In 1954, Axelrod took a leave of absence from the NIH to attend The George Washington University, where his advisor, George Mandel, permitted him to submit some of his recent NIH laboratory work as the basis for his doctoral dissertation. Now in his early 40s, Axelrod graduated from GWU in 1955 with a Ph.D. in pharmacology after completing his thesis, "The Fate of Phenylisopropylamines."

In 1954, Axelrod was invited to establish a Section on Pharmacology in Edward Evarts's Laboratory of Clinic Science at the NIH's National Institute of Mental Health (NIMH). In 1957, he began his most famous research project, which focused on the activity of neurotransmitter hormones. Axelrod's work enabled researchers during the 1970s to develop a new class of antidepressant medications, selective serotonin reuptake inhibitors (SSRIs). Some commonly known SSRIs include Prozac, Zoloft, and Celexa. Over the next thirty years until his retirement in 1984, he continued to work on a wide array of research projects in pharmacological science.

In 1970, Axelrod, along with Sir Bernard Katz of University College London and Ulf von Euler of the Karolinska Institute in Stockholm, was awarded the Nobel Prize in Medicine or Physiology for "discoveries concerning the humoral transmitters in the nerve terminals and the mechanism for their storage, release and inactivation." Axelrod remained an active researcher, distinguished lecturer, and public scientist throughout the 1970s, garnering numerous honorary degrees and professional awards. In 1984, at the age of 72, he formally retired from the NIMH. In 1996, he was named Scientist Emeritus of the National Institutes of Health.

Brief Chronology

1912 May 30Born, New York City; son of Isadore Axelrod, a basketmaker, and Molly Liechtling Axelrod
1929Enrolls at New York University
1930transfers to City College of New York; studies history, philosophy, literature and biology
1933Receives Bachelor of Science degree in biology, CCNY
1933-1935Laboratory assistant in Harriman Laboratory, NYU Medical School
1935-1946Chemist, Laboratory of Industrial Hygiene, NYC Dept. of Health
1938Marries Sally Taub; 2 children
1941Receives Master of Science degree in chemistry, NYU, after taking post-graduate night courses
1946-1949Research associate with Bernard Brodie at Goldwater Memorial Hospital, Welfare Island, NY
1949-1955Continues work with Brodie at National Institutes of Health
1949-1950Associate chemist, Section on Clinical Pharmacology, NIH
1950-1953Chemist, NIH
1953-1955Senior chemist, NIH
1955Completes doctoral thesis in pharmacology, George Washington University, under George Mandel, The Fate of Phenylisopropylamines"
1954-1984Chief, Section on Pharmacology, Laboratory of Clinical Science, NIH
1958-1961Discovers reuptake action in neurotransmitter norepinephrine
1960-1965Studies pineal gland; develops "melatonin hypothesis"
1967Receives Gairdner Foundation International Award
1970Shares Nobel Prize in Physiology of Medicine with Sir Bernard Katz and Ulf von Euler
1970Member, Pyschopharmacology Study Section, NIH
1984Retires from NIH; continues as Guest Researcher at NIMH, Laboratory of Cell Biology
1987Julius Axelrod Distinguished Lecturer in Neuroscience established at CCNY by Raymond and Beverly Sackler Foundation
1992 Sep. 18One Day Scientific Symposium and 80th Birthday Celebration in Honor of Julie Axelrod
1996Named Scientist Emeritus of NIH

Selected Awards

Akademie der Wissenschaft der DDR, foreign member
Claude Bernard Medal/Professorship, University of Montreal
Bristol-Myers Award for Distinguished Achievement in Neuroscience Research
Stanley R. Dean Research Award, American College of Psychiatrists and the Foundation for Behavioral Sciences
Distinguished Achievement Award, George Washington University
Distinguished Research Award, Association for Research in Nervous and Mental Disease
Distinguished Service Award, U.S. Department of Health, Education, and Welfare
Distinguished Service Award, Modern Medicine Magazine
Albert Einstein Commemorative Award, Albert Einstein College of Medicine, Yeshiva University
Gairdner Foundation Award
Townsend Harris Medal for Distinguished Achievement, CCNY
International Physiological Union Travel Award
A. Ross McIntyre Award, University of Nebraska Medical Center
David Mahoney Institute for the Decade of the Brain Award
National Science Foundation Travel Award
Silver Medallion Award, College of Medicine of the Medical University of South Carolina
Torald Sollmann Award, American Society for Pharmacology and Experimental Therapeutics
Superior Service Award, Department of Health, Education, and Welfare
Rudolph Virchow Medal, Rudolf Virchow Medical Society [NYC]

Editorial Board Service

Circulation Research
Communications in Behavioral Biology
Currents in Modern Biology
International Journal of Psychobiology
Journal of Medicinal Chemistry
Journal of Neurobiology
Journal of Neurochemistry
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
Pharmacological Research Communications
Rassegna di Neurologia Vegetativa

Honorary Degrees

College of the City of New York
George Washington University
Hahnemann University (Philadelphia, PA)
McGill University
Medical College of Pennsylvania
Medical College of Wisconsin (Milwaukee)
New York University
University of Chicago
University of Panama
University of Pennsylvania
Ripon College
Tel Aviv University
Universite de Paris-Sud

Lectureships

Julius Axelrod Distinguished Lecture in Neuroscience of the Raymond and Beverly Sackler Foundation, College of the City of New York
British Association of Psychopharmacy
Cass Lecture, Pharmacology and Biochemistry Departments, University of Dundee (Scotland)
Lita Hazen Neuroendocrinology Lecture, Mount Sinai Medical Center (NYC)
Hodge Lecture, Rochester University
John C. Krantz, Jr., Pharmacology and Experimental Therapeutics Lectureship, School of Medicine of the University of Maryland at Baltimore
Paul Lamson Memorial Lecture, Vanderbilt University School of Medicine
Otto Loewi Memorial Lecture, NYU Medical School
Oliver H. Lowry Lecture, Washington University School of Medicine
Medicine of the University of Maryland at Baltimore
Nathanson Memorial Lecture, University of Southern California
NIH Lecture, "The Pineal Gland, a Biological Clock"
Parkinson Lecture, Columbia University
Karl E. Paschkis Memorial Lecture, Philadelphia Endocrine Society
Gregory Pincus Memorial Lecture, Worchester Foundation
Fred J. Robbins Lecturer, Pomona College (Claremont CA)
Royal College Lecturer of the Canadian Psychiatric Association, Royal College of Physicians And Surgeons of Canada
Thomas William Salmon Lecturer, New York Academy of Medicine
Fred W. Schueler Lectureship, Tulane Medical School
Edward E. Smissman Memorial Lecture, University of Kansas, School of Pharmacy
Henry H. Turner Lecture in Endocrinology, Oklahoma Medical Research Foundation
Abraham White Lecturer/Scientific Achievement Award, George Washington University

Memberships

American Academy of Arts and Sciences, fellow
American Association for the Advancement of Science, fellow
American Chemical Society
American College of Neuropsychopharmacology, fellow
American Philosophical Society
American Psychophysiol Association, honorary member
American Society of Biological Chemists
American Society of Pharmacology and Experimental Therapeutics Catecholamine Club
John M. Chermerda Lecture in Science, Pennsylvania State University College of Science
German Pharmacological Society, corresponding member
Institute of Medicine, National Academy of Sciences
International Brain Research Organization
Japanese Pharmacological Society
National Academy of Sciences
Royal Society, foreign member
Sigma Xi
Worldwide Hungarian Medical Academy, honorary member

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Collection Summary

The Julius Axelrod Papers consist of 7.4 linear feet of materials, one oversize box, and a loose collection of degrees, awards, and posters.

The collection consists primarily of materials related to Axelrod's scientific career. The bulk of these materials consist of awards, laboratory notebooks, reprints, and photographs. There are a great number of items related to Axelrod's winning of awards, honorary degrees, memberships, and lectureships. The collection is especially strong in documenting Axelrod's receipt of the Nobel Prize in 1970, including congratulatory correspondence, newspaper clippings, and print ephemera. As evidence of Axelrod's many hours in the laboratory the collection features a run of laboratory notes and notebooks from the late 1940s through the 1960s. Further, the collection boasts a large number of scientific reprints spanning his career. The collection also contains numerous photographs of Axelrod at various conferences and lectures.

The collection contains very little correspondence, either professional or personal. The laboratory notes and notebooks from the 1950s and 1960s comprise a significant part, perhaps 20%, of Axelrod's papers. Almost all the rest of the collection, however, is related in one way or another to his notoriety after receiving the Nobel. The bulk of the materials in the collection thus come from the 1970s through the early 1990s.

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Restrictions

Restrictions

Portions of the collection are restricted. Contact the Reference Staff for information regarding access. For online customer service, please visit http://www.nlm.nih.gov/contacts/custserv-email.html.

Copyright

Copyright has been dedicated to the public domain. Contact the Reference Staff for details regarding rights. For online customer service, please visit http://www.nlm.nih.gov/contacts/custserv-email.html.

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Index Terms

These terms are indexed in the National Library of Medicine's on-line catalog LocatorPlus. Researchers wishing to find related materials should search the catalog using these terms.
MeSH Subjects
Adrenic uptake inhibitors
Amphetamine
Caffeine
Ephedrine
Epinephrine
Lysergic Acid Diethylamide
Mescaline
Molecular Biology
Monoamine Oxidase
Monoamine Oxidase Inhibitors
Morphine
Neurotransmitter Uptake Inhibitors
Nobel Prize
Norepinephrine
Pharmacology
Pineal Body
Receptors, Adrenergic
Receptors, Neurotransmitter
Sympathomimetics
Personal Names
Berliner, Robert W., b. 1915
Brodie, Bernard B.
Euler, Ulf S. von (Ulf Svante), 1905-
Evarts, Edward V.
Glowinski, Jacques
Hertting, Georg
Iversen, Leslie L.
Katz, Bernard, 1911-
Mandel, H. George, b. 1924
Sokoloff, Louis, b. 1921
Synder, Solomon H., b. 1938
Thoenen, H. (Hans)
Wurtman, Richard J., 1936-
Corporate Names
George Washington University
Goldwater Memorial Hospital, New York
International Life Sciences Institute
Interneuron Pharmaceuticals
Karolinska institutet
National Alliance for Research on Schizophrenia and Depression (NARSAD)
National Institutes of Health (U.S.)
New York University
Raymond and Beverly Sackler Foundation, Inc.

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Administrative Information

Alternative Forms Available

Portions of the collection have been digitized and are available at http://profiles.nlm.nih.gov

Preferred Citation

MS C 494, Julius Axelrod Papers, [Series number], Modern Manuscripts Collection, History of Medicine Division, National Library of Medicine.

Provenance

Gift, 1998.

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Series Descriptions

 

Series I. Personal and Biographical, 1953-1994, 0.4 linear feet

Although this series offers few primary accounts of Axelrod's early life and career, secondary biographical sketches and articles cover much of his scientific activities throughout the late 1970's. Just like the Professional Activities and Travel Series, this series only has a small sampling of materials from Axelrod's career during the late-1980's and 1990's. Still, these materials give the researcher good information on Axelrod's entire career, specifically his laboratory work and discoveries, and his winning the Nobel Prize in 1970, which is also documented in the Nobel Prize and Other Awards series.
The first subseries contains biographical materials and essays about Axelrod, while the second features thee samples of Axelrod's writings, including his 1968 book on the Pineal Gland. The rest of his scientific writings are found in the Reprints and Publications series. The third subseries contains numerous articles and clippings devoted to Axelrod at various stages in his life and career. The final subseries of miscellaneous materials features two folders of clippings that cover some of the political issues with which Axelrod became involved following his 1970 receipt of the Nobel Prize.
BoxFolder
I.1 Biographical
11Hugh K. Howerton, Nobelists I Knew 1982
12Leichtling family reunion brochure, 1990 Nov. 2-4
13Scientist and Science Teachers (includes Axelrod biography), 1991
14Axelrod entry for Biographical Dictionary of Nobel Laureates in Physiology and Medicine 1988
15American Immigrant Wall of Honor certificate, Statue of Liberty, Ellis Island Foundation, [n.d.]
16Biographical essays, [n.d.]
I.2 Writings By Julius Axelrod
17Julius Axelrod, By the Year 2000, 1968
18Richard J. Wurtman, Julius Axelrod, and Douglas E. Kelly, The Pineal, 1968
19Julius Axelrod, A Tribute to Bernard Brodie, [n.d.]
I.3 Articles about Julius Axelrod
110Robert Kanigel, "The Mentor Chain," Rensslaer: The Rensslaer Alumni Bulletin Dec. 1981
111Tribute to Julius Axelrod from Congressional Record 30 May 1984
112NIH Record articles, 1953-1970
113Journal/magazine articles 1953-1970
114Journal/magazine articles 1971-1988
115Newspaper clippings 1950-1965
116Newspaper clippings 1967-1974
117Newspaper clippings 1975-1990
118Newspaper clippings [n.d.]
119Newspaper clippings [n.d.]
I.4 Miscellaneous
120Protests and Political Activism by Scientific Community 1971-1975
121Protests and Political Activism by Scientific Community [n.d.]
122Milestones in Chemistry Calendar with Axelrod's 31 May birthday listed 1994
123Greeting cards [n.d.]

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Series II. Laboratory Notes and Notebooks, 1946-1971, 2.0 linear feet

This series contains materials related to Axelrod's laboratory work. The first subseries includes four sets of lab notes from the late 1940's. The second subseries features eighteen clothbound lab notebooks, mostly from the 1950's, but some from the 1960's and 1970's. Each notebook's subject is written on the spine, and many of the experiments are undated. The notebooks document Axelrod's research into how caffeine, LSD, and narcotic drugs affect the central nervous system. Most of the work in these notebooks appears to be in Axelrod's hand, some of which is illegible. Despite their age, these items are in relatively good condition.
BoxFolder
II.1 Laboratory Notes
21Acetophenetidin 1946-47
22Antipyrine, part 1 1947-49
23Antipyrine, part 2 1947-49
24Pharmacological Studies of Acetanilide in Humans 1946
II.2 Notebooks
3volCaffeine, 20 Jan 1950-16 Mar. 1951
3vol.Codeine Ephedrine, ca. 12 Mar. 1950-25 Feb. 1952
3vol.Ephedrine, 18 Sep. 1950-1 Feb. 1952
3vol.Amphetamine Ephedrine II, ca. 10 Apr. [1952]-1 Dec. 1952
4vol.Microsomae Sympatominetics III, ca. 3 Mar. [1953]-17 Aug. 1953
4vol.Microsomal Enzymes Penacetin Morphine, ca. 5 Apr 1954-22 Aug 1956
4vol.I Narcotic Metabolism, [n.d.]
4vol.LSD and Rat, ca. 5 Sep 1954-20 Mar 1958
5vol.I Compt Esterase, ca. Mar-Apr 1957
5vol.Epinephrine Metabolism, ca. 29 Jun 1957-24 May 1958
5vol.Epinephrine Metabolism continued, 28 Aug-23 Sep 1957
5vol.Glucuronide Conjugation ca. 4 June 1958-12 Oct 1962
6vol.Epinephrine Distribution Effect of Drug MHPG, ca. 5 Nov 1958-25 June 1959
6vol.Drugs Histamine DN MT H/DMT, ca. Dec 1959-Aug 1960
6vol.Methylation AME Salivary Oxidase, ca. 25 Feb 1962-1 Jan 1963
7vol.Hydroxy Methylation PCM, ca. 7 May-9 Dec 1964
7vol.Birds and Frogs 1965 Methylation, ca. 26-27 May 1965-29 May 1968
7vol.RBC Methylation Biogenic, ca. 12 Jan 1970-26 July 1971

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Series III. Reprints and Research Publications, 1948-1998, 1.6 linear feet

This series contains reprints from scientific journals and monographs. The first of three subseries consists of Axelrod's reprints. This subseries features both loose and bound reprints. The small collection of loose reprints date between 1948-1990 and is arranged alphabetically by title. Folder titles consist of two article titles, which indicate the alphabetical span of each file. A full listing of reprint citations is contained in Appendix A. The more significant part of the first subseries is bound volumes of Axelrod reprints ranging form 1948-1969. These volumes cover drug metabolism, the pineal gland, adrenaline, noradrenaline, and catecholamines. Nearly complete in their coverage of Axelrod's enormous body of early scientific work, each volume is divided into subjects that are arranged chronologically.
The second subseries contains reprints by others authors that Axelrod collected, arranged first by general subject and then by year. Subjects of these reprints include catecholamine, the pineal gland, and narcotic miscrosomes. Some of these reprints have been marked or annotated by Axelrod or by the article's author. The third subseries consists of miscellaneous figures and charts arranged by subject. The figures were used either as overheads, slides, or diagrams for articles. To avoid further deterioration of some damaged materials, these items were copied and the originals destroyed.
BoxFolder
III.1 Reprints by Axelrod
Loose Reprints
81"Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release," TO "Bradykinin stimulates phosholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts," 19831983
82"Catecholaminergic systems in the brain" TO "Doing research in intramural program at NIH" (1977)(1986)
83"Effect of cocaine on the disposition of noradrenaline labeled with tritium" TO "Inhibition of uptake of tritiated-nonadrenaline in the intact rat brain by imipramine and structurally related compounds" (1960)(1964)
84"Mental illness, drugs, and neurotransmitters" TO "Possible mechanism of tolerance to narcotic drugs" [n.d.](1956)
85"Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase" TO "Regulation of sensitivity to beta-adrenergic stimulation in the rat pineal" (1983)(1978)
86 "The relationship between the stress hormones, catecholamines, acth and glucocorticoids" TO "An unexpected life in research" [n.d.](1988)
Bound Volumes
9vol. Drug Metabolism, Number 1, Sections: Analgesics; Anticoagulants; Ascorbic Acid; Xanthines; Adrenergic Blockers; Sympathomimetic Amines; Lysergic Acid Diethylamide (LSD); Glucuronides; SKF-525A; Microsomal Enzymes; Narcotic Drugs; Methods; Miscellaneous 1948-1962
9vol. Indoles pineal circadian rhythms, Number 6, Sections: Serotonin; Pineal: Melatonin in vivo and in vitro; Pineal: Tissue Culture; Pineal: Neural Control; Tyrosine Transaminase; Miscellaneous 1966-1969
10vol. Adrenaline and other sympathommetic amines, Number 1 [2], Sections: Metabolism in vivo; Metabolism in vitro; Psychological Disposition and Storage; Effect of Drugs; Effect of Hormones 1953-1963
10vol. Storage and metabolism of noradrenaline, Number 3, Sections: Storage and Release; Effects of Drugs; Metabolism; Brain Noradrenaline 1963-1966
11vol.Indoles pineal histamine, Number 4, Sections: Serotonin and Tryptamine; Formation and Metabolism of Melatonin; Actions of Melatonin; Control of Melatonin Synthesis; Serotonin and Adrenaline Rhythms in the Pineal; Histamine; Enzymes; Miscellaneous1959-1966
11vol.Catecholamines, Number 5, Sections: Noradrenaline: Storage and Release; Noradrenaline: Effect of Drugs; Noradrenaline: Extraneuronal Stores; Noradrenaline: Control of Phenylethanolamine-N-Methyl Transferase; Noradrenaline: Effect of Hormones; Hypertension; Monoamine Oxidase 1966-1969
III.2 Reprints by Others
Arranged by Subject
121Acetanilide
122Catecholamine Reviews
123Muscarinic
124Narcotics Microsomes, Drug Met
125Pineal
126Psychopharmacology
127Stress Hormones, Pituitary
Miscellaneous
128Reprints, 1964-68
129Reprints, 1970-1979
1210Reprints, 1980-1992
1211Reprints, 1993-1995
1212Reprints, 1996-1998
III.3 Charts and Figures
1213Adrenaline and Pineal, part 1
1214Adrenaline and Pineal, part 2
1215Drug Metabolism, part 1
1216Drug Metabolism, part 2
1217Pineal and Rhythms
1218Stress Hormones, Pituitary
1219Miscellaneous

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Series IV. Nobel Prize and Other Awards, 1949-1995, 1.0 linear foot

This series covers the numerous awards and professional honors that Axelrod received during his scientific career. Included in these files are correspondence, programs, and printed matter surrounding specific events. The most significant awards include the Nobel Prize (1970), the Gairdner Award (1967), and several important awards from the NIH. Related materials are also found in the Professional Activities and Travel series.
The first subseries covers Axelrod's Nobel Prize award, including correspondence, letters of congratulations and numerous articles and clippings. The second subseries covers awards from the NIH, including awards for government service. The third subseries covers other awards, such as honorary degrees from New York University, George Washington University, the University of Pennsylvania, and various scientific awards such as the Gairdner Award. This subseries also includes academic degrees, lectureship awards, and membership certificates. Photographs from several of the awards ceremonies, including the Nobel, are found in the Photographs series. Some of the larger items such as honorary degrees and certificates are stored with other oversize materials.
BoxFolder
IV.1 Nobel Prize
Official Documentation
131Correspondence with Bernard Katz, 27 Oct 1970
132Nobel Week Correspondence, Oct-Nov 1970
133Award Statement, 11 Dec 1970
Nobel Presentation Materials
134Nobel Acceptance Speech, Stockholm
21Nobel Foundation Portfolio, containing Axelrod's Personal Program and an empty matchbox with picture of the Nobel medal, [ca. 1970]
Nobel Trip, December 1970
135Schedules
136Programs
137Invitations
138Menus
139Seating Charts
1310Stockholm Ephemera
Notes and Letters of Congratulations
1311 15 Oct 1970
1312 16 Oct 1970
1313 17-18 Oct 1970
1314 19-22 Oct 1970
1315 22-30 Oct 1970
1316 Nov-Dec 1970
1317 January 1971
1318 n.d.
NIH Nobel Reception, 3 Nov 1970
1319Invitation
Publicity
1320Press Conference Speech, 1970 Oct
1321Journal/Magazine Articles
1322Newspaper Clippings, part 1
1323Newspaper Clippings, part 2
141Newspaper Clippings, part 3
142Newspaper Clippings, part 4
143Newspaper Clippings, part 5
Other
144Les Prix Nobel en 1970. Edited by W. Odelberg. Stockholm: Nobel Foundation. 1971
145Nobel Stamps
IV.2 National Institutes of Health (NIH) Awards
146Ten Year's Government Service Award, with service pin, 1960 Apr
147NIH Quality Increase, 1967
148Dept. Superior Service Award, NIH, 1968 May
149Distinguished Service Award, 10 Apr 1970
1410Twenty Years' Government Service Award, 1970
1411Meritorious Executive Rank in the Senior Executive Service, 1980
1412NIH Scientist Emeritus, July 1986
1413Preclinical Psychopharmacology Research Review Committee Membership, [n.d.]
IV.3 Other Awards
OversizeDiploma, Seward Park High School, 1929 June
OversizeB.S. Diploma, CUNY City College, 21 June 1933
OversizeM.S. Diploma, New York University, 1941
1414Society of the Sigma Xi, member, 13 May 1949
1415George Washington University, Ph.D., [sheet for award], 15 October 1955
OversizeInternational Congress of Pharmacology Conference, Sao Paulo, Brazil, 28 July 1966
1416University of Chicago, Honorary Degree, 16 December 1966
1417Gairdner Foundation Award, 16 November 1967
1418George Washington University, Alumni Achievement Award, 2 June 1968
1419Modern Medicine Award for Distinguished Achievement, 12 January 1970
1420George Washington University, Honorary Degree, 15 February 1971
1421Columbia University, Parkinson's Disease Award, 28 April 1971
1422American Academy of Arts and Sciences, Fellow, [sheet award] 12 May 1971
1423Montgomery County Chamber of Commerce, National Figure of the Year Award for 1970, 26 May 1971
1424Medical College of Wisconsin, Milwaukee, Honorary Degree, 30 May 1971
1425Election to the National Academy of Sciences, May 1971
1426New York University, Honorary Degree, 7 June 1971
1427Yeshiva University, Albert Einstein Commemorative Awards, 1971
1428M.S. Diploma, New York University, 1941
1428Japanese Pharmacological Society, Foreign Member, 1 April 1972
1429City University of New York, City College, Honorary Degree, [sheet award], 7 October 1972
OversizeJapanese Pharmacological Society, Member, 1972
1430American Society for Pharmacology and Experimental Therapeutics, The Torald Sollmann Award in Pharmacological Investigation and Education, August 1973
OversizeLehman College, CCNY, Biological Science Club, Honorary Member, 1973
OversizeThe College of Medicine of the Medical University of South Carolina, Silver Medallion Award, 17 October 1974
OversizeAmerican College of Clinical Pharmacology, Fellow, 2 May 1975
1431Royal College of Physicians and Surgeons of Canada, Royal College Lecturer of the Canadian Psychiatric Association, 1977
1432Election to the Royal Society, [sheet award], 27 April 1979
OversizeInstitute of Medicine [National Academy of Sciences], Member, 1980
1433Stanley R. Dean Research Award for Schizophrenia, The American College of Psychiatrists and The Fund for the Behavioral Sciences, 18 February 1981
OversizeBritish Association of Psychopharmacy, Lecturer, 3 April 1981
1434University of Nebraska Medical Center, Omaha, A. Ross McIntyre Award, 5 May 1981
1435Universite de Paris-Sud, Honorary Degree, 6 October 1982
OversizeTel Aviv University, Honorary Degree, 1984
1436Akademie der Wissenschaft der DDR, Foreign Member,[sheet award] 1984
OversizeUniversity of Pennsylvania, Honorary Degree, 1986
OversizeHahnemann University (Philadelphia, PA), Honorary Degree, 1987
151McGill University, Honorary Degree, 31 May 1989
152Bristol-Myers Award for Distinguished Achievement in Neuroscience Research, 28 June 1989
153NIMH, David Mahoney Institute for the Decade of the Brain Award, 18 July 1990
154Worldwide Hungarian Medical Academy, Honorary Member, 1990
155American Association for the Advancement of Science, Fellow, 10 February 1992
OversizeAcademia, Medicinae and Psychiatriae Foundation, Honorary Fellow, 1993
156American Philosophical Society, Member, [sheet award], 21 April 1995
157Alpha Omega International Dental Fraternity, Achievement Medal Award, 30 December 1995
158List of awards and award materials housed with oversize materials

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Series V. Professional Activities and Travel, 1962-1997, 0.8 linear feet

This series covers Axelrod's affiliations with various professional organizations and the scientific community. The first subseries consists of Axelrod's correspondence and materials related to various organizations, programs and universities.
Because of their sensitive nature, some files in this series, including peer reviews and recommendations, are restricted.
BoxFolder
V.1 Organizations, Programs and Universities
159 City University of New York, City College, 1971-1989
1510Federation of American Scientists, [n.d.]
1511Hadassah Kadima, Acknowledgement of a Gift in Honor of Julius Axelrod, [n.d.]
1512HSS [Howard S. Shulman] Productions, 1988
1513Institute for Advanced Studies, Immunology and Aging, 1985-1986
1514International Life Sciences Institute, 1966
1515Interneuron Pharmaceuticals, 1989-1996
1516Montgomery County Schools, 1974-1975
[Restricted]
1517National Alliance for Research on Schizophrenia and Depression (NARSAD), 1986-1997
[Restricted]
National Institutes of Health (NIH) and National Institutes of Mental Health (NIMH)
1518NIH Directors, 1966-1974
151920th Anniversary of the NIH Clinical Center, 6 Jul 1973
1520NIMH Board of Scientific Counselors Meeting, 4-5 Nov 1976
1521NIMH Laboratory, 1990-1991
[Restricted]
1522NIH Brochures 4-5 Nov 1976
1523Pennsylvania State University College of Medicine, 1988-1989
1524Raymond and Beverly Sackler Foundation, Inc., 1980-1988
[Restricted]
1525Seward Park High School Alumni Association, 1970
1526Sigma Tau Foundation of Rome, Italy, 1986
V.2 Conferences Attended by Julius Axelrod
1527Lederle Science Lectures, Spring Valley, NY, 15 Feb 1962
1528Association for Research in Nervous and Mental Disease, Annual Meeting, NYC, 3-4 Dec 1965
1529Intramural NIH Lecture, 25 October 1967
1530College of France Conference, Paris, 19 November 1970
1531Bennett Lecture, American Neurological Association, Annual Meeting, 28 December 1970
1532Richerche Institute of Pharmacology, Milan, Italy, 1 February 1971
1533Harold C. Hodge Lecture, University of Rochester, 7 July 1971
1534Virchow Lecture, New York Academy of Medicine, 4 October 1971
1535Thomas William Salmon Lectures, New York City, 1972
1536Fred W. Schueler Lectureship, Tulane University, 29 February 1972
1537Science Seminar Series, Joint Center for Graduate Study, Richland, Washington, 22 March 1972
1538Taylor Manor Hospital Psychiatric Award, Ellicott City, Maryland, 27 April 1972
1539Sesquicentennial Anniversary of the Institute of Living, Hartford, Connecticut, 22-24 May 1972
1540Rosemary Cass Memorial Lectureship, University of Dundee, Scotland, October 1973
1541Symposium on "The Biological Basis of Behavior," Mayo Foundation, Rochester, Minnesota, 16-17 May 1974
1542International Symposium on the Biochemistry of Adenosylmethianine, Rome, Italy 21-25 May 1974
1543Lita Hazen Neuroendocrinolgy Lecture, Mt. Sinai Medical Center, New York City, 20 December 1974
1544John C. Krantz, Jr. Lectureship in Pharmacology and Experimental Therapeutics, University of Maryland at Baltimore, 28 January 1975
1545Henry H. Turner Lecture in Endocrinology, Oklahoma Medical Research Foundation, Oklahoma City, 18 March 1975
1546Fred J. Robbins Lectureship, Pomona College, Claremont, California, 21-24 April 1975
161Meeting of Nobel Laureates, 23-27 June 1975
162Gregory Pincus Memorial Lecturer, Worcester Foundation, Shrewsbury, Massachusetts, 11 November 1976
163Pal Lamson Memorial Lecture, Vanderbilt University, 7 December 1976
164Edward E. Smissman Memorial Lecture Series, University of Kansas, 22 August 1977
165Lorenzini Foundation Lecture, Milan, Italy, 22 February 1978
166Oliver H. Lowry Lecture, Washington University, 7 March 1978
167John M. Chemerda Lectures in Science, Pennsylvania State University, 2 November 1978
168Claude Bernard Colloquium, Paris, 5-7 December 1978
169Joys of Research Colloquium in Honor of Albert Einstein, Smithsonian Institution, Washington, D.C., 16-17 March 1979
1610FIDIA Research Laboratories Conference, Italy, 17 September 1979
1611White House Visit, 20 November 1980
1612Commencement Address, Tel Aviv University, Sackler School of Medicine, New York State Program, 1982
1613Distinguished Lecture Series, Irvine Neuroscience Association, 2 February 1983
1614Biomedical Science Lecture Series, City University of New York, City College, 19 October 1983
1615Symposium Hans Selye, University of Montreal, 21-22 October 1983
1616Julius Axelrod Distinguished Lectures in Neuroscience of the Raymond and Beverly Sackler Foundation, City University of New York, City College, 10 September 1987
1617Nobel Laureate Revisiting Lectures, Karolinska Institute, Stockholm, 1987
1618Distinguished Scientist Lecture Series, Bard College Center, Annandale-on-Hudson, New York, 1987-1988
1619Theodore Koppanyi Lecture, Georgetown University, 23 May 1988
1620Society of Salk Scholars, Scientific Conference, Manhattan, 28 October 1988
1621John C. Krantz, Jr., Distinguished Lecture, Philadelphia College of Pharmacy and Science, 1 December 1988
1622Two Worlds Science Conference, Spoleto Festival, Charleston, South Carolina, 25 May 1991
1623Nobel Jubilee, Stockholm, 4-12 December 1991
1624One Day Scientific Symposium and 80th Birthday in Honor of Julie Axelrod, NIMH, Bethesda, 18 September 1992
1625Louis S. Harris Distinguished Seminars in the Neurosciences, NIMH, Bethesda, 4 October 1993
1626Other Conferences
1627Unidentified Conference Presentation Materials
V.3 Professional Correspondence
1628Correspondence, 1959-1977
1629Correspondence, 1981-1989
1630Correspondence, 1990-1997
1631Correspondence, [n.d.]
V.4 Peer Reviews and Recommendations
1632Peer Reviews, 1957-1987
1633Recommendation letters, 1990's

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Series VI. Photographs, 1915-1996, 1.4 linear feet

This rather extensive series contains photographs and a handful of slides from Axelrod's personal life and professional career. Most of the items in this series are identified by descriptions and/or dates inscribed on the back of the image.
The first subseries contains photographs of Axelrod's personal life and family members; a large number of these are snapshots. The second subseries consists of photographs from Axelrod's professional career, beginning with pictures from the Goldwater Memorial Hospital and the NIH. This subseries also contains numerous conference photographs from the 1960's-1990's showing Axelrod and other attendees, as well as a number of unidentified and undated conference photographs. Some of these conference photographs are part of files from the Conference and Travel series. The third subseries includes photographs from Axelrod's various trips. The locations of these travels are largely identified, but the professional occasions or personal events are not.
BoxFolder
VI.1 Personal
1634Childhood photographs
1635Marriage and family
1636Snapshots, ca. 1960s-1970s
1637Snapshots, November 1970
1638Snapshots, ca. 1970s
1639Snapshots, ca. 1980s
1640Snapshots, ca. 1980s-1990s
VI.2 Professional
Laboratory Work
171Goldwater Memorial Hospital, 1946-1949
172NIH Record Photo Article, 13 Mar 1973
173NIH Laboratory Photographs
Conference Photographs
174Godon Research Conference, 3-7 Aug 1964
175Japan-USA Neurochemistry Conference, 11-16 Oct 1965
176International Symposium on Catecolamine, Milan, Italy, 21 November 1970
177Harold C. Hodge Lecture, University of Rochester, 7 July 1971
178Taylor Manor Hospital Psychiatric Award, Ellicott City, Maryland, 27 April 1972
179Sesquicentennial Anniversary of the Institute of Living, Hartford, Connecticut, 22-24 May 1972
1710Lita Hazen Neuroendocrinology Lecture, Mount Sinai Medical Center, New York City, 1974
1711Clinical Research Institute of Montreal, Mural, October 1975
1712Gregory Pincus Memorial Lecturer Worcester Foundation, Shrewsbury, Massachusetts, 11 November 1976
1713Symposium on the Pineal Gland, Jerusalem, 14-17 November 1977
1714Lorenzini Foundation Lecture, Milan, Italy, 22 February 1978
1715Nobel Symposium 42, Stockholm, Sweden, 8-10 June 1978
1716The College Lectures, NIH, Bethesda, Maryland, 21 June 1978
1717National Academy of Sciences, February 1980
1718White House Visit, 19 November 1980
1719"Corticotrophin-Releasing Factor" Conference, 20-24 February 1984
1720International Life Sciences Institute, Nutritional Foundation, Board of Trustees, January 1987
1721Morris Lipton Reception, University of North Carolina, Chapel Hill, 20 September 1985
1722Georgetown University, Bicentennial Symposium, 22-24 April 1989
1723Hans Selye Symposia of Neuroendocrinology and Stress, Esterel, Quebec, Canada, 13-15 September 1989
1724First International Congress of WHMA, Worldwide Hungarian Medical Academy, Balatonaliga, Hungary, 26-30 May 1992
172580th Birthday Celebration in Honor of Julius Axelrod, NIMH, Bethesda, Maryland, 18 September 1992
1726Lecture at City University of New York, City College, ca. December 1993
Unidentified Conference Photographs
1727Conferences, 1977-1978
1728Conferences, part 1 [n.d.]
1729Conferences, part 2 [n.d.]
1730Conferences, part 3 [n.d.]
1731Conferences, part 4 [n.d.]
1732Conferences, part 5 [n.d.]
Awards Photographs
181Superior Service Award, Dept. of Health, Education and Welfare, 1968
182Nobel Prize Announcement, part 1 15 Oct 1970
183Nobel Prize Announcement, part 2 15 Oct 1970
184Nobel Prize Announcement, part 3 15 Oct 1970
185Nobel Prize Announcement, part 4 15 Oct 1970
186Nobel Prize Announcement, part 5 15 Oct 1970
187Nobel Prize Ceremony, part 1 10 December 1970
188Nobel Prize Ceremony, part 2 10 December 1970
189Nobel Prize Ceremony, part 3 10 December 1970
1810Distinguished Service Award, Department of Health, Education, and Welfare, 1970
1811Twenty Year Government Service Award, with Helen Hunt, 1970
1812George Washington University, Honorary Degree, 15 February 1971
1813Montgomery County Chamber of Commerce, National Figure of the Year Award for 1970, 26 May 1971
1814New York University, Honorary Degree, 7 June 1971
1815Rudolph Virchow Medical Society, Rudolph Virchow Medal, 29 November 1971
1816Medical College of Pennsylvania, Philadelphia, Honorary Degree, 1974
1817University of Nebraska Medical Center, Omaha, A. Ross McIntyre Award, 5 May 1981
1818High School Heart Research Award, Washington, D.C., 7 May 1983
1819Akademie der Wissenchaft der DDR, Foreign Member, 31 October 1984
1820George Washington University, Abraham White Lecturer/Scientific Achievement Award, May 1985
1821McGill University, Honorary Degree, 1989
1822Bristol-Myers Award for Distinguished Achievement in Neuroscience Research, New York City, 28 June 1989
1823David Mahoney Institute for the Decade of the Brain Award, 18 July 1990
1824Unidentified Awards Photographs
Miscellaneous
1825Axelrod with Von Euler, 11 Nov 1970
1826Helen Hunt, ca. 1970
1827Axelrod with Martin Rodbell, ca. 1994
1828Bernard Brodie, [n.d.]
1829Miscellaneous, part 1
1830Miscellaneous, part 2
1831Miscellaneous, part 3
VI.3 Travels
Dated
191Japan, 1972
192Rome, Italy, 1981
193Mantua, Italy, ca. 1982-1983
194Smolenice Castle, Czechoslovakia, May 1983
195Cancun, Mexico, June 1984
196Dallas, June, 1986
197China, ca. 1986
198McGill University, Montreal, Canada, May 1987
199Perguia, Italy, 1988
1910Berlin, Germany, October 1991
1911Stockholm, Sweden, December, 1991
1912Cancun, Mexico, January 1995
1913Long Beach, California, 26-27 February 1996
Undated
1914Rothenberg Ob Den Tauber, Germany
1915University of London, England
1916Budapest, Hungary
1917Tel Aviv University, Israel
1918Abruzzo, Italy
1919Switzerland
1920Lake Placid, New York
1921Galveston, Texas
1922Japan
1923Chapultepec, Mexico

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Series VII. Audiovisuals, 1990, 0.2 linear feet

This series consists of a video interview with Julius Axelrod. The tape contains a biographical account of Axelrod's career, created by the American Association of Neurological Surgeons. This recording contains a biographical interview with Axelrod, discussing his work in psychopharmacology and neuropharmacology. A copy of this videotape is part of the NLM general collection and can also be found at the following location WZ.100 VC no.75.57.
Robert Kanigel, "Julius Axelrod, Ph.D." American Association of Neurological Surgeons, Leaders in Neuroscience Series, number 57,VHS, Time: 1:14:00 ca. 1990,

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Oversize Materials

Oversize materials are items that were too large to house in regular sized Hollinger boxes and are therefore stored separately for preservation considerations. Except for posters, these materials are listed in the finding guide within their appropriate intellectual series and subseries. The materials are kept in a large oversize box, and the posters and other large items are kept loosely. Separation sheets found in relevant folders are used to remind researchers of the existence of oversize materials.
"Mechanisms of Synaptic Regulation. In Recognition of Julius Axelrod." NIMH, Bethesda, MD 31 May-1 June 1984,
Catecholamines and Neurotransmitters Conference, Barcelona, Spain, 1985 (2 posters)
"One Day Scientific Symposium and 80th Birthday Celebration in Honor of Julie Axelrod," NIMH, Bethesda, MD, 18 Sep 1992
Famous Nobel Prize Winners in Chemistry, Physics, and Medicine-Physiology, Historical Documents Company, ca. 1973

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Other Descriptive Information

Reisine TD, Heisler S, Hook VY, Axelrod J. "Activation of beta 2-adrenergic receptors on mouse anterior pituitary tumor cells increases cyclic adenosine 3':5'-monophosphate synthesis and adrenocorticotropin release. " J Neurosci 1983 Apr;3(4):725-32.
Axelrod, J., "Activation and inhibition of adrenaline metabolism. "Nature1959 Dec 26: 2027.
Corda D, Marcocci C, Kohn LD, Axelrod J, Luini A, "Association of the changes in cytosolic Ca2+ and iodide efflux induced by thyrotropin and by the stimulation of alpha 1-adrenergic receptors in cultured rat thyroid cells. "J Biol Chem1985 Aug 5;260(16):9230-6.
Axelrod J, Zatz, M. "The B-adrenergic receptor and the regulation of circadian rhythms in the pineal gland," 249-68, in G. Litwack, ed., Biochemical Actions of Hormones,vol. IV.Academic Press, Press, 1977.
Axelrod J. "Biochemical factors in the activation and inactivation of drugs," 24-34. No Date.
Axelrod J. "Biochemical and pharmacological approaches in the study of sympathetic nerves," 191-208.No Date.
Axelrod J. "Biochemical Pharmacology," 25-37.No Date.
Bareis DL, Manganiello VC, Hirata F, Vaughan M, Axelrod J. "Bradykinin stimulates phospholipid methylation, calcium influx, prostaglandin formation, and cAMP accumulation in human fibroblasts. "Proc Natl Acad Sci U S A. 1983 May;80(9):2514-8.
Axelrod J. "Catecholaminergic systems in the brain. "Acta Neurol Scand Suppl. 1977;64:85-9.
Axelrod J. "Catecholamine neurotransmitters, psychoactive drugs, and biological clocks. The 1981 Harvey Cushing oration. J Neurosurg 1981 Nov;55(5):669-77.
Axelrod, J. "Catecholamines" [encyclopedia article].
Snyder SH, Zweig M, Axelrod J, Fischer JE. "Control of the circadian rhythm in serotonin content of the rat pineal gland. " Proc Natl Acad Sci U S A 1965;53:301-305.
Hook VY, Heisler S, Sabol SL, Axelrod J. "Corticotropin releasing factorstimulates adrenocorticotropin and beta-endorphin release from AtT-20 mouse pituitary tumor cells. " Biochem Biophys Res Commun. 1982 Jun 30;106(4):1364-71.
Axelrod J, Wurtman RJ. Snyder SH. "Control of hydroxyindole o-methyltransferase activity in the rat pineal gland by environmental lighting. "J Biol Chem 1965 Feb; 140(2): 949-54.
Heisler S, Reisine T, Axelrod J. "Desensitization of beta 2-adrenergic receptors and adrenocorticotropin release. " Biochem Biophys Res Commun 1983 Feb 28;111(1):112-9.
Axelrod J, Brady RO, Witkop B, Evarts EV. "The Distribution and metabolism of lysergic acid diethylamide. " Anal NY Acad Sci 1957 March 14;66: 435-44.
Axelrod J. "The discovery of the microsomal drug-metabolizing enzymes. " Trends in Pharmacological Sciences 1982 Oct;10(3): 383-386.
Whitby LG, Hertting G, Axelrod J. "Effect of cocaine on the disposition of noradrenaline labelled wth tritium. " Nature 1960 August 13;187(4737):604-605.
Hertting G, Axelrod J, and Whitby G. "Effect of drugs on the uptake and metabolism of h3-norepinephrine. "J Pharm Exp Ther 1961 Nov;134(2): 146-53.
Axelrod J, Hertting G, Potter L. "Effect of drugs on the uptake and release of 3h-norepinephrine in the rat heart. "Nature 1962 April 21;194:297.
Axelrod J, Whitby LF, Hertting G. "Effect of psychotropic drugs on the uptake of h3-norepinephrine by tissues. "Science 1961 Feb 10;133(3450): 383-84.
Axelrod J. "The enzymatic deamination of amphetamine (benzedrine). "J Biol Chem 1955 June;214(2):753-63.
Axelrod J, Weissbach H. "Enzymatic o-methylation of n-acetylserotonin to melatonin. "Science 29 April 1960;131: 1312.
Brodie B, Axelrod J. "The estimation of acetanilide and its metabolic products, aniline, n-acetyl p-aminophenol and p-aminophenol (free and total conjugated) in biological fluids and tissues. "J Phar Exp Ther 1948 September;94(1):22-28.
Brodie B, Axelrod J. "The fate of acetinilide in man. "J Pharm Exp Ther 1948;94: 29-38.
Axelrod J, Reichenthal J. "The fate of caffeine in man and a method for its estimation of biological materials. " J Pharm Exp Ther 1953;107: 519-23.
Axelrod J. "Following the methyl group," 5-14, in Matthysse, Steven, ed., Psychiatry and the biology of the human brain:A symposium dedicated to Seymour S. Kety.New York:Elsevier North Holland, Inc., 1981
Glowinski J, Axelrod J. "G effects of drugs on the disposition of h3-norepinephrine in the rat brain. "Pharm Reviews 1966;18(1):775-85.
Luini A, Lewis D, Guild S, Corda D, Axelrod J. "Hormone secretagogues increase cytosolic calcium by increasing cAMP in corticotropin-secreting cells.Proc Natl Acad Sci U S A 1985 Dec;82(23):8034-8.
Crews FT, Morita Y, McGivney A, Hirata F, Siraganian RP, Axelrod J. "IgE-mediated histamine release in rat basophilic leukemia cells: receptor activation, phospholipid methylation, Ca2+ flux, and release of arachidonic acid. "Arch Biochem Biophys 1981 Dec;212(2):561-71.
Mezey E, Kiss JZ, Skirboll LR, Goldstein M, Axelrod J. "Increase of corticotropin-releasing factor staining in rat paraventricular nucleus neurones by depletion of hypothalamic adrenaline. " Nature 1984 Jul 12-18;310(5973):140-1.
Axelrod J, Tomchick R. "Increased rate of metabolism of epinephrine and norepinephrine by sympathomimetic amines. " J Pharm Exp Ther 1960 December;130(4): 367-69.
Glowinski J, Axelrod J. "Inhibition of uptake of tritiated-noradrenaline in the intact rat brain by imipramine and structurally related compounds. "Nature 1964 December 26; 204(4965):1318-1319.
Axelrod J. "Mental illness, drugs and neurotransmitters. "Unpublished mss.
Mallorga P, Tallman JF, Henneberry RC, Hirata F, Strittmatter WT, Axelrod J. "Mepacrine blocks beta-adrenergic agonist-induced desensitization in astrocytoma cells. "Proc Natl Acad Sci U S A 1980 Mar;77(3):1341-5.
Axelrod J. "Metabolism of epinephrine and other sympathomimetic amines. " Physiological Revs 1959;39(4): 751-76.
Axelrod J, Brady RO, Witkop B, Evarts EV. "Metabolism of lysergic acid diethylamide. "Nature 1956 July 12;178:143-44.
Reisine T, Heisler S, Hook VY, Axelrod J. "Multireceptor-induced release of adrenocorticotropin from anterior pituitary tumor cells. " Biochem Biophys Res Commun 1982 Oct 15;108(3):1251-7.
Axelrod J. "Neurotransmitters" Scientific American 1974 June; 230(6): 58-71.
Hirata F, del Carmine R, Nelson CA, Axelrod J, Schiffmann E, Warabi A, De Blas AL, Nirenberg M, Manganiello V, Vaughan M, Kumagai S, Green I, Decker JL, Steinberg AD. "Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases. " Proc Natl Acad Sci U S A 1981 May;78(5):3190-4.
Bareis DL, Hirata F, Schiffmann E, Axelrod J. "Phospholipid metabolism, calcium flux, and the receptor-mediated induction of chemotaxis in rabbit neutrophils. " J Cell Biol 1982 Jun;93(3):690-7.
Romero JA, Axelrod J. "Pineal beta-adrenergic receptor: diurnal variation in sensitivity.Science 1974 Jun 7;184(4141):1091-2.
Wurtman RJ, Axelrod J. "The pineal gland. "Scientific American 1965 July; 213(1):50-60.
Axelrod J. "The pineal gland: a neurochemical transducer. " Science 1974 Jun 28;184(144):1341-8.
Axelrod J. "The pineal gland as a neuroendocrine transducer. "Unidentified encyclopedia article.
Axelrod J. "Possible mechanism of tolerance to narcotic drugs. "Science 1956 August 10;124(3215):263-64.
Reisine T, Axelrod J. "Prolonged somatostatin pretreatment desensitizes somatostatin's inhibition of receptor-mediated release of adrenocorticotropin hormone and sensitizes adenylate cyclase. " Endocrinology 1983 Aug;113(2):811-3.
Axelrod J, Weissbach H. "Purification and properties of hydroxyindole-o-methyl transferase. "J Biol Chem 1961 January;236(1):211-13.
Axelrod J. "Receptor-mediated activation of phospholipase A2 and arachidonic acid release in signal transduction. "Biochem Soc Trans 1990 Aug;18(4):503-7.
Glowinski J, Axelrod J, Iversen LL. "Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. " J Pharmacol Exp Ther 1966 Jul;153(1):30-41.
Axelrod J. "Regulation of circadian rhythms of indoleamines in the pineal gland. "Unpublished mss.
Ciaranello RD, Wooten GF, Axelrod J. "Regulation of dopamine b-hydroxylase in rat adrenal glands. " J Biol Chem 1975 April 25;250(8):3204-211.
Axelrod J. "Regulation of neurotransmitter norepinephrine," 863-76, in Schmitt FO, Worden FG, eds. The Neurosciences.Cambridge, Mass:MIT Press, 1974.
Ciaranello RD, Wooten GF, Axelrod J. "Regulation of rat adrenal dopamine beta-hydroxylase. II. Receptor interaction in the regulation of enzyme synthesis and degradation. " Brain Res 1976 Aug 27;113(2):349-62.
Zatz M, Axelrod J. "Regulation of sensitivity to b-adrenergic stimulation in the rat pineal," 47-57, Academic Press, 1978.
Axelrod, J. "The relationship between the stress hormones, catecholamines, acth and glucocorticoids," 3-13.No Date.
Deguchi T, Axelrod J. "Sensitive assay for serotonin N-acetyltransferase activity in rat pineal. " Anal Biochem 1972 Nov;50(1):174-9.
Wurtman RJ, Axelrod J. "A sensitive and specific assay for the estimation of monoamine oxidase. "Biochem Pharmacol 1963;12:1439-41.Current Contents classic citation 1982 July 26;30:18.
Snyder SH, Axelrod J, Zweig M. "A sensitive and specific fluorescence assay for tissue serotonin. "Biochem Pharmacol 1965 May;14(5):831-5.Current Contents classic citation 1983 October 17;42:21.
Axelrod J. "Signal transduction in cloned cholenergic muscarinic receptors. " 28 June 1994, Unpublished MSS
Heisler S, Reisine TD, Hook VY, Axelrod J. "Somatostatin inhibits multireceptor stimulation of cyclic AMP formation and corticotropin secretion in mouse pituitary tumor cells. "Proc Natl Acad Sci U S A 1982 Nov;79(21):6502-6.
Axelrod J, Reisine TD. "Stress hormones: their interaction and regulation. " Science 1984 May 4;224(4648):452-9.
Axelrod J. "Studies on sympathomimetic amines. I. The biotransformation and physiological disposition of l-ephedrine and l-norephedrine. "J Pharm Exp Ther 1953 September;109(1): 62-73.
Axelrod J. "Studies on sympathomimetic amines. II. The biotransformation and physiological disposition of d-amphetamine, d-p-hydroxyamphetamine and d-methamphetamine. " J Pharm Exp Ther 1954 March;110(3): 315-26.
Diliberto DJ Jr, Veiveros OH, Axelrod J. "Subcellular distribution of protein carboxymethylase and its endogenous substrates in the adrenal medulla: possible role in excitation-secretion coupling. "Proc Natl Acad Sci U S A 1976 Nov;73(11):4050-4.
Axelrod J. "An unexpected life in research. "Am Rev Pharmacol Toxicol 1988;28: 1-23.

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Last updated: 21 July 2004
First published: 21 July 2004
Metadata| Permanence level: Permanent: Dynamic Content