Project Number: 6202-32000-014-00
Project Type: Appropriated

Start Date: Jan 03, 2001
End Date: Jan 02, 2006

Objective:
Evaluate cloned cytokines identified in Salmonella enteritidis-immune lymphokine (SILK) in Salmonella poultry model; 2) isolate and functionally analyze the cellular components of the innate host defenses; and 3) identify and produce molecular probes for toll receptors on cells of the innate immune system.

Approach:
We are evaluating the effect of recombinant avian cytokines (p33, IFNgamma, IL-8, IL-18, IL-15) on Salmonella enteritidis organ invasion in day-of-hatch chickens. We are currently developing DNA expression vectors constructed from PCR-generated cDNA of human Toll receptors. These vectors will be used to determine the presence of these receptors on cells of the innate host defenses. Previously was 6202-42000-015-00D (05/01).

Project Team

Kogut, Michael - Mike Genovese, Kenneth He, Haiqi

Project Annual Reports

FY 2003   FY 2002   FY 2001